metronidazole has been researched along with Lupus Erythematosus, Systemic in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we present a case of fulminant amoebic colitis in a patient with SLE which was initially misdiagnosed as ischemic colitis due to intestinal vasculitis." | 1.38 | Fulminant amoebic colitis mimicking intestinal vasculitis in a patient with systemic lupus erythematosus. ( Ju, JH; Jung, HS; Kim, HY; Kwok, SK; Lee, J; Nam, HC; Park, KS; Park, SH, 2012) |
| "We report an unusual case of acute suppurative thyroiditis associated with juvenile systemic lupus erythematosus (JSLE) onset." | 1.35 | Acute suppurative thyroiditis as the initial presentation of juvenile systemic lupus erythematosus. ( Alves, C; Mendonça, M; Robazzi, TC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Robazzi, TC | 1 |
| Alves, C | 1 |
| Mendonça, M | 1 |
| Lee, J | 1 |
| Jung, HS | 1 |
| Nam, HC | 1 |
| Kwok, SK | 1 |
| Ju, JH | 1 |
| Park, KS | 1 |
| Kim, HY | 1 |
| Park, SH | 1 |
| Taylor, JA | 1 |
1 trial available for metronidazole and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Pharmacodynamic observations on metronidazole therapy. Side effects in endocrine, metabolic and auto-immune disorders. 3. Anti-ischemic and anti-inflammatory action in peripheral vascular disorders.
Topics: Blood Circulation; Blood Flow Velocity; Blood Pressure; Clinical Trials as Topic; Diabetes Complicat | 1966 |
2 other studies available for metronidazole and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Acute suppurative thyroiditis as the initial presentation of juvenile systemic lupus erythematosus.
Topics: Amikacin; Child; Female; Humans; Lupus Erythematosus, Systemic; Metronidazole; Oxacillin; Staphyloco | 2009 |
Fulminant amoebic colitis mimicking intestinal vasculitis in a patient with systemic lupus erythematosus.
Topics: Antiprotozoal Agents; Colitis, Ischemic; Diagnosis, Differential; Diagnostic Errors; Dysentery, Ameb | 2012 |