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metronidazole and Lupus Erythematosus, Systemic

metronidazole has been researched along with Lupus Erythematosus, Systemic in 3 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Research Excerpts

ExcerptRelevanceReference
"Here we present a case of fulminant amoebic colitis in a patient with SLE which was initially misdiagnosed as ischemic colitis due to intestinal vasculitis."1.38Fulminant amoebic colitis mimicking intestinal vasculitis in a patient with systemic lupus erythematosus. ( Ju, JH; Jung, HS; Kim, HY; Kwok, SK; Lee, J; Nam, HC; Park, KS; Park, SH, 2012)
"We report an unusual case of acute suppurative thyroiditis associated with juvenile systemic lupus erythematosus (JSLE) onset."1.35Acute suppurative thyroiditis as the initial presentation of juvenile systemic lupus erythematosus. ( Alves, C; Mendonça, M; Robazzi, TC, 2009)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Robazzi, TC1
Alves, C1
Mendonça, M1
Lee, J1
Jung, HS1
Nam, HC1
Kwok, SK1
Ju, JH1
Park, KS1
Kim, HY1
Park, SH1
Taylor, JA1

Trials

1 trial available for metronidazole and Lupus Erythematosus, Systemic

ArticleYear
Pharmacodynamic observations on metronidazole therapy. Side effects in endocrine, metabolic and auto-immune disorders. 3. Anti-ischemic and anti-inflammatory action in peripheral vascular disorders.
    Proceedings of the Western Pharmacology Society, 1966, Volume: 9

    Topics: Blood Circulation; Blood Flow Velocity; Blood Pressure; Clinical Trials as Topic; Diabetes Complicat

1966

Other Studies

2 other studies available for metronidazole and Lupus Erythematosus, Systemic

ArticleYear
Acute suppurative thyroiditis as the initial presentation of juvenile systemic lupus erythematosus.
    Journal of pediatric endocrinology & metabolism : JPEM, 2009, Volume: 22, Issue:4

    Topics: Amikacin; Child; Female; Humans; Lupus Erythematosus, Systemic; Metronidazole; Oxacillin; Staphyloco

2009
Fulminant amoebic colitis mimicking intestinal vasculitis in a patient with systemic lupus erythematosus.
    Lupus, 2012, Volume: 21, Issue:12

    Topics: Antiprotozoal Agents; Colitis, Ischemic; Diagnosis, Differential; Diagnostic Errors; Dysentery, Ameb

2012