Delayed Puberty

The lack of development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations above the mean age at onset of PUBERTY in a population. Delayed puberty can be classified by defects in the hypothalamic LHRH pulse generator, the PITUITARY GLAND, or the GONADS. These patients will undergo spontaneous but delayed puberty whereas patients with SEXUAL INFANTILISM will not.

Synonym
Delayed Puberty
Puberty, Delayed

Excerpt	Reference
"Stunted growth and delayed puberty are conspicuous features of chronic renal failure (CRF)."	( Belgorosky, A; Ferraris, JR; Jasper, H; Ramirez, JA; Rivarola, MA, 1991)
"Delayed puberty is defined as the total or almost total absence of development of sex characteristics at an age exceeding the mean by two standard deviations: approximately 15 years in boys and 13 years in girls."	( Chaussain, JL; Job, JC; Toublanc, JE, 1982)
"Delayed puberty is due to constitutional growth and puberty delay in the vast majority of children."	( Beas, F, 1995)
"Delayed puberty is a very common clinical situation that affects a great number of adolescents."	( Aresté Piztzalis, A; Llop Viñolas, D; Martí-Henneberg, C; Soler Pérez, JL; Vizmanos Lamotte, B, 1999)
"Although delayed puberty is associated with compromised bone mass, suppression of estrogen should be beneficial to cortical strength."	( Yingling, VR, 2009)
"Delayed puberty is diagnosed in the absence of thelarche by 13 y or menarche by 15 y in girls and absence of testicular enlargement by 14 y in boys."	( Mohanraj, S; Prasad, HK, 2023)

Excerpt	Reference
"Thirteen boys who had constitutional delayed puberty (CDP) were treated with a combination of short- and long-acting testosterone esters (testosterone propionate, testosterone phenylpropionate, testosterone isocaproate)."	( Büyükgebiz, A, 1995)
"Third, in 5 boys with constitutionally delayed puberty, im testosterone administration also significantly increased ApEn of 24-h GH time series (P = 0."	( Keenan, B; Kerrigan, JR; Martha, PM; Mauras, N; Metzger, DL; Pincus, SM; Rogol, AD; Veldhuis, JD, 1997)
"Ten adolescents with delayed puberty were evaluated before and after 4 months of DHT administration."	( Arslanian, SA; Danadian, K; Keenan, BS; Lewy, VD; Saad, RJ, 2001)
"The medical problems involved in treating boys with delayed puberty are excluding disease and deciding on testosterone treatment."	( Adan, L; Brauner, R; Couto-Silva, AC; Lawson-Body, E; Souberbielle, JC; Trivin, C, 2005)
"Androgen therapy for delayed puberty should permit full normal pubertal development and thereby also address some of the associated psychosocial problems."	( Richmond, EJ; Rogol, AD, 2007)
"In milder cases of delayed puberty, treatment is often not required; however, considerable evidence exists for the efficacy and safety of short courses of low-dose testosterone therapy for appropriately selected individuals."	( Ambler, GR, 2009)
"This pilot study suggests that delayed puberty should be studied in future trials that address different doses and schedules of deflazacort therapy in Duchenne muscular dystrophy."	( Bobbitt, SA; Cummings, EA; Dooley, JM, 2013)
"We report three adolescent boys with delayed puberty who were treated with TT gel for pubertal induction/continuation."	( Contreras, MF; Franklin, B; Prasad, K; Raisingani, M; Shah, B, 2017)
"Thus, girls with delayed puberty should be evaluated for an underlying pathology before any treatment, including oral contraception, is initiated."	( Cleemann, L; Juul, A; Main, KM; Tønnes Pedersen, A, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	137 (25.32)	23.3326
1990's	137 (25.32)	12.5806
2000's	127 (23.48)	18.1394
2010's	111 (20.52)	28.8240
