kaempferol 3-O-sophoroside: isolated from leaves of Cassia alata [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside : A sophoroside that is kaempferol attached to a beta-D-sophorosyl residue at position 3 via a glycosidic linkage. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Cassia | genus | A plant genus of the family FABACEAE. Many species of this genus, including the medicinal C. senna and C. angustifolia, have been reclassified into the Senna genus (SENNA PLANT) and some to CHAMAECRISTA.[MeSH] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| Cassia alata | species | [no description available] | Fabaceae | The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 5282155 |
| CHEMBL ID | 2032411 |
| CHEBI ID | 31743 |
| SCHEMBL ID | 6423194 |
| MeSH ID | M0177173 |
| Synonym |
|---|
| kaempferol-3-sophoroside |
| kaempferol-3-o-sophoroside |
| kaempferol 3-o-sophoroside |
| 4h-1-benzopyran-4-one, 3-((2-o-beta-d-glucopyranosyl-beta-diglucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- |
| k3s , |
| flavone, 3,4',5,7-tetrahydroxy-, 3-(2-o-beta-d-glucopyranosyl-beta-glucopyranoside) |
| 4h-1-benzopyran-4-one, 3-((2-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- |
| kaempferol 3-o-beta-d-sophoroside |
| sophoraflavonoloside |
| kaempferol 3-o-beta-d-glucosyl-(1->2)-beta-d-glucoside |
| 19895-95-5 |
| flavone, 3,4',5,7-tetrahydroxy-, 3-(glucosylglucoside) |
| 30373-88-7 |
| kaempferol-3-o-diglucoside |
| 3-[(2s,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one |
| 3c1196z645 , |
| unii-3c1196z645 |
| chebi:31743 , |
| CHEMBL2032411 |
| 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4h-chromen-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside |
| kaempferol-3-o-beta-d-sophoroside |
| 3-((2-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one |
| flavone, 3,4',5,7-tetrahydroxy-, 3-(2-o-beta-d-glucopyranosyl-.beta.-glucopyranoside) |
| 4h-1-benzopyran-4-one, 3-((2-o-.beta.-d-glucopyranosyl-.beta.-d-glucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- |
| 4h-1-benzopyran-4-one, 3-((2-o-.beta.-d-glucopyranosyl-.beta.-diglucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- |
| SCHEMBL6423194 |
| AC-34783 |
| 3-[(2s,3r,4s,5s,6r)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one |
| kaempferol 3-o-beta-sophoroside |
| kaempferol 3-diglucoside |
| AKOS030530341 |
| mfcd01662713 |
| kaempferol-3-o-sophroside |
| 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4h-1-benzopyran-3-yl 2-o-hexopyranosylhexopyranoside |
| DTXSID20941769 |
| Q27114674 |
| CS-0018544 |
| HY-N2055 |
| MS-30700 |
| kaempferol 3-beta-sophoroside |
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| trihydroxyflavone | Any hydroxyflavone carrying three hydroxy groups at unspecified positions. |
| sophoroside | Any glycoside of sophorose (2-O-beta-D-glucopyranosyl-D-glucopyranose). |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| superpathway of flavones and derivatives biosynthesis | 17 | 44 |
| kaempferol glycoside biosynthesis (Arabidopsis) | 3 | 9 |
| kaempferol triglucoside biosynthesis | 0 | 10 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID661655 | Antiinflammatory activity in HUVEC cells assessed as inhibition of LPS-induced monocyte migration at 10 uM relative to LPS | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | Vascular barrier protective effects of eckol and its derivatives. |
| AID661652 | Antiinflammatory activity in HUVEC cells assessed as inhibition of LPS-induced hyperpermeability at 10 uM relative to LPS | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | Vascular barrier protective effects of eckol and its derivatives. |
| AID661656 | Antiinflammatory activity in mouse assessed as inhibition of CMC-Na-induced leukocyte migration into peritoneal cavity at 10 uM relative to CMC-Na | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | Vascular barrier protective effects of eckol and its derivatives. |
| AID661653 | Antiinflammatory activity in HUVEC cells assessed as inhibition of acetic acid-induced hyperpermeability at 10 uM relative to acetic acid | 2012 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 22, Issue:11 | Vascular barrier protective effects of eckol and its derivatives. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (24.24) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||