metronidazole has been researched along with Abnormalities, Drug-Induced in 33 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case-control analysis of congenital abnormalities after oral metronidazole treatment during pregnancy grouped by months of gestation." | 9.08 | A population based case-control teratologic study of oral metronidazole treatment during pregnancy. ( Czeizel, AE; Rockenbauer, M, 1998) |
| "Studies investigating the association between gestational use of oral metronidazole on human subjects and the risk of preterm birth or/and birth defects were systematically retrieved from MEDLINE and EMBASE databases." | 8.91 | The use of metronidazole during pregnancy: a review of evidence. ( Berard, A; Ferreira, E; Santos, F; Sheehy, O, 2015) |
| "Our purpose was to determine from published experience in humans whether metronidazole exposure during the first trimester of pregnancy is associated with an increased teratogenic risk." | 8.79 | Safety of metronidazole in pregnancy: a meta-analysis. ( Ariburnu, O; Burtin, P; Einarson, TR; Koren, G; Taddio, A, 1995) |
| "To assess whether treatment with metronidazole during pregnancy is associated with preterm birth, low birth weight, or major congenital anomalies, we conducted chart reviews and an analysis of electronic data from a cohort of women delivering at an urban New York State hospital." | 7.78 | Investigation of metronidazole use during pregnancy and adverse birth outcomes. ( Aubry, R; Baras, DC; Koss, CA; Koumans, EH; Lane, SD; Marcus, M; Markowitz, LE, 2012) |
| "To study the human teratogenic potential of vaginal metronidazole treatment during pregnancy." | 7.73 | Teratogenic potential of vaginal metronidazole treatment during pregnancy. ( Czeizel, AE; Kazy, Z; Puhó, E, 2005) |
| "The Israeli Teratogen Information Service prospectively collected and followed up 228 women exposed to metronidazole in pregnancy, 86." | 7.71 | Pregnancy outcome after gestational exposure to metronidazole: a prospective controlled cohort study. ( Arnon, J; Diav-Citrin, O; Gotteiner, T; Ornoy, A; Shechtman, S, 2001) |
| "A case-control analysis of congenital abnormalities after oral metronidazole treatment during pregnancy grouped by months of gestation." | 5.08 | A population based case-control teratologic study of oral metronidazole treatment during pregnancy. ( Czeizel, AE; Rockenbauer, M, 1998) |
| "Studies investigating the association between gestational use of oral metronidazole on human subjects and the risk of preterm birth or/and birth defects were systematically retrieved from MEDLINE and EMBASE databases." | 4.91 | The use of metronidazole during pregnancy: a review of evidence. ( Berard, A; Ferreira, E; Santos, F; Sheehy, O, 2015) |
| "Our purpose was to determine from published experience in humans whether metronidazole exposure during the first trimester of pregnancy is associated with an increased teratogenic risk." | 4.79 | Safety of metronidazole in pregnancy: a meta-analysis. ( Ariburnu, O; Burtin, P; Einarson, TR; Koren, G; Taddio, A, 1995) |
| "To assess whether treatment with metronidazole during pregnancy is associated with preterm birth, low birth weight, or major congenital anomalies, we conducted chart reviews and an analysis of electronic data from a cohort of women delivering at an urban New York State hospital." | 3.78 | Investigation of metronidazole use during pregnancy and adverse birth outcomes. ( Aubry, R; Baras, DC; Koss, CA; Koumans, EH; Lane, SD; Marcus, M; Markowitz, LE, 2012) |
| "To study the human teratogenic potential of vaginal metronidazole treatment during pregnancy." | 3.73 | Teratogenic potential of vaginal metronidazole treatment during pregnancy. ( Czeizel, AE; Kazy, Z; Puhó, E, 2005) |
| "The Israeli Teratogen Information Service prospectively collected and followed up 228 women exposed to metronidazole in pregnancy, 86." | 3.71 | Pregnancy outcome after gestational exposure to metronidazole: a prospective controlled cohort study. ( Arnon, J; Diav-Citrin, O; Gotteiner, T; Ornoy, A; Shechtman, S, 2001) |
