metronidazole has been researched along with AIDS Seroconversion in 15 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Necrotizing periodontitis is an extension of NG into the periodontal attachment apparatus, and the two stages are referred to collectively as necrotizing periodontal diseases (NPD)." | 2.44 | Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms. ( Feller, L; Lemmer, J, 2008) |
| "Cancrum oris (noma) is a gangrenous infection that develops in the mouth and spreads rapidly to other parts of the face." | 1.31 | Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child. ( Chikte, UM; Naidoo, S, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tambe, S | 1 |
| Zambare, U | 1 |
| Nayak, C | 1 |
| Balkus, JE | 1 |
| Richardson, BA | 1 |
| Mochache, V | 1 |
| Chohan, V | 1 |
| Chan, JD | 1 |
| Masese, L | 1 |
| Shafi, J | 1 |
| Marrazzo, J | 1 |
| Farquhar, C | 1 |
| McClelland, RS | 2 |
| Kissinger, P | 1 |
| Adamski, A | 1 |
| Clark, RA | 1 |
| Mena, L | 1 |
| Levison, J | 1 |
| Martin, DH | 1 |
| Lazenby, GB | 1 |
| Unal, ER | 1 |
| Andrews, AL | 1 |
| Simpson, K | 1 |
| Llata, E | 1 |
| Bernstein, KT | 1 |
| Kerani, RP | 1 |
| Pathela, P | 1 |
| Schwebke, JR | 1 |
| Schumacher, C | 1 |
| Stenger, M | 1 |
| Weinstock, HS | 1 |
| Kreft, B | 1 |
| Oehme, A | 1 |
| Lübbert, C | 1 |
| Marsch, WC | 1 |
| Kekulé, AS | 1 |
| Phiri, R | 1 |
| Feller, L | 2 |
| Blignaut, E | 1 |
| Anderson, BL | 1 |
| Firnhaber, C | 1 |
| Liu, T | 1 |
| Swarts, A | 1 |
| Siminya, M | 1 |
| Ingersoll, J | 1 |
| Caliendo, AM | 1 |
| Cu-Uvin, S | 1 |
| Niakara, A | 1 |
| Bougouma, A | 1 |
| Cisse, R | 1 |
| Naidoo, S | 1 |
| Chikte, UM | 1 |
| Lemmer, J | 1 |
| Smith, KJ | 1 |
| Skelton, HG | 1 |
| Yeager, J | 1 |
| Ruiz, N | 1 |
| Wagner, KF | 1 |
| Lu, SS | 1 |
| Schwartz, JM | 1 |
| Simon, DM | 1 |
| Brandt, LJ | 1 |
| Wang, CC | 1 |
| Reilly, M | 1 |
| Overbaugh, J | 1 |
| Emery, SR | 1 |
| Mandaliya, K | 1 |
| Chohan, B | 1 |
| Ndinya-Achola, J | 1 |
| Bwayo, J | 1 |
| Kreiss, JK | 1 |
| Wilson, KW | 1 |
| Winget, D | 1 |
| Wilks, S | 1 |
1 review available for metronidazole and AIDS Seroconversion
| Article | Year |
|---|---|
Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms.
Topics: Anti-Infective Agents; Candida albicans; Chlorhexidine; Cytokines; Dental Scaling; Gingivitis, Necro | 2008 |
2 trials available for metronidazole and AIDS Seroconversion
| Article | Year |
|---|---|
Clostridium difficile-associated diarrhea in patients with HIV positivity and AIDS: a prospective controlled study.
Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Clostridioides difficile; Diarrhea; Enterocoliti | 1994 |
The effect of treatment of vaginal infections on shedding of human immunodeficiency virus type 1.
Topics: Adult; Anti-Bacterial Agents; Antitrichomonal Agents; Candidiasis; DNA, Viral; Down-Regulation; Fema | 2001 |
12 other studies available for metronidazole and AIDS Seroconversion
| Article | Year |
|---|---|
Nodulo-ulcerative and erythrodermic secondary syphilis in human immunodeficiency virus-infected individuals.
Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Chancre; | 2019 |
A prospective cohort study comparing the effect of single-dose 2 g metronidazole on Trichomonas vaginalis infection in HIV-seropositive versus HIV-seronegative women.
Topics: Adult; Anti-HIV Agents; Antiprotozoal Agents; Cohort Studies; Drug Therapy, Combination; Female; HIV | 2013 |
Does Antiretroviral Therapy Interfere With the Treatment of Trichomonas vaginalis Among HIV+ Women?
Topics: Antiprotozoal Agents; Female; HIV Infections; HIV Seropositivity; Humans; Metronidazole; Trichomonas | 2013 |
Cost-effectiveness analysis of annual Trichomonas vaginalis screening and treatment in HIV-positive women to prevent HIV transmission.
Topics: Adult; Anti-Infective Agents; Cost-Benefit Analysis; Decision Support Techniques; Female; Follow-Up | 2014 |
Management of Pelvic Inflammatory Disease in Selected U.S. Sexually Transmitted Disease Clinics: Sexually Transmitted Disease Surveillance Network, January 2010-December 2011.
Topics: Adolescent; Adult; Azithromycin; Centers for Disease Control and Prevention, U.S.; Chlamydia Infecti | 2015 |
[37-year old patient with fever, diarrhea and lymphadenopathy].
Topics: Adult; AIDS Serodiagnosis; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Antifungal | 2010 |
The severity, extent and recurrence of necrotizing periodontal disease in relation to HIV status and CD4+ T cell count.
Topics: Adolescent; Adult; Anti-Infective Agents; Anti-Infective Agents, Local; CD4 Lymphocyte Count; Child; | 2010 |
Effect of trichomoniasis therapy on genital HIV viral burden among African women.
Topics: Adolescent; Adult; Antiprotozoal Agents; Cohort Studies; Female; HIV Seropositivity; Humans; Metroni | 2012 |
[A case of pneumopericardium complicating a liver abscess in a patient infected with HIV].
Topics: Adult; AIDS-Related Opportunistic Infections; Amoxicillin; Anemia; Anti-Infective Agents; Blood Tran | 1999 |
Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Child, Preschool; Female; HIV Seroposi | 2000 |
Metronidazole for eosinophilic pustular folliculitis in human immunodeficiency virus type 1-positive patients.
Topics: Adult; Eosinophils; Folliculitis; HIV Seropositivity; HIV-1; Humans; Male; Metronidazole | 1995 |
Blastocystis hominis infection: signs and symptoms in patients at Wilford Hall Medical Center.
Topics: Adult; Animals; Eukaryota; Female; HIV Seropositivity; Humans; Intestinal Diseases, Parasitic; Male; | 1990 |