metronidazole has been researched along with Lung Neoplasms in 34 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Lung Neoplasms: Tumors or cancer of the LUNG.
Excerpt | Relevance | Reference |
---|---|---|
"The influence of metronidazole, misonidazole, and desmethylmisonidazole on the induction of lung adenomas in the strain A mouse was examined." | 3.66 | Lung tumorigenic response of strain A mice exposed to hypoxic cell sensitizers alone and in combination with gamma-radiation. ( Grdina, DJ; Mian, TA; Theiss, JC, 1983) |
"Metronidazole therapy was associated with substantial nausea and vomiting but no neurotoxicity was observed." | 2.65 | Randomized trial of radiotherapy versus radiotherapy plus metronidazole for the treatment metastatic cancer to brain. A Southwest Oncology Group study. ( Eyre, HJ; Frank, J; LoBuglio, AF; Mansfield, CM; McCracken, JD; Ohlsen, JD; Weatherall, TJ, 1984) |
"The radiolabeling of EDTA-MN with (99m)Tc was performed with direct labeling method, respectively, on the reaction dosage (10 mg, 5 mg, 2 mg), stannous chloride dosage (8 mg/mL, 4 mg/mL, 2 mg/mL), mark system pH (2, 4, 5, 6) one by one test, using orthogonal design analysis, to find the optimal labeling conditions." | 1.42 | [Preparation of (99m)Tc-EDTA-MN and Its Bioimaging in Mouse]. ( Chi, X; Du, L; Huang, B; Huang, K; Li, G; Qi, Y; Zhang, H, 2015) |
"Lemierre's syndrome is a disseminated infection which is usually caused by Fusobacterium necrophorum." | 1.38 | [Lemierre's syndrome as differential diagnosis of lung cancer]. ( Reinholdt Jensen, J; Weinreich, UM, 2012) |
"Antibiotics-associated pseudomembranous colitis is well documented and caused by abnormal overgrowth of toxin producing Clostridium difficile colonizing the large bowel of patients undergoing antibiotic therapy." | 1.35 | [A case of pseudomenbranous colitis after paclitaxel and carboplatin chemotherapy]. ( Moon, W; Yang, SW, 2009) |
"Isometronidazole was shown to cause no severe side-effects in patients, improving considerably radiation injury of the tumor parenchyma." | 1.28 | [The immediate results of the use of isometronidazole in the combination therapy of patients with lung cancer]. ( Demidchik, IuE; Furmanchuk, AV; Gentshel, M; Kurchin, VP; Merkle, KKh; Moiseev, PI; Zharkov, VV, 1991) |
"A reported excess of liver tumors in rats exposed to metronidazole can be explained by the fact that the authors failed to age standardize their data despite a big and highly significant beneficial effect of the drug on survival." | 1.27 | Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential. ( Roe, FJ, 1983) |
"Metronidazole, 1." | 1.27 | Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983) |
"We assessed the risk of occurrence of cancer associated with exposure to metronidazole in the 771 female residents of Rochester, Minnesota, who were treated with metronidazole for vaginal trichomoniasis during the period 1960 through 1969 and were followed up for a total of 12,628 person-years." | 1.27 | Cancer after exposure to metronidazole. ( Beard, CM; Dahlin, DC; Kurland, LT; Noller, KL; O'Fallon, WM, 1988) |
