metronidazole has been researched along with Attachment Loss, Periodontal in 91 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Systemically healthy patients, with stages III-IV, grades B-C periodontitis, were randomly assigned to receive metronidazole or placebo adjunctive to periodontal surgery, after subgingival instrumentation." | 9.51 | Adjunctive efficacy of systemic metronidazole in the surgical treatment of periodontitis: a double-blind parallel randomized clinical trial. ( Collins, JR; Figuero, E; González, R; Herrera, D; Marín, MJ; Ogando, G; Sanz, M, 2022) |
| "The clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age." | 9.30 | Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age: An exploratory sub-analysis of the ABPARO trial. ( Ehmke, B; Eickholz, P; Harks, I; Harmsen, D; Hoffmann, T; Kaner, D; Kim, TS; Koch, R; Kocher, T; Meyle, J; Schlagenhauf, U, 2019) |
| " forsythia at baseline showed increased clinical benefits with the adjunctive use of systemic amoxicillin and metronidazole (AMX-MET) during non-surgical treatment of generalized aggressive periodontitis (GAgP)." | 9.19 | Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: an exploratory analysis from a randomized controlled clinical trial. ( Griffiths, GS; Guerrero, A; Lambertenghi, R; Nibali, L; Ready, D; Suvan, J; Tonetti, MS; Wilson, M, 2014) |
| "The aim of the present study is to assess clinical, microbiologic, and immunologic benefits of amoxicillin/metronidazole (AM) when performing full-mouth ultrasonic debridement (FMUD) in generalized aggressive periodontitis (GAgP) treatment." | 9.16 | The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. ( Casarin, RC; Casati, MZ; Gonçalves, RB; Nociti, FH; Peloso Ribeiro, ED; Sallum, EA, 2012) |
| "To evaluate the clinical effects of the adjunctive use of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of generalized aggressive periodontitis (GAgP)." | 9.16 | The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial. ( Duarte, PM; Faveri, M; Feres, M; Fermiano, D; Figueiredo, LC; Mestnik, MJ; Soares, G; Teles, RP, 2012) |
| "The aim of this study is to evaluate the effects of metronidazole-amoxicillin combination on clinical and microbiologic parameters in patients with generalized aggressive periodontitis." | 9.14 | Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. ( Cintan, S; Issever, H; Kantarci, A; Kulekci, G; Topcuoglu, N; Yek, EC, 2010) |
| "Subgingival application of chlorhexidine via a controlled-delivery device (CHX chip) improves the clinical outcome of scaling/root planing (SRP) in therapy for chronic periodontitis." | 9.12 | Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial. ( Bernimoulin, JP; Friedmann, A; Hopfenmüller, W; Kaner, D; Kleber, BM, 2007) |
| "To determine the effect of metronidazole plus amoxicillin (M+A) as the sole therapy, on the subgingival microbiota of chronic periodontitis." | 9.12 | Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. ( Da Silva, I; Haffajee, AD; Japlit, MR; López, NJ; Socransky, SS, 2006) |
| "The objective of this study was to assess the adjunctive clinical effect of the administration of systemic amoxicillin and metronidazole in the non-surgical treatment of generalized aggressive periodontitis (GAP)." | 9.11 | Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. ( Griffiths, GS; Guerrero, A; Laurell, L; Moles, DR; Nibali, L; Suvan, J; Tonetti, MS, 2005) |
| "The aim of the present study was to evaluate the clinical and microbiological effects of subgingival application of 25% metronidazole dental gel as an adjunct to scaling and root planing (SRP) in the treatment of adult periodontitis." | 9.09 | Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results. ( Bilgiç, A; Buduneli, E; Evrenosoglu, E; Tünger, A, 2001) |
| "The aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement." | 9.09 | Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. ( Timmerman, MF; Van der Velden, U; Van der Weijden, GA; Van Winkelhoff, AJ; Winkel, EG, 2001) |
| "The present study describes results on selected clinical and microbiological parameters obtained by treatment with local (Elyzol) and systemic (Flagyl) use of metronidazole alone and/or mechanical subgingival debridement in adult periodontitis." | 9.08 | A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. ( Acar, O; Büget, E; Kadir, T; Kuru, B; Noyan, U; Yilmaz, S, 1997) |
| "The present study was performed to assess and compare the clinical healing and the microbiological findings following local application of metronidazole or tetracycline to augment subgingival scaling in previously untreated adult periodontitis sites." | 9.08 | Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. ( Böe, OE; Bruun, G; Lie, T, 1998) |
| "The purpose of this study was to evaluate the clinical effects of a single application of a 5% metronidazole collagen device in periodontal pockets deeper than 5 mm, in association with debridement and without reinforcement of home care and hygiene as practiced by the patient at any time." | 9.07 | Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C; Teboul, M; Varonne, R, 1994) |
| "Our results demonstrated the effectiveness of metronidazole as an adjunct to SRP in the treatment of chronic adult periodontitis, but clinical significance and dissemination of antibiotics should be taken into account in the evaluation of metronidazole as an alternative to SRP." | 8.82 | Meta-analysis of local metronidazole in the treatment of chronic periodontitis. ( Angelillo, IF; Bianco, A; Nobile, CG; Pavia, M, 2004) |
