Compounds > adenosine-5'-carboxylic acid
Page last updated: 2024-11-07

adenosine-5'-carboxylic acid

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Adenosine-5'-carboxylic acid (A5CA) is a synthetic derivative of adenosine, a nucleoside found in DNA and RNA. It is characterized by the presence of a carboxyl group at the 5' position of the ribose moiety. A5CA has shown significant biological activity, particularly in relation to its effects on adenosine receptors and its potential as a therapeutic agent. Research on A5CA has focused on its role in various biological processes, including neurotransmission, inflammation, and cancer. Some studies have explored its potential as a drug candidate for treating conditions such as Parkinson's disease, Alzheimer's disease, and cancer. The synthesis of A5CA involves chemical modification of adenosine, typically through a carboxylation reaction. The effects of A5CA are multifaceted, including modulation of adenosine receptor signaling, inhibition of certain enzymes, and alteration of cellular signaling pathways. Its importance lies in its potential to provide insights into the role of adenosine in various physiological and pathological processes and its potential therapeutic applications.'

Cross-References

ID SourceID
PubMed CID97627
CHEMBL ID595547
CHEBI ID16009
SCHEMBL ID3815016
MeSH IDM0269195

Synonyms (22)

Synonym
3415-09-6
adenosine 5'-carboxylic acid
1-(6-amino-9h-purin-9-yl)-1-deoxy-beta-d-ribofuranuronic acid
9-beta-d-ribofuranuronosyl-9h-purin-6-amine
CHEBI:16009 ,
ado-5'-cooh
9-beta-d-ribofuranuronosyladenine
adenosine-5'-carboxylic acid
9-riburonosyladenine ,
(2s,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carboxylic acid
5'-carboxy adenosine
CHEMBL595547 ,
bdbm50331791
5''-carboxy adenosine
(2s,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-carboxylic acid
beta-d-ribofuranuronic acid, 1-(6-amino-9h-purin-9-yl)-1-deoxy-
nsc 137784
adenosineon
SCHEMBL3815016
Q27098338
(2s,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-carboxylicacid
F76797
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
purine nucleoside
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (7)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Heat shock protein HSP 90-alphaHomo sapiens (human)Ki3.00000.00020.54152.7000AID1694547
EndoplasminHomo sapiens (human)Ki10.00000.00401.32057.0000AID1694546
AdenosylhomocysteinaseHomo sapiens (human)Ki0.41000.00000.18991.9300AID199468
Sigma intracellular receptor 2Homo sapiens (human)Ki0.79600.00010.83604.6005AID1571905
Sigma non-opioid intracellular receptor 1Homo sapiens (human)Ki1.48000.00000.490110.0000AID1571915
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Heat shock protein HSP 90-alphaHomo sapiens (human)Kd50.00000.00030.94889.8000AID1694547
EndoplasminHomo sapiens (human)Kd50.00000.20001.93908.6000AID1694546
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (72)

Processvia Protein(s)Taxonomy
telomere maintenance via telomeraseHeat shock protein HSP 90-alphaHomo sapiens (human)
neuron migrationHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of protein phosphorylationHeat shock protein HSP 90-alphaHomo sapiens (human)
activation of innate immune responseHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of defense response to virus by hostHeat shock protein HSP 90-alphaHomo sapiens (human)
skeletal muscle contractionHeat shock protein HSP 90-alphaHomo sapiens (human)
mitochondrial transportHeat shock protein HSP 90-alphaHomo sapiens (human)
response to unfolded proteinHeat shock protein HSP 90-alphaHomo sapiens (human)
response to heatHeat shock protein HSP 90-alphaHomo sapiens (human)
response to coldHeat shock protein HSP 90-alphaHomo sapiens (human)
response to xenobiotic stimulusHeat shock protein HSP 90-alphaHomo sapiens (human)
response to salt stressHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of lamellipodium assemblyHeat shock protein HSP 90-alphaHomo sapiens (human)
cardiac muscle cell apoptotic processHeat shock protein HSP 90-alphaHomo sapiens (human)
regulation of protein ubiquitinationHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of protein polymerizationHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of interferon-beta productionHeat shock protein HSP 90-alphaHomo sapiens (human)
regulation of protein localizationHeat shock protein HSP 90-alphaHomo sapiens (human)
protein refoldingHeat shock protein HSP 90-alphaHomo sapiens (human)
response to cocaineHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of protein import into nucleusHeat shock protein HSP 90-alphaHomo sapiens (human)
regulation of apoptotic processHeat shock protein HSP 90-alphaHomo sapiens (human)
