metronidazole has been researched along with Gall Bladder Diseases in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Surgical wound infections were significantly reduced by the collagen-gentamicin implant." | 2.69 | Effectiveness of collagen-gentamicin implant for treatment of "dirty" abdominal wounds. ( Delgado, FJ; Guerrero, TS; Guzmán Valdivia Gomez, G; Lluck, MC, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guzmán Valdivia Gomez, G | 1 |
| Guerrero, TS | 1 |
| Lluck, MC | 1 |
| Delgado, FJ | 1 |
| Yawalkar, N | 1 |
| Reimers, A | 1 |
| Hari, Y | 1 |
| Hunziker, T | 1 |
| Gerber, H | 1 |
| Müller, U | 1 |
| Pichler, W | 1 |
| Smitskamp, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Collagen-Gentamicin Implant in the Treatment of Contaminated Surgical Abdominal Wounds - A Randomized Controlled Trial[NCT00977405] | Phase 2 | 70 participants (Anticipated) | Interventional | 2009-09-30 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metronidazole and Gall Bladder Diseases
| Article | Year |
|---|---|
Effectiveness of collagen-gentamicin implant for treatment of "dirty" abdominal wounds.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; | 1999 |
2 other studies available for metronidazole and Gall Bladder Diseases
| Article | Year |
|---|---|
Drug-induced linear IgA bullous dermatosis associated with ceftriaxone- and metronidazole-specific T cells.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; CD8-Positive T-Lymphocytes; Ceftriaxone; Cell Divisi | 1999 |
[Liver amebiasis].
Topics: Chloroquine; Diagnosis, Differential; Gallbladder Diseases; Humans; Liver Abscess, Amebic; Male; Met | 1971 |