metronidazole has been researched along with Infections, Proteus in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bacteremia was infrequently detected, but isolated pathogens were multidrug resistant." | 1.56 | Prevalence, Etiology, and Outcome of Sepsis among Critically Ill Patients in Malawi. ( Charles, A; Kadyaudzu, C; Onofrey, L; Prin, M; Purcell, L, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Prin, M | 1 |
| Onofrey, L | 1 |
| Purcell, L | 1 |
| Kadyaudzu, C | 1 |
| Charles, A | 1 |
| Smith, S | 1 |
| Bagshaw, RJ | 1 |
| Hanson, J | 1 |
| SZELL, I | 1 |
| EMBER, M | 1 |
| NOVAK, E | 1 |
| DRAPER, JW | 1 |
| AKBARI, A | 1 |
| WARD, JN | 1 |
| Namavar, F | 1 |
| van Vught, AM | 1 |
| MacLaren, DM | 1 |
| Goulton, J | 1 |
| Wilkinson, MA | 1 |
| Baker, PG | 1 |
6 other studies available for metronidazole and Infections, Proteus
| Article | Year |
|---|---|
Prevalence, Etiology, and Outcome of Sepsis among Critically Ill Patients in Malawi.
Topics: Adult; Anti-Bacterial Agents; Antifungal Agents; Bacteremia; Burkholderia Infections; Candida glabra | 2020 |
The microbiology of crocodile attacks in Far North Queensland: implications for empirical antimicrobial therapy.
Topics: Adolescent; Adult; Aged; Alligators and Crocodiles; Animals; Anti-Bacterial Agents; Bacillus cereus; | 2017 |
[TREATMENT OF TRICHOMONAL VAGINITIS WITH IMIDAZOLE DERIVATE].
Topics: Chloramphenicol; Cystitis; Escherichia coli Infections; Female; Humans; Imidazoles; Metronidazole; N | 1963 |
THERAPEUTIC PROBLEMS IN URINARY INFECTIONS.
Topics: Chloramphenicol; Enterobacter aerogenes; Escherichia coli Infections; Humans; Hydrocortisone; Imidaz | 1964 |
Bacterial synergy in mixed aerobic/anaerobic infections.
Topics: Bacteroides Infections; Humans; Metronidazole; Phagocytosis; Prevotella melaninogenica; Proteus Infe | 1980 |
Multicentre study of 'Flagyl' in the prevention of post-operative anaerobic infection.
Topics: Aged; Bacterial Infections; Bacteroides Infections; Child; Digestive System Surgical Procedures; Esc | 1979 |