Compounds > octyl dodecanol
Page last updated: 2024-12-06

octyl dodecanol

Description

octyl dodecanol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID21414
CHEMBL ID1572050
SCHEMBL ID4873
MeSH IDM0427564

Synonyms (77)

Synonym
2-octyl-1-dodecanol
nsc-2405
5333-42-6
1-dodecanol, 2-octyl-
standamul g
nsc2405
eutanol g
2-octyldodecanol
exxal 20
kalcohl 200g
isofol 20
octyldodecanol
2-octyl dodecanol
2-octyldodecan-1-ol
brn 1763479
octyl dodecanol
rilanit g 20
ai3-19966
nsc 2405
kalcohl 200gd
einecs 226-242-9
2-octyldodecyl alcohol
2-octyl-1-dodecanol, 97%
NCGC00166213-01
cas-5333-42-6
NCGC00255681-01
dtxsid3036288 ,
dtxcid1016288
tox21_302294
tox21_112351
C20338
CHEMBL1572050
octyldodecanol [nf]
3-01-00-01844 (beilstein handbook reference)
unii-461n1o614y
461n1o614y ,
ec 226-242-9
AKOS015912966
octyldodecanol [ep monograph]
2-octyldodecanol, (+/-)-
octyldodecanol [usp-rs]
octyldodecanol [who-dd]
octyldodecanol [ii]
(+/-)-2-octyldodecanol
octyldodecanol [inci]
octyldodecanol [mart.]
octyldodecanol [mi]
SCHEMBL4873
NCGC00166213-02
tox21_112351_1
2-octyl-dodecanol
jarcol i 20
guerbet c20
michel xo-150-20
fine oxocol 2000
risonol 20sp
ohv 180
BP-30229
2-n-octyl-1-dodecanol
O0429
mfcd01310428
FT-0699733
2-octyldodecane-1-ol
2-octildodecanol
SR-01000944811-1
sr-01000944811
octyldodecanol, united states pharmacopeia (usp) reference standard
octyldodecanol, european pharmacopoeia (ep) reference standard
octyldodecanol, pharmaceutical secondary standard; certified reference material
CS-W021736
DS-6274
DB14134
D77924
Q27258886
A870757
EN300-373383
8039-11-0

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Only limited safety test data were available on Octyldodecyl Stearoyl Stearate, but previous safety assessments of long-chain alcohols and fatty acids found these precursors to be safe for use in cosmetic formulations."( Final report on the safety assessment of Octyidodecyl Stearoyl Stearate.
Lanigan, RS, 2001)		0.31

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (30 Product(s))

Product Categories

Product CategoryProducts
Beauty & Personal Care27
Herbs, Botanicals & Homeopathy3

