7-diethylaminocoumarin-3-carbohydrazide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

7-diethylaminocoumarin-3-carbohydrazide: used for labeling ketone groups [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	127564
CHEMBL ID	4754071
SCHEMBL ID	580009
MeSH ID	M0202752

Synonyms (23)

Synonym
dacch
7-(diethylamino)coumarin-3-carbohydrazide, bioreagent, suitable for fluorescence, >=95% (hpce)
7-(diethylamino)-2-oxochromene-3-carbohydrazide
7-(diethylamino)coumarin-3-carbohydrazide
100343-98-4
7-diethylaminocoumarin-3-carbonylhydrazide
7-diethylaminocoumarin-3-carbohydrazide
FT-0621397
AKOS015894738
SCHEMBL580009
J-100101
7-(diethylamino)-2-oxo-2h-chromene-3-carbohydrazide
2h-1-benzopyran-3-carboxylic acid, 7-(diethylamino)-2-oxo-, hydrazide
DTXSID90143192
mfcd00467583
AS-72609
7-diethylamino-2-oxo-2h-chromene-3-carboxylic acid hydrazide
E77857
LCZC1623
BP-27947
SB86160
CHEMBL4754071
2h-1-benzopyran-3-carboxylicacid,7-(diethylamino)-2-oxo-,hydrazide

Research Excerpts

Compound-Compound Interactions

Excerpt	Reference	Relevance
" After removal of excess derivatization reagent and urine matrix components, the monoterpene derivatives were separated by high-performance liquid chromatography (HPLC) in combination with fluorescence (FLD) detection and simultaneous mass spectrometric (MS) identification."	( Sensitive determination of monoterpene alcohols in urine by HPLC-FLD combined with ESI-MS detection after online-solid phase extraction of the monoterpene-coumarincarbamate derivates. Duisken, M; Hollender, J; Jähnigen, H; Meesters, RJ, 2008)	0.35

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay ID	Title	Year	Journal	Article
AID1683174	Cytotoxicity against human NCM460 cells harboring low MCT1 expression incubated for 72 hrs by MTT assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683179	Induction of apoptosis in human HeLa cells assessed as early apoptosis measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 2.94 %)	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683191	Decrease in intracellular glucose level in human HCT-116 cells at IC50 after 24 hrs by colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683177	Antiproliferative activity against human HeLa cells assessed as reduction in cell proliferation at IC50 incubated for 6 days and measured on day 6 by MTS assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683187	Decrease in glucose consumption in human HCT-116 cells at IC50 after 4 to 24 hrs by glucose oxidase based colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683195	Inhibition of lactate uptake in human HCT-116 cells at 0.01 to 100 uM after 24 hrs by colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683176	Cytotoxicity against human HeLa cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683178	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation at IC50 incubated for 6 days and measured on day 6 by MTS assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683189	Decrease in intracellular glucose level in human HeLa cells at IC50 after 24 hrs by colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683184	Downregulation of MCT1 expression in human HCT-116 cells at 0.01 to 100 uM measured after 48 hrs by Western blot analysis	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683196	Inhibition of lactate uptake in human HeLa cells at low concentration after 24 hrs by colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683186	Reduction of lactate production in human HeLa cells at IC50 after 8 hrs by colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683183	Downregulation of MCT1 expression in human HeLa cells at 0.01 to 100 uM measured after 48 hrs by Western blot analysis	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683188	Reduction of lactate production in human HCT-116 cells at IC50 after 4 to 24 hrs by colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683175	Cytotoxicity against human HCT-116 cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683185	Decrease in glucose consumption in human HeLa cells at IC50 after 12 hrs by glucose oxidase based colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683182	Induction of apoptosis in human HCT-116 cells assessed as late apoptotic cells measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 2.78 %)	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683193	Inhibition of lactate transport in human HeLa cells assessed as increase in intracellular lactate level at IC50 measured after 8 to 24 hrs by colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683194	Inhibition of lactate transport in human HCT-116 cells assessed as increase in intracellular lactate level at IC50 measured after 8 hrs by colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683197	Inhibition of lactate uptake in human HeLa cells at high concentration after 24 hrs by colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683180	Induction of apoptosis in human HeLa cells assessed as late apoptotic cells measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 3.85 %)	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683192	Decrease in intracellular glucose level in human HCT-116 cells at IC50 after 4 hrs by colorimetric assay	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683181	Induction of apoptosis in human HCT-116 cells assessed as early apoptosis measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 3.42 %)	2021	Bioorganic & medicinal chemistry, 01-01, Volume: 29	Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (11.11)	18.2507
2000's	1 (11.11)	29.6817
2010's	5 (55.56)	24.3611
2020's	2 (22.22)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	13.05 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	5.35 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (13.05)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
menthol Menthol: A monoterpene cyclohexanol produced from mint oils.	2.04	1	p-menthane monoterpenoid; secondary alcohol	volatile oil component
1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.	2.06	1	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	2.25	1
n-hexanal [no description available]	2.11	1	medium-chain fatty aldehyde; n-alkanal; saturated fatty aldehyde	human urinary metabolite
hydrazine diamine : Any polyamine that contains two amino groups.	3.57	8	azane; hydrazines	EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
eosine yellowish-(ys) Eosine Yellowish-(YS): A versatile red dye used in cosmetics, pharmaceuticals, textiles, etc., and as tissue stain, vital stain, and counterstain with HEMATOXYLIN. It is also used in special culture media.. eosin YS dye : An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions.	2.06	1	organic sodium salt; organobromine compound	fluorochrome; histological dye
fluorescein-5-isothiocyanate Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.	2.06	1	fluorescein isothiocyanate
rhodamine wt [no description available]	2.06	1
2-chloro-1-methylpyridinium 2-chloro-1-methylpyridinium: coupling reagent for peptide synthesis	2.06	1
quercetin [no description available]	2.31	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
4-hydroxy-2-nonenal 4-hydroxy-2-nonenal: cytotoxic product from peroxidation of liver microsomal lipids; RN given refers to cpd without isomeric designation. 4-hydroxynon-2-enal : An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.. 4-hydroxynonenal : A monounsaturated fatty aldehyde that is nonanal that has undergone dehydrogenation to introduce a double bond at any position in the aliphatic chain and in which a hydrogen at position 4 has been replaced by a hydroxy group.	2.11	1	4-hydroxynon-2-enal; 4-hydroxynonenal
oregon green 488 carboxylic acid [no description available]	2.06	1	xanthene dye	epitope; fluorochrome
alpha-cyano-4-hydroxycinnamic acid alpha-cyano-4-hydroxycinnamic acid : A monohydroxycinnamic acid that is 4-hydroxycinnamic acid in which the hydrogen alpha- to the carboxy group is replaced by a cyano group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of peptides and oligonucleotides.	2.31	1	monohydroxycinnamic acid; nitrile; phenols	MALDI matrix material
fluorescein thiosemicarbazide [no description available]	2.25	1
bryostatin 1 bryostatin 1: a protein kinase C activator; macrocyclic lactone from marine Bryozoan Bugula neritina; RN given refers to (1S-(1R,3R,5Z,7S,8E,11R,12R(2E,4E),13E,15R,17S(S),21S,23S,25R))-isomer; structure given in first source; activates protein kinase c. bryostatin 1 : A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.	2.06	1
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	3.57	8	benzenes; hydroxycoumarin; methyl ketone

Condition	Indicated	Relationship Strength	Studies	Trials
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.46	2	0

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