Epiglottitis

Synonym
Epiglottitis

Excerpt	Reference
"Acute epiglottitis is a potentially fatal upper respiratory tract infection."	( Bates, GJ; Cox, GJ; Drake-Lee, AB; Watson, DJ, 1988)
"Adult epiglottitis is a disease that is well known to otolaryngologists, but is less commonly encountered in general medical practice."	( Curotta, JH; Dwyer, DE; Walker, PJ, 1988)
"Epiglottitis is rare but is often life-threatening."	( McLain, LG, 1987)
"Epiglottitis is a life-threatening infection due to Hemophilus influenzae causing respiratory obstruction."	( Grodin, MA, 1983)
"Acute epiglottitis is rare in adolescents."	( Lande, AE, 1984)
"Viral croup and epiglottitis are two major inflammatory causes of airway obstruction in children."	( Cressman, WR; Myer, CM, 1994)
"Acute epiglottitis is still a potentially lethal pathology, particularly in early childhood."	( Berni Canani, F; De Vita, C; Mansi, N; Natale, A, 1999)
"Although acute epiglottitis is not a rare disease and may be very severe or fatal, it is one not familiar, as it should be, to all physicians dealing with children."	( BERMAN, WE; HOLTZMAN, AE, 1960)
"Epiglottitis is supraglottic inflammation of the oropharynx caused by infective, thermal, or caustic insult."	( Kidney, E; Shepherd, M, 2004)
"Adult epiglottitis is an uncommon disease that may become fatal because of sudden airway obstruction."	( Frampton, MC; Hoare, TJ; Latif, SA; Winter, SC, 2003)
"Paediatric acute epiglottitis is rare in Asia."	( Leong, JL; Low, YM; Tan, HK, 2003)
"Acute adult epiglottitis is a potentially life threatening infectious and respiratory emergency as it may result in airway obstruction."	( Coninx, P; Fletcher, D; Lentz, T; Tazarourte, K; Templier, F, 2004)
"Acute epiglottitis is a disease that may become serious or even fatal because of sudden upper airway obstruction."	( Hong, JW; Kim, MG; Kim, SG; Kim, TH; Lee, JH; Park, DJ; Shim, JS; Yeo, SG, 2009)
"Thermal epiglottitis is a rare but potentially life-threatening disease."	( Berkowitz, I; Hamrick, JT; Kudchadkar, SR; Mai, CL; Tunkel, D, 2014)
"Epiglottitis is a potentially life-threatening condition resulting from infection of the epiglottis and surrounding structures, causing classical signs and symptoms related to inflammation and progressive airway obstruction."	( Bietz, MG; Lindemann, J; Westerhuis, B, 2013)
"Acute epiglottitis is a severe and potentially life-threatening condition."	( Beltrami, D; Crisinel, PA; Guilcher, P; Longchamp, D, 2018)

Excerpt	Reference
"Candida epiglottitis has been reported in immunocompromised patients, but in only one paediatric patient with human immunodeficiency virus."	( Israel, L; Sadigh, M, 1995)
"Supraglottitis and epiglottitis have been described for many years by various authors."	( Holmes, DK; McQueen, CT; Shockley, WW; Witsell, DL; Yarbrough, WG, 1995)
"Recurrent adult epiglottitis has been reported rarely in the literature."	( Frampton, MC; Hoare, TJ; Latif, SA; Winter, SC, 2003)
"Paediatric acute epiglottitis has declined markedly in the West with widespread vaccination against HiB."	( Leong, JL; Low, YM; Tan, HK, 2003)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	45 (30.20)	23.3326
1990's	46 (30.87)	12.5806
2000's	33 (22.15)	18.1394
2010's	21 (14.09)	28.8240
2020's	4 (2.68)	9.53

