Page last updated: 2024-09-27

Necatoriasis

Infection of humans or animals with hookworms of the genus NECATOR. The resulting anemia from this condition is less severe than that from ANCYLOSTOMIASIS.

Synonyms(1)

Synonym
Necatoriasis

Research Excerpts

Treatment

ExcerptReference
"An effective drug for single-dose mass treatment of necatoriasis was sought by testing three drugs and two drug combinations in Ethiopian immigrants to Israel found to have light infections."( Goldsmith, R; Greenberg, Z; Kennet, R; Nahmias, J, 1989)

Research

Studies (115)

TimeframeStudies, This Condition (%)All Conditions %
pre-199059 (51.30)23.3326
1990's23 (20.00)12.5806
2000's18 (15.65)18.1394
2010's12 (10.43)28.8240
2020's3 (2.61)9.53
DrugIndicatedRelationship StrengthStudiesTrials
quinacrine0low10
2-aminoadipic acid0low10
lactic acid0low10
histamine0low10
hydrogen0low10
niacin0low10
albendazole0medium236
fenbendazole0low10
furazolidone0low10
gentamicin0low10
hexylresorcinol0low10
tetramisole0low30
metronidazole0low10
niclosamide0low10
piperazine0low10
praziquantel0low10
thiabendazole0low40
hydrocortisone acetate0low10
sorbitol0low10
benzimidazole0low20
isoflurophate0low10
carbon tetrachloride0low10
adenosine monophosphate0medium11
niridazole0low10
emetine0low10
copper gluconate0low10
diphenylamine0low20
levamisole0medium51
tetrachloroethylene0medium83
amoscanate0low10
amidantel0low10
nsc-1727550low10
paromomycin0low10
elastin0low10
pyrantel0medium185
tribendimidine0low40
pyrantel pamoate0medium164
oxantel pamoate0low10
oxantel0low20
dextrothyroxine0low50
chiniofon0low10
heme0low10
bephenium hydroxynaphthoate0low30
agar0low10
vitamin b 120low10
exudates0low10
folic acid0low10

