metronidazole has been researched along with Encephalopathy, Toxic in 33 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 53-year-old male patient developed insidious onset of length-dependent painful neuropathy on a background of encephalopathy during prolonged treatment with metronidazole for a cumulative dose of 146 g in 88 days." | 7.77 | Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity. ( Chao, CC; Chen, CC; Chen, YF; Hsieh, ST; Liou, HH; Tan, CH, 2011) |
| "Metronidazole is an antimicrobial agent commonly used in the treatment of several protozoal and anaerobic infections." | 5.48 | Metronidazole-induced encephalopathy in a patient with pyogenic spondylitis: a case report. ( Kobatake, T; Mawatari, M; Mizuta, K; Morimoto, T; Nakayama, D; Nozaki, O; Sonohata, M, 2018) |
| "A 53-year-old male patient developed insidious onset of length-dependent painful neuropathy on a background of encephalopathy during prolonged treatment with metronidazole for a cumulative dose of 146 g in 88 days." | 3.77 | Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity. ( Chao, CC; Chen, CC; Chen, YF; Hsieh, ST; Liou, HH; Tan, CH, 2011) |
| "Metronidazole is an antibiotic widely used in different medical conditions such as trichomoniasis, amoebiasis, and giardiasis among others." | 2.61 | Therapeutic uses of metronidazole and its side effects: an update. ( Hernández Ceruelos, A; López Contreras, L; Romero-Quezada, LC; Ruvalcaba Ledezma, JC, 2019) |
| "Metronidazole is a widely used antibiotic against bacterial and protozoan infections." | 1.62 | Metronidazole Induced Cerebellar Toxicity: A Case Report. ( Dhungana, K; Niroula, A; Prajapati, R; Sapkota, S; Sharma, S, 2021) |
| "Related neurological adverse effects to metronidazole are rarely encountered in clinical practice despite its wide use as an antibacterial or antiparasitic agent." | 1.56 | Neurological complications during treatment of liver abscess: think of metronidazole toxicity. ( Arora, N; Babbar, N; Pannu, AK; Saroch, A; Sharma, N; Wasti, KP, 2020) |
| "Metronidazole, a nitroimidazole derived antibiotic used to treat many bacterial infections, is reported to penetrate the blood brain barrier after long term administration resulting into neuronal toxicity." | 1.56 | Mechanistic exploration of quercetin against metronidazole induced neurotoxicity in rats: Possible role of nitric oxide isoforms and inflammatory cytokines. ( Chaturvedi, S; Gupta, P; Malik, MY; Rashid, M; Shukla, S; Singh, S; Tiwari, V; Wahajuddin, M, 2020) |
| "Neurotoxicity is a rare but significant side effect of metronidazole." | 1.51 | Garbled speech: a rare presentation of metronidazole-induced neurotoxicity. ( Cheema, MA; Salman, F; Ullah, W; Zain, MA, 2019) |
| "Metronidazole is a commonly used antimicrobial worldwide." | 1.48 | Reversible metronidazole-induced neurotoxicity after 10 weeks of therapy. ( AlDhaleei, W; AlMarzooqi, A; Gaber, N, 2018) |
| "Metronidazole is an antimicrobial agent commonly used in the treatment of several protozoal and anaerobic infections." | 1.48 | Metronidazole-induced encephalopathy in a patient with pyogenic spondylitis: a case report. ( Kobatake, T; Mawatari, M; Mizuta, K; Morimoto, T; Nakayama, D; Nozaki, O; Sonohata, M, 2018) |