Drug	Relationship Strength	Studies	Trials
racepinephrine	low	2	0
phosphorylcholine	low	1	0
propylene glycol	low	1	0
albuterol	low	2	0
azathioprine	low	2	0
benzocaine	low	1	0
cefuroxime	low	6	0
chlorambucil	low	1	0
fluconazole	low	2	0
lidocaine	low	1	0
lomustine	low	1	0
metronidazole	low	1	0
midazolam	low	1	0
apnea	low	1	0
piracetam	low	1	0
prochlorperazine	low	1	0
sevoflurane	low	8	0
trimethoprim	medium	1	1
xylometazoline	low	1	0
prednisolone	low	1	0
thyroxine	low	1	0
prednisone	low	1	0
penicillin g	low	3	0
chloramphenicol	medium	15	1
colchicine	low	1	0
oxacillin	low	1	0
ampicillin	low	22	0
cytarabine	low	2	0
methylprednisolone	low	3	0
nitroblue tetrazolium	low	1	0
betamethasone	low	1	0
vancomycin	low	2	0
methylprednisolone hemisuccinate	low	1	0
barium sulfate	low	1	0
chlorine	low	1	0
trolamine salicylate	low	1	0
4-methoxyamphetamine	low	4	0
amoxicillin	low	3	0
ticarcillin	low	2	0
piperacillin	low	1	0
itraconazole	low	1	0
cephalosporin c	low	16	0
doripenem	low	1	0
sulbactam	low	3	0
carbapenems	low	1	0
netilmicin	low	1	0
sultamicillin	low	2	0
cocaine	low	3	0
clindamycin	low	6	0
zithromax	low	1	0
cefamandole	low	1	0
nitrogen dioxide	low	1	0
amphotericin b	low	1	0
clavulanic acid	low	1	0
phenylephrine hydrochloride	low	3	0
morphine	low	1	0
cefotaxime	low	4	0
brl 28500	low	1	0
amoxicillin-potassium clavulanate combination	low	2	0
cefdinir	low	1	0
ro13-9904	medium	16	2
cortisol succinate, sodium salt	low	1	0
warfarin	low	1	0
acyclovir	low	2	0
rifampin	medium	7	1
eye	low	1	0