2020's	29 (5.36)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
carnitine	medium	1	1
lactic acid	low	1	0
melatonin	low	11	0
phthalic acid	low	1	0
aspirin	low	1	0
azathioprine	low	1	0
busulfan	low	6	0
chlorpromazine	low	3	0
cimetidine	low	1	0
clonidine	low	1	0
deferiprone	medium	1	1
deferoxamine	medium	11	2
domperidone	low	1	0
fenofibrate	low	1	0
flutamide	low	1	0
hydroxychloroquine	low	1	0
indomethacin	low	1	0
ketoconazole	low	1	0
letrozole	medium	22	16
metoclopramide	low	4	0
metronidazole	low	1	0
metyrapone	low	1	0
pioglitazone	low	1	0
procarbazine	medium	1	1
propranolol	low	1	0
sulfasalazine	low	1	0
corticosterone	low	1	0
prednisolone	medium	8	1
thyroxine	medium	8	1
aldosterone	low	2	0
prednisone	medium	4	1
estrone	low	3	0
oxandrolone	medium	26	11
dehydroepiandrosterone	medium	14	1
triiodothyronine	low	2	0
lysine	low	1	0
ethinyl estradiol	low	8	0
testosterone propionate	medium	2	1
levodopa	low	5	0
androstenedione	medium	7	1
17-alpha-hydroxyprogesterone	medium	2	1
cytarabine	low	1	0
medroxyprogesterone acetate	low	2	0
methandrostenolone	low	1	0
isoleucine	low	1	0
arginine	low	4	0
fluoxymesterone	low	2	0
methylprednisolone	low	2	0
pyrroles	low	1	0
ziram	low	1	0
testosterone enanthate	medium	11	1
cyproterone acetate	low	1	0
medroxyprogesterone	low	2	0
dihydrotestosterone	low	6	0
megestrol acetate	low	1	0
dehydroepiandrosterone sulfate	low	12	0
testolactone	low	2	0
testosterone 17-phenylpropionate	medium	1	1
d-alpha tocopherol	low	1	0
3-phenoxybenzoic acid	low	1	0
cadmium	low	2	0
barium sulfate	low	1	0
trolamine salicylate	low	1	0
3-phenoxybenzylalcohol	low	1	0
cromolyn sodium	low	1	0
fluorides	low	1	0
danazol	low	1	0
lisuride	low	1	0
phosphotyrosine	low	1	0
bromocriptine	low	14	0
etoposide	low	1	0
desogestrel	low	2	0
buserelin	medium	4	2
cabergoline	low	2	0
atorvastatin	low	1	0
6-sulfatoxymelatonin	low	2	0
testosterone undecanoate	medium	8	4
tetrahydro-11-deoxycortisol	low	1	0
triazoles	medium	14	11
prochloraz	low	1	0
deoxypyridinoline	medium	4	2
dehydroacetic acid	low	1	0
methotrexate	low	1	0
deflazacort	low	2	0
deferasirox	medium	1	1
estradiol 3-benzoate	low	2	0
cortisone	low	1	0
testosterone isocaproate	medium	1	1
epinastine	low	1	0
carboplatin	low	1	0
glycogen	low	1	0
inositol 3-phosphate	low	2	0
cortodoxone	low	1	0
arachidonic acid	low	1	0
retinol	medium	2	1
tacrolimus	low	1	0
melphalan	low	1	0
carbenoxolone sodium	low	1	0
leuprolide	low	6	0
propylthiouracil	low	1	0
enclomiphene	low	6	0
tamoxifen	low	1	0
pica	low	1	0
cystine	low	1	0
osteoprotegerin	low	1	0
bilirubin	low	1	0
vitamin k semiquinone radical	low	2	0
beta carotene	low	1	0
cholecalciferol	low	1	0
naloxone	medium	3	1
neurokinin b	low	3	0
lead	low	7	0
cysteine	low	1	0
phosphorus	low	1	0
25-hydroxyvitamin d 2	low	1	0
ergoline	low	2	0
etonogestrel	low	1	0
pentagastrin	low	1	0
losartan potassium	low	1	0
lhrh, ala(6)-gly(10)-ethylamide-	low	1	0
acid phosphatase	low	1	0
glucagon	low	1	0
beta-endorphin	low	2	0
neuropeptide y	low	2	0
(9R)-9-chloro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one	low	1	0
menotropins	low	6	0
trelstar	medium	7	1
lhrh, n-acetyl-(4-chlorophenylalanyl)(1)-(4-chlorophenylalanyl)(2)-tryptophyl(3)-arginyl(6)-alanine(10)-	low	1	0
nafarelin	low	2	0
histrelin	low	1	0
triiodothyronine, reverse	low	2	0
natriuretic peptide, brain	low	1	0
transforming growth factor beta	low	1	0
phytoestrogens	low	1	0
pyrethrins	low	1	0
kiss1 protein, human	medium	9	2
rome	low	1	0
cyclosporine	low	2	0
technetium tc 99m medronate	low	1	0
leptin	medium	16	1

Protein Targets (1,006)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
IDH1	12	0	0	12
chromobox protein homolog 1	31	0	0	31
geminin	44	0	0	44
acetylcholinesterase	17	0	0	17
