Substance | Relationship Strength | Studies | Trials | Classes | Roles |
adenine [no description available] | 2.39 | 2 | 0 | 6-aminopurines; purine nucleobase | Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
metronidazole Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. | 2.07 | 1 | 0 | C-nitro compound; imidazoles; primary alcohol | antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic |
puromycin aminonucleoside 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine: structure in first source. 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine : Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. | 2.03 | 1 | 0 | 3'-deoxyribonucleoside; adenosines | |
cytidine [no description available] | 2.03 | 1 | 0 | cytidines | Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
cordycepin [no description available] | 2.71 | 3 | 0 | 3'-deoxyribonucleoside; adenosines | antimetabolite; nucleoside antibiotic |
2-chloroadenosine 5-chloroformycin A: structure given in first source | 2.08 | 1 | 0 | purine nucleoside | |
2-fluoroadenosine [no description available] | 2.08 | 1 | 0 | adenosines; organofluorine compound | |
2-fluoroadenine 2-fluoroadenine : An organofluorine compound that is adenine in which the hydrogen at position 2 (the carbon between the two nitrogens of the pyrimidine ring) is replaced by a fluorine. | 2.08 | 1 | 0 | organofluorine compound; purines | antineoplastic agent |
2'-deoxyadenosine 2'-deoxyformycin A: RN not in Chemline 9/85; RN and structure given in first source | 2.41 | 2 | 0 | purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside | Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
vidarabine adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. | 2.48 | 2 | 0 | beta-D-arabinoside; purine nucleoside | antineoplastic agent; bacterial metabolite; nucleoside antibiotic |
alovudine [no description available] | 1.97 | 1 | 0 | pyrimidine 2',3'-dideoxyribonucleoside | |
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase. | 1.97 | 1 | 0 | azide; pyrimidine 2',3'-dideoxyribonucleoside | antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor |
3'-azido-2',3'-dideoxyuridine [no description available] | 1.97 | 1 | 0 | | |
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit | 7.68 | 3 | 0 | adenosines; purines D-ribonucleoside | analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent |
3'-azido-2',3'-dideoxy-5-methylcytidine 3'-azido-2',3'-dideoxy-5-methylcytidine: inhibits reproduction of AIDS virus in cultured cells | 1.97 | 1 | 0 | | |
nebularine nebularine: structure. nebularine : A purine ribonucleoside that is 9H-purine attached to a beta-D-ribofuranosyl residue at position 9 via a glycosidic (N-glycosyl) linkage. | 2.08 | 1 | 0 | purine ribonucleoside; purines D-ribonucleoside | fungal metabolite |
2-aminoadenosine [no description available] | 2.07 | 1 | 0 | purine nucleoside | |
2-chloroadenine 6-amino-2-chloropurine: RN & structure given in first source | 2.08 | 1 | 0 | | |
2'-fluoro-2'-deoxyadenosine [no description available] | 2.07 | 1 | 0 | | |
3'-fluoro-3'-deoxyadenosine 3'-fluoro-3'-deoxyadenosine: structure given in first source | 2.07 | 1 | 0 | | |
5'-deoxy-5'-s-isobutylthioadenosine 5'-deoxy-5'-S-isobutylthioadenosine: considered an analog of S-adenosylhomocysteine; structure | 2.07 | 1 | 0 | | |
xylose xylopyranose: structure in first source | 1.95 | 1 | 0 | D-xylose | |
3'-fluoro-2',3'-dideoxyuridine [no description available] | 1.97 | 1 | 0 | | |
puromycin [no description available] | 2.03 | 1 | 0 | puromycins | antiinfective agent; antimicrobial agent; antineoplastic agent; EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor; EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor; nucleoside antibiotic; protein synthesis inhibitor |
3'-azido-2',3'-dideoxyadenosine [no description available] | 1.97 | 1 | 0 | | |
3'-azido-2',3'-dideoxycytidine [no description available] | 1.97 | 1 | 0 | | |
(2R,3S,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-oxolanol [no description available] | 1.97 | 1 | 0 | 3'-deoxyribonucleoside; purines | |
2-chloro-3'-deoxyadenosine 2-chloro-3'-deoxyadenosine: do not confuse with 2-chloro-2'-deoxyadenosine which is CLADRIBINE | 2.08 | 1 | 0 | | |
5'-chloro-5'-deoxyadenosine [no description available] | 2.07 | 1 | 0 | adenosines | |
2'-amino-2'-deoxyuridine 2'-amino-2'-deoxyuridine: structure in first source | 2.07 | 1 | 0 | | |
5'-amino-5'-deoxyadenosine [no description available] | 2.07 | 1 | 0 | | |
deoxyguanosine [no description available] | 1.97 | 1 | 0 | purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside | Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
inosine [no description available] | 2.07 | 1 | 0 | inosines; purines D-ribonucleoside | Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |