Cheilitis Granulomatosa

An idiopathic syndrome characterized by one or more of the following; recurrent orofacial swelling, relapsing facial paralysis, and fissured tongue (lingua plicata). The onset is usually in childhood and relapses are common. Cheilitis granulomatosa is a monosymptomatic variant of this condition. (Dermatol Clin 1996 Apr;14(2):371-9; Magalini & Magalini, Dictionary of Medical Syndromes, 4th ed, p531)

Synonym
Melkersson Syndrome
Melkersson-Rosenthal Syndrome
Melkersson-Rosenthal-Miescher Syndrome
Granulomatous Cheilitis
Miescher-Melkersson-Rosenthal Granulomatous Cheilitis
Cheilitis Granulomatosa, Orofacial Edema, Facial Neuropathy
Cheilitis Granulomatosa, Facial Neuropathy, Orofacial Edema
Cheilitis Granulomatosa
Orofacial Edema, Cheilitis Granulomatosa, Facial Neuropathy
Orofacial Edema, Facial Neuropathy, Cheilitis Granulomatosa
Syndrome, Melkerson Rosenthal
Rosenthal-Melkerson Syndrome
Rosenthal-Melkersson Syndrome
Facial Neuropathy, Cheilitis Granulomatosa, Orofacial Edema
Facial Neuropathy, Orofacial Edema, Cheilitis Granulomatosa
Macrocheilia, Facial Palsy, Edema
Melkerson-Rosenthal Syndrome

Excerpt	Reference
"The essence of granulomatous cheilitis is still to be found, this being confirmed by the literature reviewed by the authors."	( Moshkalova, IA; Raznatovskiĭ, IM, 1989)
"Cheilitis granulomatosa is one manifestation of orofacial granulomatosis."	( Bekic, M; Rogers, RS, 1997)
"Granulomatous cheilitis is a rare disorder characterized by intermittent swelling of one or both lips, which may become persistent."	( Castanet, J; Lacour, JP; Olivier, V; Ortonne, JP; Perrin, C, 2000)
"Cheilitis granulomatosa is the most frequent dermatological sign in the Melkersson-Rosenthal syndrome."	( Camacho, F; Carrizosa, A; García-Bravo, B, 2001)
"Granulomatous cheilitis is a difficult disease to treat because of recurrences."	( Akpolat, N; Cicek, D; Coskun, B; Saral, Y, 2004)
"Granulomatous cheilitis is a rare granulomatous inflammation of the lips of unknown origin; mainly young adults are affected."	( Amon, U; Bröhl, L; Kleine, R, 2011)
"Cheilitis granulomatosa is a rare disease characterised by the recurrent labial swelling of one or both lips with the possibility of the condition to remain on a permanent basis."	( Gojkov-Vukelic, M; Hadzic, S; Kantardzic, A, 2011)
"Cheilitis granulomatosa is a rare disease characterised by the recurrent labial swelling of one or both lips with the possibility of the condition to remain on a permanent basis."	( Fu, CJ; Gu, L; Huang, DY; Liu, Y; Wang, ZL; Zhu, GX, 2013)
"Cheilitis granulomatosa is characterized by granulomatous lip swelling."	( Benninga, MA; D'Haens, GR; Hoekman, DR; Roelofs, JJ; Schonenberg-Meinema, D; van Schuppen, J, 2016)

