metronidazole has been researched along with Botulism, Infantile in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clinical course of a case of infant botulism was characterized by several relapses despite therapy with amoxicillin and metronidazole." | 7.83 | A penicillin- and metronidazole-resistant Clostridium botulinum strain responsible for an infant botulism case. ( Blanc, T; Bouchier, C; Bouvet, P; Boyer, S; Courvalin, P; Doehring, I; Dumant-Forest, C; Legeay, C; Mazuet, C; Meziane-Cherif, D; Pestel-Caron, M; Pignier, S; Popoff, MR; Quijano-Roy, S; Sautereau, J; Yoon, EJ, 2016) |
| "The clinical course of a case of infant botulism was characterized by several relapses despite therapy with amoxicillin and metronidazole." | 3.83 | A penicillin- and metronidazole-resistant Clostridium botulinum strain responsible for an infant botulism case. ( Blanc, T; Bouchier, C; Bouvet, P; Boyer, S; Courvalin, P; Doehring, I; Dumant-Forest, C; Legeay, C; Mazuet, C; Meziane-Cherif, D; Pestel-Caron, M; Pignier, S; Popoff, MR; Quijano-Roy, S; Sautereau, J; Yoon, EJ, 2016) |
| "Infant botulism is a rare disease in the UK, with the first case being recognized in 1978 and only five subsequent cases being reported before 2007." | 1.35 | Report of two unlinked cases of infant botulism in the UK in October 2007. ( Courtney, M; Dixon, G; Grant, KA; Lister, P; McLauchlin, J; Mithani, V; Morgan, J; Mpamugo, O; Nixon, G; Nwarfor, I; Planche, T, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mazuet, C | 1 |
| Yoon, EJ | 1 |
| Boyer, S | 1 |
| Pignier, S | 1 |
| Blanc, T | 1 |
| Doehring, I | 1 |
| Meziane-Cherif, D | 1 |
| Dumant-Forest, C | 1 |
| Sautereau, J | 1 |
| Legeay, C | 1 |
| Bouvet, P | 1 |
| Bouchier, C | 1 |
| Quijano-Roy, S | 1 |
| Pestel-Caron, M | 1 |
| Courvalin, P | 1 |
| Popoff, MR | 1 |
| Grant, KA | 1 |
| Nwarfor, I | 1 |
| Mpamugo, O | 1 |
| Mithani, V | 1 |
| Lister, P | 1 |
| Dixon, G | 1 |
| Nixon, G | 1 |
| Planche, T | 1 |
| Courtney, M | 1 |
| Morgan, J | 1 |
| McLauchlin, J | 1 |
| Wang, Y | 1 |
| Sugiyama, H | 2 |
| Prather, JL | 1 |
| Woller, MJ | 1 |
4 other studies available for metronidazole and Botulism, Infantile
| Article | Year |
|---|---|
A penicillin- and metronidazole-resistant Clostridium botulinum strain responsible for an infant botulism case.
Topics: Anti-Bacterial Agents; Botulinum Toxins; Botulism; Clostridium botulinum; Drug Resistance, Bacterial | 2016 |
Report of two unlinked cases of infant botulism in the UK in October 2007.
Topics: Anti-Bacterial Agents; Botulism; Female; Humans; Immunoglobulins; Infant; Male; Metronidazole; Risk | 2009 |
Botulism in metronidazole- treated conventional adult mice challenged orogastrically with spores of Clostridium botulinum type A or B.
Topics: Animals; Botulinum Toxins; Botulism; Clostridium botulinum; Immunity, Innate; Intestines; Metronidaz | 1984 |
Lyophilized airborne Clostridium botulinum spores as inocula that intestinally colonize antimicrobially pretreated adult mice.
Topics: Aerosols; Animals; Botulism; Clostridium botulinum; Freeze Drying; Metronidazole; Mice; Spores, Bact | 1986 |