metronidazole has been researched along with Opportunistic Infections in 10 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Periodontitis is associated with microflorae which may consist of indigenous, exogenous or superinfecting organisms." | 2.38 | Antimicrobial therapy in periodontics. ( Slots, J; van Winkelhoff, AJ, 1993) |
| "Only few cases of noma infection in adults have been described." | 1.46 | Noma in an HIV infected patient in Guinea-Bissau: a case report. ( Hønge, BL; Jespersen, S; Madsen, T; Medina, C; Wejse, C, 2017) |
| "Metronidazole treatment was stopped at seventh day, and treatment was completed to 14 day with ceftriaxone alone." | 1.43 | [A sepsis case caused by a rare opportunistic pathogen: Bacillus pumilus]. ( Aldağ, ME; Borsa, BA; Dinç, U; Güngördü Dalar, Z; Özalp, VC; Tunalı, B, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Madsen, T | 1 |
| Medina, C | 1 |
| Jespersen, S | 1 |
| Wejse, C | 1 |
| Hønge, BL | 1 |
| Borsa, BA | 1 |
| Aldağ, ME | 1 |
| Tunalı, B | 1 |
| Dinç, U | 1 |
| Güngördü Dalar, Z | 1 |
| Özalp, VC | 1 |
| Grünewald, T | 1 |
| Kist, M | 1 |
| Mutters, R | 1 |
| Ruf, BR | 1 |
| Kern, WV | 1 |
| Gardner, E | 1 |
| Meghani, N | 1 |
| Mancuso, P | 1 |
| Thomson, A | 1 |
| Taylor, GK | 1 |
| Elliott, L | 1 |
| Sosin, MD | 1 |
| Soo, SS | 1 |
| Slots, J | 1 |
| van Winkelhoff, AJ | 1 |
| Nishiyama, T | 1 |
| Ishida, T | 1 |
| Takeuchi, H | 1 |
| Smedts Walters, H | 1 |
| Bader-Meunier, B | 1 |
| Dommergues, JP | 1 |
| Trenschel, R | 1 |
| Peceny, R | 1 |
| Runde, V | 1 |
| Elmaagacli, A | 1 |
| Dermoumi, H | 1 |
| Heintschel von Heinegg, E | 1 |
| Müller, KD | 1 |
| Schaefer, UW | 1 |
| Beelen, DW | 1 |
| Bingley, PJ | 1 |
| Harding, GM | 1 |
3 reviews available for metronidazole and Opportunistic Infections
| Article | Year |
|---|---|
[Clostridium difficile infection].
Topics: Anti-Bacterial Agents; Bacteriological Techniques; Clindamycin; Clostridioides difficile; Colectomy; | 2010 |
Antimicrobial therapy in periodontics.
Topics: Amoxicillin; Anti-Bacterial Agents; Ciprofloxacin; Clinical Protocols; Dental Prophylaxis; Drug Deli | 1993 |
[Balantidiosis coli].
Topics: Animals; Anti-Bacterial Agents; Antitrichomonal Agents; Balantidiasis; Balantidium; Diagnosis, Diffe | 1999 |
1 trial available for metronidazole and Opportunistic Infections
| Article | Year |
|---|---|
Fungal colonization and invasive fungal infections following allogeneic BMT using metronidazole, ciprofloxacin and fluconazole or ciprofloxacin and fluconazole as intestinal decontamination.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; | 2000 |
6 other studies available for metronidazole and Opportunistic Infections
| Article | Year |
|---|---|
Noma in an HIV infected patient in Guinea-Bissau: a case report.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Diagnosis, Differential | 2017 |
[A sepsis case caused by a rare opportunistic pathogen: Bacillus pumilus].
Topics: Adult; Anti-Bacterial Agents; Bacillaceae Infections; Bacillus pumilus; Blood Sedimentation; C-React | 2016 |
Recognizing metronidazole resistant C. difficile.
Topics: Anti-Infective Agents; Clostridioides difficile; Cross Infection; Drug Resistance, Bacterial; Drug T | 2011 |
Complication of etanercept treatment for rheumatoid arthritis--purulent pericarditis caused by a commensal organism.
Topics: Aged; Anti-Bacterial Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; | 2012 |
-Hemophagocytic syndrome associated with strongyloidiasis in a child treated for acute lymphoblastic leukemia.
Topics: Antinematodal Agents; Antineoplastic Combined Chemotherapy Protocols; Antitrichomonal Agents; Child; | 1998 |
Clostridium difficile colitis following treatment with metronidazole and vancomycin.
Topics: Adult; Drug Therapy, Combination; Enterocolitis, Pseudomembranous; Female; Humans; Metronidazole; Op | 1987 |