matrine profile

Matrine is an alkaloid found in the roots of the Sophora flavescens plant, which has a long history of use in traditional Chinese medicine. It exhibits a range of pharmacological activities, including anti-inflammatory, anti-tumor, and anti-viral effects. Matrine's anti-cancer activity is particularly noteworthy, as it has shown promise in inhibiting the growth of various cancer cells, including leukemia, lung cancer, and liver cancer. Researchers are exploring the mechanisms behind these effects, which are believed to involve modulation of cell signaling pathways and induction of apoptosis. Matrine's anti-inflammatory properties are attributed to its ability to suppress the production of pro-inflammatory cytokines. It also possesses anti-viral activity against certain viruses, including hepatitis B virus. Despite its potential therapeutic value, further research is necessary to optimize its clinical application and ensure its safety for long-term use. '

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Sophora	genus	A plant genus of the family FABACEAE.[MeSH]	Fabaceae	The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]
Sophora flavescens	species	[no description available]	Fabaceae	The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of beans belong to this family.[MeSH]

ID Source	ID
PubMed CID	91466
CHEMBL ID	204860
CHEBI ID	6700
SCHEMBL ID	177907
MeSH ID	M0105670

Synonym
c15h24n2o
nsc 146051
brn 0085851
nsc-318810
matrine ,
519-02-8
.alpha.-matrine
nsc146051
nsc-146051
chebi:6700 ,
CHEMBL204860
AKOS007930266
M2120
(7as,13ar,13br,13cs)-dodecahydro-1h,5h,10h-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
unii-n390w430ac
5-24-02-00301 (beilstein handbook reference)
n390w430ac ,
NCGC00346593-01
alpha-matrine
S2322
CCG-208589
HY-N0164
CS-1601
SCHEMBL177907
KS-5203
matrinium
vegard
1h,5h,10h-dipyrido(2,1-f:3',2',1'-ij)(1,6)naphthyridin-10-one, dodecahydro-, (7as,13ar,13br,13cs)-
matrine [who-dd]
matrine [inci]
matrine [mi]
mfcd00210527
DTXSID00274188 ,
a-matrine
(7as,13ar,13bs,13cs)dodecahydro-1h,5h,10h-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one
bdbm50249581
BCP08193
matrine ((+)-matrine)
matrine,(s)
AMY25701
HMS3884F13
matridin-15-one; vegard; -matrine
(1r,2r,9s,17s)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
matrine 100 microg/ml in acetonitrile
matridin-15-one;vegard;alpha-matrine
dtxcid70820575

Excerpt	Reference	Relevance
"Oxymatrine (1) is a natural anti-hepatitis B virus (HBV) drug that down-regulates host heat-stress cognate 70 (Hsc70) expression through a mechanism different from that of nucleosides. "	( Synthesis, structure-activity relationship and biological evaluation of novel N-substituted matrinic acid derivatives as host heat-stress cognate 70 (Hsc70) down-regulators. Du, NN; Gao, LM; Jiang, JD; Li, CX; Li, X; Liu, F; Liu, YX; Peng, ZG; Song, DQ; Wang, YP, 2011)	0.99
"Matrine is an alkaloid isolated from Sophora flavescens Ait."	( Research advances on anticancer activities of matrine and its derivatives: An updated overview. Jiang, J; Muhammad, Y; Rashid, HU; Wang, L; Xu, Y, 2019)	1.49

Excerpt	Reference	Relevance
"This study aims to characterize the pharmacokinetic (PK) profiles and identify important bioavailability barriers and pharmacological pathways of the key active components (KACs) of Antitumor B (ATB), a chemopreventive agent."	( Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer. Bui, D; Duan, S; Hu, M; Singh, R; Wei, B; Wong, SJ; Yang, P; Yin, T; You, M, 2021)	0.62

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51
"This study aims to characterize the pharmacokinetic (PK) profiles and identify important bioavailability barriers and pharmacological pathways of the key active components (KACs) of Antitumor B (ATB), a chemopreventive agent."	( Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer. Bui, D; Duan, S; Hu, M; Singh, R; Wei, B; Wong, SJ; Yang, P; Yin, T; You, M, 2021)	0.62

Class	Description
alkaloid	Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
EWS/FLI fusion protein	Homo sapiens (human)	Potency	0.0010	0.0013	10.1577	42.8575	AID1259256
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Advanced glycosylation end product-specific receptor	Homo sapiens (human)	Kd	23,961.9004	0.0300	0.0365	0.0430	AID1475148; AID1908569
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
response to hypoxia	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
microglial cell activation	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
regulation of T cell mediated cytotoxicity	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of protein phosphorylation	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
inflammatory response	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
cell adhesion	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
cell surface receptor signaling pathway	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
learning or memory	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
response to wounding	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
glucose mediated signaling pathway	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
neuron projection development	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
negative regulation of interleukin-10 production	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of chemokine production	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of interleukin-1 beta production	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of interleukin-12 production	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of interleukin-6 production	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of heterotypic cell-cell adhesion	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of activated T cell proliferation	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
transcytosis	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of JNK cascade	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
astrocyte activation	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
regulation of synaptic plasticity	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
induction of positive chemotaxis	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascade	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of monocyte chemotactic protein-1 production	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
protein localization to membrane	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
regulation of spontaneous synaptic transmission	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
transport across blood-brain barrier	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
regulation of long-term synaptic potentiation	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
negative regulation of long-term synaptic potentiation	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
negative regulation of long-term synaptic depression	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
regulation of p38MAPK cascade	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of p38MAPK cascade	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
regulation of non-canonical NF-kappaB signal transduction	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
negative regulation of blood circulation	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of endothelin production	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
response to amyloid-beta	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
cellular response to amyloid-beta	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of monocyte extravasation	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
regulation of CD4-positive, alpha-beta T cell activation	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
positive regulation of dendritic cell differentiation	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
regulation of inflammatory response	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
amyloid-beta binding	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
transmembrane signaling receptor activity	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
scavenger receptor activity	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
protein binding	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
signaling receptor activity	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
identical protein binding	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
S100 protein binding	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
protein-containing complex binding	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
advanced glycation end-product receptor activity	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
molecular adaptor activity	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
laminin receptor activity	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
fibrillar center	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
extracellular region	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
plasma membrane	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
cell surface	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
apical plasma membrane	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
cell junction	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
postsynapse	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
plasma membrane	Advanced glycosylation end product-specific receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (331)

Assay ID	Title	Year	Journal	Article
AID1530439	Growth inhibition of human U2OS cells at 3.2 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877725	Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 4 uM after 36 hrs by flow cytometry (Rvb = 5.84%)	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530416	Growth inhibition of human HT-29 cells at 1 mg/ml by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815107	Tmax in C57BL/6 mouse at 500 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530369	Induction of apoptosis in human RPMI8226 cells at 1000 mg/L after 48 hrs by Annexin V/propidium iodide staining based flow cytometry (Rvb = 3.02 +/- 1.19%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530312	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530392	Antiproliferative activity against human KYSE-150 cells assessed as cell viability at 2 mg/ml after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530375	Growth inhibition of human MM1R cells after 24 hrs	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530467	Growth inhibition of human GRC1 cells at 1 g/L after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1278838	Antiproliferative activity against human MCF7 cells after 3 days by SRB assay	2016	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5	Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.
AID1815122	Cmax in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815119	Tmax in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530497	Antiproliferative activity against human HK2 cells after 48 hrs by CCK8 assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530425	Synergistic growth inhibition of human HT-29 cells at 2 mg/ml cotreated with 10 ug/ml irinotecan by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530356	Induction of apoptosis in human CCRF-CEM cells at antiproliferative IC50 after 72 hrs by Annexin V/propidium iodide staining based assay (Rvb = 0.8%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530473	Growth inhibition of human GRC1 cells at 1.5 g/L after 96 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530385	Induction of apoptosis in human RD cells at 1.5 mg/ml after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530438	Growth inhibition of human HOS cells at 3.2 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877687	Antiproliferative activity against human H460 cells by CCK8 assay	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530417	Growth inhibition of human HT-29 cells at 2 mg/ml by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530373	Growth inhibition of human RPMI8226 cells at 2000 mg/ml after 24 hrs relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID697853	Inhibition of horse BChE at 2 mg/ml by Ellman's method	2012	Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22	Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
AID1530415	Growth inhibition of human HT-29 cells at 0.5 mg/ml by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530336	Growth inhibition of human SGC7901 cells at 120 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1636859	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17	Synthesis and biological evaluation of matrine derivatives as anti-hepatocellular cancer agents.
AID1636861	Antiproliferative activity against human Bel7402 cells after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17	Synthesis and biological evaluation of matrine derivatives as anti-hepatocellular cancer agents.
AID1530495	Antiproliferative activity against human C33A cells after 48 hrs by CCK8 assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530471	Growth inhibition of human GRC1 cells at 0.8 g/L after 96 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530400	Growth inhibition of human HT-29 cells at 4 ml/L after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877685	Cytotoxicity against human L02 cells by CCK8 assay	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530464	Growth inhibition of human GRC1 cells at 0.3 g/L after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530430	Antiproliferative activity against human GBC-SD cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815123	AUC (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815110	AUC (0 to infinity) in C57BL/6 mouse at 500 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815117	Half life in C57BL/6 mouse at 4000 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1242259	Immunoregulatory activity in BALC/c mouse assessed as increase in CD3+ T cells at 60 mg/kg, ip once daily for 8 days by flow cytometry	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells.
AID1242263	Immunoregulatory activity in BALC/c mouse assessed as reduction in DC cells at 60 mg/kg, ip once daily for 8 days by flow cytometry	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells.
AID1530456	Growth inhibition of human GRC1 cells at 0.8 g/L after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530359	Antiproliferative activity against human U937 cells after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1908569	Binding affinity to human RAGE by MST assay	2022	European journal of medicinal chemistry, Jun-05, Volume: 236	Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression.
AID261702	Inhibition of HBeAg release against HBV in HepG2 2.2.15 cell line at 0.2 umol/mL	2006	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5	(+)-12alpha-Hydroxysophocarpine, a new quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens.
AID1278837	Antiproliferative activity against human MDA-MB-231 cells after 3 days by SRB assay	2016	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5	Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.
AID1530424	Synergistic growth inhibition of human HT-29 cells at 1 mg/ml cotreated with 5 ug/ml irinotecan by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530446	Growth inhibition of rat UMR108 cells assessed as cell proliferation at 1 mg/ml after 24 hrs by MTT assay (Rvb = 0.405 +/- 0.007%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815127	Half life in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1877711	Induction of apoptosis in human A549 cells assessed as live cells at 4 uM after 24 hrs by flow cytometry (Rvb = 92%)	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1815097	Stability in mouse blood assessed as compound remaining measured at 20 degC for 8 hrs	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530311	Antiproliferative activity against human A549 cells at 1 mg/ml relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530494	Antiproliferative activity against human SiHa cells after 48 hrs by CCK8 assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530391	Antiproliferative activity against human KYSE-150 cells assessed as cell viability at 1.5 mg/ml after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1373740	Anticancer activity against human CNE2 cells assessed as reduction in cell viability incubated for 48 hrs MTT assay	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Design, synthesis and biological evaluation of matrine derivatives as potential anticancer agents.
AID1815108	Cmax in C57BL/6 mouse at 500 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID538685	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production after 6 hrs by ELISA	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Synthesis and in vitro inhibitory activity of matrine derivatives towards pro-inflammatory cytokines.
