GABAB receptor agonist

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ChEBI ID: 143001

Members (1)

Member	Definition	Class
3-aminopropylphosphonic acid	A phosphonic acid in which the hydrogen attached to the phosphorus of phosphonic acid is substituted by a 3-aminopropyl group. It is a partial agonist of GABAB receptors.	(3-aminopropyl)phosphonic acid zwitterion; (3-aminopropyl)phosphonic acid

Research

Studies (43)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	6 (13.95)	18.7374
1990's	14 (32.56)	18.2507
2000's	7 (16.28)	29.6817
2010's	10 (23.26)	24.3611
2020's	6 (13.95)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	3 (6.98%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	40 (93.02%)	84.16%

Protein Targets (31)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	0.5623	2	2
chromobox protein homolog 1	Homo sapiens (human)	Potency	0.0024	1	1
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	0.1585	2	2
endonuclease IV	Escherichia coli	Potency	7.9433	1	1
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	0.1585	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	0.0050	1	1
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	10.0000	1	1
NFKB1 protein, partial	Homo sapiens (human)	Potency	0.1122	2	2
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	95.2834	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	5.3233	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
1-deoxy-D-xylulose 5-phosphate reductoisomerase	Escherichia coli K-12	Ki	4,000.0000	1	1
Gamma-aminobutyric acid type B receptor subunit 1	Rattus norvegicus (Norway rat)	IC50	6.8100	1	2
Gamma-aminobutyric acid type B receptor subunit 2	Rattus norvegicus (Norway rat)	IC50	6.8100	1	2

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Gamma-aminobutyric acid receptor subunit rho-1	Homo sapiens (human)	Kb	10.0000	1	1
Gamma-aminobutyric acid receptor subunit rho-2	Homo sapiens (human)	Kb	10.0000	1	1
Gamma-aminobutyric acid receptor subunit rho-3	Homo sapiens (human)	Kb	10.0000	1	1