| "The purpose of this meta-analysis was to provide a quantitative overview of clinical trials assessing the use of systemic metronidazole (S-MET) as an adjunct to scaling and root planning (S&RP) in the treatment of adult periodontitis." | 8.79 | Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis. ( Beck, JD; Elter, JR; Lawrence, HP; Offenbacher, S, 1997) |
| "The aim of the present study is to evaluate the clinical and microbiologic changes resulting from non-surgical periodontal treatment associated with amoxicillin and metronidazole in individuals with aggressive periodontitis." | 7.78 | Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. ( De Micheli, G; Hirata, MH; Hirata, RD; Lima Neto, LG; Lotufo, RF; Lourenção, DS; Pannuti, CM; Rodrigues, AS, 2012) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 7.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| "The aim of the present study was to monitor the microbiological and clinical effects of renewed supra- and subgingival debridement in conjunction with systemic metronidazole therapy (500 mg TID for 7 days) in 27 "refractory" periodontitis patients, culture positive for Bacteroides forsythus and negative for Actinobacillus actinomycetemcomitans." | 7.69 | Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus. ( Timmerman, MF; Van der Velden, U; Van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 1997) |
| "Systemically healthy patients, with stages III-IV, grades B-C periodontitis, were randomly assigned to receive metronidazole or placebo adjunctive to periodontal surgery, after subgingival instrumentation." | 5.51 | Adjunctive efficacy of systemic metronidazole in the surgical treatment of periodontitis: a double-blind parallel randomized clinical trial. ( Collins, JR; Figuero, E; González, R; Herrera, D; Marín, MJ; Ogando, G; Sanz, M, 2022) |
| "The clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age." | 5.30 | Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age: An exploratory sub-analysis of the ABPARO trial. ( Ehmke, B; Eickholz, P; Harks, I; Harmsen, D; Hoffmann, T; Kaner, D; Kim, TS; Koch, R; Kocher, T; Meyle, J; Schlagenhauf, U, 2019) |
| "This prospective, randomized, double-blind, placebo-controlled multi-centre trial comprising patients suffering from moderate to severe periodontitis evaluated the impact of rational adjunctive use of systemic amoxicillin 500 mg plus metronidazole 400 mg (3x/day, 7 days) on attachment loss." | 5.20 | Is progression of periodontitis relevantly influenced by systemic antibiotics? A clinical randomized trial. ( Doering, S; Ehmke, B; Eickholz, P; Gravemeier, M; Harks, I; Harmsen, D; Hoffmann, T; Holtfreter, B; Kaner, D; Kim, TS; Koch, R; Kocher, T; Meyle, J; Schlagenhauf, U, 2015) |
| " forsythia at baseline showed increased clinical benefits with the adjunctive use of systemic amoxicillin and metronidazole (AMX-MET) during non-surgical treatment of generalized aggressive periodontitis (GAgP)." | 5.19 | Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: an exploratory analysis from a randomized controlled clinical trial. ( Griffiths, GS; Guerrero, A; Lambertenghi, R; Nibali, L; Ready, D; Suvan, J; Tonetti, MS; Wilson, M, 2014) |
| "A total of 184 patients with moderate-to-severe periodontitis were randomly allocated to one of four treatment groups: 1) FDIS+metronidazole; 2) FDIS+placebo; 3) SRP+metronidazole; or 4) SRP+placebo." | 5.17 | A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results. ( Baelum, V; Gjermo, P; Gunleiksrud, TM; Preus, HR; Sandvik, L, 2013) |
| "To evaluate the clinical effects of the adjunctive use of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of generalized aggressive periodontitis (GAgP)." | 5.16 | The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial. ( Duarte, PM; Faveri, M; Feres, M; Fermiano, D; Figueiredo, LC; Mestnik, MJ; Soares, G; Teles, RP, 2012) |
| "The aim of the present study is to assess clinical, microbiologic, and immunologic benefits of amoxicillin/metronidazole (AM) when performing full-mouth ultrasonic debridement (FMUD) in generalized aggressive periodontitis (GAgP) treatment." | 5.16 | The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. ( Casarin, RC; Casati, MZ; Gonçalves, RB; Nociti, FH; Peloso Ribeiro, ED; Sallum, EA, 2012) |
| "To compare the effects of systemic amoxicillin (AMX) plus metronidazole (MET) or placebos combined with anti-infective mechanical debridement on the sub-gingival microbiota of generalized aggressive periodontitis (GAP)." | 5.15 | Impact of systemic antimicrobials combined with anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: a 6-month RCT. ( Colombo, AP; Feres-Filho, EJ; Heller, D; Silva-Senem, MX; Torres, MC; Varela, VM, 2011) |
| "The aim of this study is to evaluate the effects of metronidazole-amoxicillin combination on clinical and microbiologic parameters in patients with generalized aggressive periodontitis." | 5.14 | Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. ( Cintan, S; Issever, H; Kantarci, A; Kulekci, G; Topcuoglu, N; Yek, EC, 2010) |
| "To evaluate and compare the effects of adjunctive metronidazole plus amoxicillin, doxycycline and metronidazole on clinical and microbiological parameters in patients with generalized aggressive periodontitis." | 5.12 | Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis. ( Baka, A; Konstantinidis, A; Sakellari, D; Slini, T; Xajigeorgiou, C, 2006) |
