Page last updated: 2024-09-27

Aphasia, Fluent

Impairment in the comprehension of speech and meaning of words, both spoken and written, and of the meanings conveyed by their grammatical relationships in sentences. It is caused by lesions that primarily affect Wernicke's area, which lies in the posterior perisylvian region of the temporal lobe of the dominant hemisphere. (From Brain & Bannister, Clinical Neurology, 7th ed, p141; Kandel et al., Principles of Neural Science, 3d ed, p846)

Synonyms(14)

Synonym
Fluent Aphasia, Wernicke's
Wernicke Aphasia
Dysphasia, Receptive
Dysphasia, Sensory
Aphasia, Fluent
Dysphasia, Fluent
Dysphasia, Wernicke
Aphasia, Wernicke
Aphasia, Posterior
Sensory Aphasia
Receptive Aphasia
Aphasia, Jargon
Dysphasia, Wernicke's
Aphasia, Psychosensory

Research Excerpts

Treatment

ExcerptReference
"The patient had clinical signs of sensory aphasia, which resolved completely after one-week treatment with nimodipine."( Haralanov, L; Klissurski, M; Stamenova, P, 2001)

Research

Studies (29)

TimeframeStudies, This Condition (%)All Conditions %
pre-19909 (31.03)23.3326
1990's8 (27.59)12.5806
2000's9 (31.03)18.1394
2010's3 (10.34)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
creatine0low10
phenytoin0low10
amobarbital0medium31
donepezil0medium11
flumazenil0low10
lidocaine0medium11
idebenone0low10
iofetamine0low30
metronidazole0low10
nimodipine0low10
piracetam0low10
vigabatrin0low10
fomesafen0low20
fenoxycarb0low10
xenon radioisotopes0low10
fluorodeoxyglucose f180low30
deoxyglucose0low10
riboflavin0low10
levetiracetam0low10
ro 16-01540low10
technetium tc 99m exametazime0low30
ubiquinone0low10
piperidines0medium11