AID1530458	Growth inhibition of human GRC1 cells at 1.5 g/L after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530431	Growth inhibition of human MG63 cells at 0.8 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877713	Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 4 uM after 24 hrs by flow cytometry (Rvb = 5.85%)	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530384	Induction of apoptosis in human RD cells at 1 mg/ml after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530310	Antiproliferative activity against human 95-D cells at 2 g/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1541437	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production by measuring IL-6 level at 50 uM preincubated for 2 hrs followed by LPS treatment and measured after 16 hrs by ELISA (Rvb = 100 +/-	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Alopecuroides A-E, Matrine-Type Alkaloid Dimers from the Aerial Parts of
AID1160744	Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytocidal activity after 48 hrs by CellTiter-Glo assay	2014	ACS medicinal chemistry letters, Aug-14, Volume: 5, Issue:8	Identification and synthesis of quinolizidines with anti-influenza a virus activity.
AID1815098	Stability in mouse blood assessed as compound remaining measured at - 80 degC for 4 months	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530343	Induction of apoptosis in human BxPC3 cells at 1.25 mg/ml by flow cytometry (Rvb = 2.81%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530457	Growth inhibition of human GRC1 cells at 1 g/L after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530307	Antiproliferative activity against human A549 cells at 1.5 g/L after 12 to 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1242260	Immunoregulatory activity in BALC/c mouse assessed as increase in CD4+ T cells at 60 mg/kg, ip once daily for 8 days by flow cytometry	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells.
AID1530357	Antiproliferative activity against human HL60 cells after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID662405	Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives.
AID1530402	Growth inhibition of human HT-29 cells at 16 ml/L after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530370	Induction of apoptosis in human RPMI8226 cells at 1500 mg/L after 48 hrs by Annexin V/propidium iodide staining based flow cytometry (Rvb = 3.02 +/- 1.19%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530381	Antiproliferative activity against human RPMI8226 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1666496	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay	2020	Bioorganic & medicinal chemistry, 02-15, Volume: 28, Issue:4	New modification strategy of matrine as Hsp90 inhibitors based on its specific L conformation for cancer treatment.
AID1815099	Half life in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530389	Antiproliferative activity against human KYSE-150 cells assessed as cell viability at 0.5 mg/ml after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530472	Growth inhibition of human GRC1 cells at 1 g/L after 96 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530360	Induction of apoptosis in human HL60 cells after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530309	Antiproliferative activity against human A549 cells at 2 g/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815115	AUC (0 to 24 hrs) in C57BL/6 mouse at 4000 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1278834	Antiproliferative activity against human A549 cells after 3 days by SRB assay	2016	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5	Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.
AID1530349	Induction of apoptosis in human PC3 cells assessed as late apoptotic cells at 25 mg/mL (Rvb = 2.5%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530406	Growth inhibition of human HT-29 cells at 8 ml/L after 36 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530354	Antiproliferative activity against human CCRF-CEM cells after 48 hrs by WST1 assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530387	Antiproliferative activity against human T24 cells after 48 hrs by CCK8 assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877681	Antiproliferative activity against human HeLa cells by CCK8 assay	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530433	Growth inhibition of human MNNG-HOS cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815111	Half life in C57BL/6 mouse at 500 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530333	Growth inhibition of human SGC7901 cells at 60 mg/ml after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877714	Induction of apoptosis in human A549 cells assessed as necrotic cells at 4 uM after 24 hrs by flow cytometry (Rvb = 0.955%)	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530429	Antiproliferative activity against human GBC-SD cells after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530434	Growth inhibition of human HOS cells at 0.8 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815106	Oral bioavailability in C57BL/6 mouse at 4000 mg/kg	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530403	Growth inhibition of human HT-29 cells at 32 ml/L after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530350	Induction of apoptosis in human PC3 cells assessed as late apoptotic cells at 50 mg/mL (Rvb = 2.5%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815093	Antiproliferative activity against human CAL-27 cells assessed as cell viability measured after 72 hrs by MTT assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530487	Induction of apoptosis in human M21 cells at 0.8 mg/ml after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530405	Growth inhibition of human HT-29 cells at 4 ml/L after 36 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530483	Growth inhibition of human M21 cells assessed as cell viability at 5 mg/ml after 48 hrs by MTT assay (Rvb = 98%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815129	MRT (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530346	Induction of apoptosis in human PANC1 cells at 1.25 mg/ml by flow cytometry (Rvb = 4.13%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530443	Antitumor activity against human SW480 cells xenografted in Balb/c mouse assessed as tumor growth inhibition at 30 mg/kg, ip everyday relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1234208	Antiviral activity against coxsackievirus B3 infected in African green monkey Vero cells assessed as inhibition of virus-induced cytopathogenic effect at maximal nontoxic concentration dosed 1 hr after viral adsorption	2015	Journal of natural products, Jul-24, Volume: 78, Issue:7	Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis.
AID1530378	Induction of apoptosis in human RPMI8226 cells at 1.5 g/L after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb < 3%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530413	Growth inhibition of human HT-29 cells at 32 ml/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530422	Synergistic growth inhibition of human HT-29 cells at 0.25 mg/ml cotreated with 1.25 ug/ml irinotecan by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530382	Antiproliferative activity against human U266 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530437	Growth inhibition of human MG63 cells at 3.2 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1541436	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production by measuring TNFalpha level at 50 uM preincubated for 2 hrs followed by LPS treatment and measured after 16 hrs by ELISA (Rvb =	2019	Journal of natural products, 12-27, Volume: 82, Issue:12	Alopecuroides A-E, Matrine-Type Alkaloid Dimers from the Aerial Parts of
AID1530427	Growth inhibition of human DLD1 cells after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530489	Induction of apoptosis in human HeLa cells at 50 ug/ml after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530395	Antiproliferative activity against human KYSE-150 cells after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530469	Growth inhibition of human GRC1 cells at 0.3 g/L after 96 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530462	Growth inhibition of human GRC1 cells at 1 g/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530386	Antiproliferative activity against human EJ cells after 48 hrs by CCK8 assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530449	Growth inhibition of rat UMR108 cells assessed as cell proliferation at 1 mg/ml after 48 hrs by MTT assay (Rvb = 0.404 +/- 0.008%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877686	Antiproliferative activity against human Calu-3 cells by CCK8 assay	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID261704	Cytotoxicity against HepG2 2.2.15 cell line at 0.4 umol/mL by MTT assay	2006	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5	(+)-12alpha-Hydroxysophocarpine, a new quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens.
AID1530461	Growth inhibition of human GRC1 cells at 0.8 g/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530503	Antiproliferative activity against human PANC1 cells by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1760160	Increase in glucose consumption in human HepG2 cells assessed as Gx/GDMSO ratio at 25 uM by glucose oxidase assay	2020	European journal of medicinal chemistry, Sep-01, Volume: 201	Structure-activity relationship and hypoglycemic activity of tricyclic matrines with advantage of treating diabetic nephropathy.
AID1387675	Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of HBeAg secretion at 0.4 mM supplemented with fresh medium containing compound every 3 days for 9 days measured after 9 days by ELISA relative to control	2018	Journal of natural products, 10-26, Volume: 81, Issue:10	Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Antiviral Activities against the Hepatitis B Virus.
AID1815125	AUC (0 to infinity) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530452	Growth inhibition of rat UMR108 cells assessed as cell proliferation at 1 mg/ml after 72 hrs by MTT assay (Rvb = 0.403 +/- 0.009%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530485	Induction of apoptosis in human M21 cells at 0.2 mg/ml after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530482	Growth inhibition of human HT-29 cells at 32 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877724	Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 4 uM after 36 hrs by flow cytometry (Rvb = 1.24%)	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530324	Induction of apoptosis in human HepG2 cells at 2 mg/ml by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.14%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815104	Clearance in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1207078	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay	2015	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12	Design, synthesis and anticancer activity of matrine-1H-1,2,3-triazole-chalcone conjugates.
AID1877683	Antiproliferative activity against human MCF7 cells by CCK8 assay	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530474	Growth inhibition of human D341 cells at 0.5 mg/ml after 72 hrs by CCK8 assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530344	Induction of apoptosis in human PANC1 cells at 0.25 mg/ml by flow cytometry (Rvb = 4.13%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815116	AUC (0 to infinity) in C57BL/6 mouse at 4000 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530340	Antiproliferative activity against human PANC1 cells after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530353	Antiproliferative activity against human CCRF-CEM cells after 24 hrs by WST1 assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID662406	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives.
AID1530316	Antiproliferative activity against human MCF7 cells after 72 hrs relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530479	Growth inhibition of human D341 cells at 2 mg/ml after 48 hrs by CCK8 assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1387671	Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of HBsAg secretion at 0.4 mM supplemented with fresh medium containing compound every 3 days for 9 days measured after 9 days by ELISA relative to control	2018	Journal of natural products, 10-26, Volume: 81, Issue:10	Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Antiviral Activities against the Hepatitis B Virus.
AID1530335	Growth inhibition of human SGC7901 cells at 120 mg/ml after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1234209	Antiviral activity against influenza A virus (A/Hanfang/359/95(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenic effect at maximal nontoxic concentration dosed 1 hr after viral adsorption	2015	Journal of natural products, Jul-24, Volume: 78, Issue:7	Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis.
AID1530345	Induction of apoptosis in human PANC1 cells at 0.75 mg/ml by flow cytometry (Rvb = 4.13%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530504	Antiproliferative activity against human HT-29 cells by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530361	Induction of apoptosis in human NB4 cells after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1636858	Antiproliferative activity against human SGC7901 cells after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17	Synthesis and biological evaluation of matrine derivatives as anti-hepatocellular cancer agents.
AID1242264	Immunoregulatory activity in BALC/c mouse assessed as reduction in NK cells at 60 mg/kg, ip once daily for 8 days by flow cytometry	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells.
AID1530390	Antiproliferative activity against human KYSE-150 cells assessed as cell viability at 1 mg/ml after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877712	Induction of apoptosis in human A549 cells assessed as early apoptotic cells at 4 uM after 24 hrs by flow cytometry (Rvb = 1.22%)	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530481	Growth inhibition of human HT-29 cells at 16 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530326	Antiproliferative activity against human Bel7402 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877723	Induction of apoptosis in human A549 cells assessed as live cells at 4 uM after 36 hrs by flow cytometry (Rvb = 92.5%)	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530490	Induction of apoptosis in human HeLa cells at 100 ug/ml after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815105	MRT (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530401	Growth inhibition of human HT-29 cells at 8 ml/L after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530491	Induction of apoptosis in human C33A cells at 25 ug/ml after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530342	Induction of apoptosis in human BxPC3 cells at 0.75 mg/ml by flow cytometry (Rvb = 2.81%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530355	Antiproliferative activity against human CCRF-CEM cells after 72 hrs by WST1 assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1207081	Induction of apoptosis in human A549 cells at 15 to 50 uM incubated for 24 hrs by Annexin V-FITC/propidium iodide double staining based flow cytometry	2015	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12	Design, synthesis and anticancer activity of matrine-1H-1,2,3-triazole-chalcone conjugates.
AID1530372	Growth inhibition of human MM1R cells at 2000 mg/ml after 24 hrs relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877684	Antiproliferative activity against human A549 cells by CCK8 assay	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1815124	AUC (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530338	Induction of apoptosis in human SGC7901 cells at 60 mg/ml after 48 hrs by propidium iodide staining based flow cytometry (Rvb = 3.54 +/- 0.47%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530442	Growth inhibition of human U2OS cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530404	Growth inhibition of human HT-29 cells at 2 ml/L after 36 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1160745	Cytotoxicity against MDCK cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay	2014	ACS medicinal chemistry letters, Aug-14, Volume: 5, Issue:8	Identification and synthesis of quinolizidines with anti-influenza a virus activity.
