Page last updated: 2024-10-31

metronidazole and Cleft Palate

metronidazole has been researched along with Cleft Palate in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sánchez-Corona, J1
García-Cruz, D1
Cantú, JM1
Greenberg, F1

Other Studies

2 other studies available for metronidazole and Cleft Palate

ArticleYear
[Teratogenic effect of metronidazole on the prosencephalon].
    Gaceta medica de Mexico, 1983, Volume: 119, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Brain; Cleft Lip; Cleft Palate; Female; Humans

1983
Possible metronidazole teratogenicity and clefting.
    American journal of medical genetics, 1985, Volume: 22, Issue:4

    Topics: Cleft Palate; Humans; Metronidazole; Teratogens

1985