pregnane X receptor	14	0	0	14
SMAD family member 2	18	0	0	18
SMAD family member 3	18	0	0	18
TDP1 protein	48	0	0	48
GLI family zinc finger 3	36	0	0	36
Microtubule-associated protein tau	16	0	0	16
AR protein	60	0	0	60
progesterone receptor	36	0	0	36
glucocorticoid receptor [Homo sapiens]	53	0	0	53
retinoic acid nuclear receptor alpha variant 1	39	0	0	39
retinoid X nuclear receptor alpha	38	0	0	38
estrogen-related nuclear receptor alpha	44	0	0	44
farnesoid X nuclear receptor	24	0	0	24
pregnane X nuclear receptor	47	0	0	47
estrogen nuclear receptor alpha	65	0	0	65
G	26	0	0	26
vitamin D (1,25- dihydroxyvitamin D3) receptor	35	0	0	35
arylsulfatase A	12	0	0	12
euchromatic histone-lysine N-methyltransferase 2	32	0	0	32
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	37	0	0	37
activating transcription factor 6	11	0	0	11
nuclear receptor subfamily 1, group I, member 2	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	40	0	0	40
survival motor neuron protein isoform d	16	0	0	16
histone acetyltransferase KAT2A isoform 1	12	0	0	12
lamin isoform A-delta10	38	0	0	38
Voltage-dependent calcium channel gamma-2 subunit	21	0	0	21
Interferon beta	29	0	0	29
HLA class I histocompatibility antigen, B alpha chain	26	0	0	26
Glucocorticoid receptor	0	25	3	34
Sex hormone-binding globulin	0	1	15	16
Glycine receptor subunit alpha-1	0	24	0	24
Corticosteroid-binding globulin	0	10	0	10
Adenosine receptor A3	0	15	1	16
Replicase polyprotein 1ab	0	3	3	6
Androgen receptor	0	35	1	36
Alpha-1B adrenergic receptor	0	19	1	20
Glutamate receptor 2	21	0	0	21
Glycine receptor subunit beta	0	24	0	24
Glycine receptor subunit alpha-2	0	24	0	24
Glycine receptor subunit alpha-3	0	24	0	24
Mitogen-activated protein kinase 3	0	1	0	1
Alpha-1A adrenergic receptor	0	20	2	22
Sodium-dependent dopamine transporter	0	16	0	16
TAR DNA-binding protein 43	11	0	0	11
Inositol hexakisphosphate kinase 1	26	0	0	26
cytochrome P450 2C9, partial	26	0	0	26
ATP-dependent phosphofructokinase	13	0	0	13
peroxisome proliferator-activated receptor delta	30	0	0	30
aryl hydrocarbon receptor	17	0	0	17
Regulatory protein E2	0	0	1	1
Aldo-keto reductase family 1 member C3	0	4	0	4
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Luciferase	9	0	0	9
RAR-related orphan receptor gamma	39	0	0	39
estrogen receptor 2 (ER beta)	23	0	0	23
nuclear receptor subfamily 1, group I, member 3	30	0	0	30
peroxisome proliferator activated receptor gamma	35	0	0	35
thyroid hormone receptor beta isoform a	13	0	0	13
nuclear factor erythroid 2-related factor 2 isoform 2	15	0	0	15
Mineralocorticoid receptor	0	5	4	9
Mineralocorticoid receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	2	0	4
Guanine nucleotide-binding protein G	4	0	0	4
Chain A, HADH2 protein	16	0	0	16
Chain B, HADH2 protein	16	0	0	16
interleukin 8	14	0	0	14
Smad3	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	23	0	0	23
regulator of G-protein signaling 4	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	30	0	0	30
nonstructural protein 1	8	0	0	8
Histone H2A.x	15	0	0	15
Caspase-7	5	0	0	5
Bloom syndrome protein isoform 1	11	0	0	11
peripheral myelin protein 22 isoform 1	10	0	0	10
potassium voltage-gated channel subfamily H member 2 isoform d	13	0	0	13
caspase-3	5	0	0	5
thyroid hormone receptor beta isoform 2	39	0	0	39
importin subunit beta-1 isoform 1	6	0	0	6
mitogen-activated protein kinase 1	9	0	0	9
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
snurportin-1	6	0	0	6
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	16	0	0	16
nuclear receptor ROR-gamma isoform 1	13	0	0	13
peripheral myelin protein 22	21	0	0	21
muscleblind-like protein 1 isoform 1	9	0	0	9
neuropeptide S receptor isoform A	7	0	0	7
Beta-glucuronidase	0	2	0	2