Protein Targets (411)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma5005
TDP1 protein100010
AR protein8008
nuclear receptor subfamily 1, group I, member 36006
cytochrome P450 family 3 subfamily A polypeptide 44004
glucocorticoid receptor [Homo sapiens]3003
estrogen-related nuclear receptor alpha6006
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha100010
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
nuclear factor erythroid 2-related factor 2 isoform 22002
heat shock protein beta-12002
importin subunit beta-1 isoform 11001
snurportin-11001
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta107007
Voltage-dependent calcium channel gamma-2 subunit3003
Bile salt export pump010010
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Glutamate receptor 23003
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 435005
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 52002
Ataxin-23003
farnesoid X nuclear receptor4004
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10202
euchromatic histone-lysine N-methyltransferase 2100010
geminin9009
peripheral myelin protein 224004
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Acetylcholinesterase0202
Voltage-dependent L-type calcium channel subunit alpha-1F0404
Bile salt export pump0303
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Acetylcholinesterase0101
Amyloid-beta precursor protein0101
Cholinesterase0202
ATP-dependent translocase ABCB10101
Cytochrome P450 3A40202
5-hydroxytryptamine receptor 1A0303
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A 0101
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] A 0101
Acetylcholinesterase0101
Acetylcholinesterase0325
Liver carboxylesterase 10101
Acetylcholinesterase 0202
Amine oxidase [flavin-containing] B0101
Sodium-dependent serotonin transporter0101
Choline O-acetyltransferase 0101
Acetylcholinesterase0101
Glycogen synthase kinase-3 beta0101
Beta-secretase 10101
Cholinesterase0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
Cholinesterase0101
Acetylcholine receptor subunit epsilon0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0202
Potassium voltage-gated channel subfamily H member 20303
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0404
Cytochrome P450 1B10101
Sigma non-opioid intracellular receptor 10101
Canalicular multispecific organic anion transporter 10808
Acyl-CoA:cholesterol acyltransferase 0101
Sigma non-opioid intracellular receptor 10101
Carboxylic ester hydrolase 0101
Carboxylic ester hydrolase 0202
Histamine H3 receptor0101
Luciferase3003
pregnane X receptor1001
hypoxia-inducible factor 1 alpha subunit4004
GLI family zinc finger 33003
estrogen receptor 2 (ER beta)3003
progesterone receptor6006
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha4004
peroxisome proliferator activated receptor gamma5005
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
v-jun sarcoma virus 17 oncogene homolog (avian)3003
thyroid hormone receptor beta isoform 24004
nuclear factor erythroid 2-related factor 2 isoform 15005
nuclear receptor ROR-gamma isoform 15005
Cellular tumor antigen p535005
endonuclease IV4004
thioredoxin reductase8008
phosphopantetheinyl transferase1001
aldehyde dehydrogenase 1 family, member A16006
thyroid stimulating hormone receptor4004
regulator of G-protein signaling 44004
EWS/FLI fusion protein4004
G4004
arylsulfatase A7007
Bloom syndrome protein isoform 16006
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C19 precursor1001
flap endonuclease 15005
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 12002
muscarinic acetylcholine receptor M13003
Gamma-aminobutyric acid receptor subunit pi0303
Gamma-aminobutyric acid receptor subunit pi2507
Gamma-aminobutyric acid receptor subunit delta0303
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 4004
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Neuronal acetylcholine receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-10325
Gamma-aminobutyric acid receptor subunit beta-12507
Gamma-aminobutyric acid receptor subunit beta-10314
Gamma-aminobutyric acid receptor subunit delta2507
Gamma-aminobutyric acid receptor subunit gamma-20325
Gamma-aminobutyric acid receptor subunit gamma-22518
Gamma-aminobutyric acid receptor subunit alpha-52507
Gamma-aminobutyric acid receptor subunit alpha-32507
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit gamma-12507
Gamma-aminobutyric acid receptor subunit alpha-22507
Gamma-aminobutyric acid receptor subunit alpha-42507
Gamma-aminobutyric acid receptor subunit beta-30325
Gamma-aminobutyric acid receptor subunit gamma-32507
Gamma-aminobutyric acid receptor subunit alpha-62507
Gamma-aminobutyric acid receptor subunit alpha-50325
Gamma-aminobutyric acid receptor subunit alpha-30325
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit beta-20314
Gamma-aminobutyric acid receptor subunit alpha-40314
Gamma-aminobutyric acid receptor subunit alpha-12518
Gamma-aminobutyric acid receptor subunit beta-32507
Gamma-aminobutyric acid receptor subunit beta-22518
Gamma-aminobutyric acid receptor subunit epsilon0303
Neuronal acetylcholine receptor subunit alpha-70101
Gamma-aminobutyric acid receptor subunit alpha-60314
Gamma-aminobutyric acid receptor subunit gamma-10303
GABA theta subunit2507
Inositol hexakisphosphate kinase 14004
Gamma-aminobutyric acid receptor subunit gamma-30303
Gamma-aminobutyric acid receptor subunit epsilon2507
Gamma-aminobutyric acid receptor subunit theta0303
cytochrome P450 2C9, partial4004
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
Histone H2A.x3003
Chain A, Ferritin light chain3003
Gamma-aminobutyric acid 0112
Gamma-aminobutyric acid receptor subunit rho-30011
ATAD5 protein, partial3003
Hsf1 protein0023
bromodomain adjacent to zinc finger domain 2B3003
D(1A) dopamine receptor2002
thyroid hormone receptor beta isoform a4004