Protein Targets (727)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	3	1	4
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 1A	0	5	1	6
5-hydroxytryptamine receptor 1B	0	4	1	5
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	4	1	5
5-hydroxytryptamine receptor 6	0	1	1	2
Sodium-dependent serotonin transporter	0	4	1	5
Sodium-dependent serotonin transporter	0	5	0	6
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 4	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	1	2
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	3	0	0	3
Thymidine kinase	0	1	0	1
thioredoxin reductase	13	0	0	13
phosphopantetheinyl transferase	5	0	0	5
GLS protein	9	0	0	9
TDP1 protein	20	0	0	20
Smad3	3	0	0	3
thyroid stimulating hormone receptor	11	0	0	11
EWS/FLI fusion protein	11	0	0	11
arylsulfatase A	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	19	0	0	19
activating transcription factor 6	8	0	0	8
Histone H2A.x	6	0	0	6
Bloom syndrome protein isoform 1	7	0	0	7
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
lamin isoform A-delta10	17	0	0	17
Solute carrier family 22 member 1	0	5	0	7
ATP-binding cassette sub-family C member 3	0	25	0	25
Multidrug resistance-associated protein 4	0	25	0	25
Solute carrier family 22 member 6	0	3	0	4
Bile salt export pump	0	6	0	6
Bile salt export pump	0	32	0	32
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	7	0	7
Cytochrome P450 2J2	0	4	0	4
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	3	0	4
Canalicular multispecific organic anion transporter 1	0	24	0	24
Thymidine kinase	0	2	0	2
glp-1 receptor, partial	7	0	0	7
regulator of G-protein signaling 4	2	0	0	2
estrogen-related nuclear receptor alpha	16	0	0	16
estrogen nuclear receptor alpha	25	0	0	25
NPYLR7B	0	0	2	2
thyroid stimulating hormone receptor	6	0	0	6
flap endonuclease 1	6	0	0	6
peripheral myelin protein 22	9	0	0	9
Beta-2 adrenergic receptor	0	2	2	4
Beta-1 adrenergic receptor	0	0	2	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-3 adrenergic receptor	0	0	1	1
Delta-type opioid receptor	0	2	2	5
10 kDa heat shock protein, mitochondrial	0	4	0	4
Thiosulfate sulfurtransferase	0	4	0	4
Beta-2 adrenergic receptor	0	0	1	3
60 kDa chaperonin	0	4	0	4
10 kDa chaperonin	0	4	0	4
Beta-2 adrenergic receptor	0	2	2	4
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, Beta-lactamase	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Beta-lactamase	0	1	0	5
Beta-lactamase	0	1	0	6
Beta-lactamase	0	0	0	5
Beta-lactamase	0	2	0	7
AR protein	19	0	0	19
apical membrane antigen 1, AMA1	5	0	0	5
Beta-lactamase	0	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	7	0	0	7
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
DNA polymerase kappa isoform 1	3	0	0	3
Beta-lactamase SHV-1	0	1	0	6
Beta-lactamase SHV-1	0	3	0	9
Beta-lactamase	0	2	0	7
Kappa-type opioid receptor	0	2	0	7
Solute carrier family 15 member 1	0	8	0	8
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	6	0	6
Beta-lactamase	0	1	0	6
Beta-lactamase	0	1	0	6
Solute carrier family 15 member 2	0	6	0	6
Beta-lactamase	0	1	0	6
Beta-lactamase	0	0	0	4
Chain A, Cruzipain	3	0	0	3
interleukin 8	8	0	0	8
glucocorticoid receptor [Homo sapiens]	15	0	0	15
farnesoid X nuclear receptor	9	0	0	9
peroxisome proliferator-activated receptor delta	9	0	0	9
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	14	0	0	14
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 3A4	0	8	1	9
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C19	0	1	0	1
Nuclear receptor ROR-gamma	7	0	0	7
Potassium voltage-gated channel subfamily H member 2	0	9	0	9
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Beta-lactamase	0	1	0	4
acid sphingomyelinase	1	0	0	1
GLI family zinc finger 3	18	0	0	18
retinoic acid nuclear receptor alpha variant 1	14	0	0	14
Beta-lactamase	0	2	0	5
Beta-lactamase	0	0	0	5
Metallo-beta-lactamase type 2	0	0	0	4
Metallo-beta-lactamase VIM-11	0	0	0	3
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	1	0	6
Metallo-beta-lactamase	0	0	0	4
Beta-lactamase	0	2	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
chromobox protein homolog 1	14	0	0	14
thyroid hormone receptor beta isoform 2	12	0	0	12
DNA polymerase beta	1	0	0	1
geminin	19	0	0	19
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Beta-lactamase OXA-7	0	0	0	3
Spike glycoprotein	6	0	0	6
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	2	0	4
Beta-lactamase	0	2	0	4
Beta-lactamase	0	2	0	4
Metallo-beta-lactamase VIM-13	0	0	0	4
Efflux transporter	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase Toho-1	0	0	0	3
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	2	0	6