Cholinesterase	0	2	0	2
Aromatase	0	12	0	15
Gastrin/cholecystokinin type B receptor	0	0	1	2
Testosterone 17-beta-dehydrogenase 3	0	2	0	2
Alpha-synuclein	5	4	0	9
Nuclear receptor ROR-gamma	18	0	0	18
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	15	0	0	15
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	14	0	0	14
Chain A, Beta-lactamase	10	0	0	10
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	12	0	0	12
15-lipoxygenase, partial	11	0	0	11
phosphopantetheinyl transferase	20	0	0	20
USP1 protein, partial	24	0	0	24
thioredoxin glutathione reductase	5	0	0	5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
cellular tumor antigen p53 isoform a	7	0	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
vitamin D3 receptor isoform VDRA	18	0	0	18
ubiquitin carboxyl-terminal hydrolase 2 isoform a	7	0	0	7
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
DNA polymerase kappa isoform 1	12	0	0	12
cytochrome P450 3A4 isoform 1	23	0	0	23
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	3	0	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	23	3	2	28
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Prostaglandin G/H synthase 1	0	3	0	5
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Tissue factor	0	1	0	1
Fatty acid-binding protein, adipocyte	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	23	3	2	28
Gamma-aminobutyric acid receptor subunit delta	23	3	2	28
Gamma-aminobutyric acid receptor subunit gamma-2	23	3	3	29
Gamma-aminobutyric acid receptor subunit alpha-5	23	3	2	28
Gamma-aminobutyric acid receptor subunit alpha-3	23	3	2	28
Gamma-aminobutyric acid receptor subunit gamma-1	23	3	2	28
Gamma-aminobutyric acid receptor subunit alpha-2	23	3	2	28
Gamma-aminobutyric acid receptor subunit alpha-4	23	3	2	28
Gamma-aminobutyric acid receptor subunit gamma-3	23	3	2	28
Gamma-aminobutyric acid receptor subunit alpha-6	23	3	2	28
Prostaglandin G/H synthase 2	0	6	2	9
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Histamine H2 receptor	12	2	1	15
10 kDa heat shock protein, mitochondrial	0	2	0	2
Calmodulin	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	23	4	3	30
Gamma-aminobutyric acid receptor subunit beta-3	23	3	2	28
Gamma-aminobutyric acid receptor subunit beta-2	23	3	3	29
Disintegrin and metalloproteinase domain-containing protein 17	6	0	0	6
Prostaglandin G/H synthase 2	0	3	0	4
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	4	1	5
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
GABA theta subunit	23	3	2	28
Gamma-aminobutyric acid receptor subunit epsilon	23	3	2	28
Solute carrier organic anion transporter family member 1B3	0	14	0	19
Cytosolic phospholipase A2 gamma	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	14	0	19
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	21	0	0	21
NFKB1 protein, partial	5	0	0	5
GLS protein	8	0	0	8
thyroid stimulating hormone receptor	15	0	0	15
alpha-galactosidase	5	0	0	5
cytochrome P450 2C19 precursor	10	0	0	10
flap endonuclease 1	4	0	0	4
muscarinic acetylcholine receptor M1	14	0	0	14
lethal factor (plasmid)	6	0	0	6
Cytochrome P450 3A4	0	11	0	13
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	1	0	0	1
EWS/FLI fusion protein	20	0	0	20
cytochrome P450 2D6	17	0	0	17
glucocerebrosidase	5	0	0	5
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	2	0	2
ATP-binding cassette sub-family C member 3	0	34	0	34
Multidrug resistance-associated protein 4	0	35	0	37
Solute carrier family 22 member 6	0	4	0	4
Prostaglandin G/H synthase 2	0	3	0	4
Bile salt export pump	0	43	0	43
Epidermal growth factor receptor	0	6	0	6
Carbonic anhydrase 1	0	5	0	6
Carbonic anhydrase 2	0	7	1	9
Fatty acid-binding protein, liver	0	3	1	4
Integrin beta-3	4	1	0	5