Protein Targets (505)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Glycogen Phosphorylase B0011
Chain B, Glycogen Phosphorylase B0011
Chain A, ADP-dependent glucokinase0101
Chain A, Ribonuclease pancreatic0101
Chain A, Ribonuclease pancreatic0101
Chain A, phosphodiesterase-nucleotide pyrophosphatase0101
Chain A, GLYCOGEN PHOSPHORYLASE B0011
Chain B, GLYCOGEN PHOSPHORYLASE B0011
Chain A, GLYCOGEN PHOSPHORYLASE B0011
RAR-related orphan receptor gamma130013
AR protein150015
regulator of G-protein signaling 45005
glucocorticoid receptor [Homo sapiens]7007
estrogen-related nuclear receptor alpha160016
euchromatic histone-lysine N-methyltransferase 2110011
v-jun sarcoma virus 17 oncogene homolog (avian)9009
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
Mitogen-activated protein kinase kinase kinase 70011
2'-deoxynucleoside 5'-phosphate N-hydrolase 10101
5'-AMP-activated protein kinase subunit beta-20011
Transient receptor potential cation channel subfamily M member 20101
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
L-lactate dehydrogenase A chain0112
Adenylate kinase isoenzyme 10001
Fructose-1,6-bisphosphatase 10101
Alkaline phosphatase, tissue-nonspecific isozyme0203
Fructose-1,6-bisphosphatase 10101
2-dehydropantoate 2-reductase0112
Inosine-5'-monophosphate dehydrogenase0101
Cytochrome P450 2C9 0314
Proto-oncogene tyrosine-protein kinase Src0404
Amine oxidase [flavin-containing] B0101
5'-nucleotidase0001
Choline O-acetyltransferase0101
Adenylate kinase 2, mitochondrial0102
GTP:AMP phosphotransferase AK3, mitochondrial0001
Adenosine receptor A10011
Adenylate kinase isoenzyme 1 0102
P2Y purinoceptor 20011
P2Y purinoceptor 10011
P2Y purinoceptor 10011
5'-AMP-activated protein kinase subunit gamma-10022
5'-AMP-activated protein kinase catalytic subunit alpha-20011
Adenylate kinase 2, mitochondrial0001
Glycine--tRNA ligase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Adenosine deaminase-like protein0001
Protease 0112
P2Y purinoceptor 110011
Histamine H3 receptor0101
5'-AMP-activated protein kinase subunit gamma-30011
5'-AMP-activated protein kinase subunit gamma-20011
5'-AMP-activated protein kinase subunit beta-10022
ATP-dependent phosphofructokinase5005
Chain A, Beta-lactamase6006
Luciferase7007
glp-1 receptor, partial5005
hypoxia-inducible factor 1 alpha subunit5005
ATAD5 protein, partial7007
Fumarate hydratase5005
TDP1 protein100010
GLI family zinc finger 39009
caspase 7, apoptosis-related cysteine protease4004
nuclear receptor subfamily 1, group I, member 39009
progesterone receptor7007
retinoic acid nuclear receptor alpha variant 1150015
retinoid X nuclear receptor alpha100010
farnesoid X nuclear receptor7007
pregnane X nuclear receptor110011
estrogen nuclear receptor alpha140014
polyprotein5005
67.9K protein5005
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor9009
caspase-34004
IDH14004
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
nuclear receptor subfamily 1, group I, member 25005
Histone H2A.x4004
cellular tumor antigen p53 isoform a6006
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
chromobox protein homolog 14004
nuclear factor erythroid 2-related factor 2 isoform 24004
transcriptional regulator ERG isoform 32002
thyroid hormone receptor beta isoform 2110011
histone deacetylase 9 isoform 35005
heat shock protein beta-14004
mitogen-activated protein kinase 15005
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
geminin110011
Vif0001
peripheral myelin protein 225005
survival motor neuron protein isoform d5005
muscleblind-like protein 1 isoform 13003
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
lamin isoform A-delta10100010
neuropeptide S receptor isoform A3003
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40607
Voltage-dependent calcium channel gamma-2 subunit6006
Bile salt export pump012012
Interferon beta7007
Cellular tumor antigen p53100010
Integrin beta-35005
Integrin alpha-IIb5005
Methionine aminopeptidase0404
Glutamate receptor 26006
Fatty-acid amide hydrolase 10404
Inositol monophosphatase 12002
Canalicular multispecific organic anion transporter 10606
ATPase family AAA domain-containing protein 56006
Ataxin-27007
Chain A, GTPase KRas, isoform 2B0011
Chain A, GTPase KRas, isoform 2B0011
Membrane primary amine oxidase 0101
Cytochrome P450 2B10102
Cytochrome P450 1A10102
GTPase KRas0011
Polyunsaturated fatty acid 5-lipoxygenase0001
Glutaminyl-peptide cyclotransferase0202
Lanosterol 14-alpha demethylase0202
Membrane primary amine oxidase0101
Glutaminyl-peptide cyclotransferase0101
pregnane X receptor2002
aldehyde dehydrogenase 1 family, member A17007
thyroid stimulating hormone receptor9009
peroxisome proliferator-activated receptor delta6006
potassium voltage-gated channel subfamily H member 2 isoform d3003
lethal factor (plasmid)4004
Cytochrome P450 2E10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE110011
Chain A, Ferritin light chain5005
Chain A, Cruzipain3003
endonuclease IV2002
