D-proline profile

D-proline, the enantiomer of the common L-proline, is a non-proteinogenic amino acid. It has garnered considerable interest due to its unique properties and potential applications in various fields.

D-proline synthesis typically involves enzymatic or chemical methods, with the latter often employing chiral catalysts to achieve high enantioselectivity. The compound exhibits distinct conformational preferences compared to L-proline, which influences its interactions with other molecules.

Research into D-proline has revealed its potential in fields like pharmaceuticals, materials science, and agriculture. It has been explored as a building block for novel peptides and peptidomimetics, exhibiting therapeutic potential in areas such as cancer treatment and viral inhibition.

D-proline's unique structural features make it a valuable probe for investigating protein structure and function. Its incorporation into peptides can alter their folding, stability, and biological activity, leading to insights into the fundamental principles of protein design and engineering.

In addition, D-proline has been investigated for its potential to enhance the efficiency of biocatalysts. The introduction of D-proline residues into enzymes can modulate their catalytic activity and selectivity, opening avenues for optimizing industrial processes.

D-proline's intriguing properties and potential applications continue to drive research in various areas. Its study provides valuable insights into the structure, function, and manipulation of biomolecules, potentially leading to the development of new drugs, materials, and technologies.'

ID Source	ID
PubMed CID	8988
CHEMBL ID	80257
CHEBI ID	16313
SCHEMBL ID	65555

Synonym
CHEMBL80257
CHEBI:16313 ,
(2r)-pyrrolidine-2-carboxylic acid
(r)-2-carboxypyrrolidine
d-prolin
(r)-pyrrolidine-2-carboxylic acid
d-pro
C00763
344-25-2
D-PROLINE ,
d-proline, reagentplus(r), >=99%
DB02853
NCGC00163339-02
NCI97923
NCGC00163339-01
NCISTRUC1_001918
NCISTRUC2_000132
P-7200
D2735F99-0D23-48C4-B266-5C7A7DA319A4
d-(+)-proline
h-d-pro-oh
P0994
h-pros-oh
d-d-pro-oh
AKOS015923206
pyrrolidine-2-carboxylic acid;d-proline
CCG-37784
l01q4lgz5l ,
unii-l01q4lgz5l
einecs 206-452-7
bdbm50357224
AM20090537
S6016
gtpl4676
SCHEMBL65555
mfcd00064317
pyrrolidine-2-(r)-carboxylic acid
(r)-proline
r-proline
ONIBWKKTOPOVIA-SCSAIBSYSA-N
(d)-proline
h-dpro-oh
J-300218
TS-01590
CS-W020557
d-2-pyrrolidinecarboxylic acid
AC-24083
F1905-6974
(r)-pyrrolidine-2-carboxylate
r)-2-carboxypyrrolidine
d-proline, vetec(tm) reagent grade, 98%
HY-75087
(+)-(r)-proline
proline, d-
1331908-17-8
Q20035962
DTXSID70883367
STARBLD0002768
EN300-60161
Z933632584

Role	Description
mouse metabolite	Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
D-alpha-amino acid zwitterion	Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group.
D-alpha-amino acid
proline	An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Arginine and Proline Metabolism	20	47
Prolidase Deficiency (PD)	20	47
Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)	20	47
Hyperprolinemia Type II	20	47
Hyperprolinemia Type I	20	47
Prolinemia Type II	20	47
Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)	20	47
Ornithine Aminotransferase Deficiency (OAT Deficiency)	20	47
Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency	20	47
Hyperornithinemia with Gyrate Atrophy (HOGA)	20	47
Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome]	20	47
L-Arginine:Glycine Amidinotransferase Deficiency	20	47
Biochemical pathways: part I	0	466

