Page last updated: 2024-10-24

inositol 1,4,5 trisphosphate binding

Definition

Target type: molecularfunction

Binding to inositol 1,4,5 trisphosphate. [GOC:BHF, GOC:mah]

Inositol 1,4,5-trisphosphate (IP3) binding is a crucial molecular function involved in intracellular signaling pathways. IP3, a second messenger, is generated from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C (PLC). Upon binding to its receptor, IP3 receptor (IP3R), located on the endoplasmic reticulum (ER) membrane, IP3 triggers the release of calcium ions (Ca2+) from the ER lumen into the cytoplasm. This Ca2+ release initiates a cascade of downstream signaling events that regulate various cellular processes, including muscle contraction, neurotransmitter release, cell proliferation, and apoptosis.

The IP3 binding domain (IBD) of IP3R is a highly conserved region that specifically recognizes and binds to IP3. This binding event triggers a conformational change in the IP3R, opening a channel that allows Ca2+ to flow from the ER lumen into the cytoplasm. The affinity of IP3 binding to the IP3R is crucial for regulating the release of Ca2+, and it is modulated by factors such as the concentration of IP3, Ca2+, and other cellular components.

IP3 binding is a dynamic process, and the duration of IP3R activation is tightly controlled by various mechanisms, including dephosphorylation of IP3 by phosphatases, degradation of IP3, and feedback inhibition by Ca2+. The fine-tuned regulation of IP3 binding and Ca2+ release ensures the precise control of cellular processes and responses to external stimuli.'
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Proteins (8)

ProteinDefinitionTaxonomy
Inositol 1,4,5-trisphosphate receptor type 2An inositol 1,4,5-trisphosphate receptor type 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14571]Homo sapiens (human)
Short transient receptor potential channel 5A short transient receptor potential channel 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UL62]Homo sapiens (human)
Short transient receptor potential channel 7A short transient receptor potential cation channel TRPC7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HCX4]Homo sapiens (human)
Short transient receptor potential channel 6A short transient receptor potential channel 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y210]Homo sapiens (human)
Inositol 1,4,5-trisphosphate receptor type 1An inositol 1,4,5-trisphosphate receptor type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14643]Homo sapiens (human)
Inositol 1,4,5-trisphosphate receptor type 3An inositol 1,4,5-trisphosphate receptor type 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14573]Homo sapiens (human)
Short transient receptor potential channel 3A short transient receptor potential cation channel TRPC3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13507]Homo sapiens (human)
Short transient receptor potential channel 1A short transient receptor potential channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48995]Homo sapiens (human)

Compounds (13)

CompoundDefinitionClassesRoles
ym 58483
clemizoleclemizole : A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.

clemizole: was heading 1966-94 (see under BENZIMIDAZOLES 1966-90); use BENZIMIDAZOLES to search CLEMIZOLE 1966-94; a histamine H1- blocker used to treat allergies
benzimidazoles;
monochlorobenzenes;
pyrrolidines
histamine antagonist
N-butyl-1H-benzimidazol-2-aminebenzimidazoles
inositol 1,4,5-trisphosphateInositol 1,4,5-Trisphosphate: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.myo-inositol trisphosphatemouse metabolite
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
apigeninChamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.trihydroxyflavoneantineoplastic agent;
metabolite
luteolin3'-hydroxyflavonoid;
tetrahydroxyflavone
angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
kaempferol7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone
antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
galangin5,7-dihydroxyflavonol: antimicrobial from the twigs of Populus nigra x Populus deltoides; structure in first source

galangin : A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.
7-hydroxyflavonol;
trihydroxyflavone
antimicrobial agent;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
plant metabolite
myricetin7-hydroxyflavonol;
hexahydroxyflavone
antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
4-[3-(4-fluorophenyl)-2-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]-1-piperidinecarboxylic acid ethyl esterpyrazoles;
ring assembly
englerin acinnamate ester;
glycolate ester;
guaiane sesquiterpenoid
antineoplastic agent;
metabolite
ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1h-pyrazole-4-carboxylateethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate: structure in first source