"Recently the resection of pulmonary metastases combined with chemotherapy has increased the survival rate." | 1.26 | Radiation treatment of Ewing's sarcoma and osteogenic sarcoma. ( Jenkin, RD, 1977) |
"Metronidazole was administered orally to 25 patients and its maximum concentration in blood and tumor tissues, its ability to cross the blood/brain barrier and concentrate in the cerebrospinal fluid and brain tumor tissue, its immediate and long-term toxicity, and its enhancement of irradiation in normal tissue were studied." | 1.25 | Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells. ( Band, P; Chapman, JD; Fryer, CG; Rabin, HR; Sturmwind, J; Urtasun, RC, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 19 (55.88) | 18.7374 |
1990's | 3 (8.82) | 18.2507 |
2000's | 4 (11.76) | 29.6817 |
2010's | 7 (20.59) | 24.3611 |
2020's | 1 (2.94) | 2.80 |
Authors | Studies |
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Candido, CC | 1 |
Silva, HVR | 1 |
Zavan, B | 1 |
Ionta, M | 1 |
Barbosa, MIF | 1 |
Doriguetto, AC | 1 |
Liu, YY | 1 |
Ying, Y | 1 |
Chen, C | 1 |
Hu, YK | 1 |
Yang, FF | 1 |
Shao, LY | 1 |
Cheng, XJ | 1 |
Huang, YX | 1 |
Qi, Y | 1 |
Li, G | 1 |
Chi, X | 1 |
Du, L | 1 |
Huang, K | 1 |
Zhang, H | 1 |
Huang, B | 1 |
Aebischer, B | 1 |
Elsig, S | 1 |
Taeymans, J | 1 |
Pomp, S | 1 |
Kuhness, D | 1 |
Barcaro, G | 1 |
Sementa, L | 1 |
Mankad, V | 1 |
Fortunelli, A | 1 |
Sterrer, M | 1 |
Netzer, FP | 1 |
Surnev, S | 1 |
Schmieder, AH | 1 |
Caruthers, SD | 1 |
Keupp, J | 1 |
Wickline, SA | 1 |
Lanza, GM | 1 |
Lowe, J | 1 |
Wodarcyk, AJ | 1 |
Floyd, KT | 1 |
Rastogi, N | 1 |
Schultz, EJ | 1 |
Swager, SA | 1 |
Chadwick, JA | 1 |
Tran, T | 1 |
Raman, SV | 1 |
Janssen, PM | 1 |
Rafael-Fortney, JA | 1 |
Alcalay, RN | 1 |
Levy, OA | 1 |
Wolf, P | 1 |
Oliva, P | 1 |
Zhang, XK | 1 |
Waters, CH | 1 |
Fahn, S | 1 |
Kang, U | 1 |
Liong, C | 1 |
Ford, B | 1 |
Mazzoni, P | 1 |
Kuo, S | 1 |
Johnson, A | 1 |
Xiong, L | 1 |
Rouleau, GA | 1 |
Chung, W | 1 |
Marder, KS | 1 |
Gan-Or, Z | 1 |
Kamei, K | 1 |
Terao, T | 1 |
Katayama, Y | 1 |
Hatano, K | 1 |
Kodama, K | 2 |
Shirahama, M | 1 |
Sakai, A | 1 |
Hirakawa, H | 1 |
Mizokami, Y | 1 |
Shiotsuki, I | 1 |
Ishii, N | 1 |
Inoue, Y | 1 |
Akboga, MK | 1 |
Yayla, C | 1 |
Balci, KG | 1 |
Ozeke, O | 1 |
Maden, O | 1 |
Kisacik, H | 1 |
Temizhan, A | 1 |
Aydogdu, S | 1 |
Zhu, J | 2 |
Ying, SH | 1 |
Feng, MG | 1 |
Zhang, XG | 1 |
Li, H | 1 |
Wang, L | 1 |
Hao, YY | 1 |
Liang, GD | 1 |
Ma, YH | 1 |
Yang, GS | 1 |
Hu, JH | 1 |
Pfeifer, L | 1 |
Goertz, RS | 1 |
Neurath, MF | 1 |
Strobel, D | 1 |
Wildner, D | 1 |
Lin, JT | 1 |
Yang, XN | 1 |
Zhong, WZ | 1 |
Liao, RQ | 1 |
Dong, S | 1 |
Nie, Q | 1 |
Weng, SX | 1 |
Fang, XJ | 1 |
Zheng, JY | 1 |
Wu, YL | 1 |
Řezanka, T | 1 |
