metronidazole has been researched along with Infection, Wound in 41 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An 83-year-old man presented to the acute cardiac care unit with a painful left arm and jaw." | 7.96 | [An unvaccinated man with a painful arm and jaw]. ( de Vries, PJ; Herderscheê, D; Lionarons, DA; Röttgering, JG, 2020) |
| "An 83-year-old man presented to the acute cardiac care unit with a painful left arm and jaw." | 3.96 | [An unvaccinated man with a painful arm and jaw]. ( de Vries, PJ; Herderscheê, D; Lionarons, DA; Röttgering, JG, 2020) |
| "The incidence of wound infections and the duration of hospitalization were significantly reduced in patients undergoing vaginal hysterectomy with or without vaginal repair." | 2.67 | Single-dose prophylaxis in hysterectomies. An interim analysis. ( Boodt, PJ; Janknegt, R; Snijders, WP, 1990) |
| "The incidence of post-operative wound infections and urinary tract infections were similar in both groups [wound infections in 1/75 versus 2/84 patients (NS), urinary tract infections 4/75 versus 3/84 patients (NS), respectively, in the 24-h group and single-dose group]." | 2.67 | Antibiotic prophylaxis in abdominal hysterectomy, with special reference to the duration of the prophylaxis. ( Eckenhausen, FW; Jonker, PL, 1990) |
| "The overall rate of infection was 41 percent in the oral neomycin and erythromycin group (n = 29) compared with 9." | 2.66 | Oral neomycin and erythromycin compared with single-dose systemic metronidazole and ceftriaxone prophylaxis in elective colorectal surgery. ( Burdon, DW; Keighley, MR; Weaver, M; Youngs, DJ, 1986) |
| "Metronidazole was used as a 1% solution or, more frequently, as a 0." | 2.44 | Topical metronidazole for the treatment of wound odor: a review of the literature. ( Paul, JC; Pieper, BA, 2008) |
| "Metronidazole was the most active agent against all isolates." | 1.56 | Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait. ( AlAzmi, A; AlHashem, G; Jamal, W; Khodakhast, FB; Rotimi, VO; Sόki, J, 2020) |
| "Tetanus is a preventable infectious disease with vaccination." | 1.56 | Cephalic Tetanus: A Rare Case Report. ( Bağcı, Z, 2020) |
| "Wounds with necrotising fasciitis are often malodorous and produce copious exudate." | 1.31 | Management of a heavily exuding, painful wound with necrotising subcutaneous infection. ( Fairhurst, J; Ovens, N, 2002) |
| "Metronidazole was the most effective drug against anaerobes and gentamicin against aerobes." | 1.28 | Anaerobic bacterial flora of wound sepsis. ( Arora, S; Garg, BB; Jindal, N; Prabhakar, H, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (21.95) | 18.7374 |
| 1990's | 13 (31.71) | 18.2507 |
| 2000's | 9 (21.95) | 29.6817 |
| 2010's | 5 (12.20) | 24.3611 |
| 2020's | 5 (12.20) | 2.80 |
| Authors | Studies |
|---|---|
| Jamal, W | 1 |
| Khodakhast, FB | 1 |
| AlAzmi, A | 1 |
| Sόki, J | 1 |
| AlHashem, G | 1 |
| Rotimi, VO | 1 |
| Bağcı, Z | 1 |
| Röttgering, JG | 1 |
| Herderscheê, D | 1 |
| Lionarons, DA | 1 |
| de Vries, PJ | 1 |
| Rotem, R | 1 |
| Mastrolia, SA | 1 |
| Rottenstreich, M | 1 |
| Yohay, D | 1 |
