Page last updated: 2024-10-31

metronidazole and Lung Neoplasms

metronidazole has been researched along with Lung Neoplasms in 34 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Lung Neoplasms: Tumors or cancer of the LUNG.

Research Excerpts

ExcerptRelevanceReference
"The influence of metronidazole, misonidazole, and desmethylmisonidazole on the induction of lung adenomas in the strain A mouse was examined."3.66Lung tumorigenic response of strain A mice exposed to hypoxic cell sensitizers alone and in combination with gamma-radiation. ( Grdina, DJ; Mian, TA; Theiss, JC, 1983)
"Metronidazole therapy was associated with substantial nausea and vomiting but no neurotoxicity was observed."2.65Randomized trial of radiotherapy versus radiotherapy plus metronidazole for the treatment metastatic cancer to brain. A Southwest Oncology Group study. ( Eyre, HJ; Frank, J; LoBuglio, AF; Mansfield, CM; McCracken, JD; Ohlsen, JD; Weatherall, TJ, 1984)
"The radiolabeling of EDTA-MN with (99m)Tc was performed with direct labeling method, respectively, on the reaction dosage (10 mg, 5 mg, 2 mg), stannous chloride dosage (8 mg/mL, 4 mg/mL, 2 mg/mL), mark system pH (2, 4, 5, 6) one by one test, using orthogonal design analysis, to find the optimal labeling conditions."1.42[Preparation of (99m)Tc-EDTA-MN and Its Bioimaging in Mouse]. ( Chi, X; Du, L; Huang, B; Huang, K; Li, G; Qi, Y; Zhang, H, 2015)
"Lemierre's syndrome is a disseminated infection which is usually caused by Fusobacterium necrophorum."1.38[Lemierre's syndrome as differential diagnosis of lung cancer]. ( Reinholdt Jensen, J; Weinreich, UM, 2012)
"Antibiotics-associated pseudomembranous colitis is well documented and caused by abnormal overgrowth of toxin producing Clostridium difficile colonizing the large bowel of patients undergoing antibiotic therapy."1.35[A case of pseudomenbranous colitis after paclitaxel and carboplatin chemotherapy]. ( Moon, W; Yang, SW, 2009)
"Isometronidazole was shown to cause no severe side-effects in patients, improving considerably radiation injury of the tumor parenchyma."1.28[The immediate results of the use of isometronidazole in the combination therapy of patients with lung cancer]. ( Demidchik, IuE; Furmanchuk, AV; Gentshel, M; Kurchin, VP; Merkle, KKh; Moiseev, PI; Zharkov, VV, 1991)
"A reported excess of liver tumors in rats exposed to metronidazole can be explained by the fact that the authors failed to age standardize their data despite a big and highly significant beneficial effect of the drug on survival."1.27Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential. ( Roe, FJ, 1983)
