metronidazole has been researched along with Periimplantitis in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study clinical, radiographic, and microbiological outcomes after non-surgical therapy of peri-implantitis with or without adjunctive systemic metronidazole." | 9.51 | Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial. ( Blanco, C; Blanco, J; Dopico, J; Gándara, P; Liñares, A; Pico, A, 2022) |
| "To assess the clinical and microbiological outcomes of administering metronidazole in combination with minocycline as a local adjunct to the nonsurgical treatment of peri-implantitis." | 9.41 | Adjunctive use of metronidazole-minocycline ointment in the nonsurgical treatment of peri-implantitis: A multicenter randomized controlled trial. ( Cha, JK; Kim, CS; Kim, YT; Lee, DW; Lee, JH; Lee, JS; Park, SH; Shin, HS; Song, YW, 2021) |
| "The aim of this study was to evaluate the effects of adjunct systemic antibiotic treatment with metronidazole (MTZ) and amoxicillin (AMX) in patients receiving non-surgical subgingival debridement (NSD) for peri-implantitis." | 9.30 | Microbiological and clinical effects of adjunctive systemic metronidazole and amoxicillin in the non-surgical treatment of peri-implantitis: 1 year follow-up. ( Faveri, M; Feres, M; Ferrari, DS; Figueiredo, LC; Shibli, JA; Siroma, RS, 2019) |
| "Submucosal biofilm specimens were cultured from 160 dental implants with peri-implantitis in 120 adults, with isolated putative pathogens identified to species level, and tested in vitro for susceptibility to 4 mg/l of doxycycline, 8 mg/l of amoxicillin, 16 mg/l of metronidazole, and 4 mg/l of clindamycin." | 3.80 | Antibiotic resistance in human peri-implantitis microbiota. ( Degener, JE; Rams, TE; van Winkelhoff, AJ, 2014) |
| "Thirty-six implants in 24 partially dentate patients with moderate to advanced peri-implantitis were treated using an anti-infective surgical protocol incorporating open flap debridement and implant surface decontamination, with adjunctive systemic amoxicillin and metronidazole." | 3.78 | Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study. ( Faddy, M; Heitz-Mayfield, LJA; Lang, NP; Mombelli, A; Salvi, GE, 2012) |
| "Although polymicrobial infections, such as peri-implantitis or periodontitis, were postulated in the literature to be caused by synergistic effects of bacteria, these effects remain unclear looking at antibiotic susceptibility." | 1.37 | Antibiotic susceptibility of cocultures in polymicrobial infections such as peri-implantitis or periodontitis: an in vitro model. ( Al-Nawas, B; d'Hoedt, B; Karbach, J; Mouratidou, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 6 (54.55) | 2.80 |
| Authors | Studies |
|---|---|
| Blanco, C | 1 |
| Pico, A | 1 |
| Dopico, J | 2 |
| Gándara, P | 1 |
| Blanco, J | 2 |
| Liñares, A | 2 |
| Ardila, CM | 2 |
| Vivares-Builes, AM | 2 |
| Sanz-Sánchez, I | 1 |
| Molina, A | 1 |
| Montero, E | 1 |
| López-Valverde, N | 1 |
| López-Valverde, A | 1 |
| Blanco-Rueda, JA | 1 |
| Feres, M | 2 |
| Martins, R | 1 |
| Souza, JGS | 1 |
| Bertolini, M | 1 |
| Barão, VAR | 1 |
| Shibli, JA | 2 |
| Ferrari, DS | 1 |
| Siroma, RS | 1 |
| Figueiredo, LC | 1 |
| Faveri, M | 1 |
| Park, SH | 1 |
| Song, YW | 1 |
| Cha, JK | 1 |
| Lee, JS | 1 |
| Kim, YT | 1 |
| Shin, HS | 1 |
| Lee, DW | 1 |
| Lee, JH | 1 |
| Kim, CS | 1 |
| Rams, TE | 1 |
| Degener, JE | 1 |
| van Winkelhoff, AJ | 1 |
| Jepsen, K | 1 |
| Jepsen, S | 1 |
| Laine, ML | 1 |
| Anssari Moin, D | 1 |
| Pilloni, A | 1 |
| Zeza, B | 1 |
| Sanz, M | 1 |
| Ortiz-Vigon, A | 1 |
| Roos-Jansåker, AM | 1 |
| Renvert, S | 1 |
| Mouratidou, A | 1 |
| Karbach, J | 1 |
| d'Hoedt, B | 1 |
| Al-Nawas, B | 1 |
| Heitz-Mayfield, LJA | 1 |
| Salvi, GE | 1 |
| Mombelli, A | 1 |
| Faddy, M | 1 |
| Lang, NP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metronidazole as an Adjunct of Non- Surgical Treatment of Peri-implantitis : a 6-months Placebo- Controlled Clinical Trial in Humans[NCT03564301] | Phase 4 | 20 participants (Actual) | Interventional | 2018-03-03 | Completed | ||
| Implantoplasty Versus Implant Decontamination With Erythritol Air-abrasive Device During Surgical Therapy of Peri-implantitis. Clinical, Radiographic and Microbiological Evaluation. A Randomized Controlled Clinical Study[NCT05899933] | 45 participants (Anticipated) | Interventional | 2023-07-28 | Recruiting | |||