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
phosphopantetheinyl transferase	Bacillus subtilis	Potency	44.6684	0.1413	37.9142	100.0000	AID1490
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
monoatomic ion transport	Proton-coupled amino acid transporter 1	Homo sapiens (human)
amino acid transport	Proton-coupled amino acid transporter 1	Homo sapiens (human)
taurine transmembrane transport	Proton-coupled amino acid transporter 1	Homo sapiens (human)
proline transport	Proton-coupled amino acid transporter 1	Homo sapiens (human)
alanine transport	Proton-coupled amino acid transporter 1	Homo sapiens (human)
amino acid import across plasma membrane	Proton-coupled amino acid transporter 1	Homo sapiens (human)
glycine transport	Proton-coupled amino acid transporter 1	Homo sapiens (human)
proline transmembrane transport	Proton-coupled amino acid transporter 1	Homo sapiens (human)
proton transmembrane transport	Proton-coupled amino acid transporter 1	Homo sapiens (human)
L-alanine transport	Proton-coupled amino acid transporter 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
amino acid:proton symporter activity	Proton-coupled amino acid transporter 1	Homo sapiens (human)
proline:proton symporter activity	Proton-coupled amino acid transporter 1	Homo sapiens (human)
taurine transmembrane transporter activity	Proton-coupled amino acid transporter 1	Homo sapiens (human)
protein binding	Proton-coupled amino acid transporter 1	Homo sapiens (human)
amino acid transmembrane transporter activity	Proton-coupled amino acid transporter 1	Homo sapiens (human)
alanine transmembrane transporter activity	Proton-coupled amino acid transporter 1	Homo sapiens (human)
L-alanine transmembrane transporter activity	Proton-coupled amino acid transporter 1	Homo sapiens (human)
L-proline transmembrane transporter activity	Proton-coupled amino acid transporter 1	Homo sapiens (human)
glycine transmembrane transporter activity	Proton-coupled amino acid transporter 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
lysosomal membrane	Proton-coupled amino acid transporter 1	Homo sapiens (human)
endoplasmic reticulum	Proton-coupled amino acid transporter 1	Homo sapiens (human)
plasma membrane	Proton-coupled amino acid transporter 1	Homo sapiens (human)
apical plasma membrane	Proton-coupled amino acid transporter 1	Homo sapiens (human)
vacuolar membrane	Proton-coupled amino acid transporter 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Assay ID	Title	Year	Journal	Article
AID630741	Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting	2011	Bioorganic & medicinal chemistry, Nov-01, Volume: 19, Issue:21	Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
AID143623	Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1	1992	Journal of medicinal chemistry, Jan-24, Volume: 35, Issue:2	Beta-proline analogues as agonists at the strychnine-sensitive glycine receptor.
AID1751497	Antibiofilm activity against Staphylococcus aureus assessed as inhibition of biofilm formation at 500 uM	2021	Bioorganic & medicinal chemistry letters, 09-15, Volume: 48	Discovery of non-proteinogenic amino acids inhibiting biofilm formation by S. aureus and methicillin-resistant S. aureus.
AID1347154	Primary screen GU AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630	Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	3 (60.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gamma-aminobutyric acid gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	2.06	1	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule
beta-alanine [no description available]	2.41	2	amino acid zwitterion; beta-amino acid	agonist; fundamental metabolite; human metabolite; inhibitor; neurotransmitter
betaine glycine betaine : The amino acid betaine derived from glycine.	2.06	1	amino-acid betaine; glycine derivative	fundamental metabolite
catechol [no description available]	2.31	1	catechols	allelochemical; genotoxin; plant metabolite
aminocaproic acid Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.. 6-aminohexanoic acid : An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator.	2.06	1	amino acid zwitterion; epsilon-amino acid; omega-amino fatty acid	antifibrinolytic drug; hematologic agent; metabolite
creatine [no description available]	2.06	1	glycine derivative; guanidines; zwitterion	geroprotector; human metabolite; mouse metabolite; neuroprotective agent; nutraceutical
glycine [no description available]	2.41	2	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
glycocyamine glycocyamine: RN given refers to parent cpd; structure. guanidinoacetate : A monocarboxylic acid anion that is the conjugate base of guanidinoacetic acid, obtained by deprotonation of the carboxy group.. guanidinoacetic acid : The N-amidino derivative of glycine.	2.06	1	guanidinoacetic acids; zwitterion	bacterial metabolite; human metabolite; mouse metabolite; nutraceutical; rat metabolite