AID1530323	Induction of apoptosis in human HepG2 cells at 1 mg/ml by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.14%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530339	Induction of apoptosis in human SGC7901 cells at 120 mg/ml after 48 hrs by propidium iodide staining based flow cytometry (Rvb = 3.54 +/- 0.47%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530468	Growth inhibition of human GRC1 cells at 1.5 g/L after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530460	Growth inhibition of human GRC1 cells at 0.5 g/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530318	Reversal of P-gp-mediated drug resistance in human MCF7/ADR cells assessed as increase in adriamycin accumulation at 0.2 mg/ml relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530358	Antiproliferative activity against human NB4 cells after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530331	Antiproliferative activity against human SMMC7721 cells at 200 ug/ml after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530368	Induction of apoptosis in human RPMI8226 cells at 500 mg/L after 48 hrs by Annexin V/propidium iodide staining based flow cytometry (Rvb = 3.02 +/- 1.19%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530332	Growth inhibition of human SGC7901 cells at 30 mg/ml after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1278836	Antiproliferative activity against human KBVIN cells after 3 days by SRB assay	2016	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5	Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.
AID1207076	Antiproliferative activity against human Bel7402 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay	2015	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12	Design, synthesis and anticancer activity of matrine-1H-1,2,3-triazole-chalcone conjugates.
AID538687	Inhibition of NF-kappaB transcriptional activity in LPS-stimulated mouse RAW264.7 cells by dual luciferase reporter assay relative to renilla luciferase activity	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Synthesis and in vitro inhibitory activity of matrine derivatives towards pro-inflammatory cytokines.
AID1530371	Growth inhibition of human MM1S cells at 2000 mg/ml after 24 hrs relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530426	Growth inhibition of human HT-29 cells after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1666494	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	2020	Bioorganic & medicinal chemistry, 02-15, Volume: 28, Issue:4	New modification strategy of matrine as Hsp90 inhibitors based on its specific L conformation for cancer treatment.
AID1242262	Immunoregulatory activity in BALC/c mouse assessed as reduction in B cells at 60 mg/kg, ip once daily for 8 days by flow cytometry	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells.
AID1530470	Growth inhibition of human GRC1 cells at 0.5 g/L after 96 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530351	Induction of apoptosis in human PC3 cells assessed as late apoptotic cells at 75 mg/mL (Rvb = 2.5%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID662407	Cytotoxicity against human TW03 cells after 48 hrs by MTT assay	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives.
AID1242261	Immunoregulatory activity in BALC/c mouse assessed as increase in CD8+ T cells at 60 mg/kg, ip once daily for 8 days by flow cytometry	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells.
AID1530328	Antiproliferative activity against human HepG2 cells at 1 mg/ml after 48 hrs relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530454	Growth inhibition of human GRC1 cells at 0.3 g/L after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530441	Growth inhibition of human MG63 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530317	Induction of apoptosis in human MCF7 cells at 0.25 to 2 mg/ml (Rvb = 1.1 +/- 0.08%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530306	Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815113	Tmax in C57BL/6 mouse at 4000 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530322	Induction of apoptosis in human HepG2 cells at 0.5 mg/ml by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.14%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530327	Antiproliferative activity against human HepG2 cells at 0.8 mg/ml after 48 hrs relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530476	Growth inhibition of human D341 cells at 1.5 mg/ml after 72 hrs by CCK8 assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815126	AUC (0 to infinity) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530409	Growth inhibition of human HT-29 cells at 2 ml/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530364	Antiproliferative activity against mouse NIH/3T3 cells after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530388	Antiproliferative activity against human 5637 cells after 48 hrs by CCK8 assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530367	Growth inhibition of human RPMI8226 cells at 1500 mg/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530377	Induction of apoptosis in human U266 cells at 2 g/L after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb < 3%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530379	Antiproliferative activity against human RPMI8226 cells after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1207075	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay	2015	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12	Design, synthesis and anticancer activity of matrine-1H-1,2,3-triazole-chalcone conjugates.
AID1815101	AUC (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815118	MRT (0 to 24 hrs) in C57BL/6 mouse at 4000 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530313	Antiproliferative activity against mouse 4T1 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530341	Induction of apoptosis in human BxPC3 cells at 0.25 mg/ml by flow cytometry (Rvb = 2.81%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530314	Antiproliferative activity against human MCF7 cells after 24 hrs relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530398	Antiproliferative activity against human LoVo cells after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530308	Antiproliferative activity against human 95-D cells at 1.5 g/L after 12 to 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530410	Growth inhibition of human HT-29 cells at 4 ml/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815121	Cmax in C57BL/6 mouse at 500 mg/kg, ip qd measured after 1 day	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530319	Antiproliferative activity against human HepG2 cells at 1 mg/ml after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID261700	Inhibition of HBsAg release against HBV in HepG2 2.2.15 cell line at 0.2 umol/mL	2006	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5	(+)-12alpha-Hydroxysophocarpine, a new quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens.
AID1530435	Growth inhibition of human U2OS cells at 0.8 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815130	MRT (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815128	Half life in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530466	Growth inhibition of human GRC1 cells at 0.8 g/L after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815100	Cmax in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530445	Growth inhibition of rat UMR108 cells assessed as cell proliferation at 0.5 mg/ml after 24 hrs by MTT assay (Rvb = 0.405 +/- 0.007%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815114	Cmax in C57BL/6 mouse at 4000 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530325	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530478	Growth inhibition of human D341 cells at 2 mg/ml after 24 hrs by CCK8 assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530337	Induction of apoptosis in human SGC7901 cells at 30 mg/ml after 48 hrs by propidium iodide staining based flow cytometry (Rvb = 3.54 +/- 0.47%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1278835	Antiproliferative activity against human KB cells after 3 days by SRB assay	2016	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5	Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines.
AID1530496	Antiproliferative activity against human CaSki cells after 48 hrs by CCK8 assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1242269	Antiviral activity against human enterovirus 71 infected in ICR mouse assessed as increase in survival rate at 15 mg/kg, ip qd for 8 days dosed 2 hrs post infection and measured at 14 days post infection relative to control	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells.
AID1530432	Growth inhibition of human Saos2 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530380	Antiproliferative activity against human U266 cells after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID261703	Inhibition of HBeAg release against HBV in HepG2 2.2.15 cell line at 0.1 umol/mL	2006	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5	(+)-12alpha-Hydroxysophocarpine, a new quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens.
AID1815109	AUC (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530321	Antiproliferative activity against human HepG2 cells at 1 mg/ml after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID261701	Inhibition of HBsAg release against HBV in HepG2 2.2.15 cell line at 0.1 umol/mL	2006	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 16, Issue:5	(+)-12alpha-Hydroxysophocarpine, a new quinolizidine alkaloid and related anti-HBV alkaloids from Sophora flavescens.
AID1475148	Inhibition of amyloid beta binding to human RAGE domain V (Met1 to Ala 344 residues) expressed in HEK293 cells after 10 mins by MST assay	2017	Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17	Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective.
AID1530475	Growth inhibition of human D341 cells at 1 mg/ml after 72 hrs by CCK8 assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530396	Antiproliferative activity against human LoVo cells after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530362	Induction of apoptosis in human U937 cells after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1636860	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	2016	Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17	Synthesis and biological evaluation of matrine derivatives as anti-hepatocellular cancer agents.
AID1530447	Growth inhibition of rat UMR108 cells assessed as cell proliferation at 1.5 mg/ml after 24 hrs by MTT assay (Rvb = 0.405 +/- 0.007%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1666493	Binding affinity to N-terminal Hsp90 (unknown origin) assessed as change in melting temperature at protein to compound molar ratio of 1:5 by real-time PCR/PTS-dye based thermal shift assay	2020	Bioorganic & medicinal chemistry, 02-15, Volume: 28, Issue:4	New modification strategy of matrine as Hsp90 inhibitors based on its specific L conformation for cancer treatment.
AID1530486	Induction of apoptosis in human M21 cells at 0.4 mg/ml after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530329	Antiproliferative activity against human SMMC7721 cells at 5 ug/ml after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID538688	Cytotoxicity against mouse RAW264.7 cells	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Synthesis and in vitro inhibitory activity of matrine derivatives towards pro-inflammatory cytokines.
AID1530477	Growth inhibition of human D341 cells at 2 mg/ml after 72 hrs by CCK8 assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1666495	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	2020	Bioorganic & medicinal chemistry, 02-15, Volume: 28, Issue:4	New modification strategy of matrine as Hsp90 inhibitors based on its specific L conformation for cancer treatment.
AID1530408	Growth inhibition of human HT-29 cells at 32 ml/L after 36 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1373739	Anticancer activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs MTT assay	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Design, synthesis and biological evaluation of matrine derivatives as potential anticancer agents.
AID1530423	Synergistic growth inhibition of human HT-29 cells at 0.5 mg/ml cotreated with 2.5 ug/ml irinotecan by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530365	Growth inhibition of human RPMI8226 cells at 500 mg/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877726	Induction of apoptosis in human A549 cells assessed as necrotic cells at 4 uM after 36 hrs by flow cytometry (Rvb = 0.379%)	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530493	Induction of apoptosis in human C33A cells at 100 ug/ml after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530480	Induction of apoptosis in human D341 cells at 0.5 to 2 mg/ml after 24 to 72 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 5.74 +/- 0.09%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530393	Antiproliferative activity against human KYSE-150 cells assessed as cell viability at 2.5 mg/ml after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530347	Growth inhibition of human DU145 cells at 6 g/L after 72 hrs relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530440	Growth inhibition of human Saos2 cells at 3.2 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1377553	Inhibition of P-gp in human K562/VCR cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring fold reduction in doxorubicin IC50	2017	European journal of medicinal chemistry, Sep-29, Volume: 138	Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
AID1530463	Growth inhibition of human GRC1 cells at 1.5 g/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530505	Antiproliferative activity against human HepG2 cells by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530453	Growth inhibition of rat UMR108 cells assessed as cell proliferation at 1.5 mg/ml after 72 hrs by MTT assay (Rvb = 0.403 +/- 0.009%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530450	Growth inhibition of rat UMR108 cells assessed as cell proliferation at 1.5 mg/ml after 48 hrs by MTT assay (Rvb = 0.404 +/- 0.008%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815103	Volume of distribution in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530492	Induction of apoptosis in human C33A cells at 50 ug/ml after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID570165	Inhibition of Hsc70 mRNA expression in human HepG2(2.2.15) cells at 100 ug/ml after 24 hrs by RT-PCR analysis	2011	Journal of medicinal chemistry, Feb-10, Volume: 54, Issue:3	Design and synthesis of oxymatrine analogues overcoming drug resistance in hepatitis B virus through targeting host heat stress cognate 70.
AID697852	Inhibition of electric eel AChE at 2 mg/ml by Ellman's method	2012	Bioorganic & medicinal chemistry, Nov-15, Volume: 20, Issue:22	Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
AID1530451	Growth inhibition of rat UMR108 cells assessed as cell proliferation at 0.5 mg/ml after 72 hrs by MTT assay (Rvb = 0.403 +/- 0.009%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530455	Growth inhibition of human GRC1 cells at 0.5 g/L after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530488	Induction of apoptosis in human HeLa cells at 25 ug/ml after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877682	Antiproliferative activity against human MDA-MB-231 cells by CCK8 assay	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1207077	Antiproliferative activity against human HeLa cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay	2015	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12	Design, synthesis and anticancer activity of matrine-1H-1,2,3-triazole-chalcone conjugates.
AID1530484	Growth inhibition of human M21 cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530399	Growth inhibition of human HT-29 cells at 2 ml/L after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530412	Growth inhibition of human HT-29 cells at 16 ml/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815102	AUC (0 to infinity) in C57BL/6 mouse at 500 mg/kg, iv administered as Antitumor B	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1387679	Cytotoxicity against human HepG2.2.15 cells assessed as growth inhibition at 0.8 mM by MTT assay relative to control	2018	Journal of natural products, 10-26, Volume: 81, Issue:10	Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Antiviral Activities against the Hepatitis B Virus.
AID1530330	Antiproliferative activity against human SMMC7721 cells at 100 ug/ml after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530334	Growth inhibition of human SGC7901 cells at 120 mg/ml after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530411	Growth inhibition of human HT-29 cells at 8 ml/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530352	Induction of apoptosis in human PC3 cells assessed as late apoptotic cells at 100 mg/mL (Rvb = 2.5%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1877688	Antiproliferative activity against human H1650 cells by CCK8 assay	2022	Bioorganic & medicinal chemistry letters, 02-01, Volume: 57	Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.