| "To determine the effect of metronidazole plus amoxicillin (M+A) as the sole therapy, on the subgingival microbiota of chronic periodontitis." | 5.12 | Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. ( Da Silva, I; Haffajee, AD; Japlit, MR; López, NJ; Socransky, SS, 2006) |
| "Subgingival application of chlorhexidine via a controlled-delivery device (CHX chip) improves the clinical outcome of scaling/root planing (SRP) in therapy for chronic periodontitis." | 5.12 | Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial. ( Bernimoulin, JP; Friedmann, A; Hopfenmüller, W; Kaner, D; Kleber, BM, 2007) |
| "The objective of this study was to assess the adjunctive clinical effect of the administration of systemic amoxicillin and metronidazole in the non-surgical treatment of generalized aggressive periodontitis (GAP)." | 5.11 | Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. ( Griffiths, GS; Guerrero, A; Laurell, L; Moles, DR; Nibali, L; Suvan, J; Tonetti, MS, 2005) |
| "The present controlled, single-blind study was performed to assess and compare the clinical healing and the microbiological findings following repeated intrasulcular applications of 1% metronidazole or 1% chlorhexidine gels in persistent periodontal pockets previously treated by scaling and root planing (SRP)." | 5.11 | Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients. ( Cordella, C; D'Ercole, S; Paolantonio, M; Perinetti, G; Piccolomini, R; Serra, E, 2004) |
| "Several studies have reported adjunctive benefits to scaling and root planing (SRP) of systemic amoxycillin and metronidazole in the treatment of periodontal diseases." | 5.10 | Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study. ( Addy, M; Newcombe, RG; Rooney, J; Sprague, SV; Wade, WG, 2002) |
| "The aim of the present study was to evaluate the clinical and microbiological effects of subgingival application of 25% metronidazole dental gel as an adjunct to scaling and root planing (SRP) in the treatment of adult periodontitis." | 5.09 | Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results. ( Bilgiç, A; Buduneli, E; Evrenosoglu, E; Tünger, A, 2001) |
| "The aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement." | 5.09 | Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. ( Timmerman, MF; Van der Velden, U; Van der Weijden, GA; Van Winkelhoff, AJ; Winkel, EG, 2001) |
| "A single-blind, randomised clinical trial of 28 smokers and 56 non-smokers, stratified for periodontitis disease severity and randomly allocated to 3 treatment groups: (1) Scaling and root planing using an ultrasonic scaler with local anaesthesia (SRP), (2) SRP+ metronidazole tabs 200 mg tds for 7 days, (3) SRP + 2 subgingival applications of 25% metronidazole gel." | 5.09 | Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers. ( Matthews, JP; Palmer, RM; Wilson, RF, 1999) |
| "The aim of this study was to examine the effect of doxycycline, metronidazole, and clindamycin used adjunctively in a 2-step nonsurgical procedure in patients with rapidly progressive periodontitis (RPP)." | 5.09 | A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis. ( Beier, M; Glockmann, E; Klinger, G; Pfister, W; Sigusch, B, 2001) |
| "The present study describes results on selected clinical and microbiological parameters obtained by treatment with local (Elyzol) and systemic (Flagyl) use of metronidazole alone and/or mechanical subgingival debridement in adult periodontitis." | 5.08 | A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. ( Acar, O; Büget, E; Kadir, T; Kuru, B; Noyan, U; Yilmaz, S, 1997) |
| "48 adult patients with untreated periodontitis harboring subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis as assessed by PCR were randomly assigned to receive full-mouth scaling alone (control) or scaling with systemic metronidazole plus amoxicillin and supragingival irrigation with chlorhexidine digluconate (test)." | 5.08 | Differential clinical treatment outcome after systemic metronidazole and amoxicillin in patients harboring Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis. ( Flemmig, TF; Karch, H; Klaiber, B; Milián, E, 1998) |
| "The present study was performed to assess and compare the clinical healing and the microbiological findings following local application of metronidazole or tetracycline to augment subgingival scaling in previously untreated adult periodontitis sites." | 5.08 | Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. ( Böe, OE; Bruun, G; Lie, T, 1998) |
| "The purpose of this study was to evaluate the clinical effects of a single application of a 5% metronidazole collagen device in periodontal pockets deeper than 5 mm, in association with debridement and without reinforcement of home care and hygiene as practiced by the patient at any time." | 5.07 | Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C; Teboul, M; Varonne, R, 1994) |
| "Our results demonstrated the effectiveness of metronidazole as an adjunct to SRP in the treatment of chronic adult periodontitis, but clinical significance and dissemination of antibiotics should be taken into account in the evaluation of metronidazole as an alternative to SRP." | 4.82 | Meta-analysis of local metronidazole in the treatment of chronic periodontitis. ( Angelillo, IF; Bianco, A; Nobile, CG; Pavia, M, 2004) |