picolinic acid picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206. picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.	2.06	1	pyridinemonocarboxylic acid	human metabolite; MALDI matrix material
sarcosine cocobetaine: N-alkyl-betaine; cause of shampoo dermatitis	2.06	1	N-alkylglycine zwitterion; N-alkylglycine; N-methyl-amino acid; N-methylglycines	Escherichia coli metabolite; glycine receptor agonist; glycine transporter 1 inhibitor; human metabolite; mouse metabolite
taurine [no description available]	2.06	1	amino sulfonic acid; zwitterion	antioxidant; Escherichia coli metabolite; glycine receptor agonist; human metabolite; mouse metabolite; nutrient; radical scavenger; Saccharomyces cerevisiae metabolite
tramiprosate tramiprosate: GABA receptor agonist and a glycosaminoglycan mimetic; has nootropic acitivity; structure; a sulfonate analog of GABA. 3-aminopropanesulfonic acid : An amino sulfonic acid that is the 3-amino derivative of propanesulfonic acid.	2.06	1	amino sulfonic acid; zwitterion	algal metabolite; anti-inflammatory agent; anticonvulsant; GABA agonist; nootropic agent
isoguvacine isoguvacine: A GABA agonist; RN given refers to parent cpd; structure	2.06	1	tetrahydropyridine
4-piperidinecarboxylic acid 4-piperidinecarboxylic acid: structure in first source	2.41	2
hydroxyproline Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.	2.06	1	4-hydroxyproline; L-alpha-amino acid zwitterion	human metabolite; mouse metabolite; plant metabolite
cysteine [no description available]	2.06	1	cysteine zwitterion; cysteine; L-alpha-amino acid; proteinogenic amino acid; serine family amino acid	EC 4.3.1.3 (histidine ammonia-lyase) inhibitor; flour treatment agent; human metabolite
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	2.41	2	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
serine Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.	2.06	1	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
levodopa Levodopa: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.. L-dopa : An optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease	2.31	1	amino acid zwitterion; dopa; L-tyrosine derivative; non-proteinogenic L-alpha-amino acid	allelochemical; antidyskinesia agent; antiparkinson drug; dopaminergic agent; hapten; human metabolite; mouse metabolite; neurotoxin; plant growth retardant; plant metabolite; prodrug
leucine Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.	2.06	1	amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
2-aminoisobutyric acid 2-aminoisobutyric acid: RN given refers to unlabeled cpd. 2-aminoisobutyric acid : A rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. With the exception of a few bacteria, it is non-metabolisable, and therefore used in bioassays.	2.06	1	2,2-dialkylglycine zwitterion; 2,2-dialkylglycine
cycloserine Cycloserine: Antibiotic substance produced by Streptomyces garyphalus.. D-cycloserine : A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis).	2.06	1	4-amino-1,2-oxazolidin-3-one; organonitrogen heterocyclic antibiotic; organooxygen heterocyclic antibiotic; zwitterion	antiinfective agent; antimetabolite; antitubercular agent; metabolite; NMDA receptor agonist
isoleucine Isoleucine: An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.. isoleucine : A 2-amino-3-methylpentanoic acid having either (2R,3R)- or (2S,3S)-configuration.. L-isoleucine : The L-enantiomer of isoleucine.	2.06	1	aspartate family amino acid; isoleucine; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
3-aminobenzoic acid 3-aminobenzoic acid: RN given refers to parent cpd. 3-aminobenzoic acid : An aminobenzoic acid carrying an amino group at position 3.	2.06	1	aminobenzoic acid
piperidine [no description available]	2.06	1	azacycloalkane; piperidines; saturated organic heteromonocyclic parent; secondary amine	base; catalyst; human metabolite; non-polar solvent; plant metabolite; protic solvent; reagent
3-methoxytyrosine 3-O-methyldopa : A L-tyrosine derivative that is the 3-methoxy derivative of L-dopa.	2.31	1	aromatic L-alpha-amino acid zwitterion; L-tyrosine derivative; monomethoxybenzene; non-proteinogenic L-alpha-amino acid	human metabolite
arecaidine [no description available]	1.98	1	citraconoyl group
4-hydroxybutyric acid 4-hydroxybutyric acid: was an entry term to Sodium Oxybate (74-98). 4-hydroxybutyric acid : A 4-hydroxy monocarboxylic acid that is butyric acid in which one of the hydrogens at position 4 is replaced by a hydroxy group.	2.06	1	4-hydroxy monocarboxylic acid; hydroxybutyric acid	general anaesthetic; GHB receptor agonist; neurotoxin; sedative
thiazolidines Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.	2.06	1	thiazolidine
3,5-dibromotyrosine 3,5-dibromotyrosine: used to synthesize various secondary metabolites from marine sponges	2.31	1	monocarboxylic acid