AID1530428	Antiproliferative activity against human GBC-SD cells assessed as cell survival at 1 mmol/L up to 72 hrs by MTT assay (Rvb = 100%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530448	Growth inhibition of rat UMR108 cells assessed as cell proliferation at 0.5 mg/ml after 48 hrs by MTT assay (Rvb = 0.404 +/- 0.008%)	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815095	Antiinflammatory activity against human SCC-9 cells assessed as inhibition of LPS-induced PGE2 production at 10 ug/ml preincubated for 30 mins followed by stimulation with LPS and measured after 12 hrs by LC-MS/MS analysis	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530374	Growth inhibition of human MM1S cells after 24 hrs	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530459	Growth inhibition of human GRC1 cells at 0.3 g/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530394	Antiproliferative activity against human KYSE-150 cells assessed as cell viability at 3 mg/ml after 24 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID613769	Inhibition of Hsc70 mRNA expression in human HepG2(2.2.15) cells at 100 ug/ml after 24 hrs by RT-PCR analysis	2011	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 21, Issue:16	Synthesis, structure-activity relationship and biological evaluation of novel N-substituted matrinic acid derivatives as host heat-stress cognate 70 (Hsc70) down-regulators.
AID1373738	Anticancer activity against human SMMC7721 cells assessed as reduction in cell viability incubated for 48 hrs MTT assay	2018	Bioorganic & medicinal chemistry letters, 02-15, Volume: 28, Issue:4	Design, synthesis and biological evaluation of matrine derivatives as potential anticancer agents.
AID1530414	Growth inhibition of human HT-29 cells at 0.25 mg/ml by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530320	Antiproliferative activity against human HepG2 cells at 1 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530407	Growth inhibition of human HT-29 cells at 16 ml/L after 36 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1207074	Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay	2015	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 25, Issue:12	Design, synthesis and anticancer activity of matrine-1H-1,2,3-triazole-chalcone conjugates.
AID1530436	Growth inhibition of human Saos2 cells at 0.8 mg/ml after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530465	Growth inhibition of human GRC1 cells at 0.5 g/L after 72 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530363	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530315	Antiproliferative activity against human MCF7 cells after 48 hrs relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530366	Growth inhibition of human RPMI8226 cells at 1000 mg/L after 48 hrs by MTT assay relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815094	Antiproliferative activity against human SCC-9 cells assessed as cell viability measured after 72 hrs by MTT assay	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530376	Growth inhibition of human RPMI8226 cells after 24 hrs	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1530397	Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815120	Tmax in C57BL/6 mouse at 500 mg/kg, ip qd measured after 7 days	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID662404	Cytotoxicity against human HEP7402 cells after 48 hrs by MTT assay	2012	Bioorganic & medicinal chemistry letters, Jun-15, Volume: 22, Issue:12	Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives.
AID1530383	Induction of apoptosis in human RD cells at 0.5 mg/ml after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1815112	MRT (0 to 24 hrs) in C57BL/6 mouse at 500 mg/kg, po	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1815096	Stability in mouse blood assessed as compound recovery measured at 25 degC for 4 hrs	2021	Journal of natural products, 09-24, Volume: 84, Issue:9	Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.
AID1530348	Growth inhibition of human PC3 cells at 6 g/L after 72 hrs relative to control	2019	European journal of medicinal chemistry, Jan-01, Volume: 161	Research advances on anticancer activities of matrine and its derivatives: An updated overview.
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347092	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID1347106	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347089	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347101	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347099	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347095	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154	Primary screen GU AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347098	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347107	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347094	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630	Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347090	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093	qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells	2018	Oncotarget, Jan-12, Volume: 9, Issue:4	Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (3.33)	29.6817
2010's	19 (63.33)	24.3611
2020's	10 (33.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	3 (10.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	27 (90.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-aminophenol 4-aminophenol: RN given refers to parent cpd. 4-aminophenol : An amino phenol (one of the three possible isomers) which has the single amino substituent located para to the phenolic -OH group.	2.07	1	aminophenol	allergen; metabolite
indoleacetic acid indoleacetic acid: RN given refers to unlabeled parent cpd; structure in Merck Index, 9th ed, #4841. auxin : Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").. indole-3-acetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.	2.07	1	indole-3-acetic acids; monocarboxylic acid	auxin; human metabolite; mouse metabolite; plant hormone; plant metabolite
melatonin [no description available]	2.07	1	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger
quinolinic acid Quinolinic Acid: A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.. pyridinedicarboxylic acid : Any member of the class of pyridines carrying two carboxy groups.. quinolinic acid : A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.	3.25	1	pyridinedicarboxylic acid	Escherichia coli metabolite; human metabolite; mouse metabolite; NMDA receptor agonist
epibatidine [no description available]	2.07	1	alkaloid
amantadine amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source	2.1	1	adamantanes; primary aliphatic amine	analgesic; antiparkinson drug; antiviral drug; dopaminergic agent; NMDA receptor antagonist; non-narcotic analgesic
aristolochic acid i aristolochic acid I: phospholipase A inhibitor. aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.	2.07	1	aristolochic acids; aromatic ether; C-nitro compound; cyclic acetal; monocarboxylic acid; organic heterotetracyclic compound	carcinogenic agent; metabolite; mutagen; nephrotoxin; toxin
5-methoxypsoralen 5-Methoxypsoralen: A linear furanocoumarin that has phototoxic and anti-inflammatory properties, with effects similar to METHOXSALEN. It is used in PUVA THERAPY for the treatment of PSORIASIS.. 5-methoxypsoralen : A 5-methoxyfurocoumarin that is psoralen substituted by a methoxy group at position 5.	2.07	1	5-methoxyfurocoumarin; organic heterotricyclic compound; psoralens	hepatoprotective agent; plant metabolite
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	3.25	1	aromatic ether; nitrile; polyether; tertiary amino compound
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone: ubiquinol analog. 6-decylubiquinone : A member of the class of 1,4-benzoquinones that is 2,3-dimethoxybenzoquinone which has been substituted at positions 5 and 6 by decyl and methyl groups.	2.07	1	1,4-benzoquinones	cofactor
3,3'-diindolylmethane 3,3'-diindolylmethane: anti-inflammatory from edible cruciferous vegetables; a cytochrome P-450 antagonist	2.07	1	indoles	antineoplastic agent; P450 inhibitor
ellipticine ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.	2.07	1	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound; polycyclic heteroarene	antineoplastic agent; plant metabolite
embelin embelin: from Embelia fruit (Myrsinaceae). embelin : A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, antineoplastic and inhibitory activity towards hepatitis C protease.	2.07	1	dihydroxy-1,4-benzoquinones	antimicrobial agent; antineoplastic agent; hepatitis C protease inhibitor; plant metabolite
emodin Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.. emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.	2.07	1	trihydroxyanthraquinone	antineoplastic agent; laxative; plant metabolite; tyrosine kinase inhibitor
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	3.98	3	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
foscarnet Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.. phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.	2.06	1	carboxylic acid; one-carbon compound; phosphonic acids	antiviral drug; geroprotector; HIV-1 reverse transcriptase inhibitor; sodium-dependent Pi-transporter inhibitor
gossypol Gossypol: A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.	2.07	1
hypericin [no description available]	2.07	1
indole-3-carbinol indole-3-carbinol: occurs in edible cruciferous vegetables. indole-3-methanol : An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.	2.07	1	indolyl alcohol	antineoplastic agent; plant metabolite
nsc 664704 kenpaullone: inhibits CDK1/cyclin B; structure in first source. kenpaullone : An indolobenzazepine that is paullone in which the hydrogen at position 9 is replaced by a bromo substituent. It is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3beta (GSK3beta).	2.07	1	indolobenzazepine; lactam; organobromine compound	cardioprotective agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor; EC 2.7.11.26 (tau-protein kinase) inhibitor; geroprotector
khellin Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024). khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.	2.07	1	furanochromone; organic heterotricyclic compound; oxacycle	anti-asthmatic agent; bronchodilator agent; cardiovascular drug; vasodilator agent
kinetin Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.. cytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.. kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.	2.07	1	6-aminopurines; furans	cytokinin; geroprotector
beta-lapachone beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase. beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.	2.07	1	benzochromenone; orthoquinones	anti-inflammatory agent; antineoplastic agent; plant metabolite
lavendustin a lavendustin A: from Streptomyces griseolavendus; structure given in first source	2.07	1	aromatic amine
lavendustin b [no description available]	2.07	1
vitamin k 3 Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.	2.07	1	1,4-naphthoquinones; vitamin K	angiogenesis inhibitor; antineoplastic agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; human urinary metabolite; nutraceutical
metformin Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289). metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.	2.25	1	guanidines	environmental contaminant; geroprotector; hypoglycemic agent; xenobiotic
methoxsalen Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.	2.07	1	aromatic ether; psoralens	antineoplastic agent; cross-linking reagent; dermatologic drug; photosensitizing agent; plant metabolite
myristicin myristicin: asaricin is an isomer; structure; a methylene dioxy version of elemicin;	2.07	1	organic molecular entity	metabolite
nalidixic acid [no description available]	2.07	1	1,8-naphthyridine derivative; monocarboxylic acid; quinolone antibiotic	antibacterial drug; antimicrobial agent; DNA synthesis inhibitor
6,7-dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-isobenzofuran-1-one [no description available]	2.07	1	isoquinolines
patulin Patulin: 4-Hydroxy-4H-furo(3,2-c)pyran-2(6H)-one. A mycotoxin produced by several species of Aspergillus and Penicillium. It is found in unfermented apple and grape juice and field crops. It has antibiotic properties and has been shown to be carcinogenic and mutagenic and causes chromosome damage in biological systems.. patulin : A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic.	2.07	1	furopyran; gamma-lactone; lactol	antimicrobial agent; Aspergillus metabolite; carcinogenic agent; mutagen; mycotoxin; Penicillium metabolite
phloretin [no description available]	2.07	1	dihydrochalcones	antineoplastic agent; plant metabolite
sanguinarine benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.	3.61	2	alkaloid antibiotic; benzophenanthridine alkaloid; botanical anti-fungal agent