Excerpt	Reference
"Two patients with cheilitis granulomatosa and recurrent facial edema have been treated with thalidomide (100 mg daily) for 3 and 6 months respectively."	( Boullie, MC; Joly, P; Lauret, P; Safa, G; Thomine, E, 1995)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	75 (33.48)	23.3326
1990's	44 (19.64)	12.5806
2000's	41 (18.30)	18.1394
2010's	47 (20.98)	28.8240
2020's	17 (7.59)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
benzoic acid	low	3	0
salicylic acid	low	1	0
gallic acid	low	1	0
niacin	low	2	0
pyridoxine	medium	2	1
sulfites	low	1	0
thiamine	low	1	0
acetaminophen	low	1	0
azathioprine	low	3	0
chloroquine	low	2	0
chlorpheniramine	low	1	0
clofazimine	low	23	0
dapsone	low	6	0
diclofenac	low	1	0
fluconazole	low	1	0
fluorouracil	low	1	0
gabapentin	low	1	0
hydroxychloroquine	low	6	0
lidocaine	low	1	0
mesalamine	low	1	0
metronidazole	low	4	0
potassium chloride	low	1	0
sulfasalazine	low	1	0
thalidomide	low	2	0
prednisolone	low	13	0
thyroxine	low	1	0
prednisone	low	11	0
fluprednisolone	low	1	0
pentylenetetrazole	medium	1	1
triiodothyronine	low	1	0
triamcinolone acetonide	low	15	0
pantothenic acid	medium	1	1
methylprednisolone	low	3	0
acrolein	low	2	0
meglumine	low	1	0
ephedrine	low	1	0
fluocinonide	low	1	0
betamethasone	low	3	0
lauryl gallate	low	1	0
diallyl disulfide	low	1	0
nifuratel	low	1	0
triamcinolone hexacetonide	low	1	0
mercury	low	1	0
chromates	low	1	0
danazol	low	2	0
phenyl acetate	low	1	0
triamcinolone	low	14	0
cefaclor anhydrous	low	1	0
fomesafen	low	1	0
octyl gallate	low	1	0
meglumine antimoniate	low	1	0
cephalosporin c	low	1	0
methotrexate	low	2	0
aspartame	low	1	0
tartrazine	low	1	0
disulfanilamide	low	1	0
deflazacort	low	1	0
lenalidomide	low	1	0
cortisone	low	2	0
inositol 3-phosphate	low	103	0
tacrolimus	low	1	0
zithromax	low	1	0
cinnamaldehyde	low	2	0
sodium metabisulfite	low	1	0
alpha-chymotrypsin	low	1	0
amphotericin b	low	1	0
tranilast	low	2	0
clobetasol	low	1	0
cinnamyl alcohol	low	1	0
enalapril	low	1	0
fumarates	low	1	0
nystatin a1	low	1	0
bleomycetin	low	2	0
tetracycline	low	3	0
oxytetracycline, anhydrous	low	1	0
minocycline	low	4	0
valacyclovir	low	1	0