Myeloperoxidase	0	4	0	4
Prostaglandin G/H synthase 1	0	3	0	4
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	4	1	0	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	5
Adenosine receptor A1	0	4	0	5
Adenosine receptor A2a	0	3	1	5
Substance-P receptor	0	2	0	2
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	32	0	33
Sigma non-opioid intracellular receptor 1	0	11	1	12
Sigma non-opioid intracellular receptor 1	0	1	2	3
caspase 7, apoptosis-related cysteine protease	9	0	0	9
caspase-3	9	0	0	9
Solute carrier organic anion transporter family member 2B1	0	4	0	5
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Cellular tumor antigen p53	38	0	0	38
ATP-dependent translocase ABCB1	0	13	2	17
Insulin receptor	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 2	0	2	0	2
Histone deacetylase 6	0	2	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
Chain A, Ferritin light chain	10	0	0	10
ATAD5 protein, partial	15	0	0	15
Fumarate hydratase	8	0	0	8
polyprotein	8	0	0	8
P53	1	0	0	1
thyroid stimulating hormone receptor	20	0	0	20
v-jun sarcoma virus 17 oncogene homolog (avian)	19	0	0	19
hemoglobin subunit beta	1	0	0	1
heat shock protein beta-1	16	0	0	16
M-phase phosphoprotein 8	12	0	0	12
Bile salt export pump	0	7	0	7
ATPase family AAA domain-containing protein 5	16	0	0	16
Ataxin-2	19	0	0	19
Protein-arginine deiminase type-4	0	2	0	2
core protein, partial	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Caspase-7	2	0	0	2
Inositol monophosphatase 1	4	0	0	4
Genome polyprotein	0	2	1	3
dopamine D1 receptor	4	0	0	4
D(1A) dopamine receptor	9	0	0	9
serine/threonine-protein kinase mTOR isoform 1	8	0	0	8
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
5-hydroxytryptamine receptor 4	0	18	1	19
ATP-dependent translocase ABCB1	0	5	0	5
Beta-1 adrenergic receptor	0	8	1	9
5-hydroxytryptamine receptor 1A	0	5	1	6
Alpha-2A adrenergic receptor	0	22	3	26
D(2) dopamine receptor	0	13	3	17
Alpha-2B adrenergic receptor	0	19	2	22
Alpha-2C adrenergic receptor	0	18	3	22
D	0	5	0	6
D(3) dopamine receptor	0	7	0	7
5-hydroxytryptamine receptor 1A	0	13	1	15
Alpha-2B adrenergic receptor	0	6	1	7
ATP-dependent translocase ABCB1	0	5	0	5
D(1A) dopamine receptor	0	11	1	13
Alpha-2C adrenergic receptor	0	6	1	7
Alpha-2A adrenergic receptor	0	6	1	7
Alpha-1D adrenergic receptor	0	14	2	17
D(1B) dopamine receptor	0	5	0	5
5-hydroxytryptamine receptor 2A	0	20	3	23
5-hydroxytryptamine receptor 2C	0	18	3	21
5-hydroxytryptamine receptor 1B	0	14	0	14
D(4) dopamine receptor	0	5	0	5
D(3) dopamine receptor	0	18	0	19
5-hydroxytryptamine receptor 2B	0	21	2	23
5-hydroxytryptamine receptor 6	0	14	1	15
D(2) dopamine receptor	0	7	2	11
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
apical membrane antigen 1, AMA1	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	18	0	0	18
Matrix metalloproteinase-9	0	1	0	1
Spike glycoprotein	16	1	3	20
Histamine H3 receptor	0	3	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Proteasome subunit beta type-11	0	0	0	1
Thrombopoietin	2	0	0	2
NADPH oxidase 1	0	1	0	1
67.9K protein	10	0	0	10
Snq2p	0	0	0	1
Adenylate cyclase type 1	0	2	0	2
Spike glycoprotein	0	1	3	4
Replicase polyprotein 1ab	0	1	4	5
cytochrome P450 2D6 isoform 1	7	0	0	7
histone deacetylase 9 isoform 3	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	4	0	0	4
Proteasome subunit alpha type-7	0	0	0	1
Solute carrier family 22 member 1	0	11	0	12
Transmembrane protease serine 2	0	1	3	4
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Albumin	0	1	3	4
Albumin	0	0	2	2
Major prion protein	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	3	0	3
Major prion protein	0	0	1	1
Cytochrome P450 1A2	0	4	1	5
Tyrosine-protein kinase Fyn	0	5	0	5
Procathepsin L	0	2	3	5