streptonigrin [no description available]	2.07	1	pyridines; quinolone	antimicrobial agent; antineoplastic agent
tetrahydropapaverine tetrahydropapaverine: RN given refers to parent cpd. 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline : A benzylisoquinoline alkaloid that is norlaudanosoline in which the four phenolic hydrogens have been replaced by methyl groups.	2.07	1	aromatic ether; benzylisoquinoline alkaloid; benzyltetrahydroisoquinoline; polyether; secondary amino compound
theobromine Theobromine: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9). theobromine : A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.	2.07	1	dimethylxanthine	adenosine receptor antagonist; bronchodilator agent; food component; human blood serum metabolite; mouse metabolite; plant metabolite; vasodilator agent
trioxsalen Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.. lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.. antipsoriatic : A drug used to treat psoriasis.. trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.	2.07	1	psoralens	dermatologic drug; photosensitizing agent
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	2.07	1	mitomycin	alkylating agent; antineoplastic agent
reserpine Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.	3.61	2	alkaloid ester; methyl ester; yohimban alkaloid	adrenergic uptake inhibitor; antihypertensive agent; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; environmental contaminant; first generation antipsychotic; plant metabolite; xenobiotic
pilocarpine hydrochloride pilocarpine hydrochloride : The hydrochloride salt of (+)-pilocarpine, a medication used to treat increased pressure inside the eye and dry mouth.	2.07	1	hydrochloride
cantharidin Cantharidin: A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally.. cantharidin : A monoterpenoid with an epoxy-bridged cyclic dicarboxylic anhydride structure secreted by many species of blister beetle, and most notably by the Spanish fly, Lytta vesicatoria. Natural toxin inhibitor of protein phosphatases 1 and 2A.	2.07	1	cyclic dicarboxylic anhydride; monoterpenoid	EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; herbicide
physostigmine Physostigmine: A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.	2.07	1	carbamate ester; indole alkaloid	antidote to curare poisoning; EC 3.1.1.8 (cholinesterase) inhibitor; miotic
kanamycin a Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components.	2.07	1	kanamycins	bacterial metabolite
veratramine veratramine: structure. veratramine : A piperidine alkaloid comprising the 14,15,16,17-tetradehydro derivative of veratraman having two hydroxy groups at the 3- and 23-positions.	2.07	1	piperidine alkaloid
phlorhizin [no description available]	2.07	1	aryl beta-D-glucoside; dihydrochalcones; monosaccharide derivative	antioxidant; plant metabolite
papaverine hydrochloride [no description available]	2.07	1
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	2.81	3	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
yohimbine hydrochloride [no description available]	2.07	1
cycloheximide Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.	2.07	1	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor
gliotoxin Gliotoxin: A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent.. gliotoxin : A pyrazinoindole with a disulfide bridge spanning a dioxo-substituted pyrazine ring; mycotoxin produced by several species of fungi.	2.07	1	dipeptide; organic disulfide; organic heterotetracyclic compound; pyrazinoindole	antifungal agent; EC 2.5.1.58 (protein farnesyltransferase) inhibitor; immunosuppressive agent; mycotoxin; proteasome inhibitor
tubercidin Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.. tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.	2.07	1	antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; ribonucleoside	antimetabolite; antineoplastic agent; bacterial metabolite
veratridine [no description available]	2.07	1	steroid	sodium channel modulator
gibberellic acid gibberellic acid: RN given refers to (1alpha,2beta,4aalpha,4bbeta,10beta)-isomer; structure. gibberellin A3 : A C19-gibberellin that is a pentacyclic diterpenoid responsible for promoting growth and elongation of cells in plants. Initially identified in Gibberella fujikuroi,it differs from gibberellin A1 in the presence of a double bond between C-3 and C-4.	2.07	1	C19-gibberellin; gibberellin monocarboxylic acid; lactone; organic heteropentacyclic compound	mouse metabolite; plant metabolite
visnagin visnagin: from Musineon divaricatum. visnagin : A furanochromone that is furo[3,2-g]chromen-5-one which is substituted at positions 4 and 7 by methoxy and methyl groups, respectively. Found in the toothpick-plant, Ammi visnaga.	2.07	1	aromatic ether; furanochromone; polyketide	anti-inflammatory agent; antihypertensive agent; EC 1.1.1.37 (malate dehydrogenase) inhibitor; phytotoxin; plant metabolite; vasodilator agent
rotenone Derris: A plant genus of the family FABACEAE. The root is a source of rotenoids (ROTENONE) and flavonoids. Some species of Pongamia have been reclassified to this genus and some to MILLETTIA. Some species of Deguelia have been reclassified to this genus.. rotenoid : Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.	2.07	1	organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; mitochondrial NADH:ubiquinone reductase inhibitor; phytogenic insecticide; piscicide; toxin
skimmianine skimmianine: furanoquinoline alkaloid from Teclea (RUTACEAE)	2.07	1	alkaloid antibiotic; organic heterotricyclic compound; organonitrogen heterocyclic compound; oxacycle
syrosingopine syrosingopine: was heading 1963-94; SYRINGOPINE was see SYROSINGOPINE 1977-94; use RESERPINE to search SYROSINGOPINE 1966-94	2.07	1	yohimban alkaloid
gramine gramine : An aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3.	2.07	1	aminoalkylindole; indole alkaloid; tertiary amino compound	antibacterial agent; antiviral agent; plant metabolite; serotonergic antagonist
methylergonovine Methylergonovine: A homolog of ERGONOVINE containing one more CH2 group. (Merck Index, 11th ed)	2.07	1	ergoline alkaloid
2,2'-methylenebis(4-methyl-6-tert-butylphenol) [no description available]	2.07	1	diarylmethane
indolebutyric acid indolebutyric acid: RN given refers to parent cpd. indole-3-butyric acid : A indol-3-yl carboxylic acid that is butanoic acid carrying a 1H-indol-3-yl substituent at position 1.	2.07	1	indol-3-yl carboxylic acid	auxin; plant hormone; plant metabolite
shikimic acid Shikimic Acid: A tri-hydroxy cyclohexene carboxylic acid important in biosynthesis of so many compounds that the shikimate pathway is named after it.. shikimic acid : A cyclohexenecarboxylic acid that is cyclohex-1-ene-1-carboxylic acid substituted by hydroxy groups at positions 3, 4 and 5 (the 3R,4S,5R stereoisomer). It is an intermediate metabolite in plants and microorganisms.	2.07	1	alpha,beta-unsaturated monocarboxylic acid; cyclohexenecarboxylic acid; hydroxy monocarboxylic acid	Escherichia coli metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
monocrotaline Monocrotaline: A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.	2.07	1	pyrrolizidine alkaloid
jervine jervine: teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structure	2.07	1	piperidines
glycyrrhetinic acid [no description available]	2.07	1	cyclic terpene ketone; hydroxy monocarboxylic acid; pentacyclic triterpenoid	immunomodulator; plant metabolite
boldine [no description available]	2.07	1	aporphine alkaloid
indirubin [no description available]	2.07	1
plumbagin plumbagin: a superoxide anion generator. plumbagin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.	2.07	1	hydroxy-1,4-naphthoquinone; phenols	anticoagulant; antineoplastic agent; immunological adjuvant; metabolite
cepharanthine cepharanthine: isoquinoline alkaloid from tubers of STEPHANIA; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. cepharanthine : A bisbenzylisoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation.	2.07	1	bisbenzylisoquinoline alkaloid; isoquinolines
aloe emodin aloe emodin: structure distinct from emodin; this does not mean emodin from aloe. Aloe emodin : A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.	2.07	1	aromatic primary alcohol; dihydroxyanthraquinone	antineoplastic agent; plant metabolite
osthol osthol: from Cnidium monnieri and Angelica pubescens (both Apiaceae); structure given in first source	2.07	1	botanical anti-fungal agent; coumarins	metabolite
cytisine [no description available]	2.49	2	alkaloid; bridged compound; lactam; organic heterotricyclic compound; secondary amino compound	nicotinic acetylcholine receptor agonist; phytotoxin; plant metabolite
bicuculline Bicuculline: An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.. bicuculline : A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.	2.07	1	benzylisoquinoline alkaloid; isoquinoline alkaloid; isoquinolines	agrochemical; central nervous system stimulant; GABA-gated chloride channel antagonist; GABAA receptor antagonist; neurotoxin
kainic acid Kainic Acid: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.	2.07	1	dicarboxylic acid; L-proline derivative; non-proteinogenic L-alpha-amino acid; pyrrolidinecarboxylic acid	antinematodal drug; excitatory amino acid agonist
thymoquinone thymoquinone: constituent of cedarwood; can cause dermatitis; structure. thymoquinone : A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.	2.07	1	1,4-benzoquinones	adjuvant; anti-inflammatory agent; antidepressant; antineoplastic agent; antioxidant; cardioprotective agent; plant metabolite
oleanolic acid [no description available]	2.07	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
podophyllotoxin Podophyllum: A genus of poisonous American herbs, family BERBERIDACEAE. The roots yield PODOPHYLLOTOXIN and other pharmacologically important agents. The plant was formerly used as a cholagogue and cathartic. It is different from the European mandrake, MANDRAGORA.	2.07	1	furonaphthodioxole; lignan; organic heterotetracyclic compound	antimitotic; antineoplastic agent; keratolytic drug; microtubule-destabilising agent; plant metabolite; tubulin modulator
hesperidin Hesperidin: A flavanone glycoside found in CITRUS fruit peels.. hesperidin : A disaccharide derivative that consists of hesperetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.07	1	3'-hydroxyflavanones; 4'-methoxyflavanones; dihydroxyflavanone; disaccharide derivative; flavanone glycoside; monomethoxyflavanone; rutinoside	mutagen
azomycin azomycin: RN given refers to parent cpd with specified locant; structure	2.07	1	C-nitro compound; imidazoles	antitubercular agent
Berberine chloride (TN) [no description available]	2.07	1	organic molecular entity
vincamine Vincamine: A major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.	2.07	1	alkaloid ester; hemiaminal; methyl ester; organic heteropentacyclic compound; vinca alkaloid	antihypertensive agent; metabolite; vasodilator agent
glaucine glaucine: RN given refers to (+-)-isomer	3.25	1	aporphine alkaloid; organic heterotetracyclic compound; polyether; tertiary amino compound	antibacterial agent; antineoplastic agent; antitussive; muscle relaxant; NF-kappaB inhibitor; plant metabolite; platelet aggregation inhibitor; rat metabolite
muscarine [no description available]	2.07	1
ecdysone [no description available]	2.07	1	14alpha-hydroxy steroid; 22-hydroxy steroid; 25-hydroxy steroid; 2beta-hydroxy steroid; 3beta-sterol; 6-oxo steroid; ecdysteroid	prohormone
n-deacetyl-n-formylcolchicine N-deacetyl-N-formylcolchicine: structure given in first source	2.07	1	cyclic ketone
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.07	1	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.07	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
2-bromoergocryptine mesylate [no description available]	2.07	1	methanesulfonate salt	antiparkinson drug
zingerone zingerone: pungent principle of ginger; structure. zingerone : A methyl ketone that is 4-phenylbutan-2-one in which the phenyl ring is substituted at positions 3 and 4 by methoxy and hydroxy groups respectively. The major pungent component in ginger.	2.07	1	methyl ketone; monomethoxybenzene; phenols	anti-inflammatory agent; antiemetic; antioxidant; flavouring agent; fragrance; plant metabolite; radiation protective agent
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	3.05	4	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
etoposide [no description available]	2.07	1	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
ribavirin Rebetron: Rebetron is tradename	2.52	2	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
phorbol 12,13-dibutyrate Phorbol 12,13-Dibutyrate: A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.	2.07	1	butyrate ester; phorbol ester; tertiary alpha-hydroxy ketone
