metronidazole has been researched along with Calculosis in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recurrence is rare and it can be addressed efficiently with the administration of a second course of antibiotics." | 1.40 | Long-term results of nonoperative treatment for uncomplicated acute appendicitis. ( Aygen, E; Kırkıl, C; Yiğit, MV, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, WJ | 1 |
| Wu, ZR | 1 |
| Yang, Q | 1 |
| Hu, HJ | 1 |
| Wang, JK | 1 |
| Shi, YJ | 1 |
| Li, FY | 1 |
| Cheng, NS | 1 |
| Kırkıl, C | 1 |
| Yiğit, MV | 1 |
| Aygen, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Are the Changes in Immature Granulocyte Count and Percentage Significant in the Decision to Continue Medical Treatment of Uncomplicated Acute Appendicitis Cases[NCT04462588] | 64 participants (Actual) | Observational [Patient Registry] | 2019-06-01 | Completed | |||
| Preoperative Immature Granulocyte Count and Percentage for Complicated and Uncomplicated Appendisitis[NCT04440150] | 70 participants (Actual) | Interventional | 2018-06-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for metronidazole and Calculosis
| Article | Year |
|---|---|
Biliary antibiotics irrigation for E. coli-induced chronic proliferative cholangitis and hepatolithiasis: A pathophysiological study in rabbits.
Topics: Animals; Anti-Bacterial Agents; Bacitracin; Chlorhexidine; Cholangitis; Chronic Disease; Collagen Ty | 2020 |
Long-term results of nonoperative treatment for uncomplicated acute appendicitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append | 2014 |
Long-term results of nonoperative treatment for uncomplicated acute appendicitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append | 2014 |
Long-term results of nonoperative treatment for uncomplicated acute appendicitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append | 2014 |
Long-term results of nonoperative treatment for uncomplicated acute appendicitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin; Anti-Bacterial Agents; Append | 2014 |