Aldo-keto reductase family 1 member B1	0	18	0	18
Muscarinic acetylcholine receptor M2	0	11	1	12
Muscarinic acetylcholine receptor M4	0	7	0	7
Muscarinic acetylcholine receptor M1	0	2	2	4
Muscarinic acetylcholine receptor M3	0	2	2	4
Muscarinic acetylcholine receptor M4	0	2	2	4
5-hydroxytryptamine receptor 2C	0	3	0	4
Muscarinic acetylcholine receptor M5	0	2	2	4
Muscarinic acetylcholine receptor M5	0	7	0	7
Replicase polyprotein 1a	0	1	3	4
Replicase polyprotein 1ab	0	1	3	4
Replicase polyprotein 1ab	0	2	3	5
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	2	1	3
Cytochrome P450 2D6	0	11	1	13
Muscarinic acetylcholine receptor M2	0	2	2	4
Muscarinic acetylcholine receptor M1	0	8	1	9
Cytochrome P450 2C9	0	9	0	9
Polyunsaturated fatty acid lipoxygenase ALOX15	0	6	0	6
Angiotensin-converting enzyme	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
Sphingomyelin phosphodiesterase	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	10	1	11
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	12	0	12
D(4) dopamine receptor	0	4	1	6
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	3
Alpha-1D adrenergic receptor	0	5	1	6
Sodium-dependent noradrenaline transporter	0	18	0	18
Sodium-dependent dopamine transporter	0	3	0	3
Histamine H2 receptor	0	12	0	12
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Histamine H1 receptor	0	1	2	3
Sodium-dependent serotonin transporter	0	20	0	20
Melanocortin receptor 4	0	4	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 7	0	2	1	3
Histamine H1 receptor	0	6	0	6
Mu-type opioid receptor	0	17	4	24
Glutamate receptor ionotropic, NMDA 1	0	1	0	3
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	11	4	18
Kappa-type opioid receptor	0	15	4	23
Melanocortin receptor 3	0	4	0	4
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	3	0	0	3
5-hydroxytryptamine receptor 7	0	4	0	4
Cytochrome P450 2J2	0	8	0	8
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	3
Glutamate receptor ionotropic, NMDA 2B	0	1	0	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	3
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Aldehyde oxidase	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Sodium channel protein type 5 subunit alpha	0	3	0	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	3
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	3
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	1	3	4
Sodium channel protein type 3 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	3
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Vitamin D3 receptor	0	1	1	4
Glycine receptor subunit alpha-1	0	0	1	1
Vitamin D3 receptor	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	5	0	6
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 1	0	5	0	5
Multidrug and toxin extrusion protein 2	0	3	0	3
Solute carrier family 22 member 8	0	3	0	5
Multidrug and toxin extrusion protein 1	0	6	0	6
Histamine H4 receptor	0	1	0	1
Solute carrier family 22 member 11	0	1	0	3
Solute carrier family 22 member 2	0	4	0	4
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	13	0	0	13
Beta-1 adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2C9 precursor	7	0	0	7
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	3	0	3
Alpha-1A adrenergic receptor	0	0	1	1
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	3	0	3
Adenosine receptor A2b	0	1	1	2
Alpha-2B adrenergic receptor	0	0	0	1
Delta-type opioid receptor	0	5	2	9
Alpha-1A adrenergic receptor	0	2	3	6
Alpha-1B adrenergic receptor	0	1	2	4
Mu-type opioid receptor	0	5	3	9
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Nischarin	0	1	0	1
GALC protein	5	0	0	5
Solute carrier family 22 member 3	0	1	0	1
C-8 sterol isomerase	0	3	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	4	1	5
