Page last updated: 2024-10-31

metronidazole and Gall Bladder Diseases

metronidazole has been researched along with Gall Bladder Diseases in 3 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"Surgical wound infections were significantly reduced by the collagen-gentamicin implant."2.69Effectiveness of collagen-gentamicin implant for treatment of "dirty" abdominal wounds. ( Delgado, FJ; Guerrero, TS; Guzmán Valdivia Gomez, G; Lluck, MC, 1999)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's2 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Guzmán Valdivia Gomez, G1
Guerrero, TS1
Lluck, MC1
Delgado, FJ1
Yawalkar, N1
Reimers, A1
Hari, Y1
Hunziker, T1
Gerber, H1
Müller, U1
Pichler, W1
Smitskamp, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Collagen-Gentamicin Implant in the Treatment of Contaminated Surgical Abdominal Wounds - A Randomized Controlled Trial[NCT00977405]Phase 270 participants (Anticipated)Interventional2009-09-30Terminated
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for metronidazole and Gall Bladder Diseases

ArticleYear
Effectiveness of collagen-gentamicin implant for treatment of "dirty" abdominal wounds.
    World journal of surgery, 1999, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local;

1999

Other Studies

2 other studies available for metronidazole and Gall Bladder Diseases

ArticleYear
Drug-induced linear IgA bullous dermatosis associated with ceftriaxone- and metronidazole-specific T cells.
    Dermatology (Basel, Switzerland), 1999, Volume: 199, Issue:1

    Topics: Aged; Aged, 80 and over; Anti-Infective Agents; CD8-Positive T-Lymphocytes; Ceftriaxone; Cell Divisi

1999
[Liver amebiasis].
    Nederlands tijdschrift voor geneeskunde, 1971, Sep-25, Volume: 115, Issue:39

    Topics: Chloroquine; Diagnosis, Differential; Gallbladder Diseases; Humans; Liver Abscess, Amebic; Male; Met

1971