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metronidazole and Opportunistic Infections

metronidazole has been researched along with Opportunistic Infections in 10 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.

Research Excerpts

ExcerptRelevanceReference
"Periodontitis is associated with microflorae which may consist of indigenous, exogenous or superinfecting organisms."2.38Antimicrobial therapy in periodontics. ( Slots, J; van Winkelhoff, AJ, 1993)
"Only few cases of noma infection in adults have been described."1.46Noma in an HIV infected patient in Guinea-Bissau: a case report. ( Hønge, BL; Jespersen, S; Madsen, T; Medina, C; Wejse, C, 2017)
"Metronidazole treatment was stopped at seventh day, and treatment was completed to 14 day with ceftriaxone alone."1.43[A sepsis case caused by a rare opportunistic pathogen: Bacillus pumilus]. ( Aldağ, ME; Borsa, BA; Dinç, U; Güngördü Dalar, Z; Özalp, VC; Tunalı, B, 2016)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's3 (30.00)18.2507
2000's1 (10.00)29.6817
2010's5 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Madsen, T1
Medina, C1
Jespersen, S1
Wejse, C1
Hønge, BL1
Borsa, BA1
Aldağ, ME1
Tunalı, B1
Dinç, U1
Güngördü Dalar, Z1
Özalp, VC1
Grünewald, T1
Kist, M1
Mutters, R1
Ruf, BR1
Kern, WV1
Gardner, E1
Meghani, N1
Mancuso, P1
Thomson, A1
Taylor, GK1
Elliott, L1
Sosin, MD1
Soo, SS1
Slots, J1
van Winkelhoff, AJ1
Nishiyama, T1
Ishida, T1
Takeuchi, H1
Smedts Walters, H1
Bader-Meunier, B1
Dommergues, JP1
Trenschel, R1
Peceny, R1
Runde, V1
Elmaagacli, A1
Dermoumi, H1
Heintschel von Heinegg, E1
Müller, KD1
Schaefer, UW1
Beelen, DW1
Bingley, PJ1
Harding, GM1

Reviews

3 reviews available for metronidazole and Opportunistic Infections

ArticleYear
[Clostridium difficile infection].
    Deutsche medizinische Wochenschrift (1946), 2010, Volume: 135, Issue:14

    Topics: Anti-Bacterial Agents; Bacteriological Techniques; Clindamycin; Clostridioides difficile; Colectomy;

2010
Antimicrobial therapy in periodontics.
    Journal of the California Dental Association, 1993, Volume: 21, Issue:11

    Topics: Amoxicillin; Anti-Bacterial Agents; Ciprofloxacin; Clinical Protocols; Dental Prophylaxis; Drug Deli

1993
[Balantidiosis coli].
    Ryoikibetsu shokogun shirizu, 1999, Issue:24 Pt 2

    Topics: Animals; Anti-Bacterial Agents; Antitrichomonal Agents; Balantidiasis; Balantidium; Diagnosis, Diffe

1999

Trials

1 trial available for metronidazole and Opportunistic Infections

ArticleYear
Fungal colonization and invasive fungal infections following allogeneic BMT using metronidazole, ciprofloxacin and fluconazole or ciprofloxacin and fluconazole as intestinal decontamination.
    Bone marrow transplantation, 2000, Volume: 26, Issue:9

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis;

2000

Other Studies

6 other studies available for metronidazole and Opportunistic Infections

ArticleYear
Noma in an HIV infected patient in Guinea-Bissau: a case report.
    Infection, 2017, Volume: 45, Issue:6

    Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Diagnosis, Differential

2017
[A sepsis case caused by a rare opportunistic pathogen: Bacillus pumilus].
    Mikrobiyoloji bulteni, 2016, Volume: 50, Issue:3

    Topics: Adult; Anti-Bacterial Agents; Bacillaceae Infections; Bacillus pumilus; Blood Sedimentation; C-React

2016
Recognizing metronidazole resistant C. difficile.
    The Nurse practitioner, 2011, Volume: 36, Issue:11

    Topics: Anti-Infective Agents; Clostridioides difficile; Cross Infection; Drug Resistance, Bacterial; Drug T

2011
Complication of etanercept treatment for rheumatoid arthritis--purulent pericarditis caused by a commensal organism.
    BMJ case reports, 2012, May-08, Volume: 2012

    Topics: Aged; Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination;

2012
-Hemophagocytic syndrome associated with strongyloidiasis in a child treated for acute lymphoblastic leukemia.
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1998, Volume: 5, Issue:3

    Topics: Antinematodal Agents; Antineoplastic Combined Chemotherapy Protocols; Antitrichomonal Agents; Child;

1998
Clostridium difficile colitis following treatment with metronidazole and vancomycin.
    Postgraduate medical journal, 1987, Volume: 63, Issue:745

    Topics: Adult; Drug Therapy, Combination; Enterocolitis, Pseudomembranous; Female; Humans; Metronidazole; Op

1987