| Clinical and Microbiological Effects of Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis: 1-year Randomized Double-blinded Controlled Clinical Trial[NCT05444218] | 94 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| Reconstructive Surgical Therapy of Peri-implantitis-related Osseous Defects. A Multicenter Randomized Controlled Clinical Trial[NCT03077061] | 140 participants (Actual) | Interventional | 2017-04-01 | Active, not recruiting | |||
| Reconstructive Surgical Treatment of Peri-implant Intra-osseous Defects - A MULTICENTER RANDOMIZED PROSPECTIVE CLINICAL STUDY[NCT02406001] | 70 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| Effects of a Toothpaste Containing 0.3% Triclosan in the Maintenance Phase of Peri-implantitis Treatment.[NCT03191721] | Phase 3 | 102 participants (Actual) | Interventional | 2010-06-30 | Completed | ||
| The Evaluation of Clinical, Microbiological and Immunological Parameters After Using Photodynamic Therapy in the Surgical Treatment of Peri-implantitis: Randomized Clinical Trials.[NCT05187663] | 50 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for metronidazole and Periimplantitis
| Article | Year |
|---|---|
Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Drug Resistance, Microbia | 2022 |
Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Drug Resistance, Microbia | 2022 |
Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Drug Resistance, Microbia | 2022 |
Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Drug Resistance, Microbia | 2022 |
Efficacy of adjunctive measures in the non-surgical treatment of peri-implantitis: A systematic review.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Dental Implants; Humans; Metronidazole; M | 2023 |
Efficacy of adjuvant metronidazole therapy on peri-implantitis: a systematic review and meta-analysis of randomized clinical studies.
Topics: Anti-Bacterial Agents; Bias; Combined Modality Therapy; Humans; Metronidazole; Peri-Implantitis | 2023 |
Unraveling the effectiveness of antibiotics for peri-implantitis treatment: A scoping review.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Implants; Humans; Metronidazole; Peri-Implantitis; Period | 2023 |
4 trials available for metronidazole and Periimplantitis
| Article | Year |
|---|---|
Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial.
Topics: Dental Implants; Humans; Metronidazole; Peri-Implantitis; Periodontal Index; Photochemotherapy; Trea | 2022 |
Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial.
Topics: Dental Implants; Humans; Metronidazole; Peri-Implantitis; Periodontal Index; Photochemotherapy; Trea | 2022 |
Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial.
Topics: Dental Implants; Humans; Metronidazole; Peri-Implantitis; Periodontal Index; Photochemotherapy; Trea | 2022 |
Adjunctive benefits of systemic metronidazole on non-surgical treatment of peri-implantitis. A randomized placebo-controlled clinical trial.
Topics: Dental Implants; Humans; Metronidazole; Peri-Implantitis; Periodontal Index; Photochemotherapy; Trea | 2022 |
Microbiological and clinical effects of adjunctive systemic metronidazole and amoxicillin in the non-surgical treatment of peri-implantitis: 1 year follow-up.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Drug Combinations; Female; Follow-Up Studies; Humans; Male | 2019 |
Adjunctive use of metronidazole-minocycline ointment in the nonsurgical treatment of peri-implantitis: A multicenter randomized controlled trial.
Topics: Dental Implants; Humans; Metronidazole; Minocycline; Ointments; Peri-Implantitis; Periodontal Index | 2021 |
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
3 other studies available for metronidazole and Periimplantitis
| Article | Year |
|---|---|
Antibiotic resistance in human peri-implantitis microbiota.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Biofilms; Ciprofloxacin; Clindamycin; Doxycycline; Drug | 2014 |
Antibiotic susceptibility of cocultures in polymicrobial infections such as peri-implantitis or periodontitis: an in vitro model.
Topics: Acetamides; Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicill | 2011 |
Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Debridement; Decontamination; Dental Pros | 2012 |
Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Debridement; Decontamination; Dental Pros | 2012 |
Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Debridement; Decontamination; Dental Pros | 2012 |
Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Debridement; Decontamination; Dental Pros | 2012 |