| "The purpose of this meta-analysis was to provide a quantitative overview of clinical trials assessing the use of systemic metronidazole (S-MET) as an adjunct to scaling and root planning (S&RP) in the treatment of adult periodontitis." | 4.79 | Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis. ( Beck, JD; Elter, JR; Lawrence, HP; Offenbacher, S, 1997) |
| "The aim of the present study is to evaluate the clinical and microbiologic changes resulting from non-surgical periodontal treatment associated with amoxicillin and metronidazole in individuals with aggressive periodontitis." | 3.78 | Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. ( De Micheli, G; Hirata, MH; Hirata, RD; Lima Neto, LG; Lotufo, RF; Lourenção, DS; Pannuti, CM; Rodrigues, AS, 2012) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 3.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| " actinomycetemcomitans-associated periodontitis during successive non-surgical and adjunctive metronidazole plus amoxicillin (or ciprofloxacin) (AB) therapy." | 3.70 | Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis. ( Borneff, M; Heinecke, A; Kiencke, C; Knopf, A; Müller, HP; Pohl, S, 1998) |
| "The aim of the present study was to monitor the microbiological and clinical effects of renewed supra- and subgingival debridement in conjunction with systemic metronidazole therapy (500 mg TID for 7 days) in 27 "refractory" periodontitis patients, culture positive for Bacteroides forsythus and negative for Actinobacillus actinomycetemcomitans." | 3.69 | Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus. ( Timmerman, MF; Van der Velden, U; Van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 1997) |
| "Metronidazole was applied to the free gingival margins and/or over the exposed membrane at every prophylactic visit (EG)." | 2.71 | Guided tissue regeneration in smokers: effect of aggressive anti-infective therapy in Class II furcation defects. ( Machtei, EE; Oettinger-Barak, O; Peled, M, 2003) |
| "In this study, periodontal disease progression was successfully arrested in 95% of the initially compromised lesions, while 2% to 5% experienced discrete or recurrent episodes of loss of periodontal support." | 2.70 | Aggressive periodontitis: 5-year follow-up of treatment. ( Buchmann, R; Lange, DE; Nunn, ME; Van Dyke, TE, 2002) |
| "Twenty-five localized juvenile periodontitis (LJP) patients from a Brazilian population were randomly allocated into an experimental group receiving mechanical treatment and antibiotics, and a control group receiving mechanical treatment and placebo." | 2.69 | Clinical and microbiological effects of adjunctive antibiotics in treatment of localized juvenile periodontitis. A controlled clinical trial. ( Beldi, MI; Bellini, HT; Campedelli, F; Gjermo, P; Lana, M; Loureiro, CA; Preus, HR; Rams, TE; Tinoco, EM; Tinoco, NM, 1998) |
| "Metronidazole (MET) has been suggested as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis." | 2.50 | Effectiveness of metronidazole as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis. ( Gatto, R; Monaco, A; Petrucci, A; Severino, M; Sgolastra, F, 2014) |
| "Chronic periodontitis is a multifactorial infectious disease associated with Gram-negative strict anaerobes which are immersed in the subgingival biofilm." | 1.40 | Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis. ( Acosta, A; Araya, N; Gamboa, F; García, DA; Ledergerber, R; Velosa, J, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (18.68) | 18.2507 |
| 2000's | 36 (39.56) | 29.6817 |
| 2010's | 34 (37.36) | 24.3611 |
| 2020's | 4 (4.40) | 2.80 |
| Authors | Studies |
|---|---|
| Collins, JR | 1 |
| Ogando, G | 1 |
| González, R | 1 |
| Figuero, E | 1 |
| Marín, MJ | 1 |
| Sanz, M | 1 |
| Herrera, D | 1 |
| Ardila, CM | 3 |
| Flórez-Flórez, J | 1 |
| Castañeda-Parra, LD | 1 |
| Guzmán, IC | 2 |
| Bedoya-García, JA | 2 |
| Hernández-Casas, C | 1 |
| Qureshi, A | 1 |
| Bokhari, SAH | 1 |
| Haque, Z | 1 |
| Baloch, AA | 1 |
| Zaheer, S | 1 |
| Usin, MM | 1 |
| Tabares, SM | 1 |
| Menso, J | 1 |
| de Albera, ER | 1 |
| Sembaj, A | 1 |
| Rebeis, ES | 1 |
| Albuquerque-Souza, E | 1 |
| Paulino da Silva, M | 1 |
| Giudicissi, M | 1 |
| Mayer, MPA | 1 |
| Saraiva, L | 1 |
| Eickholz, P | 5 |
| Koch, R | 3 |
| Kocher, T | 3 |
| Hoffmann, T | 3 |
| Kim, TS | 3 |
| Meyle, J | 3 |
| Kaner, D | 5 |
| Schlagenhauf, U | 3 |
| Harmsen, D | 2 |
| Harks, I | 3 |
| Ehmke, B | 3 |
| Gonçalves, PF | 2 |
| Huang, H | 2 |
| McAninley, S | 1 |
| Alfant, B | 1 |
| Harrison, P | 2 |
| Aukhil, I | 3 |
| Walker, C | 1 |
| Shaddox, LM | 3 |
| Sgolastra, F | 1 |
| Severino, M | 1 |
| Petrucci, A | 1 |
| Gatto, R | 1 |
| Monaco, A | 1 |
| Vovk, A | 2 |
| Allin, N | 1 |
| Hou, W | 1 |
| Wallet, SM | 1 |
| Faveri, M | 5 |
| Rebello, A | 1 |
| de Oliveira Dias, R | 1 |
| Borges-Junior, I | 1 |
| Duarte, PM | 4 |
| Figueiredo, LC | 5 |
| Feres, M | 7 |
| Arweiler, NB | 1 |
| Pietruska, M | 1 |
| Skurska, A | 1 |
| Dolińska, E | 1 |
| Pietruski, JK | 1 |
| Bläs, M | 1 |
| Auschill, TM | 1 |
| Sculean, A | 4 |
| Preus, HR | 4 |
| Sandvik, L | 2 |
| Gjermo, P | 4 |
| Baelum, V | 3 |
| Soares, GM | 1 |
| Mendes, JA | 1 |
| Silva, MP | 1 |
| Teles, R | 2 |
| Socransky, SS | 6 |
| Wang, X | 1 |
| Miranda, TS | 2 |
| Perez-Chaparro, PJ | 1 |
| Tamashiro, NS | 1 |
| Bastos, MF | 1 |
| Guerrero, A | 2 |
| Nibali, L | 2 |
| Lambertenghi, R | 1 |
| Ready, D | 1 |
| Suvan, J | 3 |
| Griffiths, GS | 2 |
| Wilson, M | 1 |
| Tonetti, MS | 2 |
| Merchant, SN | 1 |