Kaineder, K | 1 |
Mezricky, D | 1 |
Řezanka, M | 1 |
Bišová, K | 1 |
Zachleder, V | 1 |
Vítová, M | 1 |
Rinker, JA | 1 |
Marshall, SA | 1 |
Mazzone, CM | 1 |
Lowery-Gionta, EG | 1 |
Gulati, V | 1 |
Pleil, KE | 1 |
Kash, TL | 1 |
Navarro, M | 1 |
Thiele, TE | 1 |
Zhang, Y | 1 |
Huang, Y | 1 |
Jin, Z | 1 |
Li, X | 1 |
Li, B | 1 |
Xu, P | 1 |
Huang, P | 1 |
Liu, C | 1 |
Fokdal, L | 1 |
Sturdza, A | 1 |
Mazeron, R | 1 |
Haie-Meder, C | 1 |
Tan, LT | 1 |
Gillham, C | 1 |
Šegedin, B | 1 |
Jürgenliemk-Schultz, I | 1 |
Kirisits, C | 1 |
Hoskin, P | 1 |
Pötter, R | 1 |
Lindegaard, JC | 1 |
Tanderup, K | 1 |
Levin, DE | 1 |
Schmitz, AJ | 1 |
Hines, SM | 1 |
Hines, KJ | 1 |
Tucker, MJ | 1 |
Brewer, SH | 1 |
Fenlon, EE | 1 |
Álvarez-Pérez, S | 1 |
Blanco, JL | 1 |
Peláez, T | 1 |
Martínez-Nevado, E | 1 |
García, ME | 1 |
Puckerin, AA | 1 |
Chang, DD | 1 |
Subramanyam, P | 1 |
Colecraft, HM | 1 |
Dogan, H | 1 |
Coteli, E | 1 |
Karatas, F | 1 |
Ceylan, O | 1 |
Sahin, MD | 1 |
Akdamar, G | 1 |
Kryczyk, A | 1 |
Żmudzki, P | 1 |
Hubicka, U | 1 |
Giovannelli, D | 1 |
Chung, M | 1 |
Staley, J | 1 |
Starovoytov, V | 1 |
Le Bris, N | 1 |
Vetriani, C | 1 |
Chen, W | 1 |
Wu, L | 1 |
Liu, X | 1 |
Shen, Y | 1 |
Liang, Y | 1 |
Tan, H | 1 |
Yang, Y | 1 |
Liu, Q | 1 |
Wang, M | 1 |
Liu, L | 1 |
Wang, X | 1 |
Liu, B | 1 |
Liu, GH | 1 |
Zhu, YJ | 1 |
Wang, JP | 1 |
Che, JM | 1 |
Chen, QQ | 1 |
Chen, Z | 1 |
Maucksch, U | 1 |
Runge, R | 1 |
Wunderlich, G | 1 |
Freudenberg, R | 1 |
Naumann, A | 1 |
Kotzerke, J | 1 |
Yang, SW | 1 |
Moon, W | 1 |
Pongcharoen, P | 1 |
Chanprapaph, K | 1 |
Vachiramon, V | 1 |
Guy, SD | 1 |
Worth, LJ | 1 |
Thursky, KA | 1 |
Francis, PA | 1 |
Slavin, MA | 1 |
Reinholdt Jensen, J | 1 |
Weinreich, UM | 1 |
Ren, W | 1 |
Li, Z | 1 |
Mi, D | 1 |
Yang, K | 1 |
Tian, J | 1 |
Zhang, Z | 1 |
Barbato, A | 1 |
Panizzolo, C | 1 |
Landi, L | 1 |
Semenzato, R | 1 |
Rugge, M | 1 |
Gibbons, FK | 1 |
Branda, JA | 1 |
Shepard, JA | 1 |
Ito, M | 1 |
Yang, DJ | 1 |
Mawlawi, O | 1 |
Mendez, R | 1 |
Oh, CS | 1 |
Azhdarinia, A | 1 |
Greenwell, AC | 1 |
Yu, DF | 1 |
Kim, EE | 1 |
Roe, FJ | 1 |
Goldobenko, GV | 1 |
Kherkheulidze, ZSh | 1 |
Shchebetenko, IuE | 1 |
Polotskiĭ, BE | 1 |
Kiseleva, ES | 1 |
Dar'ialova, SL | 1 |
Eyre, HJ | 1 |
Ohlsen, JD | 1 |
Frank, J | 1 |
LoBuglio, AF | 1 |
McCracken, JD | 1 |
Weatherall, TJ | 1 |
Mansfield, CM | 1 |
Stewart, DJ | 1 |
Maroun, JA | 1 |
Young, V | 1 |
Crook, AF | 1 |
Hopkins, HS | 1 |
Yan, RC | 1 |
Richard, MT | 1 |
Hugenholtz, H | 1 |
Bélanger, R | 1 |
Heringer, R | 1 |
Cavaliere, A | 1 |
Bacci, M | 1 |
Amorosi, A | 1 |
Del Gaudio, M | 1 |
Vitali, R | 1 |
Mian, TA | 1 |
Theiss, JC | 1 |
Grdina, DJ | 1 |
Urtasun, RC | 2 |
Band, P | 2 |
Ferri, H | 1 |
Cipolla, B | 1 |
Blanchard, Y | 1 |
Chamaillard, L | 1 |
Quemener, V | 1 |
Guillé, F | 1 |
Havouis, R | 1 |
Moulinoux, JP | 1 |
Jenkin, RD | 1 |
Beard, CM | 2 |
Noller, KL | 2 |
O'Fallon, WM | 2 |
Kurland, LT | 2 |
