Page last updated: 2024-12-06

adenosine 2',3'-ribo-epoxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Adenosine 2',3'-ribo-epoxide is a synthetic analog of adenosine that exhibits potent antitumor activity. It is known to inhibit the growth of various cancer cell lines, including leukemia, lymphoma, and melanoma. This compound is a potent inhibitor of ribonucleotide reductase, an enzyme essential for DNA synthesis. The epoxide group in adenosine 2',3'-ribo-epoxide is crucial for its activity, as it allows the compound to bind to the enzyme and prevent its function. Its mechanism of action involves the formation of a covalent adduct with the enzyme, leading to its inactivation. Research efforts focus on understanding the specific mechanisms of action, optimizing its efficacy, and exploring its potential as a therapeutic agent in cancer treatment.'

adenosine 2',3'-ribo-epoxide: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID72252
CHEMBL ID2032007
SCHEMBL ID5471536
MeSH IDM0048959

Synonyms (16)

Synonym
2',3'-epoxya down
2',3'-epoxyadenosine down
2627-64-7
[(1r,2r,4r,5r)-4-(6-aminopurin-9-yl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl]methanol
CHEMBL2032007
adenosine, 2',3'-anhydro-
adenosine 2',3'-ribo-epoxide
9-(2,3-anhydro-beta-d-ribofuranosyl)adenine
2',3'-anhydroadenosine
SCHEMBL5471536
RANSNKOSWWZYEJ-KQYNXXCUSA-N
A855616
9-(2,3-anhydropentofuranosyl)-9h-purin-6-amine
DTXSID70949134
[(1r,2r,4r,5r)-4-(6-amino-9h-purin-9-yl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl]methanol
((1r,2r,4r,5r)-4-(6-amino-9h-purin-9-yl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl)methanol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID662565Growth inhibition of Trichomonas vaginalis T1 at 100 uM after 24 hrs by hemocytometry2012Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12
S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine.
AID1065714Trypanocidal activity against bloodstream stage of Trypanosoma brucei brucei AnTat1.1E after 72 hrs by WST-1 assay2013Journal of medicinal chemistry, Dec-27, Volume: 56, Issue:24
Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis.
AID81438Dose required to inhibit cytopathic effect of human immunodeficiency virus replication in MT-4 cells.1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.
AID81069Cytotoxic dose required to reduce the viability of normal uninfected MT-4 cells.1988Journal of medicinal chemistry, Oct, Volume: 31, Issue:10
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.80 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]