metronidazole has been researched along with Alveolar Bone Atrophy in 36 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report on the microbiological and clinical effects of mechanical debridement in combination with metronidazole plus amoxicillin therapy in 118 patients with Actinobacillus actinomycetemcomitans-associated periodontitis." | 7.68 | Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. ( de Graaff, J; Tijhof, CJ; van Winkelhoff, AJ, 1992) |
| "Metronidazole is an agent with reported success in the treatment of anaerobic periodontal infections." | 6.67 | Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. ( Giordano, J; Grossman, N; Loesche, WJ, 1993) |
| " With only partial compliance to local debridement, chlorhexidine oral rinses, and systemic metronidazole therapy, alveolar bone loss resulted in tooth mobility necessitating extraction of 2 involved teeth." | 3.70 | Rapid progression of bone loss in HIV-associated necrotizing ulcerative stomatitis. ( McKaig, R; Patton, LL, 1998) |
| "The peripheral distribution of spiramycin and metronidazole, which are combined in the proprietary drug "Rodogyl", has been studied in gingival fluid, saliva and blood after a single administration to 12 healthy volunteers and after repeated administration to 4 patients with recurring severe periodontitis." | 3.69 | Kinetics of spiramycin/metronidazole (Rodogyl) in human gingival crevicular fluid, saliva and blood. ( Cimasoni, G; Le Liboux, A; Pichard, E; Rotzetter, PA, 1994) |
| "We report on the microbiological and clinical effects of mechanical debridement in combination with metronidazole plus amoxicillin therapy in 118 patients with Actinobacillus actinomycetemcomitans-associated periodontitis." | 3.68 | Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. ( de Graaff, J; Tijhof, CJ; van Winkelhoff, AJ, 1992) |
| "Metronidazole is an agent with reported success in the treatment of anaerobic periodontal infections." | 2.67 | Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. ( Giordano, J; Grossman, N; Loesche, WJ, 1993) |
| "Likewise, all three therapies attenuated alveolar bone loss." | 1.51 | Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss. ( Bull, J; Ebbers, MNB; Engelmann, R; Kneitz, S; Kreikemeyer, B; Lang, H; Lübcke, PM; Müller-Hilke, B; Volzke, J, 2019) |
| "Localized aggressive periodontitis is a distinct entity of periodontal disease and is characterized by deep vertical bony defects that typically affect the first molars and incisors of young patients." | 1.35 | Minimally invasive flap surgery and enamel matrix derivative in the treatment of localized aggressive periodontitis: case report. ( Bernimoulin, JP; Friedmann, A; Kaner, D; Kleber, BM, 2009) |
| "Periodontitis is a well-appreciated example of leukocyte-mediated bone loss and inflammation that has pathogenic features similar to those observed in other inflammatory diseases such as arthritis." | 1.33 | RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis. ( Arita, M; Chiang, N; Ebrahimi, N; Hasturk, H; Kantarci, A; Levy, BD; Ohira, T; Petasis, NA; Serhan, CN; Van Dyke, TE, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (41.67) | 18.2507 |
| 2000's | 15 (41.67) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lübcke, PM | 1 |
| Ebbers, MNB | 1 |
| Volzke, J | 1 |
| Bull, J | 1 |
| Kneitz, S | 1 |
| Engelmann, R | 1 |
| Lang, H | 1 |
| Kreikemeyer, B | 1 |
| Müller-Hilke, B | 1 |
| Neering, SH | 1 |
| Adyani-Fard, S | 1 |
| Klocke, A | 1 |
| Rüttermann, S | 1 |
| Flemmig, TF | 1 |
| Beikler, T | 1 |
| Siqueira, SJ | 1 |
| Ribeiro, FV | 1 |
| Villalpando, KT | 1 |
| Cirano, FR | 1 |
| Pimentel, SP | 1 |
| Kaner, D | 1 |
| Bernimoulin, JP | 1 |
| Kleber, BM | 1 |
| Friedmann, A | 1 |
| Cionca, N | 1 |
| Giannopoulou, C | 1 |
| Ugolotti, G | 1 |
| Mombelli, A | 1 |
| Steiger, J | 1 |
| Zeevi, A | 1 |
| Bhola, M | 1 |
| Romeo, E | 1 |
| Lops, D | 1 |
| Storelli, S | 1 |
| Ghisolfi, M | 1 |
| Simonpieri, A | 1 |
| Del Corso, M | 1 |
| Sammartino, G | 1 |
| Dohan Ehrenfest, DM | 1 |
| da Silva, LA | 1 |
| Nelson-Filho, P | 1 |
| da Silva, RA | 1 |
| Flores, DS | 1 |
| Heilborn, C | 1 |
| Johnson, JD | 1 |
| Cohenca, N | 1 |
| Kargül, B | 1 |
| Tanboga, I | 1 |
| Altinok, B | 1 |
| Seremidi, K | 1 |
| Gizani, S | 1 |
| Madianos, P | 1 |
| Loos, BG | 1 |
| Louwerse, PH | 1 |
| Van Winkelhoff, AJ | 3 |
| Burger, W | 1 |
| Gilijamse, M | 1 |
| Hart, AA | 1 |
| van der Velden, U | 1 |
| Hasturk, H | 1 |
| Kantarci, A | 1 |
| Ohira, T | 1 |
| Arita, M | 1 |
| Ebrahimi, N | 1 |
| Chiang, N | 1 |
| Petasis, NA | 1 |
| Levy, BD | 1 |
| Serhan, CN | 1 |
| Van Dyke, TE | 1 |
| Rotzetter, PA | 1 |
| Le Liboux, A | 1 |
| Pichard, E | 1 |
| Cimasoni, G | 1 |
| Sander, L | 2 |
| Frandsen, EV | 2 |
| Arnbjerg, D | 2 |
| Warrer, K | 1 |
| Karring, T | 1 |
| Theilade, E | 1 |
| Loesche, WJ | 4 |
| Grossman, N | 1 |
| Giordano, J | 1 |
| Saxén, L | 2 |
| Asikainen, S | 2 |
| Nieminen, A | 1 |
| Torkko, H | 1 |
| Kari, K | 1 |
| Uitto, VJ | 1 |
| Patton, LL | 1 |
| McKaig, R | 1 |
| Zucchelli, G | 1 |
| Sforza, NM | 1 |
| Clauser, C | 1 |
| Cesari, C | 1 |
| De Sanctis, M | 1 |
| Sculean, A | 2 |
| Donos, N | 2 |
| Blaes, A | 2 |
| Lauermann, M | 1 |
| Reich, E | 2 |
| Brecx, M | 2 |
| Danesh-Meyer, MJ | 1 |
| Persson, LG | 2 |
| Araújo, MG | 1 |
| Berglundh, T | 2 |
| Gröndahl, K | 1 |
| Lindhe, J | 3 |
| Sigusch, B | 1 |
| Pfister, W | 1 |
| Klinger, G | 1 |
| Glockmann, E | 1 |
| Arweiler, N | 1 |
| Serino, G | 1 |
| Rosling, B | 1 |
| Ramberg, P | 1 |
| Hellström, MK | 1 |
| Socransky, SS | 1 |
| Beertsen, W | 1 |
| Piscaer, M | 1 |
| Everts, V | 1 |
| Sennerby, L | 1 |
| Giordano, JR | 2 |
| Soehren, S | 1 |
| Kaciroti, N | 1 |
| Pacheco, JJ | 1 |
| Coelho, C | 1 |
| Salazar, F | 1 |
| Contreras, A | 1 |
| Slots, J | 1 |
| Velazco, CH | 1 |
| Bodur, A | 1 |
| Bodur, H | 1 |
| Bal, B | 1 |
| Baloş, K | 1 |
| Tijhof, CJ | 1 |
| de Graaff, J | 1 |
| Hujoel, P | 1 |
| Schwarcz, J | 1 |
| Smith, BA | 2 |
| Cattabriga, M | 1 |
| Di Murro, C | 1 |
| Paolantonio, M | 1 |
| Schmidt, E | 1 |
| Morrison, EC | 1 |
| Caffesse, R | 1 |
| Hujoel, PP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial[NCT02735395] | Phase 4 | 110 participants (Actual) | Interventional | 2011-07-31 | Active, not recruiting | ||
| Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial[NCT02135952] | Phase 4 | 58 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Alveolar Bone Atrophy
| Article | Year |
|---|---|
General considerations in the treatment of periodontal disease: infection control, medications, and wound healing.
Topics: Alveolar Bone Loss; Dentin Sensitivity; Epithelial Attachment; Humans; Metronidazole; Periodontal Di | 1991 |
14 trials available for metronidazole and Alveolar Bone Atrophy
| Article | Year |
|---|---|
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Use of barrier membranes and systemic antibiotics in the treatment of intraosseous defects.
Topics: Abscess; Absorbable Implants; Adult; Alveolar Bone Loss; Amoxicillin; Biocompatible Materials; Bone | 2002 |
Effect of local metronidazole application on periodontal healing following guided tissue regeneration. Clinical findings.
Topics: Administration, Topical; Adult; Alveolar Bone Loss; Dental Plaque; Female; Gels; Gingival Hemorrhage | 1994 |
Effect of local metronidazole application on periodontal healing following guided tissue regeneration. Microbiological findings.
Topics: Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Colony Co | 1994 |
Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters.
Topics: Alveolar Bone Loss; Colony Count, Microbial; Dental Plaque; Dental Scaling; Double-Blind Method; Fem | 1993 |
Metronidazole in the treatment of localized juvenile periodontitis.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Bone Lo | 1993 |
Value of some laboratory and clinical measurements in the treatment plan for advanced periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Anti-Bacterial Agents; Denta | 1996 |
Topical and systemic antimicrobial therapy in guided tissue regeneration.
