metronidazole has been researched along with Esophagitis, Reflux in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We therefore assessed the incidence of GERD among comparable patients having undergone successful versus failed H." | 2.69 | Is Helicobacter pylori eradication associated with gastroesophageal reflux disease? ( Barkun, AN; Beech, R; Best, L; Fallone, CA; Friedman, G; Joseph, L; Loo, V; Mayrand, S, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fraser, A | 1 |
| Sato, R | 1 |
| Kubota, T | 1 |
| Murakami, K | 1 |
| Fujioka, T | 1 |
| Fallone, CA | 1 |
| Barkun, AN | 1 |
| Friedman, G | 1 |
| Mayrand, S | 1 |
| Loo, V | 1 |
| Beech, R | 1 |
| Best, L | 1 |
| Joseph, L | 1 |
1 review available for metronidazole and Esophagitis, Reflux
| Article | Year |
|---|---|
[Problems following antibiotic therapy for eradication of Helicobacter pylori].
Topics: Amoxicillin; Anti-Bacterial Agents; Antitrichomonal Agents; Clarithromycin; Drug Resistance, Microbi | 1998 |
1 trial available for metronidazole and Esophagitis, Reflux
| Article | Year |
|---|---|
Is Helicobacter pylori eradication associated with gastroesophageal reflux disease?
Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Ulcer Agents; Bismuth; Double-Blind Method; Drug Therapy, | 2000 |
1 other study available for metronidazole and Esophagitis, Reflux
| Article | Year |
|---|---|
Helicobacter pylori: a historical perspective 1983-2003.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Comorbidity; Drug Therapy, Combination; Esophagitis, Peptic | 2004 |