thioredoxin reductase8008
Microtubule-associated protein tau5005
nonstructural protein 12002
glucocerebrosidase2002
Bloom syndrome protein isoform 13003
peripheral myelin protein 22 isoform 12002
DNA polymerase beta2002
DNA polymerase iota isoform a (long)4004
M-phase phosphoprotein 84004
Spike glycoprotein3115
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
ClpP1001
SMAD family member 24004
SMAD family member 34004
estrogen receptor 2 (ER beta)8008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
nuclear factor erythroid 2-related factor 2 isoform 18008
Glycoprotein hormones alpha chain1001
UDP-glucuronosyltransferase 1A40001
NS5 0011
PPM1D protein4004
cytochrome P450 family 3 subfamily A polypeptide 47007
Parkin2002
activating transcription factor 64004
Spike glycoprotein0112
Replicase polyprotein 1ab0112
NPC intracellular cholesterol transporter 1 precursor4004
flap endonuclease 15005
ras-related protein Rab-9A4004
serine/threonine-protein kinase mTOR isoform 13003
Transmembrane protease serine 20112
Glucose transporter0101
Serine hydrolase RBBP90101
Hexose transporter 1 0101
Procathepsin L0112
ATP-dependent translocase ABCB10113
Alpha-2A adrenergic receptor0404
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0112
Replicase polyprotein 1ab0213
Solute carrier family 2, facilitated glucose transporter member 10101
Alpha-2C adrenergic receptor0404
Hypoxia-inducible factor 1-alpha0102
Dihydroorotate dehydrogenase 0101
Endothelial PAS domain-containing protein 10102
Angiotensin-converting enzyme 2 0112
Smad31001
EWS/FLI fusion protein6006
thyroid stimulating hormone receptor2002
Caspase-71001
caspase-31001
nuclear receptor ROR-gamma isoform 13003
Nuclear receptor subfamily 1 group I member 20011
Rap guanine nucleotide exchange factor 31001
Mitogen-activated protein kinase 140101
Nuclear receptor subfamily 1 group I member 20011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Dihydrofolate reductase0011
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, 2-oxoglutarate Oxygenase2002
acid sphingomyelinase1001
USP1 protein, partial7007
alpha-galactosidase1001
lysosomal alpha-glucosidase preproprotein2002
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein2002
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
15-lipoxygenase, partial2002
GALC protein4004
G3003
cytochrome P450 2D66006
bromodomain adjacent to zinc finger domain 2B3003
vitamin D3 receptor isoform VDRA3003
huntingtin isoform 23003
DNA polymerase kappa isoform 13003
cytochrome P450 3A4 isoform 16006
Gamma-aminobutyric acid receptor subunit pi6006
Polyphenol oxidase 20202
HLA class I histocompatibility antigen, B alpha chain 3003
Polyunsaturated fatty acid 5-lipoxygenase0101
Tyrosinase0202
Gamma-aminobutyric acid receptor subunit beta-16006
Polyunsaturated fatty acid lipoxygenase ALOX150101
Polyunsaturated fatty acid lipoxygenase ALOX120101
Gamma-aminobutyric acid receptor subunit delta6006
Gamma-aminobutyric acid receptor subunit gamma-26006
Gamma-aminobutyric acid receptor subunit alpha-56006
Gamma-aminobutyric acid receptor subunit alpha-36006
Gamma-aminobutyric acid receptor subunit gamma-16006
Gamma-aminobutyric acid receptor subunit alpha-26006
Gamma-aminobutyric acid receptor subunit alpha-46006
Gamma-aminobutyric acid receptor subunit gamma-36006
Gamma-aminobutyric acid receptor subunit alpha-66006
Nuclear receptor ROR-gamma2002
Gamma-aminobutyric acid receptor subunit alpha-16006
Gamma-aminobutyric acid receptor subunit beta-36006
Gamma-aminobutyric acid receptor subunit beta-26006
GABA theta subunit6006
Inositol hexakisphosphate kinase 13003
Gamma-aminobutyric acid receptor subunit epsilon6006
cytochrome P450 2C9, partial3003
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Protein (female-specific Histamine Binding Protein 2)0011
aryl hydrocarbon receptor nuclear translocator0001
phosphopantetheinyl transferase1001
GLS protein1001
apical membrane antigen 1, AMA11001
transforming acidic coiled-coil-containing protein 30001
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0001
Carbonic anhydrase 120001
Solute carrier family 22 member 30102
Carbonic anhydrase 10001
Carbonic anhydrase 20002
Plasma kallikrein0001
Carbonic anhydrase 30001
Macrophage migration inhibitory factor0202
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Histamine H2 receptor0325
Adenosine receptor A10001
5-hydroxytryptamine receptor 1D0001
Adenosine receptor A2a0001
Histamine H1 receptor0123
Histamine H1 receptor0213
Metabotropic glutamate receptor 50112
Carbonic anhydrase 5A, mitochondrial0001
Histamine H1 receptor0224
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Histamine H2 receptor3014
Carbonic anhydrase0002
Histamine H3 receptor0101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Histamine N-methyltransferase 0101
Carbonic anhydrase 90001
Carbonic anhydrase 0002
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0002
Carbonic anhydrase0002
Glutamate receptor ionotropic, NMDA 2D0001