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
All Good Tinted Mineral Sunscreen Butter Tin SPF 50 -- 1 fl ozAll GoodBeauty & Personal Carevitamin E, vitamin E, octyldodecanol2024-11-29 10:47:42
Aquaphor Lip Repair Immediate Relief -- 0.35 fl ozAquaphorBeauty & Personal Careglyceryl oleate, ascorbyl palmitate, bisabolol, tocopherol, panthenol, tocopherol, glyceryl stearate, glycerin, magnesium sulfate, Octyldodecanol2024-11-29 10:47:42
Babe Original Intensifying Lash Primer -- 0.21 ozBabe OriginalBeauty & Personal Carecaprylyl glycol, aminomethyl propanol, panthenol, ethylhexylglycerin, glyceryl stearate, glycerin, pvp, octyldodecanol, phenoxyethanol, stearic acid2024-11-29 10:47:42
Earth Therapeutics Green Tea Hydrogel Under-Eye Patch -- 5 Under-Eye PatchesEarth TherapeuticsBeauty & Personal Carebutylene glycol, allantoin, disodium EDTA, glycerin, kaolin, octyldodecanol, phenoxyethanol, sorbitol, tartaric acid, titanium dioxide2024-11-29 10:47:42
Eucerin Advanced Repair Creme - Fragrance Free -- 16 ozEucerinBeauty & Personal CareAlanine, Ceramide 3, Cetearyl Alcohol, Glycerin, Glycine, Dimethicone, Lactic Acid, Octyldodecanol, Phenoxyethanol, Sodium Lactate, Urea2024-11-29 10:47:42
Eucerin Advanced Repair Light Feel Foot Creme Fragrance Free -- 3 ozEucerinBeauty & Personal Carecarbomer, cetearyl alcohol, glycerin, dimethicone, lactic acid, octenylsuccinate, octyldodecanol, sodium lactate, urea2024-11-29 10:47:42
Eucerin Daily Hydration Moisturizing Lotion Fragrance Free -- 16.9 fl ozEucerinBeauty & Personal Carecarbomer, cetearyl alcohol, panthenol, glycerin, dimethicone, octyldodecanol, phenoxyethanol, sodium hydroxide, stearic acid2024-11-29 10:47:42
Eucerin Q10 Anti-Wrinkle Face Cream Sensitive Skin Fragrance Free -- 1.7 ozEucerinBeauty & Personal Carebutylene glycol, beta-carotene, biotin, carbomer, cetyl alcohol, tocopherol, dehydroacetic acid, tocopherol, glycerin, octyldodecanol, sodium hydroxide, stearyl alcohol, ubiquinone2024-11-29 10:47:42
Eucerin Skin Calming Daily Moisturizing Creme -- 8 ozEucerinBeauty & Personal Carebenzyl alcohol, carbomer, cetyl alcohol, cetyl palmitate, glyceryl stearate, glycerin, dimethicone, octyldodecanol, phenoxyethanol, piroctone olamine, PEG-40 stearate2024-11-29 10:47:42
Eucerin Skin Calming Daily Moisturizing Creme Fragrance Free -- 14 ozEucerinBeauty & Personal Caremethylpropanediol, benzyl alcohol, carbomer, cetyl alcohol, cetyl palmitate, glyceryl stearate, glycerin, dimethicone, octyldodecanol, phenoxyethanol, piroctone olamine, PEG-40 stearate2024-11-29 10:47:42
Hempz Scalp Care Herbal Conditioner Tea Tree & Chamomile -- 17 fl ozHempzBeauty & Personal Careaminomethyl propanol, iodopropynyl butylcarbamate, citric acid, acetic acid, cetearyl alcohol, cetyl alcohol, chlorphenesin, citric acid, tocopherol, panthenol, disodium EDTA, etidronic acid, tocopherol, glycerin, PEG-4, dimethicone, hydroxyethylcellulose, menthol, octyldodecanol, phenoxyethanol, laureth-9, sodium acetate, stearyl alcohol2024-11-29 10:47:42
Hempz Triple Moisture Herbal Conditioner Fresh Citrus -- 17 fl ozHempzBeauty & Personal Careiodopropynyl butylcarbamate, citric acid, acetic acid, benzyl benzoate, cetearyl alcohol, cetyl alcohol, chlorphenesin, citric acid, tocopherol, panthenol, disodium EDTA, etidronic acid, tocopherol, glycerin, PEG-4, dimethicone, hydroxyethylcellulose, limonene, linalool, octyldodecanol, phenoxyethanol, sodium acetate, sodium benzoate, stearyl alcohol2024-11-29 10:47:42
Honeybee Gardens Royal Lip Elixir - Flutter -- 0.16 fl ozHoneybee GardensBeauty & Personal Careethylhexylglycerin, octyldodecanol, phenoxyethanol, titanium dioxide2024-11-29 10:47:42
Mad Hippie Sheer Tint Sun Serum SPF 29 Light-Medium -- 1.02 fl ozMad HippieBeauty & Personal Carecaprylyl glycol, maltose, bisabolol, cetearyl alcohol, tocopherol, decyl glucoside, ethyl ferulate, ferulic acid, tocopherol, sodium gluconate, glycerin, octyldodecanol, resveratrol, squalane2024-11-29 10:47:42
