Compounds > cryptocaryone
Page last updated: 2024-11-12

cryptocaryone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

cryptocaryone: inhibitor of the NF-kappaB activation pathway from Cryptocarya rugulosa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
CryptocaryagenusA plant genus of the family LAURACEAE. Members contain cryptofolione, caryachine, grandisin and other compounds. Some PEUMUS species have been reclassified as CRYPTOCARYA.[MeSH]LauraceaeA family of mainly aromatic evergreen plants in the order Laurales. The laurel family includes 2,200 species in 45 genera and from these are derived medicinal extracts, essential oils, camphor and other products.[MeSH]

Cross-References

ID SourceID
PubMed CID10379026
CHEMBL ID1782085
CHEBI ID184734
MeSH IDM0545451

Synonyms (11)

Synonym
CHEMBL1782085
cryptocaryone
(3ar,4z,7as)-4-[(e)-1-hydroxy-3-phenylprop-2-enylidene]-3a,7a-dihydro-3h-1-benzouran-2,5-dione
CHEBI:184734
(4z)-3a,4-dihydro-4-((e)-1-hydroxy-3-phenylallylidene)benzofuran-2,5(3h,7ah)-dione
nsc-752463
nsc752463
39012-05-0
(3ar,4z,7as)-4-[(e)-1-hydroxy-3-phenyl-prop-2-enylidene]-3a,7a-dihydro-3h-benzofuran-2,5-dione
DTXSID60439014
(3ar,4z,7as)-4-[(e)-1-hydroxy-3-phenylprop-2-enylidene]-3a,7a-dihydro-3h-1-benzofuran-2,5-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzofurans
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID600598Induction of IkappaB in human OCI-LY3 cells assessed as fold increase in luciferase reporter gene after 10 hrs2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa.
AID1425904Cytotoxicity against mouse P388 cells by MTT assay2016MedChemComm, Sep-01, Volume: 7, Issue:9
Anticancer agents interacting with membrane glucose transporters.
AID600596Induction of IkappaB in human OCI-LY3 cells assessed as fold increase in luciferase reporter gene at 16 uM2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa.
AID1073030Cytotoxicity against human HT-29 cells2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Constituents of an extract of Cryptocarya rubra housed in a repository with cytotoxic and glucose transport inhibitory effects.
AID600597Induction of IkappaB in human OCI-LY3 cells assessed as fold increase in luciferase reporter gene2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa.
AID600594Cytotoxicity against human K562 cells2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa.
AID682812Cytotoxicity against human DU145 cells after 48 hrs by alamar blue assay2012ACS medicinal chemistry letters, Jun-14, Volume: 3, Issue:6
Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling.
AID1073031Cytotoxicity against mouse P388 cells2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Constituents of an extract of Cryptocarya rubra housed in a repository with cytotoxic and glucose transport inhibitory effects.
AID1073029Inhibition of GLUT-1 in human H1299 cells assessed as 2-deoxy-D-[3H]glucose uptake at 30 uM incubated for 15 mins prior to 2-deoxy-D-[3H]glucose challenge measured after 10 mins by liquid scintillation counting analysis (Rvb = 100%)2014Journal of natural products, Mar-28, Volume: 77, Issue:3
Constituents of an extract of Cryptocarya rubra housed in a repository with cytotoxic and glucose transport inhibitory effects.
AID600592Cytotoxicity against human KB cells2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa.
AID1425903Cytotoxicity against human HT-29 cells by MTT assay2016MedChemComm, Sep-01, Volume: 7, Issue:9
Anticancer agents interacting with membrane glucose transporters.
AID1425905Cytotoxicity against human PC3 cells after 48 hrs by SRB assay2016MedChemComm, Sep-01, Volume: 7, Issue:9
Anticancer agents interacting with membrane glucose transporters.
AID600593Cytotoxicity against doxorubicin-resistant human K562 cells2009Journal of natural products, Mar-27, Volume: 72, Issue:3
Inhibitors of the NF-kappaB activation pathway from Cryptocarya rugulosa.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's8 (80.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.78 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gossypol
Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.		2.1310
iridium
Iridium: A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.		2.0510cobalt group element atom;
platinum group metal atom
tiletamine hydrochloride
Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.		2.0510
silybin
silibinin : A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.		2.1310aromatic ether;
benzodioxine;
flavonolignan;
polyphenol;
secondary alpha-hydroxy ketone		antineoplastic agent;
antioxidant;
hepatoprotective agent;
plant metabolite
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.110taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
pinocembrin
pinocembrin : A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.		2.4720(2S)-flavan-4-one;
dihydroxyflavanone		antineoplastic agent;
antioxidant;
metabolite;
neuroprotective agent;
vasodilator agent
naringenin
(S)-naringenin : The (S)-enantiomer of naringenin.		2.1310(2S)-flavan-4-one;
naringenin		expectorant;
plant metabolite
xanthohumol
xanthohumol: from hop plant, Humulus lupulus. xanthohumol : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells.		2.1310aromatic ether;
chalcones;
polyphenol		anti-HIV-1 agent;
antineoplastic agent;
antiviral agent;
apoptosis inducer;
EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor;
metabolite
stf-31
STF-31: antineoplastic		2.1310
quercetin
[no description available]		2.13107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
kaempferol
[no description available]		2.13107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
genistein
[no description available]		2.13107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
myricetin
[no description available]		2.13107-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
glucopiericidin a
glucopiericidin A: from Streptomyces pactum S48727 as co-metabolite of piericidin A(1); structure given in first source; glycoside antibiotic		2.1310
wzb117
WZB117: structure in first source		2.5220
methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1h-indole-2-carboxylate
methyl 1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate: inhibits lactate dehydrogenase A; structure in first source		2.1310
rugulactone
rugulactone: inhibitor of the NF-kappaB activation pathway from Cryptocarya rugulosa; structure in first source		2.0510
8-hydroxy-2'-deoxyguanosine
8-Hydroxy-2'-Deoxyguanosine: Common oxidized form of deoxyguanosine in which C-8 position of guanine base has a carbonyl group.. 8-hydroxy-2'-deoxyguanosine : Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.		2.4110guanosinesbiomarker
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Mouth
[description not available]		02.6120
Mouth Neoplasms
Tumors or cancer of the MOUTH.		02.6120
Cancer of Prostate
[description not available]		02.0510
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0510