regulation of protein-containing complex assemblyHeat shock protein HSP 90-alphaHomo sapiens (human)
protein unfoldingHeat shock protein HSP 90-alphaHomo sapiens (human)
response to estrogenHeat shock protein HSP 90-alphaHomo sapiens (human)
protein insertion into mitochondrial outer membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of nitric oxide biosynthetic processHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of protein catabolic processHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of cell sizeHeat shock protein HSP 90-alphaHomo sapiens (human)
response to antibioticHeat shock protein HSP 90-alphaHomo sapiens (human)
protein stabilizationHeat shock protein HSP 90-alphaHomo sapiens (human)
chaperone-mediated protein complex assemblyHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of cardiac muscle contractionHeat shock protein HSP 90-alphaHomo sapiens (human)
chaperone-mediated autophagyHeat shock protein HSP 90-alphaHomo sapiens (human)
cellular response to virusHeat shock protein HSP 90-alphaHomo sapiens (human)
regulation of postsynaptic membrane neurotransmitter receptor levelsHeat shock protein HSP 90-alphaHomo sapiens (human)
positive regulation of tau-protein kinase activityHeat shock protein HSP 90-alphaHomo sapiens (human)
telomerase holoenzyme complex assemblyHeat shock protein HSP 90-alphaHomo sapiens (human)
cellular response to heatHeat shock protein HSP 90-alphaHomo sapiens (human)
protein foldingHeat shock protein HSP 90-alphaHomo sapiens (human)
actin rod assemblyEndoplasminHomo sapiens (human)
regulation of phosphoprotein phosphatase activityEndoplasminHomo sapiens (human)
cellular response to ATPEndoplasminHomo sapiens (human)
response to hypoxiaEndoplasminHomo sapiens (human)
protein transportEndoplasminHomo sapiens (human)
retrograde protein transport, ER to cytosolEndoplasminHomo sapiens (human)
protein folding in endoplasmic reticulumEndoplasminHomo sapiens (human)
response to endoplasmic reticulum stressEndoplasminHomo sapiens (human)
ERAD pathwayEndoplasminHomo sapiens (human)
negative regulation of apoptotic processEndoplasminHomo sapiens (human)
sequestering of calcium ionEndoplasminHomo sapiens (human)
cellular response to manganese ionEndoplasminHomo sapiens (human)
protein foldingEndoplasminHomo sapiens (human)
one-carbon metabolic processAdenosylhomocysteinaseHomo sapiens (human)
S-adenosylmethionine cycleAdenosylhomocysteinaseHomo sapiens (human)
regulation of cell growthSigma intracellular receptor 2Homo sapiens (human)
regulation of intracellular lipid transportSigma intracellular receptor 2Homo sapiens (human)
regulation of intracellular cholesterol transportSigma intracellular receptor 2Homo sapiens (human)
cholesterol homeostasisSigma intracellular receptor 2Homo sapiens (human)
positive regulation of wound healingSigma intracellular receptor 2Homo sapiens (human)
positive regulation of lipoprotein transportSigma intracellular receptor 2Homo sapiens (human)
chromatin remodelingSerine/threonine-protein kinase haspinHomo sapiens (human)
protein phosphorylationSerine/threonine-protein kinase haspinHomo sapiens (human)
mitotic sister chromatid cohesionSerine/threonine-protein kinase haspinHomo sapiens (human)
mitotic spindle assembly checkpoint signalingSerine/threonine-protein kinase haspinHomo sapiens (human)
intracellular signal transductionSerine/threonine-protein kinase haspinHomo sapiens (human)
protein localization to chromosome, centromeric regionSerine/threonine-protein kinase haspinHomo sapiens (human)
mitotic cell cycleSerine/threonine-protein kinase haspinHomo sapiens (human)
lipid transportSigma non-opioid intracellular receptor 1Homo sapiens (human)
nervous system developmentSigma non-opioid intracellular receptor 1Homo sapiens (human)
G protein-coupled opioid receptor signaling pathwaySigma non-opioid intracellular receptor 1Homo sapiens (human)
regulation of neuron apoptotic processSigma non-opioid intracellular receptor 1Homo sapiens (human)
protein homotrimerizationSigma non-opioid intracellular receptor 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (40)

Processvia Protein(s)Taxonomy
UTP bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
CTP bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
RNA bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
mRNA bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
protein bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
ATP bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
GTP bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
ATP hydrolysis activityHeat shock protein HSP 90-alphaHomo sapiens (human)
sulfonylurea receptor bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