"Metronidazole, 1."1.27Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983)
"We assessed the risk of occurrence of cancer associated with exposure to metronidazole in the 771 female residents of Rochester, Minnesota, who were treated with metronidazole for vaginal trichomoniasis during the period 1960 through 1969 and were followed up for a total of 12,628 person-years."1.27Cancer after exposure to metronidazole. ( Beard, CM; Dahlin, DC; Kurland, LT; Noller, KL; O'Fallon, WM, 1988)
"Recently the resection of pulmonary metastases combined with chemotherapy has increased the survival rate."1.26Radiation treatment of Ewing's sarcoma and osteogenic sarcoma. ( Jenkin, RD, 1977)
"Metronidazole was administered orally to 25 patients and its maximum concentration in blood and tumor tissues, its ability to cross the blood/brain barrier and concentrate in the cerebrospinal fluid and brain tumor tissue, its immediate and long-term toxicity, and its enhancement of irradiation in normal tissue were studied."1.25Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells. ( Band, P; Chapman, JD; Fryer, CG; Rabin, HR; Sturmwind, J; Urtasun, RC, 1975)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199019 (55.88)18.7374
1990's3 (8.82)18.2507
2000's4 (11.76)29.6817
2010's7 (20.59)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Candido, CC1
Silva, HVR1
Zavan, B1
Ionta, M1
Barbosa, MIF1
Doriguetto, AC1
Liu, YY1
Ying, Y1
Chen, C1
Hu, YK1
Yang, FF1
Shao, LY1
Cheng, XJ1
Huang, YX1
Qi, Y1
Li, G1
Chi, X1
Du, L1
Huang, K1
Zhang, H1
Huang, B1
Aebischer, B1
Elsig, S1
Taeymans, J1
Pomp, S1
Kuhness, D1
Barcaro, G1
Sementa, L1
Mankad, V1
Fortunelli, A1
Sterrer, M1
Netzer, FP1
Surnev, S1
Schmieder, AH1
Caruthers, SD1
Keupp, J1
Wickline, SA1
Lanza, GM1
Lowe, J1
Wodarcyk, AJ1
Floyd, KT1
Rastogi, N1
Schultz, EJ1
Swager, SA1
Chadwick, JA1
Tran, T1
Raman, SV1
Janssen, PM1
Rafael-Fortney, JA1
Alcalay, RN1
Levy, OA1
Wolf, P1
Oliva, P1
Zhang, XK1
Waters, CH1
Fahn, S1
Kang, U1
Liong, C1
Ford, B1
Mazzoni, P1
Kuo, S1
Johnson, A1
Xiong, L1
Rouleau, GA1
Chung, W1
Marder, KS1
Gan-Or, Z1
Kamei, K1
Terao, T1
Katayama, Y1
Hatano, K1
Kodama, K2
Shirahama, M1
Sakai, A1
Hirakawa, H1
Mizokami, Y1
Shiotsuki, I1
Ishii, N1
Inoue, Y1
Akboga, MK1
Yayla, C1
Balci, KG1
Ozeke, O1
Maden, O1
Kisacik, H1
Temizhan, A1
Aydogdu, S1
Zhu, J2
Ying, SH1
Feng, MG1
Zhang, XG1
Li, H1
Wang, L1
Hao, YY1
Liang, GD1
Ma, YH1
Yang, GS1
Hu, JH1
Pfeifer, L1
Goertz, RS1
Neurath, MF1
Strobel, D1
Wildner, D1
Lin, JT1
Yang, XN1
Zhong, WZ1
Liao, RQ1
Dong, S1
