metronidazole has been researched along with Glial Cell Tumors in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole, 1." | 1.27 | Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stewart, DJ | 1 |
| Maroun, JA | 1 |
| Young, V | 1 |
| Crook, AF | 1 |
| Hopkins, HS | 1 |
| Yan, RC | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Bélanger, R | 1 |
| Heringer, R | 1 |
| Potapov, SL | 1 |
| Karakulov, RK | 1 |
| Kachkov, IA | 2 |
| Pelevina, II | 2 |
| Liass, FM | 1 |
| Konradov, SA | 1 |
| Vartanian, LP | 1 |
| Rudenko, IIa | 1 |
| Volchkov, VA | 1 |
| Nelson, DF | 1 |
| Urtasun, RC | 1 |
| Saunders, WM | 1 |
| Gutin, PH | 1 |
| Sheline, GE | 1 |
1 review available for metronidazole and Glial Cell Tumors
| Article | Year |
|---|---|
Recent and current investigations of radiation therapy of malignant gliomas.
Topics: Brachytherapy; Brain; Brain Neoplasms; Bromodeoxyuridine; Carmustine; Glioma; Helium; Humans; Hyperb | 1986 |
4 other studies available for metronidazole and Glial Cell Tumors
| Article | Year |
|---|---|
Feasibility study of combining metronidazole with chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq | 1983 |
[Sensitivity of human brain tumors to radiation and to the combined effect of metronidazole and radiation].
Topics: Animals; Astrocytoma; Brain Neoplasms; Ependymoma; Glioma; Hemangioma; Humans; In Vitro Techniques; | 1982 |
[Metronidazole in the large split-dose concentrated irradiation of malignant gliomas].
Topics: Adult; Brain Neoplasms; Drug Evaluation; Glioma; Humans; Metronidazole; Radiation Tolerance; Radioth | 1980 |
[The radiation therapy of experimental brain tumors by using the radiosensitizing preparation xanthobin (8-bromocaffeine)].
Topics: Animals; Brain Neoplasms; Caffeine; Drug Evaluation, Preclinical; Glioma; Metronidazole; Neoplasm Tr | 1989 |