cephradine Cephradine: A semi-synthetic cephalosporin antibiotic.. cephradine : A first-generation cephalosporin antibiotic with a methyl substituent at position 3, and a (2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetamido substituent at position 7, of the cephem skeleton.	2.07	1	beta-lactam antibiotic allergen; cephalosporin	antibacterial drug
quisqualic acid Quisqualic Acid: An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.	2.07	1	non-proteinogenic alpha-amino acid
staurosporine [no description available]	3.25	1	indolocarbazole alkaloid; organic heterooctacyclic compound	apoptosis inducer; bacterial metabolite; EC 2.7.11.13 (protein kinase C) inhibitor; geroprotector
colforsin Colforsin: Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.	2.07	1	acetate ester; cyclic ketone; labdane diterpenoid; organic heterotricyclic compound; tertiary alpha-hydroxy ketone; triol	adenylate cyclase agonist; anti-HIV agent; antihypertensive agent; plant metabolite; platelet aggregation inhibitor; protein kinase A agonist
swainsonine Swainsonine: An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.. swainsonine : An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8.	2.07	1	indolizidine alkaloid	antineoplastic agent; EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor; immunological adjuvant; plant metabolite
castanospermine castanospermine: indolizidine alkaloid from seeds of Australian legume, Castanospermum australe. castanospermine : A tetrahydroxyindolizidine alkaloid that consists of octahydroindolizine having four hydroxy substituents located at positions 1, 6, 7 and 8 (the 1S,6S,7R,8R,8aR-diastereomer).	2.07	1	indolizidine alkaloid	anti-HIV-1 agent; anti-inflammatory agent; EC 3.2.1.* (glycosidase) inhibitor; metabolite
lamivudine [no description available]	2.51	2	monothioacetal; nucleoside analogue; oxacycle; primary alcohol	allergen; anti-HBV agent; antiviral drug; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor; HIV-1 reverse transcriptase inhibitor; prodrug
irinotecan [no description available]	3.31	1	carbamate ester; delta-lactone; N-acylpiperidine; pyranoindolizinoquinoline; ring assembly; tertiary alcohol; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 5.99.1.2 (DNA topoisomerase) inhibitor; prodrug
daunorubicin hydrochloride [no description available]	2.07	1	anthracycline
mevastatin mevastatin: antifungal metabolite from Penicillium brevicopactum; potent inhibitory activity to sterol synthesis; structure. mevastatin : A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.	2.07	1	2-pyranones; carboxylic ester; hexahydronaphthalenes; polyketide; statin (naturally occurring)	antifungal agent; apoptosis inducer; EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor; fungal metabolite; Penicillium metabolite
ursolic acid [no description available]	2.07	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	geroprotector; plant metabolite
norharman norharman: RN given refers to parent cpd. beta-carboline : The parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring.	2.07	1	beta-carbolines; mancude organic heterotricyclic parent	fungal metabolite; marine metabolite
betulinic acid [no description available]	2.07	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-HIV agent; anti-inflammatory agent; antimalarial; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; plant metabolite
oseltamivir Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.	2.51	2	acetamides; amino acid ester; cyclohexenecarboxylate ester; primary amino compound	antiviral drug; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; environmental contaminant; prodrug; xenobiotic
epigallocatechin gallate epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.	2.55	2	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite
baccatin iii [no description available]	2.07	1	acetate ester; benzoate ester; tetracyclic diterpenoid	plant metabolite
taleranol taleranol: a metabolite of ZEARALENONE which is a non-steroidal estrogenic lactone used as an anabolic compound in animal feed; a stereoisomer of ZERANOL (alpha-zearalanol)	2.07	1	macrolide
narasin [no description available]	2.07	1	diterpene glycoside
quassin quassin: article discusses quassinoid principle; structure	2.07	1	triterpenoid
tomatidine tomatidine: RN given refers to (3beta,5alpha,22beta,25S)-isomer; structure. tomatidine : A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.	2.07	1	3beta-hydroxy steroid; azaspiro compound; oxaspiro compound
aloxistatin aloxistatin: a membrane-permeable cysteine protease inhibitor. aloxistatin : An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylic acid with the amino group of N-(3-methylbutyl)-L-leucinamide.	2.07	1	epoxide; ethyl ester; L-leucine derivative; monocarboxylic acid amide	anticoronaviral agent; cathepsin B inhibitor
rutecarpine rutacarpine: from Evodia rutaecarpa; an ingredient in zhuyu hewei zhitong capsules	2.07	1	beta-carbolines
bergenin bergenin: RN refers to (2R-(2alpha,3beta,4alpha,4aalpha,10bbeta))-isomer; structure	2.07	1	trihydroxybenzoic acid	metabolite
pinocembrin pinocembrin : A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.	2.07	1	(2S)-flavan-4-one; dihydroxyflavanone	antineoplastic agent; antioxidant; metabolite; neuroprotective agent; vasodilator agent
dictamnine dictamnine: furanoquinoline alkaloid; crosslinks DNA in presence of ultraviolet light	2.31	1	alkaloid antibiotic; organic heterotricyclic compound; organonitrogen heterocyclic compound; oxacycle
isoscopoletin isoscopoletin : A hydroxycoumarin that is esculetin in which the hydroxy group at position 7 is replaced by a methoxy group. It is the major primary metabolite of scoparone.	2.07	1	aromatic ether; hydroxycoumarin	plant metabolite
vinburnine [no description available]	2.07	1	alkaloid
epicatechin (-)-epicatechin : A catechin with (2R,3R)-configuration.	2.07	1	catechin; polyphenol	antioxidant
hesperetin [no description available]	2.07	1	3'-hydroxyflavanones; 4'-methoxyflavanones; monomethoxyflavanone; trihydroxyflavanone	antineoplastic agent; antioxidant; plant metabolite
magnolol [no description available]	2.07	1	biphenyls
honokiol [no description available]	2.07	1	biphenyls
chelerythrine chloride [no description available]	2.07	1
betulin betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.	2.07	1	diol; pentacyclic triterpenoid	analgesic; anti-inflammatory agent; antineoplastic agent; antiviral agent; metabolite
tetrahydroalstonine tetrahydroalstonine : A heteropentacyclic compound that is (20alpha)-16,17-didehydro-18-oxayohimban which is substituted at position 16 by a methoxycarbonyl group and at position 19 by a methyl group. It is a metabolite found in several plant species.	2.07	1	methyl ester; organic heteropentacyclic compound; yohimban alkaloid	plant metabolite
hernandezine hernandezine: from Thalictrum glandulosissimum; structure given in first source; RN given refers to (1beta)-isomer; RN for cpd without isomeric designation not avail 3/91	2.07	1	bisbenzylisoquinoline alkaloid; isoquinolines
picropodophyllin picropodophyllin: isolated from American May apple (Podophyllum); inhibits IGF-I autophosphorylation without interfering with tyrosine kinase activity. picropodophyllotoxin : An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.	2.07	1	furonaphthodioxole; lignan; organic heterotetracyclic compound	antineoplastic agent; insulin-like growth factor receptor 1 antagonist; plant metabolite; tyrosine kinase inhibitor
tetrandrine tetrandrine: a bisbenzylisoquinoline that exhibits antifibrogenic activity	2.07	1	bisbenzylisoquinoline alkaloid; isoquinolines
dehydrocostus lactone dehydrocostus lactone : An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.	2.07	1	gamma-lactone; guaiane sesquiterpenoid; organic heterotricyclic compound; sesquiterpene lactone	antimycobacterial drug; antineoplastic agent; apoptosis inducer; cyclooxygenase 2 inhibitor; metabolite; trypanocidal drug
madecassic acid [no description available]	2.07	1	monocarboxylic acid; pentacyclic triterpenoid; tetrol	antioxidant; plant metabolite
panaxadiol panaxadiol: a protopanaxadiol with the side chain cyclized into a pyran which is an artifact of acidic hydrolysis; RN refers to (3 beta,12 beta,20R)-isomer	2.07	1	triterpenoid saponin
tryptanthrine tryptanthrine: minor constituent of traditional Chinese medicine qing dai	3.61	2	alkaloid antibiotic; organic heterotetracyclic compound; organonitrogen heterocyclic compound
homoeriodictyol homoeriodictyol: structure in first source. homoeriodictyol : A trihydroxyflavanone that consists of 3'-methoxyflavanone in which the three hydroxy substituents are located at positions 4', 5, and 7.	2.07	1	3'-methoxyflavanones; 4'-hydroxyflavanones; monomethoxyflavanone; trihydroxyflavanone	flavouring agent; metabolite
4-hydroxyindole hydroxyindoles : Any member of the class of indoles carrying at least one hydroxy group.	2.07	1	hydroxyindoles; phenols
rosiglitazone [no description available]	2.25	1	aminopyridine; thiazolidinediones	EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; insulin-sensitizing drug
eriocitrin eriocitrin: structure in first source. eriocitrin : A disaccharide derivative that consists of eriodictyol substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.07	1	3'-hydroxyflavanones; 4'-hydroxyflavanones; disaccharide derivative; flavanone glycoside; rutinoside; trihydroxyflavanone	antioxidant
7,8-dihydromethysticin [no description available]	2.07	1	2-pyranones; aromatic ether
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	2.07	1	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
cinchonine [no description available]	2.07	1	(8xi)-cinchonan-9-ol; cinchona alkaloid	metabolite
aucubin [no description available]	2.07	1	organic molecular entity	metabolite
lupinine lupinine: RN given refers to parent cpd(1R-trans)-isomer; structure	2.07	1	quinolizidine alkaloid
friedelin 3-friedelanone: from the stem bark of Irvingia gabonensis; structure in first source. friedelin : A pentacyclic triterpenoid that is perhydropicene which is substituted by an oxo group at position 3 and by methyl groups at the 4, 4a, 6b, 8a, 11, 11, 12b, and 14a-positions (the 4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS-enantiomer). It is the major triterpenoid constituent of cork.	2.07	1	cyclic terpene ketone; pentacyclic triterpenoid	anti-inflammatory drug; antipyretic; non-narcotic analgesic; plant metabolite
catalpol [no description available]	2.07	1	organic molecular entity	metabolite
quinine hydrochloride [no description available]	2.07	1
sarsasapogenin [no description available]	2.07	1	sapogenin
corynanthine Corynanthine: A stereoisomer of yohimbine.	2.07	1	yohimban alkaloid
prunin protein, prunus prunin protein, Prunus: a legumin-like type of globulin; structure given in first source. naringenin 7-O-beta-D-glucoside : A flavanone 7-O-beta-D-glucoside that is (S)-naringenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.07	1	(2S)-flavan-4-one; 4'-hydroxyflavanones; dihydroxyflavanone; flavanone 7-O-beta-D-glucoside; monosaccharide derivative	antibacterial agent; antilipemic drug; hypoglycemic agent; metabolite
podocarpic acid podocarpic acid: structure. podocarpic acid : An abietane diterpenoid lacking the isopropyl substituent with an aromatic C-ring and a hydroxy group at the 12-position.	2.07	1	abietane diterpenoid
harmol hydrochloride [no description available]	2.07	1
5-Methoxyflavone 5-methoxyflavone: DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity; structure in first source	2.07	1	ether; flavonoids
10-hydroxycamptothecin [no description available]	2.07	1	pyranoindolizinoquinoline
corydaline [no description available]	2.07	1	isoquinoline alkaloid; isoquinolines
demissidine [no description available]	2.07	1	alkaloid; organic heteropolycyclic compound; steroid
cinchonidine cinchonidine: has antimalarial activity; diastereoisomer of cinchonine with distinct physiochemical properties; RN given refers to parent cpd(8alpha,9R)-isomer. cinchonidine : 8-epi-Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (R configuration). A diasteroisomer of cinchonine, it occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.	2.07	1	(8xi)-cinchonan-9-ol; cinchona alkaloid	metabolite
propidium iodide [no description available]	2.07	1	organic iodide salt
tryptoline tryptoline: neurotoxic factor that may be involved in development of Parkinson's disease; enzymatic prep from human brain converts tryptamine to tryptoline; RN given refers to parent cpd; structure	2.07	1	beta-carbolines
deguelin deguelin: a natural product from Mundulea sericea; RN refers to (7aS-cis)-isomer; structure given in first source. deguelin : A rotenone that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted by methoxy groups at positions 9 and 10, and by two methyl groups at position 3 (the 7aS,13aS-stereoisomer). It exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants and reported to exert anti-tumour effects in various cancers.	2.07	1	aromatic ether; diether; organic heteropentacyclic compound; rotenones	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antiviral agent; apoptosis inducer; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; mitochondrial NADH:ubiquinone reductase inhibitor; plant metabolite