Nie, Q1
Weng, SX1
Fang, XJ1
Zheng, JY1
Wu, YL1
Řezanka, T1
Kaineder, K1
Mezricky, D1
Řezanka, M1
Bišová, K1
Zachleder, V1
Vítová, M1
Rinker, JA1
Marshall, SA1
Mazzone, CM1
Lowery-Gionta, EG1
Gulati, V1
Pleil, KE1
Kash, TL1
Navarro, M1
Thiele, TE1
Zhang, Y1
Huang, Y1
Jin, Z1
Li, X1
Li, B1
Xu, P1
Huang, P1
Liu, C1
Fokdal, L1
Sturdza, A1
Mazeron, R1
Haie-Meder, C1
Tan, LT1
Gillham, C1
Šegedin, B1
Jürgenliemk-Schultz, I1
Kirisits, C1
Hoskin, P1
Pötter, R1
Lindegaard, JC1
Tanderup, K1
Levin, DE1
Schmitz, AJ1
Hines, SM1
Hines, KJ1
Tucker, MJ1
Brewer, SH1
Fenlon, EE1
Álvarez-Pérez, S1
Blanco, JL1
Peláez, T1
Martínez-Nevado, E1
García, ME1
Puckerin, AA1
Chang, DD1
Subramanyam, P1
Colecraft, HM1
Dogan, H1
Coteli, E1
Karatas, F1
Ceylan, O1
Sahin, MD1
Akdamar, G1
Kryczyk, A1
Żmudzki, P1
Hubicka, U1
Giovannelli, D1
Chung, M1
Staley, J1
Starovoytov, V1
Le Bris, N1
Vetriani, C1
Chen, W1
Wu, L1
Liu, X1
Shen, Y1
Liang, Y1
Tan, H1
Yang, Y1
Liu, Q1
Wang, M1
Liu, L1
Wang, X1
Liu, B1
Liu, GH1
Zhu, YJ1
Wang, JP1
Che, JM1
Chen, QQ1
Chen, Z1
Maucksch, U1
Runge, R1
Wunderlich, G1
Freudenberg, R1
Naumann, A1
Kotzerke, J1
Yang, SW1
Moon, W1
Pongcharoen, P1
Chanprapaph, K1
Vachiramon, V1
Guy, SD1
Worth, LJ1
Thursky, KA1
Francis, PA1
Slavin, MA1
Reinholdt Jensen, J1
Weinreich, UM1
Ren, W1
Li, Z1
Mi, D1
Yang, K1
Tian, J1
Zhang, Z1
Barbato, A1
Panizzolo, C1
Landi, L1
Semenzato, R1
Rugge, M1
Gibbons, FK1
Branda, JA1
Shepard, JA1
Ito, M1
Yang, DJ1
Mawlawi, O1
Mendez, R1
Oh, CS1
Azhdarinia, A1
Greenwell, AC1
Yu, DF1
Kim, EE1
Roe, FJ1
Goldobenko, GV1
Kherkheulidze, ZSh1
Shchebetenko, IuE1
Polotskiĭ, BE1
Kiseleva, ES1
Dar'ialova, SL1
Eyre, HJ1
Ohlsen, JD1
Frank, J1
LoBuglio, AF1
McCracken, JD1
Weatherall, TJ1
Mansfield, CM1
Stewart, DJ1
Maroun, JA1
Young, V1
Crook, AF1
Hopkins, HS1
Yan, RC1
Richard, MT1
Hugenholtz, H1
Bélanger, R1
Heringer, R1
Cavaliere, A1
Bacci, M1
Amorosi, A1
Del Gaudio, M1
Vitali, R1
Mian, TA1
Theiss, JC1
Grdina, DJ1
Urtasun, RC2
Band, P2
Ferri, H1
Cipolla, B1
Blanchard, Y1
Chamaillard, L1
Quemener, V1
Guillé, F1
Havouis, R1
Moulinoux, JP1
Jenkin, RD1
Beard, CM2
Noller, KL2
O'Fallon, WM2
Kurland, LT2
Dockerty, MB1
Chapman, JD1
Rabin, HR1
Fryer, CG1
Sturmwind, J1
Bower, M1
Stein, R1
Evans, TR1
Hedley, A1
Pert, P1
Coombes, RC1
Zharkov, VV2
Merkle, KKh1
Gentshel, M1
Furmanchuk, AV1
Kurchin, VP1
Demidchik, IuE2
Moiseev, PI1
Prokhorova, VI1
Rubanova, VZ1
Pivniuk, VM1
Semenchuk, DD1
Shkliarskaia, LA1
Dahlin, DC1
Zolkiver, KI1
Muchambetova, GA1
Toktamysova, ZS1
Chacko, M1
Bhide, SV1
Doi, O1
Kurokawa, E1
Kabuto, T1
Terasawa, T1
Rustia, M1
Shubik, P1