| Kalash, D | 1 |
| Hovencamp, N | 1 |
| Zapert, E | 1 |
| Bidwell, J | 1 |
| Varnado, P | 1 |
| Gamboa, F | 1 |
| Acosta, A | 1 |
| García, DA | 1 |
| Velosa, J | 1 |
| Araya, N | 1 |
| Ledergerber, R | 1 |
| Dahlen, G | 1 |
| Bergamaschi, CC | 1 |
| Santamaria, MP | 1 |
| Berto, LA | 1 |
| Cogo-Müller, K | 1 |
| Motta, RH | 1 |
| Salum, EA | 1 |
| Nociti Júnior, FH | 1 |
| Goodson, JM | 2 |
| Groppo, FC | 1 |
| Neering, SH | 1 |
| Adyani-Fard, S | 1 |
| Klocke, A | 1 |
| Rüttermann, S | 1 |
| Flemmig, TF | 2 |
| Beikler, T | 1 |
| Siqueira, SJ | 1 |
| Ribeiro, FV | 2 |
| Villalpando, KT | 1 |
| Cirano, FR | 1 |
| Pimentel, SP | 1 |
| Rabelo, CC | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Adjunctive Use of Antimicrobial Photodynamic Therapy, Light-emitting-diode Photobiomodulation, and Ozone Therapy in Regenerative Treatment of Stage III Grade C Periodontitis[NCT05447026] | 48 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| Efficacy of the Application of Moxifloxacin and Cefixime in Reduction of Inflammatory Sequelae and Complications After Mandibular Third Molar Surgery[NCT05027893] | 157 participants (Actual) | Interventional | 2019-06-07 | Active, not recruiting | |||
| Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization[NCT00707369] | Phase 4 | 540 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| Mechanisms and Treatment Response of Aggressive Periodontitis in Children: Aberrant Immunological Phenotypes/Functions in the Progression of AgP[NCT01330719] | 514 participants (Actual) | Interventional | 2006-12-31 | Active, not recruiting | |||
| Timing of Administration of Systemic Antibiotics Associated With Scaling and Root Planing in the Treatment of Periodontitis: Clinical and Microbiological Evaluation[NCT06177119] | 72 participants (Actual) | Interventional | 2012-01-31 | Active, not recruiting | |||
| Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial[NCT02735395] | Phase 4 | 110 participants (Actual) | Interventional | 2011-07-31 | Active, not recruiting | ||
| Clinical Effects of Doxycycline in the Treatment of Aggressive Periodontitis: Comparative Clinical Study[NCT03727620] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2014-01-06 | Completed | ||
| Comparing the Effect of 0,06 % -, 0,12 % and 0,2 % Chlorhexidine on Plaque, Bleeding and Side Effects in an Experimental Gingivitis Model. A Parallel, Double Masked, Randomized, Placebo-controlled Clinical Trial[NCT02911766] | Phase 4 | 59 participants (Anticipated) | Interventional | 2016-11-30 | Not yet recruiting | ||
| The Plaque- and Gingivitis Inhibiting Capacity of a Commercially Available Mouthwash Containing Essential Oils and Ethyl Lauroyl Arginate: A Parallel, Split-mouth, Double Blind, Randomized, Placebo-controlled Clinical Study[NCT02884817] | Phase 4 | 59 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial[NCT02135952] | Phase 4 | 58 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | ||
| Effect of Non Surgical Therapy on Calprotectin and Periostin Levels in Patients With Periodontitis and Cardiovascular Diseases - An Interventional Study[NCT05618743] | 45 participants (Anticipated) | Interventional | 2021-06-30 | Recruiting | |||
| Clarithromycin as Adjuvant to Periodontal Debridement in the Treatment of Generalized Aggressive Periodontitis: Randomized Clinical Trial[NCT02829983] | 40 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
| Influence of Moment of Systemic Metronidazole and Amoxicillin Administration in the Treatment of Chronic Periodontitis: a Randomized Clinical Trial.[NCT02954393] | 180 participants (Anticipated) | Interventional | 2015-05-31 | Active, not recruiting | |||
| Clinical Outcomes Following Non-Surgical Treatment of Chronic Periodontitis, Using Scaling and Root Planing (SRP) in Conjunction With PerioWave, Compared to SRP Alone[NCT00296881] | Phase 4 | 80 participants (Actual) | Interventional | 2006-04-30 | Active, not recruiting | ||
| A Multicenter, Randomized, Blinded Study of Two Treatments of Photoactivated Disinfection With SRP Against One Treatment of Photoactivated Disinfection With SRP Against SRP Alone in the Treatment of Chronic Periodontitis[NCT00336661] | Phase 3 | 105 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| Photodynamic Disinfection in Combination With Scaling and Root Planing in the Treatment of Chronic Periodontitis[NCT00297531] | Phase 4 | 120 participants (Anticipated) | Interventional | 2006-04-30 | Active, not recruiting | ||
| A Multicenter, Randomized, Examiner Blinded Study of Photoactivated Disinfection With Scaling and Root Planing in the Treatment of Chronic Periodontitis[NCT00297518] | Phase 4 | 40 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| EFFECT OF LOCALLY DELIVERED ALOE VERA GEL AS AN ADJUNCT TO SCALING AND ROOT PLANING IN THE TREATMENT OF CHRONIC PERIODONTITIS: A SPLIT-MOUTH CLINICAL AND MICROBIOLOGICAL STUDY[NCT02462993] | Phase 2/Phase 3 | 12 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| Effectiveness of Metronidazole Gel and Mobile Telephone Short- Message Service Reminders on Gingivitis in Orthodontic Patients: A Randomized Controlled Trial[NCT03508999] | Phase 4 | 63 participants (Actual) | Interventional | 2018-05-23 | Completed | ||
| Vital Root-resective Therapy in Furcation-involved Maxillary Molars[NCT05259982] | 10 participants (Anticipated) | Interventional | 2022-03-04 | Active, not recruiting | |||