Protein Targets (806)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	10	0	0	10
RAR-related orphan receptor gamma	21	0	0	21
GLI family zinc finger 3	21	0	0	21
AR protein	32	0	0	32
aldehyde dehydrogenase 1 family, member A1	24	0	0	24
retinoic acid nuclear receptor alpha variant 1	21	0	0	21
retinoid X nuclear receptor alpha	20	0	0	20
estrogen nuclear receptor alpha	42	0	0	42
peroxisome proliferator-activated receptor delta	14	0	0	14
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	24	0	0	24
activating transcription factor 6	8	0	0	8
v-jun sarcoma virus 17 oncogene homolog (avian)	15	0	0	15
Histone H2A.x	16	0	0	16
thyroid hormone receptor beta isoform a	9	0	0	9
heat shock protein beta-1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	23	0	0	23
lamin isoform A-delta10	23	0	0	23
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
Glutamate receptor 2	13	0	0	13
ATAD5 protein, partial	11	0	0	11
GLS protein	11	0	0	11
Microtubule-associated protein tau	10	0	0	10
Smad3	5	0	0	5
thyroid stimulating hormone receptor	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	13	0	0	13
progesterone receptor	18	0	0	18
EWS/FLI fusion protein	16	0	0	16
estrogen-related nuclear receptor alpha	29	0	0	29
peroxisome proliferator activated receptor gamma	19	0	0	19
aryl hydrocarbon receptor	17	0	0	17
chromobox protein homolog 1	14	0	0	14
thyroid hormone receptor beta isoform 2	16	0	0	16
peripheral myelin protein 22	13	0	0	13
cytochrome P450 3A4 isoform 1	11	0	0	11
Gamma-aminobutyric acid receptor subunit pi	11	2	1	14
ATP-binding cassette sub-family C member 3	0	24	0	24
Multidrug resistance-associated protein 4	0	24	0	25
Solute carrier family 22 member 6	0	2	0	3
Carbonic anhydrase 12	0	3	0	3
UDP-glucuronosyltransferase 1A9	0	1	0	3
Bile salt export pump	0	7	0	7
Bile salt export pump	0	35	0	35
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	10	0	10
Carbonic anhydrase 2	0	10	1	11
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	2	0	3
Prostaglandin G/H synthase 1	0	4	0	4
Carbonic anhydrase 3	0	3	0	3
Cytochrome P450 3A4	0	7	0	7
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	11	1	13
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	11	2	1	14
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	11	2	1	14
Gamma-aminobutyric acid receptor subunit gamma-2	11	2	2	15
UDP-glucuronosyltransferase 1-6	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	11	2	1	14
Gamma-aminobutyric acid receptor subunit alpha-3	11	2	1	14
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	3	0	4
Carbonic anhydrase 4	0	5	0	5
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	11	2	1	14
Gamma-aminobutyric acid receptor subunit alpha-2	11	2	1	14
Gamma-aminobutyric acid receptor subunit alpha-4	11	2	1	14
Gamma-aminobutyric acid receptor subunit gamma-3	11	2	1	14
Gamma-aminobutyric acid receptor subunit alpha-6	11	2	1	14
Carbonic anhydrase 5A, mitochondrial	0	5	0	5
Prostaglandin G/H synthase 2	0	5	0	6
Carbonic anhydrase 7	0	3	0	3
Nuclear receptor ROR-gamma	7	0	0	7
Cytochrome P450 2J2	0	9	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	11	2	2	15
Gamma-aminobutyric acid receptor subunit beta-3	11	2	1	14
Gamma-aminobutyric acid receptor subunit beta-2	11	2	2	15
Carbonic anhydrase 9	0	6	0	6
GABA theta subunit	11	2	1	14
Canalicular multispecific organic anion transporter 1	0	23	0	23
Carbonic anhydrase 15	0	2	0	2
Carbonic anhydrase 13	0	3	0	3
Gamma-aminobutyric acid receptor subunit epsilon	11	2	1	14
Carbonic anhydrase 14	0	3	0	3
Carbonic anhydrase 5B, mitochondrial	0	3	0	3
toxin B	0	0	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	4	6
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Ferritin light chain	5	0	0	5
Thymidine kinase	0	1	0	1
thioredoxin reductase	14	0	0	14
phosphopantetheinyl transferase	9	0	0	9
TDP1 protein	25	0	0	25
arylsulfatase A	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
Bloom syndrome protein isoform 1	8	0	0	8
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Solute carrier family 22 member 1	0	1	0	3
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	1	0	3
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	4
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	6
Thymidine kinase	0	1	0	1
Chain A, Cruzipain	1	0	0	1
interleukin 8	7	0	0	7
glucocorticoid receptor [Homo sapiens]	30	0	0	30
farnesoid X nuclear receptor	13	0	0	13
vitamin D (1,25- dihydroxyvitamin D3) receptor	16	0	0	16
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	10	0	0	10
Cytochrome P450 2C19	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	5
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
pregnane X nuclear receptor	24	0	0	24
geminin	23	0	0	23
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	14	0	0	14
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
acetylcholinesterase	10	0	0	10
SMAD family member 2	6	0	0	6
Fumarate hydratase	1	0	0	1
SMAD family member 3	6	0	0	6
thioredoxin glutathione reductase	6	0	0	6
G	9	0	0	9
polyprotein	1	0	0	1
P53	1	0	0	1
IDH1	10	0	0	10
thyroid stimulating hormone receptor	7	0	0	7