catechin (+)-catechin monohydrate : The monohydrate of (+)-catechin.	2.07	1	hydrate	geroprotector
daidzin daidzin: a potent, selective, and reversible inhibitor of human mitochondrial aldehyde dehydrogenase. daidzein 7-O-beta-D-glucoside : A glycosyloxyisoflavone that is daidzein attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It is used in the treatment of alcohol dependency (antidipsotropic).	2.07	1	7-hydroxyisoflavones 7-O-beta-D-glucoside; hydroxyisoflavone; monosaccharide derivative	plant metabolite
cafestol [no description available]	2.07	1	diterpenoid; furans; organic heteropentacyclic compound; primary alcohol; tertiary alcohol	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; hypoglycemic agent; plant metabolite
parthenolide [no description available]	2.07	1	germacranolide
ecteinascidin 743 [no description available]	3.25	1	acetate ester; azaspiro compound; bridged compound; hemiaminal; isoquinoline alkaloid; lactone; organic heteropolycyclic compound; organic sulfide; oxaspiro compound; polyphenol; tertiary amino compound	alkylating agent; angiogenesis modulating agent; anti-inflammatory agent; antineoplastic agent; marine metabolite
homoorientin homoorientin: isolated from Swertia japonica; structure given in first source	2.07	1	flavone C-glycoside; tetrahydroxyflavone	antineoplastic agent; radical scavenger
oxymatrine oxysophoridine: an alkaloid isolated from Sophra alope; structure in first source	8.47	7	alkaloid; tertiary amine oxide
sophocarpine [no description available]	3.47	7
asiatic acid [no description available]	2.07	1	monocarboxylic acid; pentacyclic triterpenoid; triol	angiogenesis modulating agent; metabolite
angustmycin a angustmycin A: structure; from Streptomyces hygroscopicus; inhibits GMP synthesis	2.07	1	6-aminopurines
razadyne Razadyne: Name of the FDA approved preparation from J&J.	2.07	1
phytosphingosine phytosphingosine: differ with an additional hydroxyl at C-4 & no double bond between C-4 & C-5	2.07	1	amino alcohol; sphingoid; triol	mouse metabolite; Saccharomyces cerevisiae metabolite
tetradecanoylphorbol acetate [no description available]	2.07	1
celastrol [no description available]	2.07	1	monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite
4'-demethylepipodophyllotoxin 4'-demethylepipodophyllotoxin: structure in first source. 4'-demethylepipodophyllotoxin : An organic heterotetracyclic compound that is the 9- epimer of 4'-demethylpodophyllotoxin.	2.07	1	furonaphthodioxole; organic heterotetracyclic compound; phenols	antineoplastic agent
gefitinib [no description available]	2.41	1	aromatic ether; monochlorobenzenes; monofluorobenzenes; morpholines; quinazolines; secondary amino compound; tertiary amino compound	antineoplastic agent; epidermal growth factor receptor antagonist
n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine N-(N-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine: inhibits calcium-activated neutral protease; see also record for E-64; RN given refers to (2-S-(2alpha,3beta)(R*)-isomer)	2.07	1	leucine derivative
e 64 E 64: cysteine protease inhibitor of microbial origin, which inhibits cathepsin B (EC 3.4.22.1) and cathepsin L (EC 3.4.22.-)	2.07	1	dicarboxylic acid monoamide; epoxy monocarboxylic acid; guanidines; L-leucine derivative; zwitterion	antimalarial; antiparasitic agent; protease inhibitor
fraxinellone fraxinellone: structure given in first source; RN given for (3R-cis)-isomer	2.31	1	2-benzofurans
5'-(sulfonylbenzoyl)adenosine 5'-(sulfonylbenzoyl)adenosine: covalently binds to platelet membrane	3.25	1
sinensetin sinensetin: isolated from citrus fruit; exhibit antiadhesive action on platelets. sinensetin : A pentamethoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 3' and 4' respectively.	2.07	1	pentamethoxyflavone	plant metabolite
harmalol hydrochloride [no description available]	2.07	1
hyoscyamine Hyoscyamine: The 3(S)-endo isomer of atropine.. (S)-atropine : An atropine with a 2S-configuration.	2.07	1	tropane alkaloid
schizandrin a schizandrin A: the major lignan, 2-9%, of Schisandra plant; has hepatoprotective, antioxidant, and antineoplastic activities	2.07	1
schizandrin b (+)-schisandrin B : An organic heterotetracyclic compound that is found in Fructus Schisandrae and Schisandra chinensis.	2.07	1	aromatic ether; cyclic acetal; organic heterotetracyclic compound; oxacycle; tannin	anti-asthmatic agent; anti-inflammatory agent; antilipemic drug; antioxidant; apoptosis inhibitor; hepatoprotective agent; nephroprotective agent; neuroprotective agent; plant metabolite
cryptotanshinone cryptotanshinone: from Salvia miltiorrhiza	2.07	1	abietane diterpenoid	anticoronaviral agent
isosakuranetin isosakuranetin: structure in first source. 4'-methoxy-5,7-dihydroxyflavanone : A dihydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5 and 7 and a methoxy group at position 4' (the 2S stereoisomer).	2.07	1	(2S)-flavan-4-one; 4'-methoxyflavanones; dihydroxyflavanone; monomethoxyflavanone	plant metabolite
isovitexin [no description available]	2.07	1	C-glycosyl compound; trihydroxyflavone	EC 3.2.1.20 (alpha-glucosidase) inhibitor; metabolite
sclareol sclareol: structure given in first source. sclareol : A labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea.	2.07	1	labdane diterpenoid	antifungal agent; antimicrobial agent; apoptosis inducer; fragrance; plant metabolite
tanshinone ii a tashinone IIA: a cardiovascular agent with antineoplastic activity; isolated from Salvia miltiorrhiza; structure in first source	2.07	1	abietane diterpenoid
matrine, (5beta)-isomer [no description available]	3.07	4
leucodin leucodin: structure in first source	2.07	1	sesquiterpene lactone
sophoramine sophoramine: structure given in first source	3.04	4	naphthyridine derivative
limonin [no description available]	2.07	1	epoxide; furans; hexacyclic triterpenoid; lactone; limonoid; organic heterohexacyclic compound	inhibitor; metabolite; volatile oil component
maduramicin maduramicin: isolated from Actinomadura rubra	2.07	1
chelidonine chelidonine: benzophenanthridine derived from scoulerine from Chelidonium majus; RN given refers to parent cpd (chelidonine, (5bR-(5balpha,6beta,12alpha))-isomer)	2.07	1	alkaloid antibiotic; alkaloid fundamental parent; benzophenanthridine alkaloid
troleandomycin Troleandomycin: A macrolide antibiotic that is similar to ERYTHROMYCIN.. troleandomycin : A semi-synthetic macrolide antibiotic obtained by acetylation of the three free hydroxy groups of oleandomycin. Troleandomycin is only found in individuals that have taken the drug.	2.07	1	acetate ester; epoxide; macrolide antibiotic; monosaccharide derivative; polyketide; semisynthetic derivative	EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitor; xenobiotic
santonin Santonin: Anthelmintic isolated from the dried unexpanded flower heads of Artemisia maritima and other species of Artemisia found principally in Russian and Chinese Turkestan and the Southern Ural region. (From Merck, 11th ed.)	2.07	1	botanical anti-fungal agent; santonin	plant metabolite
sitosterol, (3beta)-isomer Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.	2.07	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; C29-steroid; phytosterols; stigmastane sterol	anticholesteremic drug; antioxidant; mouse metabolite; plant metabolite; sterol methyltransferase inhibitor
vincristine sulfate [no description available]	2.07	1	organic sulfate salt	antineoplastic agent; geroprotector
anisomycin Anisomycin: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.. (-)-anisomycin : An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.	2.07	1	monohydroxypyrrolidine; organonitrogen heterocyclic antibiotic	anticoronaviral agent; antimicrobial agent; antineoplastic agent; antiparasitic agent; bacterial metabolite; DNA synthesis inhibitor; protein synthesis inhibitor
acetylstrophanthidin acetylstrophanthidin: structure. acetylstrophanthidin : An acetate ester that is strophanidin acetylated at the 3beta-hydroxy group.	2.07	1	acetate ester	anti-arrhythmia drug
Harringtonine harringtonin: alkaloid C from Caphalotaxus fortunei	2.07	1	alkaloid
acivicin [no description available]	2.07	1	isoxazoles; non-proteinogenic L-alpha-amino acid; organochlorine compound	antileishmanial agent; antimetabolite; antimicrobial agent; antineoplastic agent; EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor; glutamine antagonist; metabolite
ketopinic acid ketopinic acid: structure in first source	2.07	1
wortmannin [no description available]	2.07	1	acetate ester; cyclic ketone; delta-lactone; organic heteropentacyclic compound	anticoronaviral agent; antineoplastic agent; autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector; Penicillium metabolite; radiosensitizing agent
gitoxigenin gitoxigenin: structure	2.07	1	14beta-hydroxy steroid; 16beta-hydroxy steroid; 3beta-hydroxy steroid
graveoline graveoline: structure in first source	2.07	1	quinolines
4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en 4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en: RN given for (3R-(3alpha,3abeta,4beta,8aalpha))-isomer; a natural benzyl ester of a carotyl type azulene sesquiterpenoid; structure in first source	2.07	1
maackiain [no description available]	2.31	1	phenols; pterocarpans
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	2.07	1	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
ouabain Ouabain: A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.. cardiac glycoside : Steroid lactones containing sugar residues that act on the contractile force of the cardiac muscles.. ouabain : A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.	2.07	1	11alpha-hydroxy steroid; 14beta-hydroxy steroid; 5beta-hydroxy steroid; alpha-L-rhamnoside; cardenolide glycoside; steroid hormone	anti-arrhythmia drug; cardiotonic drug; EC 2.3.3.1 [citrate (Si)-synthase] inhibitor; EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; ion transport inhibitor; plant metabolite
puromycin [no description available]	2.07	1	puromycins	antiinfective agent; antimicrobial agent; antineoplastic agent; EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor; EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor; nucleoside antibiotic; protein synthesis inhibitor
taxifolin (+)-taxifolin : A taxifolin that has (2R,3R)-configuration.	2.07	1	taxifolin	metabolite
mimosine L-mimosine : An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.	2.07	1	4-pyridones; amino acid zwitterion; non-proteinogenic L-alpha-amino acid	EC 1.14.18.1 (tyrosinase) inhibitor; plant metabolite
eriodictyol eriodictyol: structure. eriodictyol : A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.	2.07	1	3'-hydroxyflavanones; tetrahydroxyflavanone
arbutin hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.	2.07	1	beta-D-glucoside; monosaccharide derivative	Escherichia coli metabolite; plant metabolite
quinidine Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.	3.61	2	cinchona alkaloid	alpha-adrenergic antagonist; anti-arrhythmia drug; antimalarial; drug allergen; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; muscarinic antagonist; P450 inhibitor; potassium channel blocker; sodium channel blocker
conessine conessine : A steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae.	2.07	1	steroid alkaloid; tertiary amino compound	antibacterial agent; antimalarial; H3-receptor antagonist; plant metabolite
griseofulvin Griseofulvin: An antifungal agent used in the treatment of TINEA infections.. griseofulvin : An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.	2.07	1	1-benzofurans; antibiotic antifungal drug; benzofuran antifungal drug; organochlorine compound; oxaspiro compound	antibacterial agent; Penicillium metabolite
digitoxin Digitoxin: A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). digitoxin : A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.	2.07	1	cardenolide glycoside	EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
hyperforin hyperforin: a prenylated acylphloroglucinol derivative; antibiotic component of novoimanine; psychoactive agent in St. John's wort; Russian; structure;. hyperforin : A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.	2.07	1
deltaline [no description available]	2.07	1	acetate ester; cyclic acetal; diterpene alkaloid; organic polycyclic compound; tertiary alcohol; tertiary amino compound
ingenol [no description available]	2.07	1	cyclic terpene ketone; tetracyclic diterpenoid
picrotin picrotin: the less toxic component of PICROTOXIN lacking GABA activity. picrotin : An organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity.	2.07	1	diol; epoxide; gamma-lactone; organic heteropentacyclic compound; picrotoxane sesquiterpenoid; tertiary alcohol	plant metabolite