Topics: Administration, Topical; Adult; Aged; Alveolar Bone Loss; Amoxicillin-Potassium Clavulanate Combinat | 1999 |
Comparison of enamel matrix proteins and bioabsorbable membranes in the treatment of intrabony periodontal defects. A split-mouth study.
Topics: Absorbable Implants; Alveolar Bone Loss; Amoxicillin; Anti-Infective Agents; Dental Enamel Proteins; | 1999 |
[Adjuvant antibiotic therapy as a 2-step treatment concept in early-onset periodontitis: a strategy for eradication of bacteria that cause periodontitis].
Topics: Administration, Oral; Adolescent; Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria; Chemot | 2000 |
The effect of postsurgical antibiotics on the healing of intrabony defects following treatment with enamel matrix proteins.
Topics: Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bone Substitutes; Den | 2001 |
The nonsurgical treatment of patients with periodontal disease: results after five years.
Topics: Age Factors; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; D | 2002 |
Metronidazole in periodontitis: reduced need for surgery.
Topics: Adult; Alveolar Bone Loss; Bacteria; Bacteroidaceae; Bacteroides; Colony Count, Microbial; Combined | 1992 |
Effects of metronidazole on periodontal treatment needs.
Topics: Alveolar Bone Loss; Bacteria; Dental Plaque; Dental Scaling; Double-Blind Method; Female; Humans; Ma | 1991 |
21 other studies available for metronidazole and Alveolar Bone Atrophy
| Article | Year |
|---|---|
Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss.
Topics: Alveolar Bone Loss; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Chlorhe | 2019 |
Periodontitis associated with plasminogen deficiency: a case report.
Topics: Adolescent; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Conju | 2015 |
Maintenance periodontal therapy after systemic antibiotic and regenerative therapy of generalized aggressive periodontitis. A case report with 10-year follow-up.
Topics: Adult; Aggressive Periodontitis; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Combined Mo | 2015 |
Minimally invasive flap surgery and enamel matrix derivative in the treatment of localized aggressive periodontitis: case report.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Bone Loss; Amoxicil | 2009 |
Aggressive periodontitis: a case report.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Bone Loss; Amoxicillin; An | 2008 |
Clinical peri-implant sounding accuracy in the presence of chronic inflammation of peri-implant tissues. Clinical observation study.
Topics: Alveolar Bone Loss; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Debride | 2009 |
The relevance of Choukroun's platelet-rich fibrin and metronidazole during complex maxillary rehabilitations using bone allograft. Part II: implant surgery, prosthodontics, and survival.
Topics: Alveolar Bone Loss; Alveolar Ridge Augmentation; Anti-Infective Agents, Local; Blood Platelets; Bone | 2009 |
Revascularization and periapical repair after endodontic treatment using apical negative pressure irrigation versus conventional irrigation plus triantibiotic intracanal dressing in dogs' teeth with apical periodontitis.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Anti-Bacterial Agents; Ciprofloxacin; Connective Tiss | 2010 |
Conventional endodontic treatment of primary molars using metronidazole as an intra-canal medicament: a pilot study.
Topics: Abscess; Alveolar Bone Loss; Anti-Infective Agents; Child; Dental Fistula; Dental Pulp Diseases; Fem | 2010 |
Therapeutic management of a case of generalised aggressive periodontitis in an 8-year old child: 18-month results.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Bone Loss; Amoxicillin; An | 2012 |
RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis.
Topics: Administration, Topical; Alveolar Bone Loss; Animals; Eicosapentaenoic Acid; Humans; Inflammation; L | 2006 |
Kinetics of spiramycin/metronidazole (Rodogyl) in human gingival crevicular fluid, saliva and blood.
Topics: Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria; Drug Combinations; Female; Gingival Crev | 1994 |
Rapid progression of bone loss in HIV-associated necrotizing ulcerative stomatitis.
Topics: Adult; AIDS-Related Opportunistic Infections; Alveolar Bone Loss; Anti-Infective Agents; Anti-Infect | 1998 |
Complicated management of a patient with rapidly progressive periodontitis: a case report.
Topics: Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Ciprofloxacin; Dental Scaling; Drug Therapy, Combi | 1997 |
Resolution of peri-implantitis following treatment. An experimental study in the dog.
Topics: Administration, Oral; Administration, Topical; Alveolar Bone Loss; Amoxicillin; Animals; Anti-Bacter | 1999 |
The effect of systemic antibiotics in the treatment of patients with recurrent periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents | 2001 |
Generalized cervical root resorption associated with periodontal disease.
Topics: Acids; Adult; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial | 2001 |
Re-osseointegration after treatment of peri-implantitis at different implant surfaces. An experimental study in the dog.
Topics: Alveolar Bone Loss; Amoxicillin; Animals; Anti-Bacterial Agents; Bone Regeneration; Dental Implantat | 2001 |
Treatment of Papillon-Lefèvre syndrome periodontitis.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti- | 2002 |
Generalized aggressive periodontitis in a prepubertal patient: a case report.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar | 2001 |
Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis.
Topics: Adult; Age Factors; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Bacteroi | 1992 |