| "Metronidazole is an antibacterial, antiprotozoal and anthelmintic medication commonly used in veterinary medicine." | 1.48 | Metronidazole-induced neurotoxicity in 26 dogs. ( Beltran, E; Cherubini, GB; Coelho, AT; Driver, CJ; Rusbridge, CJ; Tauro, A; Wessmann, A, 2018) |
| "Metronidazole is an antimicrobial used for the treatment of anaerobic bacterial and protozoal infections." | 1.43 | Metronidazole Induced Encephalopathy. ( Chand, R; Mahavar, S; Palawat, A; Sharma, R; Srivastava, S; Thakkar, N, 2016) |
| "Metronidazole (Flagyl®) is an antimicrobial agent commonly used in clinical practice." | 1.39 | Neurologic complications of metronidazole. ( Brownell, AK; Furtado, S; Sarna, JR, 2013) |
| " In this pictorial essay, we review the two most common brain injury patterns, posterior reversible encephalopathy syndrome (PRES) and acute toxic leukoencephalopathy (ATL)." | 1.37 | Medication neurotoxicity in children. ( Chaturvedi, A; Ishak, GE; Iyer, RS; Khanna, PC; Pruthi, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (15.15) | 29.6817 |
| 2010's | 20 (60.61) | 24.3611 |
| 2020's | 8 (24.24) | 2.80 |
| Authors | Studies |
|---|---|
| Quickfall, D | 1 |
| Daneman, N | 1 |
| Dmytriw, AA | 1 |
| Juurlink, DN | 1 |
| Sapkota, S | 1 |
| Niroula, A | 1 |
| Prajapati, R | 1 |
| Sharma, S | 1 |
| Dhungana, K | 1 |
| Arora, N | 1 |
| Wasti, KP | 1 |
| Babbar, N | 1 |
| Saroch, A | 1 |
| Pannu, AK | 1 |
| Sharma, N | 1 |
| Chaturvedi, S | 1 |
| Malik, MY | 1 |
| Rashid, M | 1 |
| Singh, S | 2 |
| Tiwari, V | 1 |
| Gupta, P | 1 |
| Shukla, S | 1 |
| Wahajuddin, M | 1 |
| Oliveira, LP | 1 |
| Marques, PT | 1 |
| Lange, MC | 1 |
| Mach, JC | 1 |
| Russell, J | 1 |
| Muir, RT | 1 |
| Mercado, M | 1 |
| Walter, VR | 1 |
| Singhal, N | 1 |
| Kwan, P | 1 |
| Kucharczyk, W | 1 |
| Stall, NM | 1 |
| Carlen, PL | 1 |
| John, KJ | 1 |
| P Pillai, D | 1 |
| Pillai, V | 1 |
| John, JK | 1 |
| AlDhaleei, W | 1 |
| AlMarzooqi, A | 1 |
| Gaber, N | 1 |
| Lefkowitz, A | 1 |
| Shadowitz, S | 1 |
| Mizuta, K | 1 |
| Sonohata, M | 1 |
| Nozaki, O | 1 |
| Kobatake, T | 1 |
| Nakayama, D | 1 |
| Morimoto, T | 1 |
| Mawatari, M | 1 |
| Tauro, A | 1 |
| Beltran, E | 1 |
| Cherubini, GB | 1 |
| Coelho, AT | 1 |
| Wessmann, A | 1 |
| Driver, CJ | 1 |
| Rusbridge, CJ | 1 |
| Hernández Ceruelos, A | 1 |
| Romero-Quezada, LC | 1 |
| Ruvalcaba Ledezma, JC | 1 |
| López Contreras, L | 1 |
| Cheema, MA | 1 |
| Salman, F | 1 |
| Ullah, W | 1 |
| Zain, MA | 1 |
| Ueno, T | 1 |
| Ito, M | 1 |
| Arai, A | 1 |
| Suzuki, C | 1 |
| Tomiyama, M | 1 |
| Guiard, E | 1 |
| Lelievre, B | 1 |
| Rouyer, M | 1 |
| Zerbib, F | 1 |
| Diquet, B | 1 |
| Mégraud, F | 1 |
| Tison, F | 1 |
| Bignon, E | 1 |
| Lassalle, R | 1 |
| Droz-Perroteau, C | 1 |
| Moore, N | 1 |
| Blin, P | 1 |
| Sarna, JR | 1 |
| Furtado, S | 1 |
| Brownell, AK | 1 |
| Mehndiratta, MM | 2 |
| Pandey, S | 1 |
| Nayak, R | 1 |
| Lakshmi, GS | 1 |
| Cação, G | 1 |
| Fontes, S | 1 |
| Salgado, M | 1 |
| Rodrigues, T | 1 |
| Damásio, J | 1 |
| Bonda, C | 1 |
| Evans, MS | 1 |
| Vivas, LLY | 1 |
| Gold, WL | 1 |
| Mandell, DM | 1 |
| Wu, PE | 1 |
| Agah, E | 1 |
| Habibi, A | 1 |
| Naderi, H | 1 |
| Tafakhori, A | 1 |
| Thakkar, N | 1 |
| Chand, R | 1 |
| Sharma, R | 1 |
| Mahavar, S | 1 |
| Srivastava, S | 1 |
| Palawat, A | 1 |
| Tan, CH | 1 |
| Chen, YF | 1 |
| Chen, CC | 1 |