Dockerty, MB | 1 |
Chapman, JD | 1 |
Rabin, HR | 1 |
Fryer, CG | 1 |
Sturmwind, J | 1 |
Bower, M | 1 |
Stein, R | 1 |
Evans, TR | 1 |
Hedley, A | 1 |
Pert, P | 1 |
Coombes, RC | 1 |
Zharkov, VV | 2 |
Merkle, KKh | 1 |
Gentshel, M | 1 |
Furmanchuk, AV | 1 |
Kurchin, VP | 1 |
Demidchik, IuE | 2 |
Moiseev, PI | 1 |
Prokhorova, VI | 1 |
Rubanova, VZ | 1 |
Pivniuk, VM | 1 |
Semenchuk, DD | 1 |
Shkliarskaia, LA | 1 |
Dahlin, DC | 1 |
Zolkiver, KI | 1 |
Muchambetova, GA | 1 |
Toktamysova, ZS | 1 |
Chacko, M | 1 |
Bhide, SV | 1 |
Doi, O | 1 |
Kurokawa, E | 1 |
Kabuto, T | 1 |
Terasawa, T | 1 |
Rustia, M | 1 |
Shubik, P | 1 |
6 reviews available for metronidazole and Lung Neoplasms
Article | Year |
---|---|
Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A | 2016 |
Legionella pneumophila lung abscess associated with immune suppression.
Topics: Adult; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Australia; Azithromyci | 2011 |
[A meta analysis of radiosensitivity on non-small cell lung cancer by metronidazole amino acidum natrium].
Topics: Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Metronidazole; Middle Aged; Ra | 2012 |
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
[Electron acceptor compounds as radiation sensitizers of hypoxic cells in human tumors].
Topics: Brain Neoplasms; Combined Modality Therapy; Esophageal Neoplasms; Female; Head and Neck Neoplasms; H | 1984 |
Radiation sensitizers.
Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs | 1976 |
3 trials available for metronidazole and Lung Neoplasms
Article | Year |
---|---|
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
Randomized trial of radiotherapy versus radiotherapy plus metronidazole for the treatment metastatic cancer to brain. A Southwest Oncology Group study.
Topics: Age Factors; Brain Neoplasms; Breast Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; | 1984 |
A double-blind study of the efficacy of metronidazole gel in the treatment of malodorous fungating tumours.
Topics: Administration, Topical; Aged; Aged, 80 and over; Bacteria, Anaerobic; Bacterial Infections; Breast | 1992 |
26 other studies available for metronidazole and Lung Neoplasms
Article | Year |
---|---|
Synthesis, characterization and in vitro cytotoxicity of ruthenium(II) metronidazole complexes: Cell cycle arrest at G1/S transition and apoptosis induction in MCF-7 cells.
Topics: 2,2'-Dipyridyl; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpo | 2022 |
Primary pulmonary amebic abscess in a patient with pulmonary adenocarcinoma: a case report.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aged; Amebiasis; Antineoplastic Agents; Antiprotozoal Agents | 2018 |
[Preparation of (99m)Tc-EDTA-MN and Its Bioimaging in Mouse].
Topics: Animals; Cell Line, Tumor; Edetic Acid; Female; Humans; Lung Neoplasms; Male; Metronidazole; Mice; M | 2015 |
[A case of pseudomenbranous colitis after paclitaxel and carboplatin chemotherapy].