Mad Hippie Sheer Tint Sun Serum SPF 29 Medium-Dark -- 1.02 fl ozMad HippieBeauty & Personal Carecaprylyl glycol, maltose, bisabolol, cetearyl alcohol, tocopherol, decyl glucoside, ethyl ferulate, ferulic acid, tocopherol, sodium gluconate, glycerin, octyldodecanol, resveratrol, squalane2024-11-29 10:47:42
Mineral Fusion Sheer Moisture Lip Tint - Confident -- 0.1 ozMineral FusionBeauty & Personal Carecarmine, CI 75470, tocopherol, tocopherol, glyceryl behenate, limonene, octyldodecanol, titanium dioxide2024-11-29 10:47:42
Mineral Fusion Sheer Moisture Lip Tint - Courageous -- 0.1 ozMineral FusionBeauty & Personal Carecarmine, CI 75470, tocopherol, tocopherol, glyceryl behenate, limonene, octyldodecanol, titanium dioxide2024-11-29 10:47:42
MyChelle Dermaceuticals Hydrate 3-in-1 Super Serum SPF 30 - Light -- 1 fl ozMyChelle DermaceuticalsBeauty & Personal Carecaprylyl glycol, maltose, cetearyl alcohol, cetyl alcohol, tocopherol, tocopherol, sodium gluconate, glycerin, octyldodecanol, squalane2024-11-29 10:47:42
MyChelle Dermaceuticals Hydrate 3-in-1 Super Serum SPF 30 - Medium Dark -- 1 fl ozMyChelle DermaceuticalsBeauty & Personal Carecaprylyl glycol, maltose, cetearyl alcohol, cetyl alcohol, tocopherol, tocopherol, sodium gluconate, glycerin, octyldodecanol, squalane2024-11-29 10:47:42
MyChelle Dermaceuticals Protect Sun Shield Liquid Sunscreen SPF 30 Light-Medium -- 1 ozMyChelle DermaceuticalsBeauty & Personal Carecaprylyl glycol, maltose, bisabolol, cetearyl alcohol, tocopherol, ethyl ferulate, tocopherol, sodium gluconate, glycerin, octyldodecanol2024-11-29 10:47:42
MyChelle Dermaceuticals Protect Sun Shield Liquid Sunscreen SPF 30 Medium-Dark -- 1 ozMyChelle DermaceuticalsBeauty & Personal Carecaprylyl glycol, maltose, bisabolol, cetearyl alcohol, tocopherol, ethyl ferulate, tocopherol, sodium gluconate, glycerin, octyldodecanol2024-11-29 10:47:42
Ollois Ollopain Arnica Bundle OlloPain Cream + Arnica 30c -- 4 ozOlloisHerbs, Botanicals & HomeopathyCarbomer, Cetearyl Alcohol, Cetyl Alcohol, Cetyl Palmitate, Diazolidinyl Urea, Glyceryl Stearate, Glycerin, Isopropyl Myristate, Isopropyl Palmitate, Octyldodecanol, Sodium Benzoate2024-11-29 10:47:42
Pacifica Dream Big Brushed Up Brows - Light -- 0.19 ozPacificaBeauty & Personal Careaminomethyl propanol, cellulose, ethylhexylglycerin, glyceryl stearate, glycerin, octyldodecanol, phenoxyethanol, stearic acid, CI 778912024-11-29 10:47:42
Pacifica Vegan Collagen Fluffy Mascara -- 0.24 ozPacificaBeauty & Personal Careaminomethyl propanol, cellulose, glyceryl stearate, glycerin, octyldodecanol, stearic acid2024-11-29 10:47:42
Terry Naturally Traumaplant Comfrey Cream -- 1.76 ozTerry NaturallyHerbs, Botanicals & Homeopathycomfrey, glyceryl stearate, glycol salicylate, dimethicone, octyldodecanol, propylene glycol, sorbic acid2024-11-29 10:47:42
Terry Naturally Traumaplant Comfrey Cream -- 3.53 ozTerry NaturallyHerbs, Botanicals & Homeopathycomfrey, glyceryl stearate, glycol salicylate, dimethicone, isopropyl myristate, octyldodecanol, propylene glycol, sorbic acid2024-11-29 10:47:42
The Organic Skin Co The Only Glow Tinted Face Oil - Deep -- 1 fl ozThe Organic Skin CoBeauty & Personal Carelotus, tocopherol, and, tocopherol, kaolin, octyldodecanol, CI 778912024-11-29 10:47:42
The Organic Skin Co The Only Glow Tinted Face Oil - Light -- 1 fl ozThe Organic Skin CoBeauty & Personal Carelotus, tocopherol, and, tocopherol, kaolin, octyldodecanol, CI 778912024-11-29 10:47:42
The Organic Skin Co The Only Glow Tinted Face Oil - Medium -- 1 fl ozThe Organic Skin CoBeauty & Personal Carelotus, tocopherol, and, tocopherol, kaolin, octyldodecanol, CI 778912024-11-29 10:47:42
Vitabath Original Spring Green Moisturizing Lotion -- 20 fl ozVitabathBeauty & Personal Careallantoin, carbomer, creatine, glyceryl stearate, dimethicone, isopropyl palmitate, octyldodecanol, propylene glycol, retinyl palmitate, stearic acid, triethanolamine2024-11-29 10:47:42