| Chao, CC | 1 |
| Liou, HH | 1 |
| Hsieh, ST | 1 |
| Khodakaram, K | 1 |
| Barmano, N | 1 |
| Iyer, RS | 1 |
| Chaturvedi, A | 1 |
| Pruthi, S | 1 |
| Khanna, PC | 1 |
| Ishak, GE | 1 |
| Heaney, CJ | 1 |
| Campeau, NG | 1 |
| Lindell, EP | 1 |
| Gupta, AK | 1 |
| Agarwal, MP | 1 |
| Avasthi, R | 1 |
| Bhadoria, DP | 1 |
| Rohatgi, N | 1 |
| Deenadayalu, VP | 1 |
| Orinion, EJ | 1 |
| Chalasani, NP | 1 |
| Yoo, HY | 1 |
| Pham, CQ | 1 |
| Thirion, DJ | 1 |
| Gupta, BS | 1 |
| Baldwa, S | 1 |
| Verma, S | 1 |
| Gupta, JB | 1 |
| Singhal, A | 1 |
1 review available for metronidazole and Encephalopathy, Toxic
| Article | Year |
|---|---|
Therapeutic uses of metronidazole and its side effects: an update.
Topics: Animals; Antiprotozoal Agents; Carcinogenesis; Disease Models, Animal; DNA Damage; Drug Utilization; | 2019 |
32 other studies available for metronidazole and Encephalopathy, Toxic
| Article | Year |
|---|---|
Metronidazole-induced neurotoxicity.
Topics: Anti-Infective Agents; Humans; Metronidazole; Neurotoxicity Syndromes; Peripheral Nervous System Dis | 2021 |
Metronidazole Induced Cerebellar Toxicity: A Case Report.
Topics: Anti-Bacterial Agents; Brain Diseases; Humans; Magnetic Resonance Imaging; Male; Metronidazole; Neur | 2021 |
Neurological complications during treatment of liver abscess: think of metronidazole toxicity.
Topics: Antiprotozoal Agents; Humans; Liver Abscess, Amebic; Magnetic Resonance Imaging; Male; Metronidazole | 2020 |
Mechanistic exploration of quercetin against metronidazole induced neurotoxicity in rats: Possible role of nitric oxide isoforms and inflammatory cytokines.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis Regulatory Proteins; Brain; Cytokines; Disease Models, | 2020 |
Metronidazole neurotoxicity in late liver transplantation.
Topics: Brain; Humans; Liver Transplantation; Metronidazole; Neurotoxicity Syndromes | 2020 |
A combined case of wernicke and metronidazole induced encephalopathy? Overlapping pathophysiologic pathways and MR imaging features.
Topics: Aged; Anti-Infective Agents; Brain; Humans; Magnetic Resonance Imaging; Male; Metronidazole; Neuroto | 2020 |
Ataxia and Parkinsonism in Metronidazole Neurotoxicity.
Topics: Ataxia; Brain Diseases; Cerebellar Ataxia; Humans; Magnetic Resonance Imaging; Metronidazole; Neurot | 2021 |
Metronidazole-induced reversible cerebellar dysfunction.
Topics: Aged; Anti-Bacterial Agents; Ataxia; Cerebellar Diseases; Cerebellar Nuclei; Duration of Therapy; Dy | 2021 |
Reversible metronidazole-induced neurotoxicity after 10 weeks of therapy.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; beta-Lactamase Inhibito | 2018 |
Reversible cerebellar neurotoxicity induced by metronidazole.
Topics: Anti-Bacterial Agents; Brain; Cerebellum; Humans; Magnetic Resonance Imaging; Male; Metronidazole; M | 2018 |
Metronidazole-induced encephalopathy in a patient with pyogenic spondylitis: a case report.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Diffusion Magnetic Resonance Imaging; Female; Gram-Positiv | 2018 |
Metronidazole-induced neurotoxicity in 26 dogs.
Topics: Animals; Anti-Infective Agents; Brain; Dog Diseases; Dogs; Female; Magnetic Resonance Imaging; Male; | 2018 |
Garbled speech: a rare presentation of metronidazole-induced neurotoxicity.