Reviews

6 reviews available for metronidazole and Lung Neoplasms

ArticleYear
    Hand therapy, 2016, Volume: 21, Issue:1

    Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A

2016
Legionella pneumophila lung abscess associated with immune suppression.
    Internal medicine journal, 2011, Volume: 41, Issue:10

    Topics: Adult; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Australia; Azithromyci

2011
[A meta analysis of radiosensitivity on non-small cell lung cancer by metronidazole amino acidum natrium].
    Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2012, Volume: 15, Issue:6

    Topics: Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Metronidazole; Middle Aged; Ra

2012
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
    Meditsinskaia radiologiia, 1983, Volume: 28, Issue:7

    Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female;

1983
[Electron acceptor compounds as radiation sensitizers of hypoxic cells in human tumors].
    Meditsinskaia radiologiia, 1984, Volume: 29, Issue:9

    Topics: Brain Neoplasms; Combined Modality Therapy; Esophageal Neoplasms; Female; Head and Neck Neoplasms; H

1984
Radiation sensitizers.
    Cancer, 1976, Volume: 37, Issue:4 Suppl

    Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs

1976

Trials

3 trials available for metronidazole and Lung Neoplasms

ArticleYear
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
    Meditsinskaia radiologiia, 1983, Volume: 28, Issue:7

    Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female;

1983
Randomized trial of radiotherapy versus radiotherapy plus metronidazole for the treatment metastatic cancer to brain. A Southwest Oncology Group study.
    Journal of neuro-oncology, 1984, Volume: 2, Issue:4

    Topics: Age Factors; Brain Neoplasms; Breast Neoplasms; Clinical Trials as Topic; Combined Modality Therapy;

1984
A double-blind study of the efficacy of metronidazole gel in the treatment of malodorous fungating tumours.
    European journal of cancer (Oxford, England : 1990), 1992, Volume: 28A, Issue:4-5

    Topics: Administration, Topical; Aged; Aged, 80 and over; Bacteria, Anaerobic; Bacterial Infections; Breast

1992

Other Studies

26 other studies available for metronidazole and Lung Neoplasms

ArticleYear
Synthesis, characterization and in vitro cytotoxicity of ruthenium(II) metronidazole complexes: Cell cycle arrest at G1/S transition and apoptosis induction in MCF-7 cells.
    Journal of inorganic biochemistry, 2022, Volume: 237

    Topics: 2,2'-Dipyridyl; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpo

2022
Primary pulmonary amebic abscess in a patient with pulmonary adenocarcinoma: a case report.
    Infectious diseases of poverty, 2018, Apr-27, Volume: 7, Issue:1

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aged; Amebiasis; Antineoplastic Agents; Antiprotozoal Agents

2018
[Preparation of (99m)Tc-EDTA-MN and Its Bioimaging in Mouse].
    Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2015, Volume: 18, Issue:7

    Topics: Animals; Cell Line, Tumor; Edetic Acid; Female; Humans; Lung Neoplasms; Male; Metronidazole; Mice; M

2015
[A case of pseudomenbranous colitis after paclitaxel and carboplatin chemotherapy].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2009, Volume: 54, Issue:5

    Topics: Aged; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma,

2009
Papulopustular eruptions in a 32-year-old woman after lung cancer treatment.
    Archives of dermatology, 2011, Volume: 147, Issue:6

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Antineoplastic Agents; Dermatologic Agents; Drug Erup

2011
[Lemierre's syndrome as differential diagnosis of lung cancer].
    Ugeskrift for laeger, 2012, May-28, Volume: 174, Issue:22

    Topics: Abscess; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Diagnosis, Differential; Fusobacterium

2012
Asthma-like syndrome in a teenager.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2003, Volume: 14, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Albuterol; Amoxicillin; Androstadienes; Anti-Ba

2003
Case records of the Massachusetts General Hospital. Case 12-2006. A 37-year-old man with hemoptysis and a pulmonary infiltrate.
    The New England journal of medicine, 2006, Apr-20, Volume: 354, Issue:16

    Topics: Adult; Anti-Infective Agents; Diagnosis, Differential; Hemoptysis; Humans; Lung; Lung Neoplasms; Mal

2006
PET and planar imaging of tumor hypoxia with labeled metronidazole.
    Academic radiology, 2006, Volume: 13, Issue:5

    Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Feasibility Studies; Female; Isotope Labeling; Lung Neoplas

2006
Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential.
    Surgery, 1983, Volume: 93, Issue:1 Pt 2

    Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; Crohn Disease; Female; Follow-Up Studies; Humans;

1983
Feasibility study of combining metronidazole with chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1983, Volume: 1, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq

1983
Induction of lung tumors and lymphomas in BALB/c mice by metronidazole.
    Tumori, 1983, Oct-31, Volume: 69, Issue:5

