| Assay ID | Title | Year | Journal | Article |
|---|
| AID212485 | Concentration required to inhibit 50% activity of Thymidylate synthase was determined | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID212486 | Concentration required for in vitro inhibition of thymidylate synthase | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. |
| AID97636 | Percent control for L1210 cell growth in the presence of thymidine (in vitro) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series. |
| AID93927 | Compound was tested for relative resistance to L1210 (1565) cell line | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID212664 | Inhibition of thymidylate synthase, partially purified from L1210 mouse leukemia cells overexpressing TS | 1992 | Journal of medicinal chemistry, Mar-06, Volume: 35, Issue:5
| Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates. |
| AID58146 | Inhibitory activity against Dihydrofolate reductase in rat liver | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. |
| AID93928 | Compound was tested for relative resistance to L1210 (R7A) cell line | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID21135 | Solubility in 0.92 M aqueous NaH2PO4 buffer at pH 7.0 and 25 degree C | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. |
| AID93925 | Concentration required to inhibit 50% growth of L1210 /1565 mutant mouse leukemia cell line was determined | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID99336 | Relative resistance ratio evaluated for murine tumor L1210:RD1694 cells with 10% horse serum as supplement | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID228250 | Inhibition of thymidylate synthase from L1210 cells | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
| Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues. |
| AID99330 | Inhibition of cell growth in culture against murine tumor L1210:1565 cell lines | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID99331 | Relative resistance ratio evaluated for murine tumor L1210:1565 cells with 10% fetal calf serum as supplement | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID212153 | Inhibitory activity against thymidylate synthase (TS) | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives. |
| AID99335 | Tested for inhibition of cell growth in culture against murine tumor L1210:RD1694 cell lines | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID101072 | Concentration required to inhibit 50 percent growth of L1210 mouse leukemia cells | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. |
| AID98199 | Growth inhibition of murine tumor L1210 cell line | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID98516 | The compound was tested in vitro for the inhibition of L1210 cell growth in culture | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
| Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues. |
| AID94431 | In vitro inhibition of L1210 cell growth in culture. | 1991 | Journal of medicinal chemistry, May, Volume: 34, Issue:5
| Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications. |
| AID212653 | Binding affinity against Thymidylate synthase was measured in vitro | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position. |
| AID212479 | In vitro inhibition of partially purified L1210 thymidylate synthase (TS). | 1991 | Journal of medicinal chemistry, May, Volume: 34, Issue:5
| Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications. |
| AID212492 | In vitro inhibition against L1210 thymidylate synthase (TS) | 1991 | Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
| Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series. |
| AID97899 | The compound was tested for inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cells | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID212478 | Inhibition of partially purified thymidylate synthase (TS) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series. |
| AID100451 | Tested for the concentration to inhibit 50% of L1210 cell growth in culture. | 1991 | Journal of medicinal chemistry, Jul, Volume: 34, Issue:7
| Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series. |
| AID98129 | Growth inhibition of L1210 cells in culture. | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series. |
| AID477806 | Inhibition of thymidylate synthase | 2010 | European journal of medicinal chemistry, Apr, Volume: 45, Issue:4
| 3D-QSAR studies on quinazoline antifolate thymidylate synthase inhibitors by CoMFA and CoMSIA models. |
| AID212643 | Inhibition of isolated thymidylate synthase partially purified from L1210 mouse leukemia cells | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors. |
| AID93926 | Concentration required to inhibit 50% growth of L1210 of R7A mutant mouse leukemia cell line was determined | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID97666 | The compound was tested in vitro for the inhibition of L1210 cell growth in the presence of thymidine | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12
| Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues. |
| AID96477 | Inhibition concentration against L1210 cells | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives. |
| AID100494 | The inhibitory activity was determined on L1210 mouse leukemia cell in presence of thymidine | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| AID100496 | Concentration required to inhibit 50% growth of L1210 mouse leukemia cells was determined | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |