metronidazole has been researched along with Mastoiditis in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Mastoiditis: Inflammation of the honeycomb-like MASTOID BONE in the skull just behind the ear. It is usually a complication of OTITIS MEDIA.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Demirci, T | 1 |
| O'Brien, S | 1 |
| Siegler, D | 1 |
| Faiers, MC | 1 |
| Willis, AT | 1 |
| Ducroz, V | 1 |
| Le Pajolec, C | 1 |
| Harboun, E | 1 |
| Bobin, S | 1 |
1 review available for metronidazole and Mastoiditis
| Article | Year |
|---|---|
[Acute mastoiditis due to anaerobic bacteria. Review of the literature apropos of a case].
Topics: Acute Disease; Child, Preschool; Ear, Middle; Fusobacterium Infections; Fusobacterium necrophorum; H | 1993 |
2 other studies available for metronidazole and Mastoiditis
| Article | Year |
|---|---|
Complicated Necrotizing Otitis Externa Progressing to Coalescent Mastoiditis and Temporal Lobe Abscess.
Topics: Aged; Anti-Bacterial Agents; Brain Abscess; Cefepime; Gram-Positive Bacterial Infections; Humans; Ma | 2019 |
Bacteroides meningitis complicating chronic mastoiditis.
Topics: Aged; Bacteroides Infections; Chronic Disease; Humans; Male; Mastoiditis; Meningitis; Metronidazole | 1982 |