    Topics: Animals; Female; Lung Neoplasms; Lymphoma; Male; Metronidazole; Mice; Mice, Inbred BALB C; Sex Facto

1983
Lung tumorigenic response of strain A mice exposed to hypoxic cell sensitizers alone and in combination with gamma-radiation.
    Cancer research, 1983, Volume: 43, Issue:1

    Topics: Adenoma; Animals; Hypoxia; Lung; Lung Neoplasms; Metronidazole; Mice; Mice, Inbred A; Misonidazole;

1983
Tumor growth delay studies in patients with multiple metastatic nodules: practical difficulties.
    International journal of radiation oncology, biology, physics, 1980, Volume: 6, Issue:7

    Topics: Humans; Lung Neoplasms; Male; Metronidazole; Middle Aged; Neoplasm Metastasis; Neoplasms; Regression

1980
In vivo, synergestic inhibition of MAT-LyLu rat prostatic adenocarcinoma growth by polyamine deprivation and low-dose cyclophosphamide.
    Urological research, 1996, Volume: 24, Issue:2

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Co

1996
Radiation treatment of Ewing's sarcoma and osteogenic sarcoma.
    Canadian journal of surgery. Journal canadien de chirurgie, 1977, Volume: 20, Issue:6

    Topics: Adolescent; Adult; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Lung Neoplasms; Methotrexate;

1977
Lack of evidence for cancer due to use of metronidazole.
    The New England journal of medicine, 1979, Sep-06, Volume: 301, Issue:10

    Topics: Adolescent; Adult; Aged; Breast Neoplasms; Female; Humans; Lung Neoplasms; Metronidazole; Middle Age

1979
Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells.
    Radiology, 1975, Volume: 117, Issue:1

    Topics: Brain Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Mediasti

1975
[The immediate results of the use of isometronidazole in the combination therapy of patients with lung cancer].
    Meditsinskaia radiologiia, 1991, Volume: 36, Issue:7

    Topics: Adult; Combined Modality Therapy; Humans; Lung Neoplasms; Male; Metronidazole; Middle Aged; Radiatio

1991
[Peripheral blood indices in preoperative radiotherapy (using radiomodifiers) of lung cancer].
    Meditsinskaia radiologiia, 1989, Volume: 34, Issue:9

    Topics: Blood Cell Count; Blood Glucose; Combined Modality Therapy; Humans; Lung Neoplasms; Metronidazole; R

1989
[Effect of electron-acceptor compounds on the immunoregulatory mechanisms and ATPase activity of the erythrocyte membranes from patients with inoperable lung cancer].
    Eksperimental'naia onkologiia, 1988, Volume: 10, Issue:2

    Topics: Adenosine Triphosphatases; Combined Modality Therapy; Electron Transport; Erythrocyte Membrane; Huma

1988
Cancer after exposure to metronidazole.
    Mayo Clinic proceedings, 1988, Volume: 63, Issue:2

    Topics: Carcinoma, Bronchogenic; Female; Follow-Up Studies; Humans; Lung Neoplasms; Metronidazole; Minnesota

1988
[Metronidazole in radiotherapy of squamous cell carcinoma of the lung].
    Radiobiologia, radiotherapia, 1986, Volume: 27, Issue:6

    Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Lung Neoplasms; Male; Metronida

1986
Carcinogenicity, perinatal carcinogenicity and teratogenicity of low dose metronidazole (MNZ) in Swiss mice.
    Journal of cancer research and clinical oncology, 1986, Volume: 112, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Lung Neoplasms; Male; Metronidazole; Mice; Neop

1986
[Chemo-hyperthermotherapy following thoracic surgery].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:12

    Topics: Aged; Cisplatin; Female; Humans; Hyperthermia, Induced; Lung Neoplasms; Male; Metronidazole; Middle

1985
Induction of lung tumors and malignant lymphomas in mice by metronidazole.
    Journal of the National Cancer Institute, 1972, Volume: 48, Issue:3

    Topics: Adenocarcinoma; Animals; Carcinogens; Female; Hodgkin Disease; Kidney; Lung Neoplasms; Male; Metroni

1972