peripheral myelin protein 22 isoform 1	5	0	0	5
cellular tumor antigen p53 isoform a	4	0	0	4
DNA polymerase iota isoform a (long)	5	0	0	5
survival motor neuron protein isoform d	8	0	0	8
M-phase phosphoprotein 8	4	0	0	4
muscleblind-like protein 1 isoform 1	10	0	0	10
muscarinic acetylcholine receptor M1	5	0	0	5
Interferon beta	15	0	0	15
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Cellular tumor antigen p53	20	0	0	20
Inositol hexakisphosphate kinase 1	9	0	0	9
ATPase family AAA domain-containing protein 5	13	0	0	13
Ataxin-2	15	0	0	15
Protein-arginine deiminase type-4	0	7	0	7
cytochrome P450 2C9, partial	9	0	0	9
Chain A, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Chain B, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Luciferase	8	0	0	8
estrogen receptor 2 (ER beta)	7	0	0	7
lethal factor (plasmid)	2	0	0	2
Polyphenol oxidase 2	0	5	0	6
D-amino-acid oxidase	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Tyrosinase	0	1	0	1
D-amino-acid oxidase	0	3	1	4
Metabotropic glutamate receptor 5	0	0	1	1
Alpha-glucosidase MAL12	0	1	0	1
Monocarboxylate transporter 1	0	0	0	1
Beta-lactamase	0	1	1	2
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
D-aspartate oxidase	0	2	0	2
Serine racemase	0	1	0	1
pregnane X receptor	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
nuclear receptor subfamily 1, group I, member 2	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	18	2	25
Glycine receptor subunit alpha-1	0	18	0	18
Glycine receptor subunit beta	0	18	0	18
Glycine receptor subunit alpha-2	0	18	0	18
Glycine receptor subunit alpha-3	0	18	0	18
ORF73	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	7	0	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	10	0	0	10
importin subunit beta-1 isoform 1	4	0	0	4
serine/threonine-protein kinase PLK1	3	0	0	3
snurportin-1	4	0	0	4
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase kappa isoform 1	9	0	0	9
histone acetyltransferase KAT2A isoform 1	10	0	0	10
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
streptokinase A precursor	0	0	3	3
Estrogen receptor	0	0	2	2
Solute carrier family 15 member 1	0	5	0	6
Solute carrier family 15 member 2	0	1	0	1
Estrogen receptor beta	0	0	2	2
Solute carrier family 15 member 2	0	2	0	2
PPM1D protein	3	0	0	3
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	3	4
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
flap endonuclease 1	7	0	0	7
Transmembrane protease serine 2	0	1	2	3
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	1	2	0	3
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	1	2	3
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	4	0	4
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	2	2	4
Muscarinic acetylcholine receptor M1	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	4	0	4
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	4	0	4
Serine/threonine-protein kinase mTOR	0	2	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Spike glycoprotein	7	1	2	10
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Angiotensin-converting enzyme 2	0	2	2	4
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
Histamine H1 receptor	0	2	0	2
MBT domain-containing protein 1	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
ATP-dependent phosphofructokinase	9	0	0	9
67.9K protein	7	0	0	7
shiga toxin 1 variant A subunit	1	0	0	1
shiga toxin 1 B subunit	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
mitogen-activated protein kinase 1	6	0	0	6
nuclear receptor ROR-gamma isoform 1	6	0	0	6
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cell division protein FtsZ	0	1	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
USP1 protein, partial	11	0	0	11
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
cytochrome P450 2D6	6	0	0	6
cytochrome P450 2D6 isoform 1	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
transcriptional regulator ERG isoform 3	5	0	0	5
mitogen-activated protein kinase kinase kinase kinase 2 isoform 1	0	0	1	1
eyes absent homolog 2 isoform a	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
mitogen-activated protein kinase kinase kinase 3 isoform 1	0	0	1	1
ATP-dependent translocase ABCB1	0	2	1	3
5-hydroxytryptamine receptor 1A	0	0	1	1
Cruzipain	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
endonuclease IV	3	0	0	3
dopamine D1 receptor	3	0	0	3
regulator of G-protein signaling 4	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	7	0	0	7
Multidrug and toxin extrusion protein 1	0	5	0	5
glp-1 receptor, partial	6	0	0	6
Rap guanine nucleotide exchange factor 3	4	0	0	4
Estrogen receptor	0	5	0	5
Aldo-keto reductase family 1 member B1	0	2	0	2
Adenosine receptor A3	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Androgen receptor	0	7	0	7
Alpha-1B adrenergic receptor	0	3	0	3
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
Sodium-dependent dopamine transporter	0	2	0	2
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
cytochrome P450 2C9 precursor	3	0	0	3
Myeloperoxidase	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Histamine H2 receptor	3	0	0	3
5-hydroxytryptamine receptor 6	0	1	0	1