| Weintraub, AY | 1 |
| Guo, J | 1 |
| Ji, F | 1 |
| Zhang, X | 1 |
| Han, J | 1 |
| Zhang, J | 1 |
| Smith, S | 1 |
| Bagshaw, RJ | 1 |
| Hanson, J | 1 |
| Denes, E | 1 |
| Cypierre, A | 1 |
| Vacquier, J | 1 |
| Matt, M | 1 |
| Weinbreck, P | 1 |
| Oya, M | 1 |
| Tanimoto, T | 1 |
| Yamamoto, T | 1 |
| Hakozaki, Y | 1 |
| Melendez, J | 1 |
| Claxton, A | 1 |
| Erskine, K | 1 |
| Tumram, NK | 1 |
| Bardale, RV | 1 |
| Dixit, PG | 1 |
| Deshmukh, AY | 1 |
| Bale, S | 1 |
| Tebbie, N | 1 |
| Price, P | 1 |
| Al-Ebous, AD | 1 |
| Hiasat, B | 1 |
| Sarayrah, M | 1 |
| Al-Jahmi, M | 1 |
| Al-Zuriqat, AN | 1 |
| Al-Arabi, YB | 1 |
| Nader, M | 2 |
| Hamidian-Jahromi, AR | 1 |
| Woods, DA | 1 |
| Lo, SF | 1 |
| Hsu, MY | 1 |
| Hu, WY | 1 |
| Cattin, I | 1 |
| Liehmann, L | 1 |
| Ammon, P | 1 |
| Dupre, G | 1 |
| Paul, JC | 1 |
| Pieper, BA | 1 |
| Pierleoni, EE | 1 |
| Kauppila, A | 1 |
| Rautiainen, H | 1 |
| Tuimala, R | 1 |
| Melious, N | 1 |
| Carruth, AK | 1 |
| Hampson, JP | 1 |
| Donkor, P | 1 |
| Bankas, DO | 1 |
| Sims, EH | 1 |
| Thadepalli, H | 2 |
| Ganesan, K | 1 |
| Mandal, AK | 1 |
| Deng, F | 1 |
| Tang, Z | 1 |
| Liu, B | 1 |
| Wang, C | 1 |
| Jian, X | 1 |
| Blatun, LA | 1 |
| Lyapunov, NA | 1 |
| Kalinichenko, NF | 1 |
| Osolodchenko, TP | 1 |
| Svetukhin, AM | 1 |
| Pavlova, MV | 1 |
| Grishina, IA | 1 |
| Goncharova, ZG | 1 |
| Zelenitsky, SA | 1 |
| Silverman, RE | 1 |
| Duckworth, H | 1 |
| Harding, GK | 1 |
| Ovens, N | 1 |
| Fairhurst, J | 1 |
| Clark, J | 1 |
| Galgiani, JN | 1 |
| Busch, DF | 1 |
| Brass, C | 1 |
| Rumans, LW | 1 |
| Mangels, JI | 1 |
| Stevens, DA | 1 |
| Ankra-Badu, GA | 1 |
| Uchendu, BO | 1 |
| Warren, RA | 1 |
| Warren, MA | 1 |
| Buswell, WA | 1 |
| Shanson, DC | 1 |
| Boodt, PJ | 1 |
| Snijders, WP | 1 |
| Janknegt, R | 1 |
| Eckenhausen, FW | 1 |
| Jonker, PL | 1 |
| Arora, S | 1 |
| Prabhakar, H | 1 |
| Garg, BB | 1 |
| Jindal, N | 1 |
| Martens, F | 1 |
| Van Velthofen, V | 1 |
| Calliauw, L | 1 |
| Ahmed, ME | 1 |
| Ibrahim, SZ | 1 |
| Arabi, YE | 1 |
| Hassan, MA | 1 |
| Weaver, M | 1 |
| Burdon, DW | 1 |
| Youngs, DJ | 1 |
| Keighley, MR | 1 |
| Ramakrishnan, KM | 1 |
| Jayaraman, V | 1 |
| Ramachandran, K | 1 |
| Madhivanan, T | 1 |
| Haverkorn, MJ | 1 |
6 reviews available for metronidazole and Infection, Wound
| Article | Year |
|---|---|
The use of metronidazole in women undergoing obstetric anal sphincter injuries: a systematic review of the literature.
Topics: Adult; Anal Canal; Anti-Bacterial Agents; Antibiotic Prophylaxis; Delivery, Obstetric; Female; Human | 2020 |
Combination of metronidazole and pearl powders for the treatment of stage 2 pressure injury wounds: Case report and literature review.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Female; Humans; Metronidazole; Powders; Pressure Ulc | 2021 |
Using wound bed preparation to heal a malignant fungating wound: a single case study.
Topics: Adult; Bandages, Hydrocolloid; Breast Neoplasms; Carboxymethylcellulose Sodium; Clinical Protocols; | 2007 |
Topical metronidazole for the treatment of wound odor: a review of the literature.
