metronidazole has been researched along with Rupture in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Rupture: Forcible or traumatic tear or break of an organ or other soft part of the body.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A study on 42 surgical patients was carried out to find out whether cefuroxime may be substituted for gentamicin in combination with metronidazole in the treatment of peritonitis secondary to perforation of appendix." | 9.05 | Comparison of cefuroxime and gentamicin in combination with metronidazole in the treatment of peritonitis due to perforation of the appendix. ( Arvilommi, H; Saario, I; Silvola, H, 1983) |
| "A study on 42 surgical patients was carried out to find out whether cefuroxime may be substituted for gentamicin in combination with metronidazole in the treatment of peritonitis secondary to perforation of appendix." | 5.05 | Comparison of cefuroxime and gentamicin in combination with metronidazole in the treatment of peritonitis due to perforation of the appendix. ( Arvilommi, H; Saario, I; Silvola, H, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jung, J | 1 |
| Choi, M | 1 |
| Kim, YS | 1 |
| Kwon, H | 1 |
| Choi, DH | 1 |
| Tomás, ME | 1 |
| Pérez Carreras, M | 1 |
| Morillasa, JD | 1 |
| Castellano, G | 1 |
| Solís, JA | 1 |
| Karantanis, E | 1 |
| Fynes, MM | 1 |
| Thum, MY | 1 |
| Bircher, M | 1 |
| Stanton, SL | 1 |
| Saario, I | 1 |
| Arvilommi, H | 1 |
| Silvola, H | 1 |
| Alexander, GR | 1 |
| Gibson, KT | 1 |
| Heller, RF | 1 |
| Gorbach, SL | 1 |
| Tatooles, CJ | 1 |
| Loeb, HS | 1 |
| Rahimtoda, SH | 1 |
1 trial available for metronidazole and Rupture
| Article | Year |
|---|---|
Comparison of cefuroxime and gentamicin in combination with metronidazole in the treatment of peritonitis due to perforation of the appendix.
Topics: Adult; Appendicitis; Bacteria; Cefuroxime; Cephalosporins; Clinical Trials as Topic; Drug Therapy, C | 1983 |
6 other studies available for metronidazole and Rupture
| Article | Year |
|---|---|
Nonsurgical resolution of caudal mediastinal paraesophageal abscess in a cat.
Topics: Abscess; Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Cat Diseases | 2015 |
Ruptured pyosalpinx following a fetal reduction procedure.
Topics: Abdominal Pain; Adult; Anti-Bacterial Agents; C-Reactive Protein; Cephalosporins; Fallopian Tubes; F | 2012 |
[Rupture of the Achilles' tendon secondary to levofloxacin].
Topics: Achilles Tendon; Adult; Ceftriaxone; Ciprofloxacin; Crohn Disease; Drug Therapy, Combination; Humans | 2003 |
Symphyseal diastasis and vestibular rupture during spontaneous vaginal delivery.
Topics: Adult; Anti-Infective Agents; Cephalosporins; Cephradine; Female; Humans; Metronidazole; Obstetric L | 2003 |
Non-surgical management of rectal tears in two mares.
Topics: Animals; Clonixin; Diet; Drug Therapy, Combination; Female; Gentamicins; Horses; Magnesium Sulfate; | 2002 |
Amebic pericarditis.
Topics: Adult; Amebiasis; Angiocardiography; Biopsy; Cardiac Tamponade; Chloroquine; Emetine; Female; Hemagg | 1972 |