metronidazole has been researched along with Fistula in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Fistula: Abnormal communication most commonly seen between two internal organs, or between an internal organ and the surface of the body.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An evaluation of the different radiotherapy schedules used during this period allowed a dose-response curve to be constructed." | 5.27 | Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole. ( Elbrønd, O; Johansen, LV; Overgaard, J, 1988) |
| "Genital fistulas are a significant problem in female Crohn's disease patients." | 1.38 | Genital fistulas in female Crohn's disease patients.: clinical characteristics and response to therapy. ( Bermejo, F; de la Poza, G; Gisbert, JP; López-Sanroman, A; Marín-Jimenez, I; Muriel, A; Opio, V; Taxonera, C, 2012) |
| "Of 33 patients with amoebic liver abscess (ALA) seen over a 5-year period, 24 had intrathoracic complications." | 1.27 | Intrathoracic complications of amoebic liver abscess. ( Aderounmu, A; Adeyemo, AO, 1984) |
| " An evaluation of the different radiotherapy schedules used during this period allowed a dose-response curve to be constructed." | 1.27 | Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole. ( Elbrønd, O; Johansen, LV; Overgaard, J, 1988) |
| "The meningitis was refractory to chloramphenicol and penicillin but responded to oral metronidazole." | 1.26 | Meningorectal fistula as a cause of polymicrobial anaerobic meningitis. ( Berelowitz, BA; Breyer, MD; Malinoff, H; Walsh, TJ; Weinstein, RA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (50.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Samaha, M | 1 |
| Moloney, M | 1 |
| Scotton, W | 1 |
| Cobb, R | 1 |
| Pang, L | 1 |
| Nixon, I | 1 |
| Joshi, A | 1 |
| Jeannon, JP | 1 |
| Oakley, R | 1 |
| French, G | 1 |
| Hemsley, C | 1 |
| Simo, R | 1 |
| de la Poza, G | 1 |
| López-Sanroman, A | 1 |
| Taxonera, C | 1 |
| Marín-Jimenez, I | 1 |
| Gisbert, JP | 1 |
| Bermejo, F | 1 |
| Opio, V | 1 |
| Muriel, A | 1 |
| Englert, C | 1 |
| Aebert, H | 1 |
| Lenhart, M | 1 |
| Solleder, A | 1 |
| Nerlich, M | 1 |
| Neumann, C | 1 |
| Loprinzi, C | 1 |
| Heaton, JW | 1 |
| Kelly, PC | 1 |
| Adeyemo, AO | 1 |
| Aderounmu, A | 1 |
| Walsh, TJ | 1 |
| Weinstein, RA | 1 |
| Malinoff, H | 1 |
| Breyer, MD | 1 |
| Berelowitz, BA | 1 |
| Innes, AJ | 1 |
| Windle-Taylor, PC | 1 |
| Harrison, DF | 1 |
| von Birgelen, C | 1 |
| von Schönfeld, J | 1 |
| Görge, G | 1 |
| Fabry, W | 1 |
| Layer, P | 1 |
| Adams, EB | 1 |
| MacLeod, IN | 1 |
| Hjortrup, A | 1 |
| Moesgaard, F | 1 |
| Kjaergård, J | 1 |
| Johansen, LV | 1 |
| Overgaard, J | 1 |
| Elbrønd, O | 1 |
12 other studies available for metronidazole and Fistula
| Article | Year |
|---|---|
Long-term antibiotic therapy in late onset pouch-urethral fistula after ileoanal anastomosis for ulcerative colitis may be effective and well tolerated.
Topics: Adult; Anal Canal; Anastomosis, Surgical; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; | 2013 |
Post-operative wound infection in salvage laryngectomy: does antibiotic prophylaxis have an impact?
Topics: Administration, Intravenous; Anti-Bacterial Agents; Antibiotic Prophylaxis; Cefuroxime; Cohort Studi | 2012 |
Genital fistulas in female Crohn's disease patients.: clinical characteristics and response to therapy.
Topics: Adalimumab; Adolescent; Adult; Age Factors; Anti-Infective Agents; Anti-Inflammatory Agents; Antibod | 2012 |
Thoracic spondylitis from a mycotic (Streptococcus pneumoniae) aortic aneurysm: a case report.
Topics: Aneurysm, Infected; Anti-Bacterial Agents; Aortic Aneurysm, Thoracic; Blood Vessel Prosthesis Implan | 2004 |
Enterohepatic fistula associated with amebic liver abscess.
Topics: Adult; Aged; Biopsy, Needle; Entamoeba histolytica; Entamoebiasis; Female; Fistula; Humans; Intestin | 1983 |
Intrathoracic complications of amoebic liver abscess.
Topics: Adolescent; Adult; Central Nervous System Diseases; Child; Drainage; Empyema; Female; Fistula; Human | 1984 |
Meningorectal fistula as a cause of polymicrobial anaerobic meningitis.
Topics: Female; Fistula; Humans; Meninges; Meningitis; Metronidazole; Middle Aged; Radiotherapy; Rectal Fist | 1982 |
The role of metronidazole in the prevention of fistulae following total laryngectomy.
Topics: Bacterial Infections; Fistula; Humans; Laryngeal Neoplasms; Laryngectomy; Metronidazole; Pharyngeal | 1980 |
[Amebic liver abscess with hepatobronchial fistula].
Topics: Bronchial Fistula; Female; Fistula; Humans; Liver Abscess, Amebic; Liver Diseases; Metronidazole; Mi | 1994 |
Invasive amebiasis. II. Amebic liver abscess and its complications.
Topics: Bronchial Fistula; Cardiac Tamponade; Drainage; Fistula; Heart Diseases; Humans; Liver Abscess, Ameb | 1977 |
Fibrin adhesive in the treatment of perineal fistulas.
Topics: Administration, Topical; Adult; Aged; Cefotaxime; Drug Therapy, Combination; Female; Fibrin Tissue A | 1991 |
Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole.
Topics: Fistula; Humans; Laryngeal Neoplasms; Laryngectomy; Metronidazole; Pharyngeal Diseases; Radiation In | 1988 |