Topics: Administration, Cutaneous; Administration, Oral; Anti-Infective Agents; Exudates and Transudates; Hu | 2008 |
The use of metronidazole in the treatment of malodorous wounds.
Topics: Humans; Metronidazole; Odorants; Wound Infection | 1996 |
Principles and practice of antibiotic therapy for post-traumatic abdominal injuries.
Topics: Abdomen; Abdominal Injuries; Aminoglycosides; Anti-Bacterial Agents; Antisepsis; Asepsis; Cephalospo | 1979 |
13 trials available for metronidazole and Infection, Wound
| Article | Year |
|---|---|
A topical metronidazole gel used to treat malodorous wounds.
Topics: Administration, Cutaneous; Anti-Infective Agents; Attitude of Health Personnel; Attitude to Health; | 2004 |
Management of diabetic foot in a Jordanian hospital.
Topics: Amikacin; Amputation, Surgical; Anti-Bacterial Agents; Ceftazidime; Chemotherapy, Adjuvant; Debridem | 2005 |
Prevention of posthysterectomy infection with a combination of preoperative vaginal and perioperative intravenous administration of metronidazole.
Topics: Adult; Aged; Bacteria, Anaerobic; Bacterial Infections; Female; Humans; Hysterectomy; Infusions, Par | 1983 |
How many antibiotics are necessary to treat abdominal trauma victims?
Topics: Abdominal Injuries; Adolescent; Adult; Antibiotic Prophylaxis; Cefoperazone; Ceftriaxone; Cephalospo | 1997 |
[A study of anaerobic infection in maxillofacial region].
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacteroidaceae Infections; Child; Child, Preschool; | 1997 |
A prospective, randomized, double-blind studyof single high dose versus multiple standard dose gentamicin both in combination withmetronidazole for colorectal surgicalprophylaxis.
Topics: Aged; Anti-Bacterial Agents; Anti-Infective Agents; Antibiotic Prophylaxis; Colorectal Neoplasms; Di | 2000 |
Principles and practice of antibiotic therapy for post-traumatic abdominal injuries.
Topics: Abdomen; Abdominal Injuries; Aminoglycosides; Anti-Bacterial Agents; Antisepsis; Asepsis; Cephalospo | 1979 |
Wound healing and infection in pretibial lacerations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Drug Therapy, Combination; Female; Floxacillin; Humans; | 1991 |
Single-dose prophylaxis in hysterectomies. An interim analysis.
Topics: Anti-Bacterial Agents; Cefuroxime; Double-Blind Method; Drug Administration Schedule; Female; Fever; | 1990 |
Antibiotic prophylaxis in abdominal hysterectomy, with special reference to the duration of the prophylaxis.
Topics: Adult; Anti-Bacterial Agents; Cefuroxime; Drug Administration Schedule; Drug Therapy, Combination; F | 1990 |
Metronidazole prophylaxis in acute mural appendicitis: failure of a single intra-operative infusion to reduce wound infection.
Topics: Adolescent; Adult; Appendectomy; Child; Drug Evaluation; Female; Humans; Infusions, Intravenous; Int | 1987 |
Oral neomycin and erythromycin compared with single-dose systemic metronidazole and ceftriaxone prophylaxis in elective colorectal surgery.
Topics: Administration, Oral; Bacteroides fragilis; Ceftriaxone; Clinical Trials as Topic; Clostridium; Colo | 1986 |
Peroperative systemic prophylaxis in colorectal surgery.
Topics: Cefuroxime; Cephalosporins; Clinical Trials as Topic; Colon; Double-Blind Method; Drug Evaluation; D | 1985 |
23 other studies available for metronidazole and Infection, Wound
| Article | Year |
|---|---|
Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait.
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacterial Toxins; Bacteroides | 2020 |
Cephalic Tetanus: A Rare Case Report.
Topics: Administration, Intravenous; Cranial Nerves; Female; Humans; Infant; Injections, Intramuscular; Metr | 2020 |
[An unvaccinated man with a painful arm and jaw].