Topics: Adult; Anti-Infective Agents; Diagnosis, Differential; Humans; Male; Metronidazole; Neurotoxicity Sy | 2019 |
Convulsive seizures caused by metronidazole-induced encephalopathy.
Topics: Abdominal Abscess; Anti-Infective Agents; Brain Diseases; Cerebellar Nuclei; Humans; Magnetic Resona | 2019 |
Bismuth Concentrations in Patients Treated in Real-Life Practice with a Bismuth Subcitrate-Metronidazole-Tetracycline Preparation: The SAPHARY Study.
Topics: Aged; Bismuth; Cohort Studies; Drug Combinations; Female; Helicobacter Infections; Helicobacter pylo | 2019 |
Neurologic complications of metronidazole.
Topics: Anti-Infective Agents; Humans; Metronidazole; Neurotoxicity Syndromes | 2013 |
Metronidazole encephalopathy.
Topics: Adult; Anti-Infective Agents; Brain; Humans; Magnetic Resonance Imaging; Male; Metronidazole; Neurot | 2013 |
Metronidazole encephalopathy.
Topics: Anti-Infective Agents; Humans; Male; Metronidazole; Neurotoxicity Syndromes | 2014 |
Reply from author.
Topics: Anti-Infective Agents; Humans; Male; Metronidazole; Neurotoxicity Syndromes | 2014 |
Metronidazole-induced central and peripheral nervous system toxicity.
Topics: Adult; Anti-Infective Agents; Brain; Crohn Disease; Female; Follow-Up Studies; Humans; Metronidazole | 2015 |
Metronidazole CNS toxicity.
Topics: Anti-Infective Agents; Central Nervous System; Diffusion Magnetic Resonance Imaging; Humans; Male; M | 2015 |
An 82-year-old man with ataxia and dysarthria.
Topics: Aged, 80 and over; Anti-Infective Agents; Ataxia; Brain; Cerebellar Nuclei; Diabetes Mellitus, Type | 2016 |
Metronidazole-induced neurotoxicity presenting with sudden bilateral hearing loss, encephalopathy, and cerebellar dysfunction.
Topics: Adult; Anti-Bacterial Agents; Brain Diseases; Female; Hearing Loss, Bilateral; Helicobacter Infectio | 2017 |
Metronidazole Induced Encephalopathy.
Topics: Adult; Anti-Infective Agents; Humans; Male; Metronidazole; Neurotoxicity Syndromes | 2016 |
Painful neuropathy due to skin denervation after metronidazole-induced neurotoxicity.
Topics: Denervation; Humans; Magnetic Resonance Imaging; Male; Metronidazole; Middle Aged; Neural Conduction | 2011 |
Uncommon reaction to a common prescription.
Topics: Abdominal Abscess; Anti-Infective Agents; Appendix; Brain; Delayed Diagnosis; Humans; Magnetic Reson | 2011 |
Medication neurotoxicity in children.
Topics: Adolescent; Angiogenesis Inhibitors; Anti-Infective Agents; Antibodies, Monoclonal, Humanized; Bevac | 2011 |
MR imaging and diffusion-weighted imaging changes in metronidazole (Flagyl)-induced cerebellar toxicity.
Topics: Abdominal Abscess; Abdominal Neoplasms; Aged; Amoxicillin; Anti-Infective Agents; Carcinoid Tumor; C | 2003 |
Metrondazole-induced neurotoxicity.
Topics: Anti-Infective Agents; Brain; Humans; Male; Metronidazole; Middle Aged; Neurotoxicity Syndromes; Tom | 2003 |
Abnormal enhancing lesion of dentate nuclei causing neurologic symptoms induced by metronidazole toxicity.
Topics: Anti-Infective Agents; Cerebellar Nuclei; Hepatic Encephalopathy; Humans; Magnetic Resonance Imaging | 2005 |
The art of assessing metronidazole toxicity.
Topics: Anti-Infective Agents; Humans; Metronidazole; Neurotoxicity Syndromes | 2006 |
Metronidazole induced neuropathy.
Topics: Adult; Antiprotozoal Agents; Humans; Liver Abscess, Amebic; Male; Metronidazole; Neurotoxicity Syndr | 2000 |