inositol 1,4,5 trisphosphate binding

Definition

Target type: molecularfunction

Binding to inositol 1,4,5 trisphosphate. [GOC:BHF, GOC:mah]

Inositol 1,4,5-trisphosphate (IP3) binding is a crucial molecular function involved in intracellular signaling pathways. IP3, a second messenger, is generated from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C (PLC). Upon binding to its receptor, IP3 receptor (IP3R), located on the endoplasmic reticulum (ER) membrane, IP3 triggers the release of calcium ions (Ca2+) from the ER lumen into the cytoplasm. This Ca2+ release initiates a cascade of downstream signaling events that regulate various cellular processes, including muscle contraction, neurotransmitter release, cell proliferation, and apoptosis.

The IP3 binding domain (IBD) of IP3R is a highly conserved region that specifically recognizes and binds to IP3. This binding event triggers a conformational change in the IP3R, opening a channel that allows Ca2+ to flow from the ER lumen into the cytoplasm. The affinity of IP3 binding to the IP3R is crucial for regulating the release of Ca2+, and it is modulated by factors such as the concentration of IP3, Ca2+, and other cellular components.

IP3 binding is a dynamic process, and the duration of IP3R activation is tightly controlled by various mechanisms, including dephosphorylation of IP3 by phosphatases, degradation of IP3, and feedback inhibition by Ca2+. The fine-tuned regulation of IP3 binding and Ca2+ release ensures the precise control of cellular processes and responses to external stimuli.'
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Proteins (8)

Compounds (13)