Topics: Aged, 80 and over; Anti-Bacterial Agents; Arm; Clostridium tetani; Humans; Jaw; Male; Metronidazole; | 2020 |
The microbiology of crocodile attacks in Far North Queensland: implications for empirical antimicrobial therapy.
Topics: Adolescent; Adult; Aged; Alligators and Crocodiles; Animals; Anti-Bacterial Agents; Bacillus cereus; | 2017 |
Meningitis due to Fusobacterium nucleatum after a kart crash.
Topics: Anti-Infective Agents; Athletic Injuries; Bacteremia; Bacterial Translocation; Bacterial Typing Tech | 2013 |
Lemierre's Syndrome Associated with Periodontal Injury-derived Odontogenic Infection that Did Not Respond to Meropenem.
Topics: Adult; Anti-Bacterial Agents; Clindamycin; Dyspnea; Fever; Fusobacterium Infections; Fusobacterium n | 2015 |
MRSA bacteraemia after caesarean section wound infection: when screening is missed and things go wrong.
Topics: Adult; Amikacin; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacteremia; Cefuroxime; Cesarean Sec | 2012 |
A fatal mongoose bite.
Topics: Animals; Anti-Infective Agents; Bites and Stings; Cefoperazone; Drug Therapy, Combination; Fatal Out | 2012 |
The effect of the timing of antibiotics and surgical treatment on infection rates in open long-bone fractures: a 9-year prospective study from a district general hospital.
Topics: Anti-Bacterial Agents; Arm Bones; Cefuroxime; Debridement; Fracture Healing; Fractures, Open; Humans | 2007 |
Subcutaneous abscess caused by Clostridium perfringens and osteomyelitis in a dog.
Topics: Abscess; Amoxicillin-Potassium Clavulanate Combination; Animals; Anti-Bacterial Agents; Clostridium | 2008 |
Topical metronidazole therapy for infected decubitus ulcers.
Topics: Administration, Topical; Aged; Female; Humans; Male; Metronidazole; Pressure Ulcer; Wound Infection | 1984 |
Using metronidazole (Flagyl) for odor control.
Topics: Anti-Bacterial Agents; Antitrichomonal Agents; Humans; Metronidazole; Neoplasms; Odorants; Wound Inf | 1995 |
Antifungal agent used topically to control odor.
Topics: Humans; Male; Metronidazole; Mycoses; Odorants; Solutions; Wound Infection | 1993 |
A study of primary closure of human bite injuries to the face.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bites, Human; Facial Injuries; Female; Humans; Male; Metro | 1997 |
[Laboratory and clinical study of nitazole].
Topics: Aerosols; Animals; Anti-Infective Agents; Metronidazole; Microbial Sensitivity Tests; Rabbits; Thiaz | 1998 |
Management of a heavily exuding, painful wound with necrotising subcutaneous infection.
Topics: Anti-Bacterial Agents; Ciprofloxacin; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasciiti | 2002 |
Metronidazole gel in managing malodorous fungating wounds.
Topics: Bacteria, Anaerobic; Bacterial Infections; Clinical Trials as Topic; Gels; Humans; Metronidazole; Ne | 2002 |
Bacteroides fragilis endocarditis, bacteremia and other infections treated with oral or intravenous metronidazole.
Topics: Abscess; Administration, Oral; Adult; Anti-Bacterial Agents; Bacteroides fragilis; Bacteroides Infec | 1978 |
Sickle cell leg ulcers in Ghana.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Anti-Bacterial Agents; Borates; Drug Therapy, Combination; F | 1992 |
Primary closure of human bite losses of the lip.
Topics: Ampicillin; Bites, Human; Female; Humans; Lip; Male; Metronidazole; Nigeria; Surgery, Plastic; Time | 1992 |
Anaerobic bacterial flora of wound sepsis.
Topics: Bacteria, Aerobic; Bacteria, Anaerobic; Gentamicins; Humans; Metronidazole; Wound Infection | 1990 |
Post-traumatic brain abscess with Clostridium perfringens.
Topics: Adolescent; Brain Abscess; Combined Modality Therapy; Frontal Bone; Gas Gangrene; Humans; Male; Metr | 1989 |
The management of anaerobic infection in extensive burns.
Topics: Adolescent; Adult; Bacteria, Anaerobic; Bacterial Infections; Burns; Child; Humans; Metronidazole; M | 1986 |