endonuclease IV	6	0	0	6
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	9	0	0	9
Alkaline phosphatase, germ cell type	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	6	0	0	6
Progesterone receptor	0	7	2	10
Androgen receptor	0	16	6	25
ORF73	0	0	1	1
glp-1 receptor, partial	9	0	0	9
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	2	0	3
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Rap guanine nucleotide exchange factor 3	5	0	0	5
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	12	0	0	12
Estrogen receptor	0	16	4	22
Beta-3 adrenergic receptor	0	10	1	11
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4A	0	3	1	4
Lysine-specific demethylase 5A	0	1	0	1
Flavin reductase (NADPH)	0	0	2	2
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Lysine-specific demethylase 6A	0	1	0	1
Lysine-specific demethylase 5C	0	1	0	1
Lysine-specific demethylase 2B	0	1	0	1
Deoxyhypusine hydroxylase	0	2	0	2
Lysine-specific demethylase 2A	0	1	0	1
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	4
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
G-protein coupled bile acid receptor 1	0	0	3	3
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	1	0	4
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Steryl-sulfatase	0	3	0	4
Multidrug resistance-associated protein 1	0	1	0	3
Solute carrier organic anion transporter family member 1A2	0	0	0	3
Solute carrier organic anion transporter family member 1A3	0	1	0	5
ATP-binding cassette sub-family C member 11	0	0	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Chain A, Sex Hormone-Binding Globulin	0	0	1	1
thyrotropin-releasing hormone receptor	3	0	0	3
transcriptional regulator ERG isoform 3	6	0	0	6
Plasma kallikrein	0	1	0	2
Progesterone receptor	0	1	0	1
Glucocorticoid receptor	0	2	1	3
Sex hormone-binding globulin	0	1	0	1
Androgen receptor	0	1	3	4
Angiotensin-converting enzyme	0	0	1	1
Cannabinoid receptor 2	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
Neuropeptide FF receptor 2	0	0	0	2
ALK tyrosine kinase receptor	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	3	3
5-hydroxytryptamine receptor 3A	0	3	0	3
5-hydroxytryptamine receptor 3B	0	3	0	3
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	2	0	2
protein AF-9 isoform a	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
serine-protein kinase ATM isoform a	2	0	0	2
huntingtin isoform 2	2	0	0	2
streptokinase A precursor	0	0	2	2
Estrogen receptor	0	0	2	3
Estrogen receptor beta	0	0	2	3
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Mu-type opioid receptor	0	6	4	10
Cytochrome P450 1B1	0	2	0	2
Estrogen receptor beta	0	7	4	12
Ghrelin O-acyltransferase	0	1	0	1
PPM1D protein	3	0	0	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Vpr	1	0	0	1
Cytochrome P450 2B1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Cytochrome P450 2B6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	3	0	6
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Adenosine receptor A2a	0	5	1	6
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Prothrombin	0	0	1	2
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	1	2
Acetylcholinesterase	0	3	0	3
Peroxisome proliferator-activated receptor alpha	0	1	1	2
Cruzipain	0	1	0	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	3	8	12
Peroxisome proliferator-activated receptor gamma	0	1	2	3
Peroxisome proliferator-activated receptor alpha	0	2	2	4
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 15	0	1	0	2
Cocaine esterase	0	1	0	2
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Histone deacetylase 7	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Parkin	3	0	0	3
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	2	0	2
