6-demethyl-9-(N,N-dimethylglycylamido)-6-deoxytetracycline: a glycylcycline; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 54692950 |
| SCHEMBL ID | 2612773 |
| MeSH ID | M0226443 |
| Synonym |
|---|
| cl331,002 |
| dmg-6-demethyl-6-deoxytetracycline |
| (4s,4as,5ar,12as)-4-(dimethylamino)-9-[[2-(dimethylamino)acetyl]amino]-3,10,12,12a-tetrahydroxy-1,11-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide |
| dmg-dmdot |
| cl-331,928 |
| cl-331928 |
| 1ORK , |
| 9-(n,n-dimethylglycylamido)-6-deoxy-6-demethyl-tetracycline |
| 6-demethyl-9-(n,n-dimethylglycylamido)-6-deoxytetracycline |
| 4-(dimethylamino)-9-(((dimethylamino)acetyl)amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide (4s-(4alpha,4aalpha,5aalpha,12aalpha))- |
| dmg-dm dot |
| 2-naphthacenecarboxamide, 4-(dimethylamino)-9-(((dimethylamino)acetyl)amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4s-(4alpha,4aalpha,5aalpha,12aalpha))- |
| 151922-17-7 |
| SCHEMBL2612773 |
| (4s,4as,5ar,12as)-4-(dimethylamino)-9-[(n,n-dimethylglycyl)amino]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide |
| Excerpt | Relevance | Reference |
|---|---|---|
| " The in vivo efficacies of the glycylcyclines against acute lethal infections in mice when dosed intravenously were reflective of their in vitro activities." | ( In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines. Jacobus, NV; Lee, VJ; Petersen, PJ; Sum, PE; Tally, FP; Testa, RT, 1993) | 0.29 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Tetracycline Repressor | Escherichia coli | Kd | 0.0016 | 0.0016 | 0.0016 | 0.0016 | AID977611 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1811 | Experimentally measured binding affinity data derived from PDB | 1999 | Journal of molecular biology, Jan-15, Volume: 285, Issue:2 | Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 1999 | Journal of molecular biology, Jan-15, Volume: 285, Issue:2 | Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (93.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.68) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (13.33%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (86.67%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||