Compounds > 7-diethylaminocoumarin-3-carbohydrazide
Page last updated: 2024-11-07

7-diethylaminocoumarin-3-carbohydrazide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

7-diethylaminocoumarin-3-carbohydrazide: used for labeling ketone groups [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID127564
CHEMBL ID4754071
SCHEMBL ID580009
MeSH IDM0202752

Synonyms (23)

Synonym
dacch
7-(diethylamino)coumarin-3-carbohydrazide, bioreagent, suitable for fluorescence, >=95% (hpce)
7-(diethylamino)-2-oxochromene-3-carbohydrazide
7-(diethylamino)coumarin-3-carbohydrazide
100343-98-4
7-diethylaminocoumarin-3-carbonylhydrazide
7-diethylaminocoumarin-3-carbohydrazide
FT-0621397
AKOS015894738
SCHEMBL580009
J-100101
7-(diethylamino)-2-oxo-2h-chromene-3-carbohydrazide
2h-1-benzopyran-3-carboxylic acid, 7-(diethylamino)-2-oxo-, hydrazide
DTXSID90143192
mfcd00467583
AS-72609
7-diethylamino-2-oxo-2h-chromene-3-carboxylic acid hydrazide
E77857
LCZC1623
BP-27947
SB86160
CHEMBL4754071
2h-1-benzopyran-3-carboxylicacid,7-(diethylamino)-2-oxo-,hydrazide

Research Excerpts

Compound-Compound Interactions

ExcerptReferenceRelevance
" After removal of excess derivatization reagent and urine matrix components, the monoterpene derivatives were separated by high-performance liquid chromatography (HPLC) in combination with fluorescence (FLD) detection and simultaneous mass spectrometric (MS) identification."( Sensitive determination of monoterpene alcohols in urine by HPLC-FLD combined with ESI-MS detection after online-solid phase extraction of the monoterpene-coumarincarbamate derivates.
Duisken, M; Hollender, J; Jähnigen, H; Meesters, RJ, 2008)		0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID1683174Cytotoxicity against human NCM460 cells harboring low MCT1 expression incubated for 72 hrs by MTT assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683179Induction of apoptosis in human HeLa cells assessed as early apoptosis measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 2.94 %)2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683191Decrease in intracellular glucose level in human HCT-116 cells at IC50 after 24 hrs by colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683177Antiproliferative activity against human HeLa cells assessed as reduction in cell proliferation at IC50 incubated for 6 days and measured on day 6 by MTS assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683187Decrease in glucose consumption in human HCT-116 cells at IC50 after 4 to 24 hrs by glucose oxidase based colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683195Inhibition of lactate uptake in human HCT-116 cells at 0.01 to 100 uM after 24 hrs by colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683176Cytotoxicity against human HeLa cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683178Antiproliferative activity against human HCT-116 cells assessed as reduction in cell proliferation at IC50 incubated for 6 days and measured on day 6 by MTS assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683189Decrease in intracellular glucose level in human HeLa cells at IC50 after 24 hrs by colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683184Downregulation of MCT1 expression in human HCT-116 cells at 0.01 to 100 uM measured after 48 hrs by Western blot analysis2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683196Inhibition of lactate uptake in human HeLa cells at low concentration after 24 hrs by colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683186Reduction of lactate production in human HeLa cells at IC50 after 8 hrs by colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683183Downregulation of MCT1 expression in human HeLa cells at 0.01 to 100 uM measured after 48 hrs by Western blot analysis2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683188Reduction of lactate production in human HCT-116 cells at IC50 after 4 to 24 hrs by colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683175Cytotoxicity against human HCT-116 cells overexpressing MCT-1 assessed as reduction in cell viability measured after 72 hrs by MTT assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683185Decrease in glucose consumption in human HeLa cells at IC50 after 12 hrs by glucose oxidase based colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683182Induction of apoptosis in human HCT-116 cells assessed as late apoptotic cells measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 2.78 %)2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683193Inhibition of lactate transport in human HeLa cells assessed as increase in intracellular lactate level at IC50 measured after 8 to 24 hrs by colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683194Inhibition of lactate transport in human HCT-116 cells assessed as increase in intracellular lactate level at IC50 measured after 8 hrs by colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683197Inhibition of lactate uptake in human HeLa cells at high concentration after 24 hrs by colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683180Induction of apoptosis in human HeLa cells assessed as late apoptotic cells measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 3.85 %)2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683192Decrease in intracellular glucose level in human HCT-116 cells at IC50 after 4 hrs by colorimetric assay2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
AID1683181Induction of apoptosis in human HCT-116 cells assessed as early apoptosis measured after 48 hrs by annexinV-FITC/propidium iodide staining based by flow cytometry (Rvb = 3.42 %)2021Bioorganic & medicinal chemistry, 01-01, Volume: 29Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactatetransportinhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's1 (11.11)29.6817
2010's5 (55.56)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.05 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index5.35 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
menthol
Menthol: A monoterpene cyclohexanol produced from mint oils.		2.0410p-menthane monoterpenoid;
secondary alcohol		volatile oil component
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.0610aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		2.2510
n-hexanal
[no description available]		2.1110medium-chain fatty aldehyde;
n-alkanal;
saturated fatty aldehyde		human urinary metabolite
hydrazine
diamine : Any polyamine that contains two amino groups.		3.5780azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
eosine yellowish-(ys)
Eosine Yellowish-(YS): A versatile red dye used in cosmetics, pharmaceuticals, textiles, etc., and as tissue stain, vital stain, and counterstain with HEMATOXYLIN. It is also used in special culture media.. eosin YS dye : An organic sodium salt that is 2',4',5',7'-tetrabromofluorescein in which the carboxy group and the phenolic hydroxy group have been deprotonated and the resulting charge is neutralised by two sodium ions.		2.0610organic sodium salt;
organobromine compound		fluorochrome;
histological dye
fluorescein-5-isothiocyanate
Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.		2.0610fluorescein isothiocyanate
rhodamine wt
[no description available]		2.0610
2-chloro-1-methylpyridinium
2-chloro-1-methylpyridinium: coupling reagent for peptide synthesis		2.0610
quercetin
[no description available]		2.31107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
4-hydroxy-2-nonenal
4-hydroxy-2-nonenal: cytotoxic product from peroxidation of liver microsomal lipids; RN given refers to cpd without isomeric designation. 4-hydroxynon-2-enal : An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.. 4-hydroxynonenal : A monounsaturated fatty aldehyde that is nonanal that has undergone dehydrogenation to introduce a double bond at any position in the aliphatic chain and in which a hydrogen at position 4 has been replaced by a hydroxy group.		2.11104-hydroxynon-2-enal;
4-hydroxynonenal
oregon green 488 carboxylic acid
[no description available]		2.0610xanthene dyeepitope;
fluorochrome
alpha-cyano-4-hydroxycinnamic acid
alpha-cyano-4-hydroxycinnamic acid : A monohydroxycinnamic acid that is 4-hydroxycinnamic acid in which the hydrogen alpha- to the carboxy group is replaced by a cyano group. It is used as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of peptides and oligonucleotides.		2.3110monohydroxycinnamic acid;
nitrile;
phenols		MALDI matrix material
fluorescein thiosemicarbazide
[no description available]		2.2510
bryostatin 1
bryostatin 1: a protein kinase C activator; macrocyclic lactone from marine Bryozoan Bugula neritina; RN given refers to (1S*-(1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*))-isomer; structure given in first source; activates protein kinase c. bryostatin 1 : A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoethylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of bryostatins.		2.0610
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		3.5780benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.4620