metronidazole has been researched along with Anal Fissure in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " There is scarce information regarding the prophylactic effects of oral metronidazole on postoperative complications of anal fissure." | 5.13 | A randomized clinical trial on the effect of oral metronidazole on wound healing and pain after anal sphincterotomy and fissurectomy. ( Bolandparvaz, S; Hosseini, SV; Nouri Amirkolaee, M; Sabet, B, 2008) |
| "Perianal involvement in Crohn's disease is common but often mild and asymptomatic." | 2.40 | Perianal Crohn's disease. ( Hyland, JM; O'Donoghue, DP, 1997) |
| "The mean age at diagnosis of Crohn's disease was 11." | 1.28 | Perianal complications of pediatric Crohn's disease. ( Bilik, R; Griffiths, AM; Palder, SB; Shandling, B; Sherman, P, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sosa Solís, AM | 1 |
| Fernández Antuña, L | 1 |
| Royo Cuadra, Y | 1 |
| Castellarnau Figueras, E | 1 |
| Grekova, NM | 1 |
| Maleva, EA | 1 |
| Lebedeva, Y | 1 |
| Bordunovsky, VN | 1 |
| Telesheva, LF | 1 |
| Bychkovskikh, VA | 1 |
| Hosseini, SV | 1 |
| Sabet, B | 1 |
| Nouri Amirkolaee, M | 1 |
| Bolandparvaz, S | 1 |
| O'Donoghue, DP | 1 |
| Hyland, JM | 1 |
| Chazan, B | 1 |
| Strahilevitz, J | 1 |
| Millgram, MA | 1 |
| Kaufmann, S | 1 |
| Raz, R | 1 |
| Palder, SB | 1 |
| Shandling, B | 1 |
| Bilik, R | 1 |
| Griffiths, AM | 1 |
| Sherman, P | 1 |
1 review available for metronidazole and Anal Fissure
| Article | Year |
|---|---|
Perianal Crohn's disease.
Topics: Anus Diseases; Crohn Disease; Fissure in Ano; Humans; Hyperbaric Oxygenation; Immunosuppressive Agen | 1997 |
2 trials available for metronidazole and Anal Fissure
| Article | Year |
|---|---|
The effects of topical application of metronidazole for treatment of chronic anal fissure: A randomized, controlled pilot study.
Topics: Administration, Topical; Adult; Anti-Infective Agents; Bacteria, Anaerobic; Chronic Disease; Female; | 2015 |
A randomized clinical trial on the effect of oral metronidazole on wound healing and pain after anal sphincterotomy and fissurectomy.
Topics: Administration, Oral; Adult; Anal Canal; Anti-Infective Agents; Female; Fissure in Ano; Humans; Male | 2008 |
3 other studies available for metronidazole and Anal Fissure
| Article | Year |
|---|---|
Perianal disease as the first manifestation in paediatric Crohn's disease.
Topics: Abscess; Adalimumab; Anemia, Hypochromic; Azathioprine; Child; Crohn Disease; Fissure in Ano; Gastro | 2020 |
Bacteroides fragilis vertebral osteomyelitis secondary to anal dilatation.
Topics: Adolescent; Bacteroides fragilis; Bacteroides Infections; Dilatation; Fissure in Ano; Humans; Low Ba | 2001 |
Perianal complications of pediatric Crohn's disease.
Topics: Abscess; Adolescent; Anus Diseases; Child; Child, Preschool; Crohn Disease; Female; Fissure in Ano; | 1991 |