protein phosphatase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
MHC class II protein complex bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
nitric-oxide synthase regulator activityHeat shock protein HSP 90-alphaHomo sapiens (human)
TPR domain bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
ubiquitin protein ligase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
dATP bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
identical protein bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
protein homodimerization activityHeat shock protein HSP 90-alphaHomo sapiens (human)
histone deacetylase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
transmembrane transporter bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
tau protein bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
GTPase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
Rho GDP-dissociation inhibitor bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
DNA polymerase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
scaffold protein bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
disordered domain specific bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
ATP-dependent protein folding chaperoneHeat shock protein HSP 90-alphaHomo sapiens (human)
protein tyrosine kinase bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
unfolded protein bindingHeat shock protein HSP 90-alphaHomo sapiens (human)
RNA bindingEndoplasminHomo sapiens (human)
calcium ion bindingEndoplasminHomo sapiens (human)
protein bindingEndoplasminHomo sapiens (human)
ATP bindingEndoplasminHomo sapiens (human)
ATP hydrolysis activityEndoplasminHomo sapiens (human)
protein phosphatase bindingEndoplasminHomo sapiens (human)
low-density lipoprotein particle receptor bindingEndoplasminHomo sapiens (human)
ATP-dependent protein folding chaperoneEndoplasminHomo sapiens (human)
unfolded protein bindingEndoplasminHomo sapiens (human)
adenosylhomocysteinase activityAdenosylhomocysteinaseHomo sapiens (human)
protein bindingAdenosylhomocysteinaseHomo sapiens (human)
nucleic acid bindingRibonuclease pancreaticBos taurus (cattle)
ribonuclease A activityRibonuclease pancreaticBos taurus (cattle)
protein bindingRibonuclease pancreaticBos taurus (cattle)
lyase activityRibonuclease pancreaticBos taurus (cattle)
protein bindingSigma intracellular receptor 2Homo sapiens (human)
oxysterol bindingSigma intracellular receptor 2Homo sapiens (human)
cholesterol bindingSigma intracellular receptor 2Homo sapiens (human)
protein kinase activitySerine/threonine-protein kinase haspinHomo sapiens (human)
protein bindingSerine/threonine-protein kinase haspinHomo sapiens (human)
ATP bindingSerine/threonine-protein kinase haspinHomo sapiens (human)
histone H3T3 kinase activitySerine/threonine-protein kinase haspinHomo sapiens (human)
protein serine kinase activitySerine/threonine-protein kinase haspinHomo sapiens (human)
G protein-coupled opioid receptor activitySigma non-opioid intracellular receptor 1Homo sapiens (human)
protein bindingSigma non-opioid intracellular receptor 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (51)

Processvia Protein(s)Taxonomy
extracellular regionHeat shock protein HSP 90-alphaHomo sapiens (human)
nucleusHeat shock protein HSP 90-alphaHomo sapiens (human)
nucleoplasmHeat shock protein HSP 90-alphaHomo sapiens (human)
cytoplasmHeat shock protein HSP 90-alphaHomo sapiens (human)
mitochondrionHeat shock protein HSP 90-alphaHomo sapiens (human)
cytosolHeat shock protein HSP 90-alphaHomo sapiens (human)
plasma membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
cell surfaceHeat shock protein HSP 90-alphaHomo sapiens (human)
membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
basolateral plasma membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
apical plasma membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
brush border membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
secretory granule lumenHeat shock protein HSP 90-alphaHomo sapiens (human)
melanosomeHeat shock protein HSP 90-alphaHomo sapiens (human)
neuronal cell bodyHeat shock protein HSP 90-alphaHomo sapiens (human)
lysosomal lumenHeat shock protein HSP 90-alphaHomo sapiens (human)
dendritic growth coneHeat shock protein HSP 90-alphaHomo sapiens (human)
axonal growth coneHeat shock protein HSP 90-alphaHomo sapiens (human)
perinuclear region of cytoplasmHeat shock protein HSP 90-alphaHomo sapiens (human)
collagen-containing extracellular matrixHeat shock protein HSP 90-alphaHomo sapiens (human)
extracellular exosomeHeat shock protein HSP 90-alphaHomo sapiens (human)
endocytic vesicle lumenHeat shock protein HSP 90-alphaHomo sapiens (human)
