Compounds > dibenzyl disulfide
Page last updated: 2024-12-05

dibenzyl disulfide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Dibenzyl disulfide (DBDS) is a naturally occurring organosulfur compound found in various plants, including garlic and onion. It exhibits antimicrobial and antioxidant properties, potentially contributing to the health benefits associated with these plants. DBDS is synthesized through the oxidation of benzyl mercaptan. Research focuses on its potential applications in medicine, agriculture, and food preservation due to its antimicrobial and antioxidant properties. For instance, studies have explored its efficacy in inhibiting bacterial growth and reducing oxidative stress in cells. Additionally, DBDS has shown promise as a potential agent for controlling plant diseases and improving food shelf life.'

dibenzyl disulfide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

dibenzyl disulfide : An organic disulfide that results from the formal oxidative dimerisation of benzyl thiol. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID9012
CHEMBL ID121047
CHEBI ID72752
SCHEMBL ID160895
MeSH IDM0473990

Synonyms (77)

Synonym
dibenzyldisulfid
150-60-7
wln: r1ss1r
nsc6841
1,3-dithiabutane
.alpha.-(benzyldithio)toluene
benzyl disulfide
benzyl bisulfide
disulfide, bis(phenylmethyl)
nsc-6841
di(phenylmethyl)disulfide
dibenzyl disulfide
disulfide, dibenzyl
BDS ,
benzyldisulfide
nsc-677465
4,4'-biphenyldiglyoxal disodium bisulfite
fema no. 3617
nsc 6841
dibenzyl disulphide
1,4-diphenyl-2,3-dithiobutane
einecs 205-764-0
di(phenylmethyl) disulfide
alpha-(benzyldithio)toluene
nsc 677465
1,4-diphenyl-2,3-dithiabutane
ccris 6924
dibenzyldisulfid [czech]
bis(phenylmethyl) disulfide
1,1'-[dithiobis(methylene)]dibenzene
inchi=1/c14h14s2/c1-3-7-13(8-4-1)11-15-16-12-14-9-5-2-6-10-14/h1-10h,11-12h
nsc677465
(benzyldisulfanyl)methylbenzene
diphenylmethyl disulfide
GHL.PD_MITSCHER_LEG0.312 ,
dibenzyl disulfide, 98%
benzyl disulfide, 98%, fg
B0417
1,1'-(disulfanediyldimethanediyl)dibenzene
STK831913
CHEMBL121047
chebi:72752 ,
A809057
[(benzyldisulfanyl)methyl]benzene
unii-bg7680605n
bg7680605n ,
AKOS005177808
FT-0624652
dibenzyldisulfide
dailube s 700
benzyl disulfide [fhfi]
benzyl disulfide [usp-rs]
dibenzyl disulfide [mi]
1,2-dibenzyldisulfane
benzyl disulphide
dibenzyldisulphide
dibenzyl-disulfide
SCHEMBL160895
DTXSID6059738
[(benzyldisulfanyl)methyl]benzene #
dibenzyl disulfide, analytical standard
mfcd00004783
benzyl disulfide, united states pharmacopeia (usp) reference standard
bis(phenylmethyl) disulfide, 9ci
benzyldisulfanyl-methyl-benzene
fema 3617
benzyl disulfide, 8ci
benzyl disulfide (8ci)
J-008720
Q27140119
CS-W010232
D77707
HY-W009516
EN300-16500
dibenzyl disulfide 2 microg/ml in transformer oil
dibenzyl disulfide 10 microg/ml in transformer oil
Z55949860
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
organic disulfideCompounds of structure RSSR in which R and R' are organic groups.
organic aromatic compound
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID89802Inhibition of HIV-1 replication in a proliferating human T-cell line assayed using an XTT assay.1996Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
AID681123TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytes1999The Biochemical journal, Aug-01, Volume: 341 ( Pt 3)Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes.
AID681133TP_TRANSPORTER: inhibition of lactate uptake in Xenopus laevis oocytes1999The Biochemical journal, Aug-01, Volume: 341 ( Pt 3)Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes.
AID89654Inhibition of HIV-1 replication in human T-cell by using XTT assay; Inactive1996Journal of medicinal chemistry, Sep-13, Volume: 39, Issue:19
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's3 (33.33)29.6817
2010's2 (22.22)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.15 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.01 (4.65)
Search Engine Demand Index40.85 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (35.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
alpha-ketoisovalerate
alpha-ketoisovalerate: RN given refers to parent cpd. 3-methyl-2-oxobutanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 3-methyl-2-oxobutanoic acid, arising from deprotonation of the carboxy group.. 3-methyl-2-oxobutanoic acid : A 2-oxo monocarboxylic acid that is the 2-oxo derivative of isovaleric acid.		2102-oxo monocarboxylic acid;
branched-chain keto acid		human metabolite;
Saccharomyces cerevisiae metabolite
2-keto-4-methylvalerate
alpha-ketoisocaproic acid: RN given refers to parent cpd. 4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.. 4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.		2102-oxo monocarboxylic acid;
branched-chain keto acid		algal metabolite;
human metabolite
acetoacetic acid
acetoacetic acid : A 3-oxo monocarboxylic acid that is butyric acid bearing a 3-oxo substituent.		2103-oxo fatty acid;
ketone body		metabolite
3-hydroxybutyric acid