| Short & Medium Term Outcomes of Periodontal Regenerative Procedures. A Two-part Study With a) Analysis of Periodontal Records of a Cohort of Periodontitis Patients and b) a Single Visit Recall and Comprehensive Periodontal Re-evaluation[NCT04971174] | 200 participants (Anticipated) | Observational | 2022-09-30 | Enrolling by invitation | |||
| Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial[NCT02223702] | Phase 4 | 39 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| Observational Study on Cytokine Production by Leukocytes of Papillon-Lefèvre Syndrome Patients and Healthy Probands in Whole Blood Cultures[NCT01116934] | 17 participants (Actual) | Observational | 2006-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Distance from bottom of pocket to the cement-enamel junction (CEJ). (NCT02829983)
Timeframe: 6 months
| Intervention | milimeter (Mean) |
|---|---|
| Clarithromycin Group | 2.71 |
| Placebo Group | 3.03 |
Distance from the bottom of sulcus/pocket to gingival margin (NCT02829983)
Timeframe: 6 months
| Intervention | milimeter (Mean) |
|---|---|
| Clarithromycin Group | 2.53 |
| Placebo Group | 2.86 |
Attachment loss were recorded at baseline, 1st, 3rd and 6th months as millimeters. The data were compared among and between groups. (NCT02223702)
Timeframe: 6-months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline | 1st month | 3rd month | 6th month | |
| Amoxicillin+Metronidazole | 5.03 | 4.37 | 4.41 | 4.33 |
| Moxifloxacin | 4.94 | 4.14 | 3.98 | 4.30 |
We measured the probing depth at baseline, 1st, 3rd and 6th months. The changes were evaluated among and between groups. (NCT02223702)
Timeframe: 6-months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline | 1st month | 3rd month | 6th month | |
| Amoxicillin+Metronidazole | 4.57 | 3.12 | 3.11 | 3.15 |
| Moxifloxacin | 4.18 | 2.91 | 2.79 | 3.01 |
Concentrations of IL-8, IL-6, IP-10, interferon (IFN)-gamma, and IL-1 beta, in plasma/RPMI samples were determined by enzyme linked immunosorbent assay (ELISA) according to the manufacturers' instructions (NCT01116934)
Timeframe: 2006
| Intervention | pg/ml (Median) | ||||
|---|---|---|---|---|---|
| interleukin-1 beta | interleukin-6 | interferon-inducible protein-10 | interferon gamma | interleukin-8 | |
| Healthy Controls | 896.21 | 45734 | 11563 | 3317.4 | 44390 |
| Papillon-Lefèvre Syndrome (PLS) Patients | 1100.00 | 65559 | 12902.5 | 3704.5 | 50520 |
7 reviews available for metronidazole and Attachment Loss, Periodontal
| Article | Year |
|---|---|
Effectiveness of metronidazole as an adjunct to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis.
Topics: Anti-Infective Agents; Chronic Periodontitis; Combined Modality Therapy; Dental Scaling; Humans; Met | 2014 |
Systemic antibiotics in the treatment of aggressive periodontitis. A systematic review and a Bayesian Network meta-analysis.
Topics: Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Bayes Theorem; Combined Modality Thera | 2015 |
Amoxicillin/metronidazole or scaling and root planing in the treatment of chronic periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Chronic Periodontitis; Dental Plaque Inde | 2010 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Meta-analysis of the effect of scaling and root planing, surgical treatment and antibiotic therapies on periodontal probing depth and attachment loss.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Follow-Up S | 2002 |
Systemic anti-infective periodontal therapy. A systematic review.
Topics: Administration, Oral; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Age | 2003 |
Meta-analysis of local metronidazole in the treatment of chronic periodontitis.
Topics: Administration, Topical; Adult; Anti-Infective Agents, Local; Chronic Disease; Dental Scaling; Human | 2004 |
Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis.
Topics: Adult; Anti-Infective Agents; Combined Modality Therapy; Confidence Intervals; Dental Scaling; Dose- | 1997 |
64 trials available for metronidazole and Attachment Loss, Periodontal
| Article | Year |
|---|---|
Adjunctive efficacy of systemic metronidazole in the surgical treatment of periodontitis: a double-blind parallel randomized clinical trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Double-Blind Method; Humans; Metronidazole; Peri | 2022 |
Moxifloxacin versus amoxicillin plus metronidazole as adjunctive therapy for generalized aggressive periodontitis: a pilot randomized controlled clinical trial.
Topics: Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; | 2020 |
Effects on clinical outcomes of adjunctive moxifloxacin versus amoxicillin plus metronidazole in periodontitis patients harboring Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia: exploratory analyses from a clinic
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Humans; Metronidaz | 2021 |
Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial.
Topics: Blood Glucose; Chronic Periodontitis; Dental Scaling; Humans; Metronidazole; Periodontal Attachment | 2021 |
Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age: An exploratory sub-analysis of the ABPARO trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontal Attachment Lo | 2019 |
Periodontal treatment reduces matrix metalloproteinase levels in localized aggressive periodontitis.
Topics: Adolescent; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Black or African American; | 2013 |
LPS-induced inflammatory response after therapy of aggressive periodontitis.
