Page last updated: 2024-12-07

beta-amyrin acetate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Beta-amyrin acetate is a pentacyclic triterpenoid compound found in various plants, including the bark of Acacia nilotica, the leaves of Moringa oleifera, and the roots of Glycyrrhiza glabra. It exhibits a range of biological activities, including anti-inflammatory, antioxidant, antimicrobial, and anticancer properties. Research suggests that beta-amyrin acetate may modulate the immune system, protect cells from oxidative damage, inhibit the growth of bacteria and fungi, and suppress the proliferation of cancer cells. These properties have led to interest in exploring its potential therapeutic applications. Studies have investigated its role in wound healing, treating inflammatory diseases, and developing novel drugs. The compound's synthesis involves chemical modifications of beta-amyrin, a naturally occurring triterpene. It has also been shown to possess anti-HIV activity.'

Cross-References

ID SourceID
PubMed CID92156
CHEMBL ID489760
CHEBI ID190930

Synonyms (24)

Synonym
bdbm50260203
beta-amyrinacetate
CHEMBL489760 ,
germanicol 3-acetate
CHEBI:190930
o-acetyl-beta-amyrin
beta-amyrenyl acetate
3-o-acetyl-beta-amyrin
unii-am1h7102oc
nsc 403166
(3beta)-olean-12-en-3-yl acetate
amyrin, acetate, b-
am1h7102oc ,
olean-12-en-3beta-ol, acetate
olean-12-en-3-ol, 3-acetate, (3.beta.)-
Q27273993
MS-28662
EX-A6673
olean-12-en-3-ol, acetate, (3)-
CS-0023529
HY-N2923
olean-12-en-3-ol, 3-acetate, (3beta)-
AKOS040760296
AC-37067
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Nitric oxide synthase, inducibleMus musculus (house mouse)IC50 (µMol)50.00000.00103.39119.6000AID344829
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID466799Growth inhibition of human HT-29 cells by MTT assay2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity.
AID977599Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID466801Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimulated TNFalpha production at 100 nM pretreated 1 hr before LPS challenge measured after 24 hrs by sandwich ELISA relative to control2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity.
AID735305Cytotoxicity against C57BL/6 mouse BMDCs at 2 to 50 microM by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
AID375389Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced TNFalpha secretion at 0.01 uM after 12 hrs2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris.
AID481003Cytotoxicity against human MRC5 cells at 25 uM after 48 hrs by WST8 assay2010Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.
AID466798Growth inhibition of human A549 cells by MTT assay2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity.
AID735308Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
AID977602Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID489305Antituberculosis activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 2 weeks by microbroth dilution method2010Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum.
AID481167Inhibition of human DNA topoisomerase 1-mediated relaxation of supercoiled DNA at 312 uM2010Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.
AID481001Cytotoxicity against human PANC1 cells at 25 uM after 48 hrs by WST8 assay2010Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.
AID489306Antituberculosis activity against Mycobacterium tuberculosis H37Rv ATCC 27294 in stationary phase culture at pH 5.8 up to 200 ug/ml after 3 days followed by washout from day 4 to week 4 by microbroth dilution method2010Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum.
AID480999Cytotoxicity against human HL60 cells at 25 uM after 48 hrs by WST8 assay2010Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.
AID344828Inhibition of NADPH oxidase in LPS-induced mouse BV2 cells assessed as NOX-dependent ROS production at 50 uM2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
New diterpenoids and the bioactivity of Erythrophleum fordii.
AID466797Growth inhibition of human SKOV3 cells by MTT assay2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity.
AID375391Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition LPS-induced IL6 secretion at 1 uM after 12 hrs2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris.
AID480997Cytotoxicity against human PC3 cells at 25 uM after 48 hrs by WST8 assay2010Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.
AID344829Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
New diterpenoids and the bioactivity of Erythrophleum fordii.
AID466800Cytotoxicity against human A2780 cells2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity.
AID375386Cytotoxicity against human HeLa cells by MTT assay2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris.
AID735307Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
AID335874Cytotoxicity against human A2780 cells2002Journal of natural products, Aug, Volume: 65, Issue:8
Two new triterpene esters from the twigs of Brachylaena ramiflora from the Madagascar rainforest.
AID375387Cytotoxicity against human MCF7 cells by MTT assay2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris.
AID735306Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
AID480995Cytotoxicity against human A549 cells at 25 uM after 48 hrs by WST8 assay2010Bioorganic & medicinal chemistry letters, May-01, Volume: 20, Issue:9
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.
AID1297379Antitrichomonal activity against metronidazole-sensitive Trichomonas vaginalis ATCC 30236 clinical isolate trophozoites assessed as parasite viability at 100 uM after 24 hrs by trypan blue dye based hemocytometry2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
Caatinga plants: Natural and semi-synthetic compounds potentially active against Trichomonas vaginalis.
AID375388Cytotoxicity against human SK-MEL-1 cells by MTT assay2009Bioorganic & medicinal chemistry letters, Jul-01, Volume: 19, Issue:13
The regulation of inflammatory cytokine secretion in macrophage cell line by the chemical constituents of Rhus sylvestris.
AID466796Growth inhibition of human HL60 cells by MTT assay2010Bioorganic & medicinal chemistry letters, Mar-01, Volume: 20, Issue:5
Triterpene compounds isolated from Acer mandshuricum and their anti-inflammatory activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's6 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.70

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.70 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.37 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.70)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]