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	2	0	5
Beta-lactamase	0	0	0	2
Metallo-b-lactamase	0	0	0	6
Carbapenem-hydrolyzing beta-lactamase KPC	0	3	0	8
Histamine H3 receptor	0	0	0	3
Beta-lactamase class B VIM-2	0	0	0	7
Beta-lactamase VIM-1	0	0	0	4
ATAD5 protein, partial	7	0	0	7
Microtubule-associated protein tau	6	0	0	6
D(1A) dopamine receptor	3	0	0	3
neuropeptide S receptor isoform A	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
acetylcholinesterase	5	0	0	5
RAR-related orphan receptor gamma	16	0	0	16
SMAD family member 2	1	0	0	1
Fumarate hydratase	3	0	0	3
SMAD family member 3	1	0	0	1
thioredoxin glutathione reductase	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
retinoid X nuclear receptor alpha	11	0	0	11
pregnane X nuclear receptor	16	0	0	16
G	9	0	0	9
polyprotein	3	0	0	3
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	9	0	0	9
IDH1	9	0	0	9
aryl hydrocarbon receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
peripheral myelin protein 22 isoform 1	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
heat shock protein beta-1	3	0	0	3
survival motor neuron protein isoform d	3	0	0	3
cytochrome P450 3A4 isoform 1	8	0	0	8
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	5	0	0	5
muscarinic acetylcholine receptor M1	8	0	0	8
Gamma-aminobutyric acid receptor subunit pi	8	1	0	9
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Interferon beta	14	0	0	14
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Cellular tumor antigen p53	19	0	0	19
Gamma-aminobutyric acid receptor subunit beta-1	8	1	0	9
Gamma-aminobutyric acid receptor subunit delta	8	1	0	9
Gamma-aminobutyric acid receptor subunit gamma-2	8	1	0	9
Glutamate receptor 2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-3	8	1	0	9
Gamma-aminobutyric acid receptor subunit gamma-1	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-2	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-4	8	1	0	9
Gamma-aminobutyric acid receptor subunit gamma-3	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-6	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	8	1	0	9
Gamma-aminobutyric acid receptor subunit beta-3	8	1	0	9
Gamma-aminobutyric acid receptor subunit beta-2	8	1	0	9
GABA theta subunit	8	1	0	9
Inositol hexakisphosphate kinase 1	9	0	0	9
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit epsilon	8	1	0	9
Protein-arginine deiminase type-4	0	4	0	4
cytochrome P450 2C9, partial	9	0	0	9
USP1 protein, partial	7	0	0	7
nuclear receptor ROR-gamma isoform 1	5	0	0	5
TAR DNA-binding protein 43	4	0	0	4
pregnane X receptor	3	0	0	3
progesterone receptor	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
thyroid hormone receptor beta isoform a	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
Solute carrier family 22 member 7	0	2	0	2
Solute carrier family 22 member 11	0	2	0	2
Solute carrier family 22 member 8	0	3	0	4
Solute carrier family 22 member 7	0	2	0	2
Beta-lactamase	0	2	0	5
Beta-lactamase	0	2	0	4
Metallo-beta-lactamase VIM-19	0	0	0	3
Beta-lactamase	0	2	0	5
Albumin	0	0	4	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	2	0	5
Metallo-beta-lactamase VIM-2	0	0	0	3
BlaVIM-1	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	4
Luciferase	3	0	0	3
NFKB1 protein, partial	3	0	0	3
GALC protein	3	0	0	3
Thrombopoietin	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
caspase-3	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Carbonic anhydrase 12	0	1	0	1
Carbonic anhydrase 9	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	5
cytochrome P450 2D6	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
streptokinase A precursor	0	0	3	3
lethal factor (plasmid)	4	0	0	4
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	3	0	3
30S ribosomal protein S7	0	3	0	3
50S ribosomal protein L15	0	3	0	3
50S ribosomal protein L10	0	3	0	3
50S ribosomal protein L11	0	3	0	3
50S ribosomal protein L7/L12	0	3	0	3
50S ribosomal protein L19	0	3	0	3
50S ribosomal protein L1	0	3	0	3
50S ribosomal protein L20	0	3	0	3
50S ribosomal protein L27	0	3	0	3
50S ribosomal protein L28	0	3	0	3
50S ribosomal protein L29	0	3	0	3
50S ribosomal protein L31	0	3	0	3
50S ribosomal protein L31 type B	0	3	0	3
50S ribosomal protein L32	0	3	0	3
50S ribosomal protein L33	0	3	0	3
50S ribosomal protein L34	0	3	0	3
50S ribosomal protein L35	0	3	0	3
50S ribosomal protein L36	0	3	0	3
30S ribosomal protein S10	0	3	0	3
30S ribosomal protein S11	0	3	0	3
30S ribosomal protein S12	0	3	0	3
30S ribosomal protein S13	0	3	0	3
30S ribosomal protein S16	0	3	0	3
30S ribosomal protein S18	0	3	0	3