| " Teratogenicity tests in animals have given negative results in the case of metronidazole, ornidazole and tinidazole, and in the case of metronidazole no evidence of any adverse effect on the outcome of pregnancy was seen in women treated for trichomoniasis at various times during gestation, including the first trimester." | 3.67 | Safety of nitroimidazoles. ( Roe, FJ, 1985) |
| "Tinidazole, a synthetic imidazole derivative, has been used in the oral treatment of several protozoal infections - trichomoniasis, giardiasis and amoebiasis." | 3.65 | Tinidazole: a review of its antiprotozoal activity and therapeutic efficacy. ( Avery, GS; Brogden, RN; Pinder, RM; Sawyer, PR; Speight, TM, 1976) |
| "A reported excess of liver tumors in rats exposed to metronidazole can be explained by the fact that the authors failed to age standardize their data despite a big and highly significant beneficial effect of the drug on survival." | 1.27 | Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential. ( Roe, FJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (60.61) | 18.7374 |
| 1990's | 8 (24.24) | 18.2507 |
| 2000's | 3 (9.09) | 29.6817 |
| 2010's | 2 (6.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sheehy, O | 1 |
| Santos, F | 1 |
| Ferreira, E | 1 |
| Berard, A | 1 |
| Koss, CA | 1 |
| Baras, DC | 1 |
| Lane, SD | 1 |
| Aubry, R | 1 |
| Marcus, M | 1 |
| Markowitz, LE | 1 |
| Koumans, EH | 1 |
| SCOTT-GRAY, M | 1 |
| KOVAR, WR | 1 |
| Palermo, AM | 1 |
| Reynoso, AS | 1 |
| López Nigro, M | 1 |
| Carballo, MA | 1 |
| Mudry, MD | 1 |
| Kazy, Z | 1 |
| Puhó, E | 1 |
| Czeizel, AE | 2 |
| Roe, FJ | 2 |
| Robbie, MO | 1 |
| Sweet, RL | 1 |
| Hill, LM | 1 |
| Kleinberg, F | 1 |
| Sánchez-Corona, J | 1 |
| García-Cruz, D | 2 |
| Cantú, JM | 2 |
| Dobiás, L | 1 |
| Cerná, M | 1 |
| Rössner, P | 1 |
| Srám, R | 1 |
| Burtin, P | 1 |
| Taddio, A | 1 |
| Ariburnu, O | 1 |
| Einarson, TR | 1 |
| Koren, G | 1 |
| Piper, JM | 1 |
| Mitchel, EF | 1 |
| Ray, WA | 1 |
| Saurina, GR | 1 |
| McCormack, WM | 1 |
| Rockenbauer, M | 1 |
| Coustan, DR | 1 |
| Sørensen, HT | 1 |
| Larsen, H | 1 |
| Jensen, ES | 1 |
| Thulstrup, AM | 1 |
| Schønheyder, HC | 1 |
| Nielsen, GL | 1 |
| Czeizel, A | 1 |
| Diav-Citrin, O | 1 |
| Shechtman, S | 1 |
| Gotteiner, T | 1 |
| Arnon, J | 1 |
| Ornoy, A | 1 |
| Morgan, I | 1 |
| Oakley, GP | 1 |
| Sawyer, PR | 1 |
| Brogden, RN | 1 |
| Pinder, RM | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| Hawkins, DF | 1 |
| Setekleiv, J | 1 |
| Borchgrevink, CH | 1 |
| Naess, K | 1 |
| McAuley, JB | 1 |
| Juranek, DD | 1 |
| Boiadzhieva, N | 1 |
| Chacko, M | 1 |
| Bhide, SV | 1 |
| Berget, A | 1 |
| Weber, T | 1 |
| Farkas, G | 2 |
| Robinson, SC | 1 |
| Mirchandani, G | 1 |
| Ivanov, I | 1 |
8 reviews available for metronidazole and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
The use of metronidazole during pregnancy: a review of evidence.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Bacterial Agents; Female; Humans; Infant, Newborn; Metronid | 2015 |
FETAL RESPONSE TO MATERNAL MEDICATION.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antineoplastic Agents; | 1964 |
Metronidazole use in obstetrics and gynecology: a review.
Topics: Abnormalities, Drug-Induced; Animals; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Fem | 1983 |
Effects of drugs and chemicals on the fetus and newborn (2).
Topics: Abnormalities, Drug-Induced; Anticoagulants; Anticonvulsants; Diazepam; Drug-Related Side Effects an | 1984 |
Genotoxicity and carcinogenicity of metronidazole.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Carcinogenicity Tests; Carcinogens; DNA Dam | 1994 |
Safety of metronidazole in pregnancy: a meta-analysis.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Metronidazole; Odds Ratio; Pregnancy; | 1995 |
Drug influences on malformations.
Topics: Abnormalities, Drug-Induced; Amphetamines; Anesthetics; Animals; Anti-Anxiety Agents; Anticonvulsant | 1979 |
[Metronidazole and pregnancy].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Female; Fetal Death; Humans; Metronidazole; Preg | 1972 |
2 trials available for metronidazole and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
A population based case-control teratologic study of oral metronidazole treatment during pregnancy.
