ugonin K: an antioxidant; isolated from the rhizomes of Helminthostachys zeylanica [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Helminthostachys | genus | [no description available] | Ophioglossaceae | [no description available] |
| Helminthostachys zeylanica | species | [no description available] | Ophioglossaceae | [no description available] |
| ID Source | ID |
|---|---|
| PubMed CID | 12114698 |
| CHEMBL ID | 563689 |
| MeSH ID | M0536061 |
| Synonym |
|---|
| CHEMBL563689 |
| ugonin k |
| 2-(3,4-dihydroxyphenyl)-6-[[(1s)-2,2-dimethyl-6-methylidenecyclohexyl]methyl]-5-hydroxy-7-methoxychromen-4-one |
Ugonin K is a flavonoid isolated from the roots of Helminthostachys zeylanica, a folk medicine used to strengthen bone mass and cure bone fracture.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Ugonin K is a flavonoid isolated from the roots of Helminthostachys zeylanica, a folk medicine used to strengthen bone mass and cure bone fracture. " | ( Ugonin K promotes osteoblastic differentiation and mineralization by activation of p38 MAPK- and ERK-mediated expression of Runx2 and osterix. Chiou, WF; Huang, YL; Lee, CH; Liao, JF, 2011) | 3.25 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Pretreatment with ugonin K attenuated H(2)O(2)-induced cell death in a dose-dependent manner." | ( Neuroprotective effects of ugonin K on hydrogen peroxide-induced cell death in human neuroblastoma SH-SY5Y cells. Chen, SC; Gean, PW; Huang, LJ; Huang, YC; Kuo, SC; Liaw, CC; Lin, YC, 2009) | 0.97 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID426990 | Cytotoxicity against human MCF7 cells by MTT assay | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7 | Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica. |
| AID426991 | Cytotoxicity against human neutrophils assessed as inhibition of LDH releses at 10 uM | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7 | Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica. |
| AID426989 | Cytotoxicity against human HepG2 cells by MTT assay | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7 | Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica. |
| AID426988 | Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/Cytochalasin B-induced elastase release | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7 | Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica. |
| AID426987 | Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/cytochalasin B-induced superoxide radical anion generation | 2009 | Journal of natural products, Jul, Volume: 72, Issue:7 | Anti-inflammatory flavonoids from the rhizomes of Helminthostachys zeylanica. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.79) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||