sperm mitochondrial sheathHeat shock protein HSP 90-alphaHomo sapiens (human)
sperm plasma membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
ficolin-1-rich granule lumenHeat shock protein HSP 90-alphaHomo sapiens (human)
protein-containing complexHeat shock protein HSP 90-alphaHomo sapiens (human)
plasma membraneHeat shock protein HSP 90-alphaHomo sapiens (human)
neuronal cell bodyHeat shock protein HSP 90-alphaHomo sapiens (human)
perinuclear region of cytoplasmHeat shock protein HSP 90-alphaHomo sapiens (human)
myelin sheathHeat shock protein HSP 90-alphaHomo sapiens (human)
cytosolHeat shock protein HSP 90-alphaHomo sapiens (human)
nucleusHeat shock protein HSP 90-alphaHomo sapiens (human)
extracellular regionEndoplasminHomo sapiens (human)
nucleusEndoplasminHomo sapiens (human)
endoplasmic reticulumEndoplasminHomo sapiens (human)
endoplasmic reticulum lumenEndoplasminHomo sapiens (human)
endoplasmic reticulum membraneEndoplasminHomo sapiens (human)
smooth endoplasmic reticulumEndoplasminHomo sapiens (human)
cytosolEndoplasminHomo sapiens (human)
focal adhesionEndoplasminHomo sapiens (human)
membraneEndoplasminHomo sapiens (human)
midbodyEndoplasminHomo sapiens (human)
sarcoplasmic reticulum lumenEndoplasminHomo sapiens (human)
melanosomeEndoplasminHomo sapiens (human)
perinuclear region of cytoplasmEndoplasminHomo sapiens (human)
collagen-containing extracellular matrixEndoplasminHomo sapiens (human)
extracellular exosomeEndoplasminHomo sapiens (human)
endocytic vesicle lumenEndoplasminHomo sapiens (human)
sperm plasma membraneEndoplasminHomo sapiens (human)
protein-containing complexEndoplasminHomo sapiens (human)
endoplasmic reticulum chaperone complexEndoplasminHomo sapiens (human)
endoplasmic reticulumEndoplasminHomo sapiens (human)
perinuclear region of cytoplasmEndoplasminHomo sapiens (human)
nucleusAdenosylhomocysteinaseHomo sapiens (human)
endoplasmic reticulumAdenosylhomocysteinaseHomo sapiens (human)
cytosolAdenosylhomocysteinaseHomo sapiens (human)
melanosomeAdenosylhomocysteinaseHomo sapiens (human)
extracellular exosomeAdenosylhomocysteinaseHomo sapiens (human)
cytosolAdenosylhomocysteinaseHomo sapiens (human)
extracellular regionRibonuclease pancreaticBos taurus (cattle)
endoplasmic reticulumSigma intracellular receptor 2Homo sapiens (human)
lysosomeSigma intracellular receptor 2Homo sapiens (human)
endoplasmic reticulumSigma intracellular receptor 2Homo sapiens (human)
rough endoplasmic reticulumSigma intracellular receptor 2Homo sapiens (human)
plasma membraneSigma intracellular receptor 2Homo sapiens (human)
rough endoplasmic reticulum membraneSigma intracellular receptor 2Homo sapiens (human)
nuclear membraneSigma intracellular receptor 2Homo sapiens (human)
nucleusSerine/threonine-protein kinase haspinHomo sapiens (human)
nucleoplasmSerine/threonine-protein kinase haspinHomo sapiens (human)
chromosomeSerine/threonine-protein kinase haspinHomo sapiens (human)
centrosomeSerine/threonine-protein kinase haspinHomo sapiens (human)
spindleSerine/threonine-protein kinase haspinHomo sapiens (human)
cytoplasmSerine/threonine-protein kinase haspinHomo sapiens (human)
nucleusSerine/threonine-protein kinase haspinHomo sapiens (human)
nuclear envelopeSigma non-opioid intracellular receptor 1Homo sapiens (human)
nuclear inner membraneSigma non-opioid intracellular receptor 1Homo sapiens (human)
nuclear outer membraneSigma non-opioid intracellular receptor 1Homo sapiens (human)
endoplasmic reticulumSigma non-opioid intracellular receptor 1Homo sapiens (human)
endoplasmic reticulum membraneSigma non-opioid intracellular receptor 1Homo sapiens (human)
lipid dropletSigma non-opioid intracellular receptor 1Homo sapiens (human)
cytosolSigma non-opioid intracellular receptor 1Homo sapiens (human)
postsynaptic densitySigma non-opioid intracellular receptor 1Homo sapiens (human)
membraneSigma non-opioid intracellular receptor 1Homo sapiens (human)
growth coneSigma non-opioid intracellular receptor 1Homo sapiens (human)
cytoplasmic vesicleSigma non-opioid intracellular receptor 1Homo sapiens (human)
anchoring junctionSigma non-opioid intracellular receptor 1Homo sapiens (human)
postsynaptic density membraneSigma non-opioid intracellular receptor 1Homo sapiens (human)
endoplasmic reticulumSigma non-opioid intracellular receptor 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID538871Inhibition of bovine pancreatic RNase A assessed as degradation of tRNA at 1.9 mM after 6 hrs using ethidium bromide staining by agarose gel-based assay2010Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
Comparative inhibitory activity of 3'- and 5'-functionalized nucleosides on ribonuclease A.