Topics: Abnormalities, Drug-Induced; Administration, Intravaginal; Administration, Oral; Animals; Antitricho | 1998 |
Trichomonas vaginalis. V. Further observations on metronidazole (Flagyl) (including infant follow-up).
Topics: Abnormalities, Drug-Induced; Adult; Clinical Trials as Topic; Drug Resistance, Microbial; Female; Fe | 1965 |
23 other studies available for metronidazole and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Investigation of metronidazole use during pregnancy and adverse birth outcomes.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antifungal Agents; Cohort Studies; Female; Fungi; Hu | 2012 |
METRONIDAZOLE IN OBSTETRIC PRACTICE.
Topics: Abnormalities, Drug-Induced; Fetal Diseases; Imidazoles; Infant, Newborn; Metronidazole; Pregnancy; | 1964 |
Teratogenic evaluation of metronidazole and ornidazole using Drosophila melanogaster as an experimental model.
Topics: Abdomen; Abnormalities, Drug-Induced; Animals; Antiprotozoal Agents; Drosophila melanogaster; Larva; | 2004 |
Teratogenic potential of vaginal metronidazole treatment during pregnancy.
Topics: Abnormalities, Drug-Induced; Administration, Intravaginal; Adult; Anti-Infective Agents, Local; Case | 2005 |
Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential.
Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; Crohn Disease; Female; Follow-Up Studies; Humans; | 1983 |
[Teratogenic effect of metronidazole on the prosencephalon].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Brain; Cleft Lip; Cleft Palate; Female; Humans | 1983 |
Midline facial defect as a teratogenic effect of metronidazole.
Topics: Abnormalities, Drug-Induced; Amebiasis; Child, Preschool; Face; Female; Humans; Infant; Infant, Newb | 1982 |
Prenatal use of metronidazole and birth defects: no association.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Cohort Studies; Female; Humans; Metronidazole; Pregn | 1993 |
Trichomoniasis in pregnancy.
Topics: Abnormalities, Drug-Induced; Female; Humans; Metronidazole; Pregnancy; Pregnancy Complications, Para | 1997 |
Use of metronidazole during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anti-Infective Agents; Contraindications; Female; Hu | 1999 |
Safety of metronidazole during pregnancy: a cohort study of risk of congenital abnormalities, preterm delivery and low birth weight in 124 women.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Infective Agents; Cohort Studies; Female; Humans; Infant, L | 1999 |
Pregnancy outcome after gestational exposure to metronidazole: a prospective controlled cohort study.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Infective Agents; Cohort Studies; Female; Humans; Infant, N | 2001 |
Metronidazole treatment in pregnancy.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Drug Evaluation; Female; Humans; Metronidazole; P | 1978 |
Tinidazole: a review of its antiprotozoal activity and therapeutic efficacy.
Topics: Abnormalities, Drug-Induced; Amebiasis; Animals; Eukaryota; Giardiasis; Gonorrhea; Humans; Kinetics; | 1976 |
Teratogens in the human: current problems.
Topics: Abnormalities, Drug-Induced; Barbiturates; Contraceptives, Oral; Ethanol; Female; Fetal Diseases; Hu | 1976 |
[Editorial: Metronidazole].
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Metronidazole; Mutagens; Neoplasms; Pregnancy | 1975 |
[Editorial: Drugs and abnormalities. Background and consequences of warnings].
Topics: Abnormalities, Drug-Induced; Carbimazole; Clofibrate; Female; Humans; Maternal-Fetal Exchange; Metro | 1976 |
Paromomycin in the treatment of mild-to-moderate intestinal amebiasis.
Topics: Abnormalities, Drug-Induced; Dysentery, Amebic; Female; Humans; Metronidazole; Paromomycin; Pregnanc | 1992 |
[Effect of the combined use of metronidazole and alcohol on fetal development in rats].
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Drug Interactions; Embryo Loss; Embryonic an | 1988 |
Carcinogenicity, perinatal carcinogenicity and teratogenicity of low dose metronidazole (MNZ) in Swiss mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Lung Neoplasms; Male; Metronidazole; Mice; Neop | 1986 |
Safety of nitroimidazoles.
Topics: Abnormalities, Drug-Induced; Animals; Chromosome Aberrations; Cricetinae; Dose-Response Relationship | 1985 |
[Proceedings: Is hemorrhage in early pregnancy and its drug therapy an increased risk of teratogenesis?].
Topics: Abnormalities, Drug-Induced; Abortion, Threatened; Allyl Compounds; Aminopyrine; Chlordiazepoxide; C | 1973 |
[Effect of the preparation trichomonacid on pregnancy in experimental animals].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Gestational Age; Guinea Pigs; Metronidazo | 1969 |