Topics: Adolescent; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Chemokine CCL2; Chemokine | 2013 |
Clinical and microbiologic effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized chronic periodontitis: smokers versus non-smokers.
Topics: Actinomyces; Adult; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Cohort Studies; Combi | 2014 |
Nonsurgical treatment of aggressive periodontitis with photodynamic therapy or systemic antibiotics. Three-month results of a randomized, prospective, controlled clinical study.
Topics: Administration, Oral; Adult; Aggressive Periodontitis; Amoxicillin; Analysis of Variance; Anti-Bacte | 2013 |
Baseline adjustment and change revisited: effect of smoking on change in periodontal status following periodontal therapy.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Anti-Infective Agents; Bias; Combined Modality Thera | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bact | 2014 |
Metronidazole and amoxicillin as adjuncts to scaling and root planing for the treatment of type 2 diabetic subjects with periodontitis: 1-year outcomes of a randomized placebo-controlled clinical trial.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Chronic Periodonti | 2014 |
Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: an exploratory analysis from a randomized controlled clinical trial.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; | 2014 |
Localized aggressive periodontitis treatment response in primary and permanent dentitions.
Topics: Adolescent; Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Child; Child, Presc | 2014 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Microbiologic Observations After Four Treatment Strategies Among Patients With Periodontitis Maintaining a High Standard of Oral Hygiene: Secondary Analysis of a Randomized Controlled Clinical Trial.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Bacterial Load; Chlorhexidine; Chr | 2015 |
Full mouth periodontal debridement with or without adjunctive metronidazole gel in smoking patients with chronic periodontitis: A pilot study.
Topics: Chronic Periodontitis; Dental Scaling; Follow-Up Studies; Humans; Metronidazole; Periodontal Attachm | 2016 |
Is progression of periodontitis relevantly influenced by systemic antibiotics? A clinical randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Disease Progression; Double-Blind Method; Drug Therapy, Combinat | 2015 |
Is furcation involvement affected by adjunctive systemic amoxicillin plus metronidazole? A clinical trials exploratory subanalysis.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Double-Blind Method; Follow-Up Studies; Humans; | 2016 |
Systemic administration of doxycycline versus metronidazole plus amoxicillin in the treatment of localized aggressive periodontitis: a clinical and microbiologic study.
Topics: Administration, Oral; Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Ba | 2008 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Full-mouth ultrasonic debridement associated with amoxicillin and metronidazole in the treatment of severe chronic periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Bacteroides; | 2009 |
Efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Ant | 2010 |
Short-term effects of systemic antibiotics during periodontal healing.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; A | 2010 |
Impact of systemic antimicrobials combined with anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: a 6-month RCT.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Ant | 2011 |
Calprotectin levels in gingival crevicular fluid predict disease activity in patients treated for generalized aggressive periodontitis.
Topics: Administration, Topical; Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Anti-I | 2011 |
The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2012 |
Surgical and non-surgical therapy with systemic antimicrobials for residual pockets in type 2 diabetics with chronic periodontitis: a pilot study.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Cytokines; Dental Scaling; D | 2012 |
Control of periodontal infections: a randomized controlled trial I. The primary outcome attachment gain and pocket depth reduction at treated sites.
Topics: Amoxicillin; Analysis of Variance; Anti-Infective Agents; Cellulose; Chemotherapy, Adjuvant; Chlorhe | 2012 |
The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Combined Modality Therapy; Dent | 2012 |
The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Combined Modality Therapy; Dent | 2012 |
The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Combined Modality Therapy; Dent | 2012 |
The effects of adjunctive metronidazole plus amoxicillin in the treatment of generalized aggressive periodontitis: a 1-year double-blinded, placebo-controlled, randomized clinical trial.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Infective Agents; Combined Modality Therapy; Dent | 2012 |
A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Combined Modality T | 2013 |
Local antimicrobial therapy after initial periodontal treatment.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Analysis of Variance; Anti-Bacterial Agents; Ant | 2002 |
Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results.
Topics: Administration, Topical; Adult; Analysis of Variance; Anti-Bacterial Agents; Colony Count, Microbial | 2001 |
Clinical outcome observed in subjects with recurrent periodontal disease following local treatment with 25% metronidazole gel.
Topics: Adult; Anti-Infective Agents; Dental Plaque Index; Dental Scaling; Follow-Up Studies; Gels; Gingival | 2003 |
Guided tissue regeneration in smokers: effect of aggressive anti-infective therapy in Class II furcation defects.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Cl | 2003 |
Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients.
Topics: Adult; Anti-Infective Agents, Local; Case-Control Studies; Chlorhexidine; Chronic Disease; Colony Co | 2004 |
Enamel matrix proteins and systemic antibiotics as adjuncts to non-surgical periodontal treatment: clinical effects.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bone Density; Chronic Diseas | 2005 |
Enhanced root planing and systemic metronidazole administration improve clinical and microbiological outcomes in a two-step treatment procedure.
Topics: Adult; Anti-Infective Agents; Combined Modality Therapy; Female; Humans; Male; Metronidazole; Period | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Local oxygen therapy for treating acute necrotizing periodontal disease in smokers.
Topics: Acute Disease; Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin-Po | 2006 |
Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Case-Control Studi | 2006 |
Topical use of a metronidazole gel in the treatment of sites with symptoms of recurring chronic inflammation.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Chronic Disease; Delayed-Action Prepara | 2007 |
Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chlorhexidine; Delayed-Acti | 2007 |
A comparative clinical study: the use of human type I collagen with and without the addition of metronidazole in the GTR method of treatment of periodontal disease.