AID1571892Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes at 10 uM after 60 mins by scintillation proximity assay relative to adenosine 5-N-ethyluronamide2019Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
Design and in Vivo Characterization of A
AID1694547Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) after 24 hrs by fluorescence polarization assay2021ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
Biological Evaluation of 5'-(
AID1571894Displacement of [3H]2-[p-(2-carboxyethyl)phenylethylamino]-5-N-ethylcarboxamidoadenosine from human A2A adenosine receptor expressed in HEK293 cell membranes at 10 uM after 60 mins by scintillation proximity assay relative to adenosine 5-N-ethyluronamide2019Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
Design and in Vivo Characterization of A
AID1694548Displacement of FITC-geldanamycin from GRP94 (unknown origin) at 50 uM after 24 hrs by fluorescence polarization assay relative to control2021ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
Biological Evaluation of 5'-(
AID1694546Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assay2021ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
Biological Evaluation of 5'-(
AID1846305Binding affinity to a TEV-cleavable N-terminal His6-tagged human recombinant haspin (470 to 798 residues) assessed as dissociation constant2021European journal of medicinal chemistry, Apr-15, Volume: 216Recent advances in development of hetero-bivalent kinase inhibitors.
AID1571905Inhibition of sigma receptor 2 (unknown origin)2019Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
Design and in Vivo Characterization of A
AID451370Inhibition of PKA assessed as [gamma-32P]ATP labeling of kemptide by liquid scintillation counting2009Bioorganic & medicinal chemistry, Sep-01, Volume: 17, Issue:17
Staurosporine tethered peptide ligands that target cAMP-dependent protein kinase (PKA): optimization and selectivity profiling.
AID199468Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.1996Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
Inactivation of S-adenosyl-L-homocysteine hydrolase by amide and ester derivatives of adenosine-5'-carboxylic acid.
AID1571915Inhibition of sigma receptor 1 (unknown origin)2019Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
Design and in Vivo Characterization of A
AID538872Inhibition of bovine pancreatic RNase A ribonucleolytic activity of RNase A at 2.5 mM after 2 hrs by precipitation assay2010Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
Comparative inhibitory activity of 3'- and 5'-functionalized nucleosides on ribonuclease A.
AID538978Antiparasitic activity against Trichomonas vaginalis T1 at 10 uL after 24 hrs by hemocytometric analysis2010Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24
AdoHcy hydrolase of Trichomonas vaginalis: studies of the effects of 5'-modified adenosine analogues and related 6-N-cyclopropyl derivatives.
AID538873Competitive inhibition of bovine pancreatic RNase A ribonucleolytic activity of by Dixon plot analysis2010Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
Comparative inhibitory activity of 3'- and 5'-functionalized nucleosides on ribonuclease A.
AID229491Inhibition of S-adenosyl-L-homocysteine hydrolase, second order rate constant k2/KI1996Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
Inactivation of S-adenosyl-L-homocysteine hydrolase by amide and ester derivatives of adenosine-5'-carboxylic acid.
AID1694549Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) at 50 uM after 24 hrs by fluorescence polarization assay relative to control2021ACS medicinal chemistry letters, Mar-11, Volume: 12, Issue:3
Biological Evaluation of 5'-(
AID199467Inhibition of S-adenosyl-L-homocysteine hydrolase, dissociation constant.1996Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
Inactivation of S-adenosyl-L-homocysteine hydrolase by amide and ester derivatives of adenosine-5'-carboxylic acid.
AID1571967Inhibition of rat benzodiazepine receptor2019Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
Design and in Vivo Characterization of A
AID1571900Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5-N-methyluronamide from human A3A adenosine receptor expressed in CHO cell membranes at 10 uM after 60 mins by scintillation proximity assay relative to adenosine 5-N-ethyluronamide2019Journal of medicinal chemistry, 02-14, Volume: 62, Issue:3
Design and in Vivo Characterization of A
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's2 (22.22)29.6817
2010's3 (33.33)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.71 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.01 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.71)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (11.11%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fasudil
fasudil: intracellular calcium antagonist; structure in first source. fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.		3.4110isoquinolines;
N-sulfonyldiazepane		antihypertensive agent;
calcium channel blocker;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
geroprotector;
neuroprotective agent;
nootropic agent;
vasodilator agent
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.		2.0510C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic
ag 1879
3-(4-chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo(3,4-d)pyrimidin-4-amine: Fyn kinase inhibitor		3.4110aromatic amine;
monochlorobenzenes;
pyrazolopyrimidine		beta-adrenergic antagonist;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
geroprotector
adenosine monophosphate
Adenosine Monophosphate: Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.		210adenosine 5'-phosphate;
purine ribonucleoside 5'-monophosphate		adenosine A1 receptor agonist;
cofactor;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
EC 3.1.3.11 (fructose-bisphosphatase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
xylitol
xylooligosaccharide: structure in first source. pentitol : An alditol obtained by reduction of any pentose.. xylooligosaccharide : An oligosaccharide comprised of xylose residues.		210
2-chloroadenosine
5-chloroformycin A: structure given in first source		2.3110purine nucleoside
ribavirin
Rebetron: Rebetron is tradename		2.21101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
staurosporine
[no description available]		3.6120indolocarbazole alkaloid;
organic heterooctacyclic compound		apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		2.7230adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
aristeromycin
aristeromycin: RN given refers to (1R-(1alpha,2alpha,3beta,5alpha)-isomer		2.0510
adenosine 5'-carboxamide
adenosine 5'-carboxamide: structure		2.3110
5'-n-methylcarboxamideadenosine
5'-N-methylcarboxamideadenosine: RN given refers to (beta-D)-isomer		2.7730
n-methyladenosine
N-methyladenosine: is a inhibitor of cell differentiation. N(6)-methyladenosine : A methyladenosine compound with one methyl group attached to N(6) of the adenine nucleobase.		2.3110methyladenosine
2-chloro-n(6)cyclopentyladenosine
2-chloro-N(6)cyclopentyladenosine: highly selective agonist at A1 adenosine receptors		2.2110
adenosine 5'-phosphoramidate
adenosine 5'-phosphoramidate : The phosphoramadite analogue of AMP.		2.3110organic phosphoramidateMycoplasma genitalium metabolite
adenosine-5'-carboxaldehyde
adenosine-5'-carboxaldehyde: potent inhibitor of S-adenosyl-L-homocysteine hydrolase; structure given in first source. 5'-dehydroadenosine : A member of the class of adenosines that is 5'-dehydro derivative of adenosine.		1.9910adenosines
adenosine-5'-(n-ethylcarboxamide)
Adenosine-5'-(N-ethylcarboxamide): A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.. N-ethyl-5'-carboxamidoadenosine : A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group.		2.6620adenosines;
monocarboxylic acid amide		adenosine A1 receptor agonist;
adenosine A2A receptor agonist;
antineoplastic agent;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent
n(6)-cyclopentyladenosine
[no description available]		2.2110
adenosine-5'-(N-propyl)carboxamide
adenosine-5'-(N-propyl)carboxamide : A monocarboxylic acid amide that is the propyl amide of adenosine 5'-carboxylic acid.		2.3110adenosines;
monocarboxylic acid amide
1-aminoadenosine
1-aminoadenosine: structure		2.3110
5'-amino-5'-deoxyadenosine
[no description available]		2.3110
n(6)-(2,2-diphenylethyl)adenosine
N(6)-(2,2-diphenylethyl)adenosine: adenosine receptor agonist; structure given in first source		2.3110
n-cyclopropyl adenosine-5'-carboxamide
[no description available]		2.6620
methyl 4-(adenin-9-yl)-2-hydroxybutanoate
methyl 4-(adenin-9-yl)-2-hydroxybutanoate: suppresses antigen-induced specific immune responses, particularly Th1 responses, through inhibition of AdoHcy hydrolase and elevation of endogenous AdoHcy		2.0510
cx 4945
[no description available]		3.4110
chr-6494
[no description available]		3.4110
ConditionIndicatedRelationship StrengthStudiesTrials