transcriptional regulator ERG isoform 32002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
histone acetyltransferase KAT2A isoform 13003
neuropeptide S receptor isoform A2002
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20112
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-60112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit delta0112
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit gamma-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10112
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30112
4-aminobutyrate aminotransferase, mitochondrial0102
4-aminobutyrate aminotransferase, mitochondrial0102
Histone deacetylase 10101
Sterol O-acyltransferase 10011
Gamma-aminobutyric acid receptor subunit alpha-50112
Gamma-aminobutyric acid receptor subunit pi0112
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40112
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0112
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10112
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10112
Histone deacetylase 90101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Beta-lactamase4004
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Microtubule-associated protein tau3003
thioredoxin glutathione reductase1001
cytochrome P450 2D63003
peroxisome proliferator-activated receptor delta2002
vitamin D3 receptor isoform VDRA3003
huntingtin isoform 21001
mitogen-activated protein kinase 14004
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2D60101
Cytochrome P450 2C9 0303
Cytochrome P450 2C190202
Spike glycoprotein4004
NAD-dependent protein deacetylase sirtuin-20101
NAD-dependent protein deacetylase 0101
atrial natriuretic peptide receptor 1 precursor2002
ATP-dependent phosphofructokinase3003
chaperonin-containing TCP-1 beta subunit homolog2002
Synaptic vesicle glycoprotein 2A0202
GLS protein4004
IDH11001
chromobox protein homolog 15005
cytochrome P450 3A4 isoform 12002
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0203
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0202
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Multidrug and toxin extrusion protein 10101
Sodium channel protein type 3 subunit alpha0202
Thioredoxin reductase 0101
Flavodoxin0001
Lanosterol 14-alpha demethylase0101
Chain A, Cruzipain1001
glp-1 receptor, partial1001
USP1 protein, partial2002
nonstructural protein 11001
Parkin1001
aryl hydrocarbon receptor3003
peripheral myelin protein 22 isoform 12002
potassium voltage-gated channel subfamily H member 2 isoform d1001
DNA polymerase iota isoform a (long)1001
M-phase phosphoprotein 82002
Voltage-dependent L-type calcium channel subunit beta-40101
Voltage-dependent P/Q-type calcium channel subunit alpha-1A0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Voltage-dependent T-type calcium channel subunit alpha-1G0101
Voltage-dependent calcium channel gamma-3 subunit0101
Nuclear receptor subfamily 1 group I member 20011
Voltage-dependent T-type calcium channel subunit alpha-1H0101
Adenosine receptor A30101
Cannabinoid receptor 10202
Adenosine receptor A2a0101
Cytochrome P450 2J20101
Voltage-dependent L-type calcium channel subunit beta-30101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Voltage-dependent calcium channel gamma-7 subunit0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Voltage-dependent L-type calcium channel subunit beta-10101
Voltage-dependent calcium channel gamma-1 subunit0101
Voltage-dependent L-type calcium channel subunit beta-20101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Voltage-dependent R-type calcium channel subunit alpha-1E0101
Voltage-dependent calcium channel subunit alpha-2/delta-40101
Transient receptor potential cation channel subfamily A member 10011
Voltage-dependent calcium channel subunit alpha-2/delta-30101
Voltage-dependent calcium channel gamma-8 subunit0101
Rap guanine nucleotide exchange factor 41001
Bile acid receptor0101
Voltage-dependent calcium channel gamma-6 subunit0101
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Voltage-dependent T-type calcium channel subunit alpha-1I0101
Voltage-dependent calcium channel gamma-4 subunit0101
Voltage-dependent calcium channel gamma-5 subunit0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Voltage-dependent calcium channel gamma-2 subunit0101
cytochrome P450 2C9 precursor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Dihydrofolate reductase 0101
Aldo-keto reductase family 1 member B10101
Sodium channel protein type 1 subunit alpha0101
Histamine H2 receptor1001
Inositol monophosphatase 12002
Sodium channel protein type 2 subunit alpha0101
Guanine nucleotide-binding protein G1001
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain A, Breast cancer type 1 susceptibility protein1001
Chain H, Immunoglobulin Igg1 Heavy chain0011
Chain L, Immunoglobulin Igg1 Lambda Light Chain0011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, DODECIN0011
Chain A, DODECIN0011
Chain C, DODECIN0011
Chain E, DODECIN0011
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
acetylcholinesterase1001
15-lipoxygenase, partial1001
SMAD family member 21001
SMAD family member 31001
NPYLR7B0011
thyroid stimulating hormone receptor1001
activating transcription factor 61001
thyrotropin-releasing hormone receptor1001
tumor necrosis factor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
nuclear factor NF-kappa-B p105 subunit isoform 11001
caspase-1 isoform alpha precursor1001
lethal factor (plasmid)1001
Riboflavin-binding protein0112
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Caspase-71001
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Chain A, 2-oxoglutarate Oxygenase1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Albumin0101
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
4-aminobutyrate aminotransferase, mitochondrial0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]