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metronidazole and AIDS Seroconversion

metronidazole has been researched along with AIDS Seroconversion in 15 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"Necrotizing periodontitis is an extension of NG into the periodontal attachment apparatus, and the two stages are referred to collectively as necrotizing periodontal diseases (NPD)."2.44Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms. ( Feller, L; Lemmer, J, 2008)
"Cancrum oris (noma) is a gangrenous infection that develops in the mouth and spreads rapidly to other parts of the face."1.31Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child. ( Chikte, UM; Naidoo, S, 2000)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (26.67)18.2507
2000's3 (20.00)29.6817
2010's8 (53.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tambe, S1
Zambare, U1
Nayak, C1
Balkus, JE1
Richardson, BA1
Mochache, V1
Chohan, V1
Chan, JD1
Masese, L1
Shafi, J1
Marrazzo, J1
Farquhar, C1
McClelland, RS2
Kissinger, P1
Adamski, A1
Clark, RA1
Mena, L1
Levison, J1
Martin, DH1
Lazenby, GB1
Unal, ER1
Andrews, AL1
Simpson, K1
Llata, E1
Bernstein, KT1
Kerani, RP1
Pathela, P1
Schwebke, JR1
Schumacher, C1
Stenger, M1
Weinstock, HS1
Kreft, B1
Oehme, A1
Lübbert, C1
Marsch, WC1
Kekulé, AS1
Phiri, R1
Feller, L2
Blignaut, E1
Anderson, BL1
Firnhaber, C1
Liu, T1
Swarts, A1
Siminya, M1
Ingersoll, J1
Caliendo, AM1
Cu-Uvin, S1
Niakara, A1
Bougouma, A1
Cisse, R1
Naidoo, S1
Chikte, UM1
Lemmer, J1
Smith, KJ1
Skelton, HG1
Yeager, J1
Ruiz, N1
Wagner, KF1
Lu, SS1
Schwartz, JM1
Simon, DM1
Brandt, LJ1
Wang, CC1
Reilly, M1
Overbaugh, J1
Emery, SR1
Mandaliya, K1
Chohan, B1
Ndinya-Achola, J1
Bwayo, J1
Kreiss, JK1
Wilson, KW1
Winget, D1
Wilks, S1

Reviews

1 review available for metronidazole and AIDS Seroconversion

ArticleYear
Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms.
    Journal of the International Academy of Periodontology, 2008, Volume: 10, Issue:1

    Topics: Anti-Infective Agents; Candida albicans; Chlorhexidine; Cytokines; Dental Scaling; Gingivitis, Necro

2008

Trials

2 trials available for metronidazole and AIDS Seroconversion

ArticleYear
Clostridium difficile-associated diarrhea in patients with HIV positivity and AIDS: a prospective controlled study.
    The American journal of gastroenterology, 1994, Volume: 89, Issue:8

    Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Clostridioides difficile; Diarrhea; Enterocoliti

1994
The effect of treatment of vaginal infections on shedding of human immunodeficiency virus type 1.
    The Journal of infectious diseases, 2001, Apr-01, Volume: 183, Issue:7

    Topics: Adult; Anti-Bacterial Agents; Antitrichomonal Agents; Candidiasis; DNA, Viral; Down-Regulation; Fema

2001

Other Studies

12 other studies available for metronidazole and AIDS Seroconversion

ArticleYear
Nodulo-ulcerative and erythrodermic secondary syphilis in human immunodeficiency virus-infected individuals.
    International journal of STD & AIDS, 2019, Volume: 30, Issue:5

    Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Chancre;

2019
A prospective cohort study comparing the effect of single-dose 2 g metronidazole on Trichomonas vaginalis infection in HIV-seropositive versus HIV-seronegative women.
    Sexually transmitted diseases, 2013, Volume: 40, Issue:6

    Topics: Adult; Anti-HIV Agents; Antiprotozoal Agents; Cohort Studies; Drug Therapy, Combination; Female; HIV

2013
Does Antiretroviral Therapy Interfere With the Treatment of Trichomonas vaginalis Among HIV+ Women?
    Sexually transmitted diseases, 2013, Volume: 40, Issue:6

    Topics: Antiprotozoal Agents; Female; HIV Infections; HIV Seropositivity; Humans; Metronidazole; Trichomonas

2013
Cost-effectiveness analysis of annual Trichomonas vaginalis screening and treatment in HIV-positive women to prevent HIV transmission.
    Sexually transmitted diseases, 2014, Volume: 41, Issue:6

    Topics: Adult; Anti-Infective Agents; Cost-Benefit Analysis; Decision Support Techniques; Female; Follow-Up

2014
Management of Pelvic Inflammatory Disease in Selected U.S. Sexually Transmitted Disease Clinics: Sexually Transmitted Disease Surveillance Network, January 2010-December 2011.
    Sexually transmitted diseases, 2015, Volume: 42, Issue:8

    Topics: Adolescent; Adult; Azithromycin; Centers for Disease Control and Prevention, U.S.; Chlamydia Infecti

2015
[37-year old patient with fever, diarrhea and lymphadenopathy].
    Der Internist, 2010, Volume: 51, Issue:8

    Topics: Adult; AIDS Serodiagnosis; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Antifungal

2010
The severity, extent and recurrence of necrotizing periodontal disease in relation to HIV status and CD4+ T cell count.
    Journal of the International Academy of Periodontology, 2010, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Anti-Infective Agents; Anti-Infective Agents, Local; CD4 Lymphocyte Count; Child;

2010
Effect of trichomoniasis therapy on genital HIV viral burden among African women.
    Sexually transmitted diseases, 2012, Volume: 39, Issue:8

    Topics: Adolescent; Adult; Antiprotozoal Agents; Cohort Studies; Female; HIV Seropositivity; Humans; Metroni

2012
[A case of pneumopericardium complicating a liver abscess in a patient infected with HIV].
    Annales de cardiologie et d'angeiologie, 1999, Volume: 48, Issue:6

    Topics: Adult; AIDS-Related Opportunistic Infections; Amoxicillin; Anemia; Anti-Infective Agents; Blood Tran

1999
Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child.
    SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, 2000, Volume: 55, Issue:12

    Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Child, Preschool; Female; HIV Seroposi

2000
Metronidazole for eosinophilic pustular folliculitis in human immunodeficiency virus type 1-positive patients.
    Archives of dermatology, 1995, Volume: 131, Issue:9

    Topics: Adult; Eosinophils; Folliculitis; HIV Seropositivity; HIV-1; Humans; Male; Metronidazole

1995
Blastocystis hominis infection: signs and symptoms in patients at Wilford Hall Medical Center.
    Military medicine, 1990, Volume: 155, Issue:9

    Topics: Adult; Animals; Eukaryota; Female; HIV Seropositivity; Humans; Intestinal Diseases, Parasitic; Male;

1990