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
RAR-related orphan receptor gammaMus musculus (house mouse)Potency10.63760.006038.004119,952.5996AID1159521; AID1159523
USP1 protein, partialHomo sapiens (human)Potency19.95260.031637.5844354.8130AID504865
GLI family zinc finger 3Homo sapiens (human)Potency21.13170.000714.592883.7951AID1259369
AR proteinHomo sapiens (human)Potency55.93330.000221.22318,912.5098AID1259243; AID1259247
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency24.54120.001019.414170.9645AID743191
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency5.353819.739145.978464.9432AID1159509
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency14.12540.01789.637444.6684AID588834
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency13.33220.000627.21521,122.0200AID743202
lamin isoform A-delta10Homo sapiens (human)Potency0.02510.891312.067628.1838AID1487
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (34)

Assay IDTitleYearJournalArticle
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347425Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347407qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347424RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (4.55)18.7374
1990's2 (9.09)18.2507
2000's6 (27.27)29.6817
2010's7 (31.82)24.3611
2020's6 (27.27)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 68.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index68.59 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index5.07 (4.65)
Search Engine Demand Index112.01 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (68.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.17%)6.00%
Case Studies4 (16.67%)4.05%
Observational0 (0.00%)0.25%
Other19 (79.17%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
clotrimazole
[no description available]		2.3820conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes		antiinfective agent;
environmental contaminant;
xenobiotic
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		1.9710aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
ethylene
Plastipore: high density polyethylene sponge biocompatible material; used as posts in dental bridges		2.0310alkene;
gas molecular entity		plant hormone;
refrigerant
tromethamine
Tromethamine: An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)		2.0310primary amino compound;
triol		buffer
vinyl acetate
[no description available]		2.0310acetate ester
isopropyl palmitate
isopropyl palmitate : A fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan-2-ol. Metabolite observed in cancer metabolism.		2.0110fatty acid ester;
isopropyl ester		human metabolite
oleic acid
Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.		2.0110octadec-9-enoic acidantioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent
quercetin
[no description available]		2.13107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
genistein
[no description available]		2.07107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
cellulose
DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.		2.4220glycoside
stearates
Stearates: Salts and esters of the 18-carbon saturated, monocarboxylic acid--stearic acid.		3.110
ethyl cellulose
[no description available]		2.4220glycoside
ConditionIndicatedRelationship StrengthStudiesTrials
Congenital Zika Syndrome
[description not available]		02.2510
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2510
Zika Virus Infection
A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.		02.2510
Contact Dermatitis
[description not available]		01.9610
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.		01.9610
Allergic Contact Dermatitis
[description not available]		02.730
Dermatitis, Eczematous
[description not available]		01.9910
Eczema
A pruritic papulovesicular dermatitis occurring as a reaction to many endogenous and exogenous agents (Dorland, 27th ed).		01.9910
Dermatitis, Allergic Contact
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.		02.730
Dermatitis Medicamentosa
[description not available]		02.0110
Genital Diseases, Male
Pathological processes involving the male reproductive tract (GENITALIA, MALE).		02.0110
Eye Disorders
[description not available]		02.9210
Dermatoses
[description not available]		02.9210
Eye Diseases
Diseases affecting the eye.		02.9210
Skin Diseases
Diseases involving the DERMIS or EPIDERMIS.		02.9210
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