metronidazole has been researched along with Viral Diseases in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Other causes of vaginitis are also discussed." | 2.37 | Vaginitis: current microbiologic and clinical concepts. ( Embil, JA; Hill, LV, 1986) |
| "Metronidazole treatment amplified these proinflammatory responses." | 1.38 | Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapy. ( Beach, DH; Buck, OR; Chepa-Lotrea, X; Fichorova, RN; Goodman, RP; Hayes, GR; Kula, T; Lee, Y; Murray, R; Nibert, ML; Singh, BN; Takagi, Y; Yamamoto, HS, 2012) |
| "The septicemia is most commonly, but not always preceded by an obvious oropharyngeal focus." | 1.27 | Fusobacterium necrophorum septicemia without a primary focus. ( Armstrong, RD; Bouvier, DP; Bradshaw, DM; Hoenzsch, RE, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fichorova, RN | 1 |
| Lee, Y | 1 |
| Yamamoto, HS | 1 |
| Takagi, Y | 1 |
| Hayes, GR | 1 |
| Goodman, RP | 1 |
| Chepa-Lotrea, X | 1 |
| Buck, OR | 1 |
| Murray, R | 1 |
| Kula, T | 1 |
| Beach, DH | 1 |
| Singh, BN | 1 |
| Nibert, ML | 1 |
| Hill, LV | 1 |
| Embil, JA | 1 |
| Bouvier, DP | 1 |
| Armstrong, RD | 1 |
| Bradshaw, DM | 1 |
| Hoenzsch, RE | 1 |
1 review available for metronidazole and Viral Diseases
| Article | Year |
|---|---|
Vaginitis: current microbiologic and clinical concepts.
Topics: Antibody Formation; Antifungal Agents; Candidiasis; Candidiasis, Vulvovaginal; Carrier State; Female | 1986 |
2 other studies available for metronidazole and Viral Diseases
| Article | Year |
|---|---|
Endobiont viruses sensed by the human host - beyond conventional antiparasitic therapy.
Topics: Animals; Anti-Bacterial Agents; Antiparasitic Agents; Female; Host-Pathogen Interactions; Humans; Im | 2012 |
Fusobacterium necrophorum septicemia without a primary focus.
Topics: Adolescent; Diagnosis, Differential; Fusobacterium Infections; Fusobacterium necrophorum; Humans; Hy | 1985 |