azetidyl-2-carboxylic acid azetidyl-2-carboxylic acid: a proline analog (with 4-membered ring in place of 5); a toxic non-protein amino acid that is misincorporated into protein in place of proline; induces nonfunctional heat-shock proteins; inhibits acquired thermotolerance; RN given refers to (L)-isomer; found in beets and Liliaceae. (S)-azetidine-2-carboxylic acid : The (S)-enantiomer of azetidine-2-carboxylic acid.. azetidinecarboxylic acid : A member of the class of azetidines that is azetidine substituted by at least one carboxy group at unspecified position.	2.06	1	azetidine-2-carboxylic acid
pyrrolidine [no description available]	2.06	1	azacycloalkane; pyrrolidines; saturated organic heteromonocyclic parent
norvaline norvaline: differs from valine in being 1 carbon longer instead of branched; RN given refers to (L)-isomer; structure. L-2-aminopentanoic acid : A 2-aminopentanoic acid that has S-configuration.	2.06	1	2-aminopentanoic acid; L-alpha-amino acid zwitterion	bacterial metabolite; hypoglycemic agent; neuroprotective agent
guanidinopropionic acid guanidinopropionic acid: alters creatine metabolism; structure. 3-guanidinopropanoic acid : A guanidine compound bearing an N-(2-carboxyethyl) substituent. It is a creatine analogue that has been found to decreases plasma glucose levels	2.06	1	guanidines; zwitterion	hypoglycemic agent
D-serine [no description available]	2.53	2	D-alpha-amino acid; serine zwitterion; serine	Escherichia coli metabolite; human metabolite; NMDA receptor agonist
D-alanine [no description available]	2.41	2	alanine zwitterion; alanine; D-alpha-amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; Escherichia coli metabolite; human metabolite
D-tyrosine [no description available]	2.31	1	D-alpha-amino acid zwitterion; D-alpha-amino acid; tyrosine	Escherichia coli metabolite
D-valine D-valine : The D-enantiomer of valine.	2.06	1	D-alpha-amino acid zwitterion; D-alpha-amino acid; valine
phenylalanine [no description available]	2.31	1	D-alpha-amino acid zwitterion; D-alpha-amino acid; phenylalanine
n-myristoylglycine N-myristoylglycine: RN given refers to parent cpd. N-myristoylglycine : An N-acylglycine in which the acyl group is specified as myristoyl (tetradecanoyl).	2.31	1	fatty amide; N-acylglycine	human blood serum metabolite; human urinary metabolite
2-(methylamino)isobutyric acid alpha-(methylamino)isobutyric acid : A non-proteinogenic alpha-amino acid that is isobutyric acid in which the alpha-hydrogen has been replaced by a methylamino group.	2.06	1	alanine derivative; alpha-amino acid zwitterion; non-proteinogenic alpha-amino acid; secondary amino compound	human urinary metabolite
thiazolidine-4-carboxylic acid, (r)-isomer l-4-thiazolidinecarboxylic acid: structure in first source. L-thioproline : An optically active version of thioproline having L-configuration.. thioproline : A sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom.	2.06	1	thiazolidinemonocarboxylic acid; thioproline	geroprotector; metabolite
beta-hydroxyphenylalanine beta-hydroxyphenylalanine: RN given refers to beta cpd	2.31	1
dehydroabietic acid dehydroabietic acid: major aquatic toxicant in effluent of pulp and paper mills. dehydroabietic acid : An abietane diterpenoid that is abieta-8,11,13-triene substituted at position 18 by a carboxy group.. dehydroabietate : A monocarboxylic acid anion that is the conjugate base of dehydroabietic acid, obtained by deprotonation of the carboxy group.	2.31	1	abietane diterpenoid; carbotricyclic compound; monocarboxylic acid	allergen; metabolite
3,4-dehydroproline 3,4-dehydroproline: RN given refers to cpd without stereoisomeric designation	1.98	1
3,4-dihydroxybenzyl alcohol 3,4-dihydroxybenzyl alcohol: structure given in first source	2.31	1
pyrrole-3-carboxylic acid [no description available]	1.98	1	pyrrolecarboxylic acid	metabolite; Penicillium metabolite
proline Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.	2.41	2	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
L-cycloserine L-cycloserine : A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora.	2.06	1	4-amino-1,2-oxazolidin-3-one	anti-HIV agent; anticonvulsant; EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor
prolinol prolinol: RN given refers to cpd without isomeric designation; structure. prolinol : An amino alcohol formed by reduction of the amino acid proline.	2.06	1
quercetin [no description available]	2.31	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
n-methylalanine N-methylalanine: RN given refers to parent cpd(DL-Ala)-isomer. methyl-L-alanine : Any alanine derivative that is L-alanine having one or more methyl groups attached to the amino group.. N-methyl-L-alanine : A methyl-L-alanine in which one of the the amino hydrogen of L-alanine is replaced by a methyl group.	2.06	1	amino acid zwitterion; methyl-L-alanine

Condition	Relationship Strength	Studies
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1

D-proline

Cross-References

Synonyms (60)

Roles (1)

Drug Classes (3)

Pathways (13)

Protein Targets (2)

Potency Measurements

Inhibition Measurements

Biological Processes (10)

Molecular Functions (9)

Ceullar Components (5)

Bioassays (5)

Research

Studies (5)

Market Indicators

Research Demand Index: 39.74

Study Types