patched binding

Definition

Target type: molecularfunction

Binding to a patched (ptc) protein, a receptor for hedgehog proteins. [GOC:ceb, PMID:11731473]

Patched (PTCH) binding is a molecular interaction that plays a crucial role in regulating the Hedgehog (Hh) signaling pathway, a critical developmental pathway involved in cell growth, differentiation, and patterning in various organisms. PTCH is a transmembrane receptor protein that binds to Hh ligands, effectively inhibiting the downstream signaling pathway. In the absence of Hh ligands, PTCH acts as a repressor, preventing the activation of the Hh signaling pathway.

Upon Hh ligand binding to PTCH, a conformational change occurs in PTCH, leading to its dissociation from its target, Smoothened (SMO). SMO is another transmembrane protein that acts as a downstream mediator of the Hh pathway. The dissociation of PTCH from SMO allows SMO to become active and initiate a cascade of events that ultimately leads to the activation of transcription factors, such as Gli proteins. These transcription factors then regulate the expression of Hh target genes, controlling cell fate and developmental processes.

Therefore, PTCH binding is an essential step in Hh signaling regulation, acting as a molecular switch that controls the activation of the pathway. Disruption of PTCH binding, often through mutations in PTCH or SMO, can lead to developmental defects and various diseases, including cancers.'
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Proteins (3)

Compounds (118)