Solute carrier family 22 member 10102
Carbonic anhydrase 0002
Equilibrative nucleoside transporter 40001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0001
Histamine H4 receptor0123
Histamine H4 receptor0123
Histamine H4 receptor 0101
Carbonic anhydrase 40001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Histamine H4 receptor0123
Histamine H3 receptor0101
Carboxylic ester hydrolase 0001
Solute carrier family 22 member 20102
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Histamine H3 receptor0123
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Corticosteroid-binding globulin0101
TAR DNA-binding protein 433003
Acetylcholinesterase0101
Acetylcholinesterase0011
Lysosomal protective protein0101
Fatty acid synthase 0101
Acetylcholinesterase0314
Liver carboxylesterase0101
acetylcholinesterase1001
dopamine D1 receptor2002
atrial natriuretic peptide receptor 1 precursor2002
Alkaline phosphatase, placental type0101
Alkaline phosphatase, tissue-nonspecific isozyme 0202
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Phospholipase A-2-activating protein0101
cytochrome P450 2C9 precursor2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a2002
Tyrosine-protein kinase ABL10303
Vascular endothelial growth factor receptor 20202
Disintegrin and metalloproteinase domain-containing protein 171001
Calmodulin-domain protein kinase 10101
Thioredoxin reductase 0101
thyroid hormone receptor beta isoform a3003
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Chain A, JmjC domain-containing histone demethylation protein 3A2002
thyrotropin-releasing hormone receptor1001
Amyloid-beta precursor protein0101
Neuronal acetylcholine receptor subunit alpha-41001
Cholesteryl ester transfer protein0101
Neuronal acetylcholine receptor subunit beta-21001
D-amino-acid oxidase0101
Xanthine dehydrogenase/oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
Multidrug and toxin extrusion protein 10202
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
TSHR protein1001
Thrombopoietin1001
PINK11001
arylsulfatase A3003
pyruvate kinase2002
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
cytochrome P450 2D6 isoform 12002
cytochrome P450 2C19 precursor2002
D(1A) dopamine receptor2002
glucose-6-phosphate 1-dehydrogenase isoform b0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
atrial natriuretic peptide receptor 2 precursor1001
muscarinic acetylcholine receptor M12002
pyruvate kinase PKM isoform b1001
Aurora kinase A0101
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
3-phosphoinositide-dependent protein kinase 10101
Tyrosine-protein kinase JAK20101
Epidermal growth factor receptor0101
Tyrosine-protein kinase Lyn0101
Ornithine decarboxylase1001
Platelet-derived growth factor receptor beta0101
Mast/stem cell growth factor receptor Kit0101
Fibroblast growth factor receptor 10101
Serine/threonine-protein kinase B-raf0101
Protein kinase C alpha type0101
Mitogen-activated protein kinase 10101
RAC-alpha serine/threonine-protein kinase0101
Receptor-type tyrosine-protein kinase FLT30101
Signal transducer and activator of transcription 30101
Mitogen-activated protein kinase 80101
Glycogen synthase kinase-3 beta0101
D(1A) dopamine receptor2002
Guanine nucleotide-binding protein G1001
Angiopoietin-1 receptor0101
Anoctamin-10101
Rap guanine nucleotide exchange factor 41001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Tyrosyl-DNA phosphodiesterase 10101
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b0011
Bile salt export pump0101
galactokinase1001
N0101
NPYLR7B0011
cystic fibrosis transmembrane conductance regulator0101
tumor susceptibility gene 101 protein1001
histone acetyltransferase KAT2A isoform 11001
Glutathione reductase, mitochondrial0101
Riboflavin-binding protein0112
Major prion protein0011
Major prion protein0101
Histidine-rich protein PFHRP-II0101
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50202
DNA-directed RNA polymerase subunit alpha0101
DNA-directed RNA polymerase subunit omega0101
DNA-directed RNA polymerase subunit beta'0101
DNA-directed RNA polymerase subunit beta0101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10202
Phospholipase A2, membrane associated0101
Phospholipase A2, membrane associated0101
Acidic phospholipase A2 20101
Alpha-2B adrenergic receptor0202
Muscarinic acetylcholine receptor M30202
Sodium-dependent noradrenaline transporter 0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
Trypanothione reductase0202
D(3) dopamine receptor0202
Aldehyde oxidase 10101
Cholinesterase0101
Aldehyde oxidase0101
Cyclic GMP-AMP synthase0101
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Chain A, Methionine aminopeptidase0101
BRCA11001
P531001
Cytochrome P450 1A20101
Endothelin receptor type B1001
Endothelin-1 receptor1001
Methionine aminopeptidase 20101
Methionine aminopeptidase 10112
Peptidyl-prolyl cis-trans isomerase FKBP1A0011
Reverse transcriptase/RNaseH 0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]