Topics: Aged; Anti-Infective Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, | 2009 |
Papulopustular eruptions in a 32-year-old woman after lung cancer treatment.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Antineoplastic Agents; Dermatologic Agents; Drug Erup | 2011 |
[Lemierre's syndrome as differential diagnosis of lung cancer].
Topics: Abscess; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Diagnosis, Differential; Fusobacterium | 2012 |
Asthma-like syndrome in a teenager.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Albuterol; Amoxicillin; Androstadienes; Anti-Ba | 2003 |
Case records of the Massachusetts General Hospital. Case 12-2006. A 37-year-old man with hemoptysis and a pulmonary infiltrate.
Topics: Adult; Anti-Infective Agents; Diagnosis, Differential; Hemoptysis; Humans; Lung; Lung Neoplasms; Mal | 2006 |
PET and planar imaging of tumor hypoxia with labeled metronidazole.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Feasibility Studies; Female; Isotope Labeling; Lung Neoplas | 2006 |
Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential.
Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; Crohn Disease; Female; Follow-Up Studies; Humans; | 1983 |
Feasibility study of combining metronidazole with chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq | 1983 |
Induction of lung tumors and lymphomas in BALB/c mice by metronidazole.
Topics: Animals; Female; Lung Neoplasms; Lymphoma; Male; Metronidazole; Mice; Mice, Inbred BALB C; Sex Facto | 1983 |
Lung tumorigenic response of strain A mice exposed to hypoxic cell sensitizers alone and in combination with gamma-radiation.
Topics: Adenoma; Animals; Hypoxia; Lung; Lung Neoplasms; Metronidazole; Mice; Mice, Inbred A; Misonidazole; | 1983 |
Tumor growth delay studies in patients with multiple metastatic nodules: practical difficulties.
Topics: Humans; Lung Neoplasms; Male; Metronidazole; Middle Aged; Neoplasm Metastasis; Neoplasms; Regression | 1980 |
In vivo, synergestic inhibition of MAT-LyLu rat prostatic adenocarcinoma growth by polyamine deprivation and low-dose cyclophosphamide.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Co | 1996 |
Radiation treatment of Ewing's sarcoma and osteogenic sarcoma.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Doxorubicin; Female; Humans; Lung Neoplasms; Methotrexate; | 1977 |
Lack of evidence for cancer due to use of metronidazole.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Female; Humans; Lung Neoplasms; Metronidazole; Middle Age | 1979 |
Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells.
Topics: Brain Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Mediasti | 1975 |
[The immediate results of the use of isometronidazole in the combination therapy of patients with lung cancer].
Topics: Adult; Combined Modality Therapy; Humans; Lung Neoplasms; Male; Metronidazole; Middle Aged; Radiatio | 1991 |
[Peripheral blood indices in preoperative radiotherapy (using radiomodifiers) of lung cancer].
Topics: Blood Cell Count; Blood Glucose; Combined Modality Therapy; Humans; Lung Neoplasms; Metronidazole; R | 1989 |
[Effect of electron-acceptor compounds on the immunoregulatory mechanisms and ATPase activity of the erythrocyte membranes from patients with inoperable lung cancer].
Topics: Adenosine Triphosphatases; Combined Modality Therapy; Electron Transport; Erythrocyte Membrane; Huma | 1988 |
Cancer after exposure to metronidazole.
Topics: Carcinoma, Bronchogenic; Female; Follow-Up Studies; Humans; Lung Neoplasms; Metronidazole; Minnesota | 1988 |
[Metronidazole in radiotherapy of squamous cell carcinoma of the lung].
Topics: Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Humans; Lung Neoplasms; Male; Metronida | 1986 |
Carcinogenicity, perinatal carcinogenicity and teratogenicity of low dose metronidazole (MNZ) in Swiss mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Lung Neoplasms; Male; Metronidazole; Mice; Neop | 1986 |
[Chemo-hyperthermotherapy following thoracic surgery].
Topics: Aged; Cisplatin; Female; Humans; Hyperthermia, Induced; Lung Neoplasms; Male; Metronidazole; Middle | 1985 |
Induction of lung tumors and malignant lymphomas in mice by metronidazole.
Topics: Adenocarcinoma; Animals; Carcinogens; Female; Hodgkin Disease; Kidney; Lung Neoplasms; Male; Metroni | 1972 |