3-Hydroxybutyric Acid: BUTYRIC ACID substituted in the beta or 3 position. It is one of the ketone bodies produced in the liver.. 3-hydroxybutyric acid : A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.		210(omega-1)-hydroxy fatty acid;
3-hydroxy monocarboxylic acid;
hydroxybutyric acid		human metabolite
pyruvic acid
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed). pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.		2102-oxo monocarboxylic acidcofactor;
fundamental metabolite
selenious acid
Selenious Acid: A selenium compound with the molecular formula H2SO3. It used as a source of SELENIUM, especially for patients that develop selenium deficiency following prolonged PARENTERAL NUTRITION.		2.0210selenium oxoacid
mandelic acid
SAMMA: mandelic acid condensation polymer		2102-hydroxy monocarboxylic acid;
benzenes		antibacterial agent;
human xenobiotic metabolite
5,8,11,14-eicosatetraynoic acid
5,8,11,14-Eicosatetraynoic Acid: A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).		210long-chain fatty acid
9-anthroic acid
9-anthroic acid: RN given refers to unlabeled parent cpd; chloride channel blocker; do not confuse with c-ANCA (anti-neutrophil cytoplasmic antibodies) which is frequently abbreviated as ANCA. 9-anthroic acid : An anthroic acid carrying the carboxy substituent at position 9.		210anthroic acid
benzbromarone
Benzbromarone: Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.. benzbromarone : 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.		2101-benzofurans;
aromatic ketone		uricosuric drug
disulfiram
[no description available]		1.9910organic disulfide;
organosulfur acaricide		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor;
EC 3.1.1.1 (carboxylesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
ferroptosis inducer;
fungicide;
NF-kappaB inhibitor
niflumic acid
Niflumic Acid: An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.		210aromatic carboxylic acid;
pyridines
5-nitro-2-(3-phenylpropylamino)benzoic acid
5-nitro-2-(3-phenylpropylamino)benzoic acid: structure given in first source; chloride channel antagonist		210nitrobenzoic acid
phloretin
[no description available]		210dihydrochalconesantineoplastic agent;
plant metabolite
probenecid
Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.. probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.		210benzoic acids;
sulfonamide		uricosuric drug
thiram
Thiram: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.. thiram : An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.		1.9910organic disulfideantibacterial drug;
antifungal agrochemical;
antiseptic drug
tert-butylhydroperoxide
tert-Butylhydroperoxide: A direct-acting oxidative stress-inducing agent used to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. It is also used as a catalyst in polymerization reactions and to introduce peroxy groups into organic molecules.. tert-butyl hydroperoxide : An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.		2.0210alkyl hydroperoxideantibacterial agent;
oxidising agent
bis(1-piperidylthiocarbonyl)disulfide
bis(1-piperidylthiocarbonyl)disulfide: indicator for analysis of copper; structure		1.9910
dithiodibenzoic acid
[no description available]		1.9910
dixanthogen
[no description available]		1.9910thiocarbonyl compound
benzyl sulfide
[no description available]		2.7730
diphenyl disulfide
[no description available]		2.0510benzenes
2,2'-diaminodiphenyldisulfide
2,2'-diaminodiphenyldisulfide: resin hardener		1.9910
2,2'-dithiobis(5-nitropyridine)
2,2'-dithiobis(5-nitropyridine): structure		1.9910
bromine
Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.		7.610diatomic bromine
d-lactic acid
(R)-lactic acid : An optically active form of lactic acid having (R)-configuration.		2102-hydroxypropanoic acidEscherichia coli metabolite;
human metabolite
2,2'-dipyridyl disulfide
2,2'-dipyridyl disulfide: disulfide is an important moiety in this cpd. aldrithiol : A member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols.		1.9910organic disulfide;
pyridines		oxidising agent
4-phenylbenzoic acid
4-phenylbenzoic acid: RN given refers to 4-carboxylic cpd		210
1-adamantaneacetic acid
[no description available]		210
quercetin
[no description available]		2107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
4,4'-dinitro-2,2'-stilbenedisulfonic acid
4,4'-dinitro-2,2'-stilbenedisulfonic acid: RN given refers to parent cpd without isomeric designation		2104,4'-dinitrostilbene-2,2'-disulfonic acid
alpha-cyano-4-hydroxycinnamic acid
alpha-cyano-4-hydroxycinnamic acid : A monohydroxycinnamic acid that is 4-hydroxycinnamic acid in which the hydrogen alpha- to the carboxy group is replaced by a cyano group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of peptides and oligonucleotides.		210monohydroxycinnamic acid;
nitrile;
phenols		MALDI matrix material
tellurium
Tellurium: An element that is a member of the chalcogen family. It has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.		2.0210chalcogen;
metalloid atom
ConditionIndicatedRelationship StrengthStudiesTrials
Extravascular Hemolysis
[description not available]		02.0110
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		02.0110