Topics: Adult; Anti-Infective Agents, Local; Collagen; Dental Plaque Index; Dental Prophylaxis; Dental Scali | 1995 |
Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis.
Topics: Adult; Aged; Chronic Disease; Collagen; Delayed-Action Preparations; Dental Plaque Index; Female; Hu | 1994 |
Value of some laboratory and clinical measurements in the treatment plan for advanced periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Anti-Bacterial Agents; Denta | 1996 |
A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients.
Topics: Administration, Oral; Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Anti-In | 1997 |
The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Biopsy; Combined M | 1998 |
Differential clinical treatment outcome after systemic metronidazole and amoxicillin in patients harboring Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 1998 |
Effects of topical metronidazole and tetracycline in treatment of adult periodontitis.
Topics: Administration, Topical; Adult; Aged; Aggregatibacter actinomycetemcomitans; Analysis of Variance; A | 1998 |
Local metronidazole application in maintenance patients. Clinical and microbiological evaluation.
Topics: Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Colony | 1998 |
Clinical and microbiological effects of adjunctive antibiotics in treatment of localized juvenile periodontitis. A controlled clinical trial.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Process | 1998 |
Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuva | 1999 |
Topical and systemic antimicrobial therapy in guided tissue regeneration.
Topics: Administration, Topical; Adult; Aged; Alveolar Bone Loss; Amoxicillin-Potassium Clavulanate Combinat | 1999 |
Comparison of enamel matrix proteins and bioabsorbable membranes in the treatment of intrabony periodontal defects. A split-mouth study.
Topics: Absorbable Implants; Alveolar Bone Loss; Amoxicillin; Anti-Infective Agents; Dental Enamel Proteins; | 1999 |
Repeated local metronidazole-therapy as adjunct to scaling and root planing in maintenance patients.
Topics: Administration, Topical; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Colony Count, | 1999 |
Repeated metronidazole and amoxicillin treatment of periodontitis. A follow-up study.
Topics: Adult; Aged; Amoxicillin; Analysis of Variance; Anti-Infective Agents; Chronic Disease; Disease Prog | 2000 |
Periodontal flap surgery with 25% metronidazole gel. (1). Clinical outcomes.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Combined Modality Therapy; Confidence I | 2000 |
The effect of postsurgical antibiotics on the healing of intrabony defects following treatment with enamel matrix proteins.
Topics: Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bone Substitutes; Den | 2001 |
Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteroides; Dental Plaque; Double-Blind Method; Drug Com | 2001 |
A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Clindamycin; Clinical Protocols | 2001 |
The nonsurgical treatment of patients with periodontal disease: results after five years.
Topics: Age Factors; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacterial Infections; D | 2002 |
Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Capsules; Chronic Disease; Colony C | 2002 |
Aggressive periodontitis: 5-year follow-up of treatment.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Dental Plaque; Den | 2002 |
20 other studies available for metronidazole and Attachment Loss, Periodontal
| Article | Year |
|---|---|
Generalized aggressive periodontitis: microbiological composition and clinical parameters in non-surgical therapy.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2016 |
Effect of periodontal treatment on Aggregatibacter actinomycetemcomitans colonization and serum IgG levels against A. actinomycetemcomitans serotypes and Omp29 of aggressive periodontitis patients.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Ant | 2019 |
Occurrence of porphyromonas gingivalis and its antibacterial susceptibility to metronidazole and tetracycline in patients with chronic periodontitis.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Load; Bacteriological Techniques; Chronic | 2014 |
Periodontitis associated with plasminogen deficiency: a case report.
Topics: Adolescent; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Conju | 2015 |
Maintenance periodontal therapy after systemic antibiotic and regenerative therapy of generalized aggressive periodontitis. A case report with 10-year follow-up.
Topics: Adult; Aggressive Periodontitis; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Combined Mo | 2015 |
Antibiotics in periodontics: right or wrong?
Topics: Amoxicillin; Anti-Bacterial Agents; Bacteroidaceae Infections; Combined Modality Therapy; Dental Pla | 2009 |
Antibiotic resistance of subgingival species in chronic periodontitis patients.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicillin-Potassium Clavulanate C | 2010 |
Maintenance after a complex orthoperio treatment in a case of generalized aggressive periodontitis: 7-year result.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Amoxicillin-Pot | 2010 |
Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2012 |
Periodontal therapy in siblings with Papillon-Lefèvre syndrome and tinea capitis: a report of two cases.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Ch | 2006 |
Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Anaerobiosis; Anti-Bacterial Agents; Bacteroidaceae In | 1997 |
Re: Non-surgical treatment of patients with periodontitis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Double-Bl | 1997 |
Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial | 1998 |
Actinobacillus actinomycetemcomitans in destructive periodontal disease. Three-year follow-up results.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial | 2000 |
A multidisciplinary approach to the diagnosis and treatment of early-onset periodontitis: a case report.
Topics: Adolescent; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacte | 2001 |
Combined mechanical and antibiotic periodontal therapy in a case of Papillon-Lefèvre syndrome.
Topics: Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; | 2001 |
The effect of systemic antibiotics in the treatment of patients with recurrent periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents | 2001 |
Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole.
Topics: Actinomyces; Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Bacteria; Bacteroides; | 2001 |
Treatment of Papillon-Lefèvre syndrome periodontitis.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti- | 2002 |
Statistical modeling of tooth mobility after treating adult periodontitis.
Topics: Adult; Anti-Bacterial Agents; Chronic Disease; Colony Count, Microbial; Dental Plaque Index; Electro | 2002 |