30S ribosomal protein S19	0	3	0	3
30S ribosomal protein S20	0	3	0	3
30S ribosomal protein S2	0	3	0	3
30S ribosomal protein S3	0	3	0	3
30S ribosomal protein S4	0	3	0	3
30S ribosomal protein S5	0	3	0	3
30S ribosomal protein S8	0	3	0	3
30S ribosomal protein S9	0	3	0	3
50S ribosomal protein L13	0	3	0	3
50S ribosomal protein L14	0	3	0	3
50S ribosomal protein L16	0	3	0	3
50S ribosomal protein L23	0	3	0	3
30S ribosomal protein S15	0	3	0	3
50S ribosomal protein L17	0	3	0	3
50S ribosomal protein L21	0	3	0	3
50S ribosomal protein L30	0	3	0	3
50S ribosomal protein L6	0	3	0	3
30S ribosomal protein S14	0	3	0	3
30S ribosomal protein S17	0	3	0	3
30S ribosomal protein S1	0	3	0	3
50S ribosomal protein L18	0	3	0	3
50S ribosomal protein L2	0	3	0	3
50S ribosomal protein L3	0	3	0	3
50S ribosomal protein L24	0	3	0	3
50S ribosomal protein L4	0	3	0	3
50S ribosomal protein L22	0	3	0	3
50S ribosomal protein L5	0	3	0	3
30S ribosomal protein S21	0	3	0	3
50S ribosomal protein L25	0	3	0	3
50S ribosomal protein L36 2	0	3	0	3
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Beta-lactamase	0	2	0	2
Beta-lactamase	0	2	0	3
Beta-lactamase	0	3	0	3
Beta-lactamase	0	2	0	4
Neutrophil elastase	0	1	0	1
Beta-lactamase OXA-1	0	2	0	2
Cytochrome P450 2B6	0	1	1	2
Beta-lactamase TEM	0	5	0	8
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Tryptophan 5-hydroxylase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
D	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	3	0	3
endonuclease IV	3	0	0	3
PAX8	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
PPM1D protein	4	0	0	4
estrogen receptor 2 (ER beta)	5	0	0	5
67.9K protein	4	0	0	4
glucocerebrosidase	2	0	0	2
cytochrome P450 2D6 isoform 1	3	0	0	3
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C19 precursor	4	0	0	4
cytochrome P450 2C9 precursor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Solute carrier family 22 member 3	0	2	0	2
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	4	0	4
Tubulin beta chain	0	2	2	5
ATP-dependent translocase ABCB1	0	4	0	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Histamine H2 receptor	3	0	0	3
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
Rap guanine nucleotide exchange factor 3	3	0	0	3
LMP1 [Human herpesvirus 4]	0	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	0	0	1
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
D(1A) dopamine receptor	2	0	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	2	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
Beta-lactamase	0	0	0	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	1	0	1
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	1	4
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
mitogen-activated protein kinase 1	5	0	0	5
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
nonstructural protein 1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Translocator protein	0	1	1	2
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	4	1	5
Muscarinic acetylcholine receptor M2	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Delta-type opioid receptor	0	1	0	2
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	6
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	0	3
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Solute carrier family 22 member 8	0	3	0	4
MecA	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	4
beta-2 adrenergic receptor	2	0	0	2
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Hsf1 protein	0	0	1	2
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Acetylcholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 1	0	2	0	2
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Mcl-1	0	1	0	1
Snq2p	0	0	0	1
neutrophil cytosol factor 1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
5-hydroxytryptamine receptor 4	0	2	0	2
Integrin beta-3	1	0	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Integrin alpha-IIb	1	0	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
Histamine H1 receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
dopamine D1 receptor	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Beta-adrenergic receptor kinase 1	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Alpha-synuclein	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	2	0	4
Replicase polyprotein 1ab	0	1	0	1
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Metabotropic glutamate receptor 5	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (149)

Protein Targets (727)

Epiglottitis

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (149)

Drugs Studied (76)

Protein Targets (727)