15-lipoxygenase, partial	3	0	0	3
Fatty acid synthase	0	1	0	1
Aldo-keto reductase family 1 member B10	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Cytochrome c oxidase subunit 2	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Transthyretin	0	1	1	6
Albumin	0	2	2	4
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	1	0	3
UDP-glucuronosyltransferase 1A4	0	1	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Type-2 angiotensin II receptor	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Solute carrier family 15 member 1	0	2	0	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
apical membrane antigen 1, AMA1	4	0	0	4
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	2	0	2
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	2	0	2
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	1	3
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Thrombopoietin	2	0	0	2
nonstructural protein 1	3	0	0	3
huntingtin isoform 2	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Thymidylate synthase	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
hypothetical protein, conserved	1	0	0	1
fructose-bisphosphate aldolase A	1	0	0	1
glyceraldehyde-3-phosphate dehydrogenase isoform 1	1	0	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Integrin beta-3	3	0	0	3
Plasminogen activator inhibitor 1	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
72 kDa type IV collagenase	0	2	0	2
Integrin alpha-IIb	3	0	0	3
Matrilysin	0	2	0	2
L-selectin	0	1	0	1
P-selectin	0	1	0	1
E-selectin	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	2	0	2
Adenosine receptor A1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Alpha-synuclein	1	2	0	3
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
Squalene monooxygenase	0	3	0	3
Autoinducer 2-binding periplasmic protein LuxP	0	1	0	1
Anthrax toxin receptor 2	0	1	0	1
Lactoperoxidase	0	0	0	1
Polypeptide N-acetylgalactosaminyltransferase 2	0	1	1	2
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
Carbonic anhydrase	0	2	0	2
Reverse transcriptase/RNaseH	0	1	0	1
Toll-like receptor 2	0	1	0	1
Gamma-aminobutyric acid	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
D(1A) dopamine receptor	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
neuropeptide S receptor isoform A	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	0	0	1	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Platelet glycoprotein VI	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Genome polyprotein	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
histone deacetylase 9 isoform 3	2	0	0	2
Cereblon isoform 4	0	3	0	3
Bromodomain-containing protein 4	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	2
Breakpoint cluster region protein	0	0	0	1
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Protein cereblon	0	4	2	9
Zinc finger protein Aiolos	0	0	1	1
Chain A, Beta-lactamase	4	0	0	4
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	2	0	2
caspase-1 isoform alpha precursor	2	0	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	3
Tumor necrosis factor	0	1	1	2
Neuraminidase	0	1	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	2	0	2
Caspase-7	2	0	0	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	5
Cystine/glutamate transporter	0	2	0	2
Hydroxyacid oxidase 1	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	3	0	6
large T antigen	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
DNA polymerase beta	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	3
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Stromelysin-1	0	2	1	3
Multidrug transporter MdfA	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Cholesteryl ester transfer protein	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
Hydroxycarboxylic acid receptor 2	0	1	1	2
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	3	0	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Pyridoxal kinase	0	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, Glutathione S-transferase	0	1	0	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Thromboxane-A synthase	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Caspase-1	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Sodium/bile acid cotransporter	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
Tetracycline resistance protein, class B	0	0	0	1
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
50S ribosomal protein L36 2	0	2	0	2
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
MSH	0	0	0	1
NFKB1 protein, partial	2	0	0	2
Parkin	1	0	0	1
pyruvate kinase	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Hematopoietic prostaglandin D synthase	0	1	0	1
Ornithine decarboxylase	1	0	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
glucocerebrosidase	1	0	0	1
Prothrombin	0	0	1	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(17)

Research Excerpts

Overview

Treatment

Research

Studies (224)

Protein Targets (806)

Cheilitis Granulomatosa

Synonyms(17)

Research Excerpts

Overview

Treatment

Research

Studies (224)

Drugs Studied (87)

Protein Targets (806)