Interleukin-8	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Thromboxane-A synthase	0	4	0	4
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	1	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	2	0	2
Prostaglandin D2 receptor	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
Estrogen receptor beta	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	4	0	4
Epoxide hydrolase 1	0	0	0	1
Cytochrome P450 2C11	0	2	0	2
Steroid 21-hydroxylase	0	1	0	1
Cytochrome P450 2C8	0	3	0	3
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	3	0	3
Cytochrome P450 11B1, mitochondrial	0	3	0	3
Translocator protein	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	3	0	3
Estrogen receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	3	1	4
Type-1 angiotensin II receptor	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	3	0	3
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
DNA polymerase eta isoform 1	3	0	0	3
Polyphenol oxidase 2	0	0	0	1
Carbonic anhydrase 12	0	0	0	1
Tyrosine-protein kinase Lck	0	2	1	4
Carbonic anhydrase 3	0	0	0	1
Tyrosinase	0	1	0	1
Carbonic anhydrase 6	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase 9	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
phosphoglycerate kinase	1	0	0	1
Beta-2 adrenergic receptor	0	4	1	5
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
PINK1	2	0	0	2
Cytochrome P450 2C19	0	3	0	3
bioA	0	0	0	1
DNA polymerase beta	2	0	0	2
ClpP	2	0	0	2
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	2	3
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Delta-type opioid receptor	0	5	3	8
Kappa-type opioid receptor	0	4	3	7
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
5-hydroxytryptamine receptor 3E	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1F	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	1	2
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	2
5-hydroxytryptamine receptor 3D	0	1	1	2
5-hydroxytryptamine receptor 3C	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Adenosine receptor A1	0	5	0	5
Kappa-type opioid receptor	0	3	1	5
Kappa-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	3	1	6
Sigma non-opioid intracellular receptor 1	0	1	1	2
Beta-2 adrenergic receptor	0	2	1	4
UDP-glucuronosyltransferase 1A8	0	0	0	2
Nociceptin receptor	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	0	1	1
Substance-P receptor	0	4	0	4
Neuromedin-K receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	1	2
Proto-oncogene tyrosine-protein kinase Src	0	0	0	1
Growth factor receptor-bound protein 2	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	0	0	1
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
tyrosine-protein kinase Yes	1	0	0	1
Free fatty acid receptor 1	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
luciferase	0	0	0	1
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Beta-1 adrenergic receptor	0	2	1	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Vasopressin V1a receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Chain A, Glutathione S-transferase	0	1	0	1
Tumor necrosis factor	0	0	1	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Cystine/glutamate transporter	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
interferon gamma precursor	0	0	0	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C eta type	0	1	0	1
B2 bradykinin receptor	0	2	0	2
Protein kinase C iota type	0	1	0	1
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
serine/threonine-protein kinase PLK1	1	0	0	1
Transthyretin	0	1	0	3
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (541)

Protein Targets (1,006)

Delayed Puberty

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (541)

Drugs Studied (170)

Protein Targets (1,006)