Page last updated: 2024-12-11

5'-chloro-5'-deoxyadenosine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5327118
CHEMBL ID404658
CHEBI ID47133
SCHEMBL ID2116089
MeSH IDM0130486

Synonyms (32)

Synonym
adenosine, 5'-chloro-5'-deoxy-
brn 0624885
5'-cida
5'-deoxy-5'-chloroadenosine
5CD ,
5'-chloro-5'-deoxyadenosine
PDSP2_001052
PDSP1_001068
(2r,3r,4s,5s)-2-(6-aminopurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol
(2r,3r,4s,5r)-2-(6-aminopurin-9-yl)-5-(iodomethyl)oxolane-3,4-diol
CHEBI:47133 ,
5'-chloroadenosine
892-48-8
CHEMBL404658
5-deoxy-5-chloroadenosine
C19768
SCHEMBL2116089
AKOS016023925
5'chloro-5'-deoxyadenosine
(2r,3r,4s,5s)-2-(6-amino-9h-purin-9-yl)-5-(chloromethyl) tetrahydrofuran-3,4-diol
IYSNPOMTKFZDHZ-KQYNXXCUSA-N
(2r,3r,4s,5s)-2-(6-amino-9h-purin-9-yl)-5-(chloromethyl)tetrahydrofuran-3,4-diol
mfcd00049038
CS-W000275
(2r,3r,4s,5s)-2-(6-amino-9h-purin-9-yl)-5-(chloromethyl)oxolane-3,4-diol
DS-8004
DTXSID10875948
F12250
Q27120769
AMY25458
5'-chloro-5'-deoxyadenosin
PD070072
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
adenosinesAny purine ribonucleoside that is a derivative of adenosine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
salinosporamide A biosynthesis1129

Bioassays (11)

Assay IDTitleYearJournalArticle
AID317708Inhibition of Escherichia coli DNA methyltransferase at 15 uM after 30 mins2008Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
Activation and inhibition of DNA methyltransferases by S-adenosyl-L-homocysteine analogues.
AID662565Growth inhibition of Trichomonas vaginalis T1 at 100 uM after 24 hrs by hemocytometry2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine.
AID498932Activity at Salinispora tropica CNB-440 wild type recombinant SalL expressed in Escherichia coli BL21(DE3) assessed as formation of S-Adenosyl methionine after 30 mins by HPLC analysis2008Nature chemical biology, Jan, Volume: 4, Issue:1
Discovery and characterization of a marine bacterial SAM-dependent chlorinase.
AID498928Activity at Salinispora tropica CNB-440 recombinant SalL W129F mutant expressed in Escherichia coli BL21(DE3) after 30 mins by HPLC analysis relative to S-Adenosyl methionine2008Nature chemical biology, Jan, Volume: 4, Issue:1
Discovery and characterization of a marine bacterial SAM-dependent chlorinase.
AID317709Inhibition of M.HhaI DNA methyltransferase expressed in ER1727 cells at 15 uM after 30 mins2008Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
Activation and inhibition of DNA methyltransferases by S-adenosyl-L-homocysteine analogues.
AID498934Ratio of Kcat to Km for Salinispora tropica CNB-440 wild type recombinant SalL expressed in Escherichia coli BL21(DE3) for formation of S-Adenosyl methionine2008Nature chemical biology, Jan, Volume: 4, Issue:1
Discovery and characterization of a marine bacterial SAM-dependent chlorinase.
AID498930Activity at Salinispora tropica CNB-440 recombinant SalL Y70T mutant expressed in Escherichia coli BL21(DE3) after 30 mins by HPLC analysis relative to S-Adenosyl methionine2008Nature chemical biology, Jan, Volume: 4, Issue:1
Discovery and characterization of a marine bacterial SAM-dependent chlorinase.
AID498933Effect on Salinispora tropica CNB-440 wild type recombinant SalL expressed in Escherichia coli BL21(DE3)-mediated S-Adenosyl methionine formation after 30 mins by HPLC analysis2008Nature chemical biology, Jan, Volume: 4, Issue:1
Discovery and characterization of a marine bacterial SAM-dependent chlorinase.
AID498927Activity at Salinispora tropica CNB-440 wild type recombinant SalL expressed in Escherichia coli BL21(DE3) after 30 mins by HPLC analysis relative to S-Adenosyl methionine2008Nature chemical biology, Jan, Volume: 4, Issue:1
Discovery and characterization of a marine bacterial SAM-dependent chlorinase.
AID498931Activity at Salinispora tropica CNB-440 recombinant SalL Y70T/G131S mutant expressed in Escherichia coli BL21(DE3) after 30 mins by HPLC analysis relative to S-Adenosyl methionine2008Nature chemical biology, Jan, Volume: 4, Issue:1
Discovery and characterization of a marine bacterial SAM-dependent chlorinase.
AID662566Growth inhibition of Trichomonas vaginalis T1 after 24 hrs by hemocytometry2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (23.53)18.7374
1990's5 (29.41)18.2507
2000's4 (23.53)29.6817
2010's4 (23.53)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.88 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]