picrotoxinin [no description available]	2.07	1	epoxide; gamma-lactone; organic heteropentacyclic compound; picrotoxane sesquiterpenoid; tertiary alcohol	GABA antagonist; plant metabolite; serotonergic antagonist
naringin [no description available]	2.07	1	(2S)-flavan-4-one; 4'-hydroxyflavanones; dihydroxyflavanone; disaccharide derivative; neohesperidoside	anti-inflammatory agent; antineoplastic agent; metabolite
isonaringin isonaringin: structure in first source. narirutin : A disaccharide derivative that is (S)-naringenin substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.07	1	(2S)-flavan-4-one; 4'-hydroxyflavanones; dihydroxyflavanone; disaccharide derivative; rutinoside	anti-inflammatory agent; antioxidant; metabolite
ochratoxin a ochratoxin A: structure in first source & in Merck, 9th ed, #6549. ochratoxin A : A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.	2.07	1	isochromanes; monocarboxylic acid amide; N-acyl-L-phenylalanine; organochlorine compound; phenylalanine derivative	Aspergillus metabolite; calcium channel blocker; carcinogenic agent; mycotoxin; nephrotoxin; Penicillium metabolite; teratogenic agent
gingerol gingerol: an active ingredient in GINGER along with SHOGAOL. a nonvolatile methoxy phenyl decanone. gingerol : A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.	2.07	1	beta-hydroxy ketone; guaiacols	antineoplastic agent; plant metabolite
securinine securinine: a quinolizine pseudoalkaloid (not from amino acid) from Securinega suffurutiosa or Securinini nitras	2.07	1	indolizines
Dubinidine [no description available]	2.07	1	organic heterotricyclic compound; organonitrogen heterocyclic compound; oxacycle
cyclopamine [no description available]	2.07	1	piperidines	glioma-associated oncogene inhibitor
doxorubicin hydrochloride [no description available]	2.07	1	anthracycline
vinpocetine vinpocetine: whole issue of Arzneim Forsch (23 articles) discuss this drug; Arzneim Forsch 26(10a);1976; RN given refers to parent cpd with unspecified isomeric designation	2.07	1	alkaloid	geroprotector
dihydroergocristine monomesylate dihydroergocristine mesylate : The methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia.	2.07	1	methanesulfonate salt	alpha-adrenergic antagonist; geroprotector; vasodilator agent
tretinoin Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).. retinoic acid : A retinoid consisting of 3,7-dimethylnona-2,4,6,8-tetraenoic acid substituted at position 9 by a 2,6,6-trimethylcyclohex-1-en-1-yl group (geometry of the four exocyclic double bonds is not specified).. all-trans-retinoic acid : A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.	2.07	1	retinoic acid; vitamin A	anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.07	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
ferulic acid ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.	2.07	1	ferulic acids	anti-inflammatory agent; antioxidant; apoptosis inhibitor; cardioprotective agent; MALDI matrix material; plant metabolite
thapsigargin Thapsigargin: A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.. thapsigargin : An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.	2.07	1	butyrate ester; organic heterotricyclic compound; sesquiterpene lactone	calcium channel blocker; EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor
mycophenolic acid Mycophenolic Acid: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.. mycophenolate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of mycophenolic acid.. mycophenolic acid : A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases.	2.07	1	2-benzofurans; gamma-lactone; monocarboxylic acid; phenols	anticoronaviral agent; antimicrobial agent; antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; environmental contaminant; immunosuppressive agent; mycotoxin; Penicillium metabolite; xenobiotic
alitretinoin Alitretinoin: A retinoid that is used for the treatment of chronic hand ECZEMA unresponsive to topical CORTICOSTEROIDS. It is also used to treat cutaneous lesions associated with AIDS-related KAPOSI SARCOMA.	2.07	1	retinoic acid	antineoplastic agent; keratolytic drug; metabolite; retinoid X receptor agonist
L-cycloserine L-cycloserine : A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora.	2.07	1	4-amino-1,2-oxazolidin-3-one	anti-HIV agent; anticonvulsant; EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor
12-deoxyphorbol 13-acetate [no description available]	2.07	1	phorbol ester	metabolite
dactinomycin Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)	2.07	1	actinomycin	mutagen
aphidicolin Aphidicolin: An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.. aphidicolin : A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.	2.07	1	tetracyclic diterpenoid	antimicrobial agent; antimitotic; antineoplastic agent; antiviral drug; apoptosis inducer; Aspergillus metabolite; DNA synthesis inhibitor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; fungal metabolite
(+)-usnic acid [no description available]	2.07	1	usnic acid
beta, beta-dimethylacrylshikonin, (+)-isomer [no description available]	2.07	1	hydroxy-1,4-naphthoquinone
shikonin shikonin: a naphthazarin; has antineoplastic and angiogenesis inhibiting activities	2.55	2	hydroxy-1,4-naphthoquinone
rhapontin rhapontin: constituent of rhubarb rhizome	2.07	1	rhaponticin	angiogenesis inhibitor; anti-allergic agent; anti-inflammatory agent; antilipemic drug; antineoplastic agent; apoptosis inducer; EC 2.3.1.85 (fatty acid synthase) inhibitor; hypoglycemic agent; neuroprotective agent; plant metabolite
piperine piperine : A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum.	3.61	2	benzodioxoles; N-acylpiperidine; piperidine alkaloid; tertiary carboxamide	food component; human blood serum metabolite; NF-kappaB inhibitor; plant metabolite
antofine antofine: structure in first source. (-)-antofine : An organic heteropentacyclic compound that is (13aR)-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline substituted at positions 2, 3 and 6 by methoxy groups. It is an alkaloid produced by relatives of the milkweed family and exhibits antiviral, anti-inflammatory, antiadipogenic and antitumorigenic activities.	3.25	1	alkaloid antibiotic; alkaloid; aromatic ether; organic heteropentacyclic compound	angiogenesis inhibitor; anti-inflammatory agent; antimicrobial agent; antineoplastic agent; antiviral agent; phytotoxin; plant metabolite
rauwolscine Rauwolscine: A stereoisomer of yohimbine.	2.07	1	methyl 17-hydroxy-20xi-yohimban-16-carboxylate
discodermolide [no description available]	3.25	1	diterpenoid
sparteine [no description available]	2.1	1	quinolizidine alkaloid fundamental parent; quinolizidine alkaloid
amygdalin (R)-amygdalin : An amygdalin in which the stereocentre on the cyanohydrin function has R-configuration.	2.07	1	amygdalin	antineoplastic agent; apoptosis inducer; plant metabolite
hydrastine, (r-(r,s))-isomer [no description available]	2.07	1	isoquinolines
tiamulin tiamulin: 81723 HFU and tiamutin are for fumarate salt; prevents senescence in ascomycete; pleuromutilin derivative; RN given refers to ((3aS-(3aalpha,4beta,5alpha,6alpha,8beta,9alpha,9abeta,10S*))-isomer. tiamulin : A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by Serpulina hyodysenteriae.	3.25	1	carbotricyclic compound; carboxylic ester; cyclic ketone; organic sulfide; secondary alcohol; semisynthetic derivative; tertiary amino compound; tetracyclic diterpenoid	antibacterial drug
vasicine vasicine: RN given refers to (R)-isomer	2.07	1
3,3',4,5'-tetrahydroxystilbene 3,3',4,5'-tetrahydroxystilbene: demethyl derivative of isorhapontigenin; structure in first source; a Syk kinase inhibitor; found in heartwood of FABACEAE; inhibitor of photosynthesis in spinach chloroplasts; may be inhibitor of plant growth; RN given refers to (E)-isomer. piceatannol : A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.	2.07	1	catechols; polyphenol; resorcinols; stilbenol	antineoplastic agent; apoptosis inducer; geroprotector; hypoglycemic agent; plant metabolite; protein kinase inhibitor; tyrosine kinase inhibitor
caffeic acid trans-caffeic acid : The trans-isomer of caffeic acid.	2.07	1	caffeic acid	geroprotector; mouse metabolite
cotinine Cotinine: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.. (-)-cotinine : An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.	2.07	1	N-alkylpyrrolidine; pyridines; pyrrolidin-2-ones; pyrrolidine alkaloid	antidepressant; biomarker; human xenobiotic metabolite; plant metabolite
heliotrine [no description available]	2.07	1	pyrrolizines
sclareolide [no description available]	2.07	1	naphthofuran
hypocrellin b hypocrellin B: photosensitive pigments isolated from Hypocrella bambusae Sacc; structure given in first source	2.07	1
capsaicin ALGRX-4975: an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. capsaicinoid : A family of aromatic fatty amides produced as secondary metabolites by chilli peppers.	2.07	1	capsaicinoid	non-narcotic analgesic; TRPV1 agonist; voltage-gated sodium channel blocker
aurapten aurapten: RN refers to (E)-isomer; structure given in first source. auraptene : A member of the class of coumarins that is umbelliferone in which the phenolic hydrogen has been replaced by a geranyl group. Ii is isolated from several edible fruits and vegetables and exhibits a variety of therapeutic properties.	2.07	1	coumarins; monoterpenoid	antihypertensive agent; antineoplastic agent; antioxidant; apoptosis inducer; dopaminergic agent; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; gamma-secretase modulator; gastrointestinal drug; hepatoprotective agent; matrix metalloproteinase inhibitor; neuroprotective agent; plant metabolite; PPARalpha agonist; vulnerary
chlorogenic acid caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.	2.07	1	cinnamate ester; tannin	food component; plant metabolite
fumonisin b2 fumonisin B2: produced by Fusarium moniliforme MRC 826; structure given in first source; has cancer-promoting ability. fumonisin B2 : A fumonisin that is (2S,3S,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,14,15-triol in which the hydroxy groups at positions 14 and 15 have each been esterified by condensation with the 1-carboxy group of 3-carboxyglutaric acid (giving a 3-carboxyglutarate ester group with R configuration in each case).	2.07	1	diester; diol; fumonisin; primary amino compound	Aspergillus metabolite; carcinogenic agent
lincomycin Lincomycin: An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.. lincomycin : A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.	2.07	1	carbohydrate-containing antibiotic; L-proline derivative; monocarboxylic acid amide; pyrrolidinecarboxamide; S-glycosyl compound	antimicrobial agent; bacterial metabolite
valinomycin Valinomycin: A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.. valinomycin : A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.	2.07	1	cyclodepsipeptide; macrocycle	antimicrobial agent; antiviral agent; bacterial metabolite; potassium ionophore
orlistat Orlistat: A lactone derivative of LEUCINE that acts as a pancreatic lipase inhibitor to limit the absorption of dietary fat; it is used in the management of obesity.. orlistat : A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.	2.07	1	beta-lactone; carboxylic ester; formamides; L-leucine derivative	anti-obesity agent; bacterial metabolite; EC 2.3.1.85 (fatty acid synthase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor
12-deoxyphorbolphenylacetate-20-acetate [no description available]	2.07	1
brassinin [no description available]	2.07	1	dithiocarbamic ester; indole phytoalexin
chaetomellic acid a chaetomellic acid A: structure given in first source; an inhibitor of farnesyl-protein transferase	2.07	1
hirsutine [no description available]	2.07	1
3-deoxyvasicine, hydrochloride [no description available]	2.07	1
emetine dihydrochloride emetine dihydrochloride : The dihydrochloride salt of emetine.. emetine dihydrochloride hydrate : A hydrate that is the monohydrate of the dihydrochloride salt of emetine.	2.07	1	hydrochloride	anticoronaviral agent; antimalarial; antineoplastic agent; antiprotozoal drug; antiviral agent; autophagy inhibitor; emetic; protein synthesis inhibitor
salinomycin salinomycin: from Streptomyces albus; RN given refers to parent cpd; structure	2.07	1	polyketide; spiroketal	animal growth promotant; potassium ionophore
silybin [no description available]	2.07	1
5,6-dehydrokawain 5,6-dehydrokawain: from Alpinia speciosa rhizoma; RN given for cpd without isomeric designation; structure given in first source	2.07	1	2-pyranones; aromatic ether
9,10-dihydrolysergol 9,10-dihydrolysergol: RN given refers to cpd without isomeric designation	2.07	1
geranylgeranic acid geranylgeranic acid: RN given refers to cpd without isomeric designation. (2E,6E,10E)-geranylgeranic acid : A diterpenoid obtained by formal oxidation of the CH2OH group of (E,E,E)-geranylgeraniol to the corresponding carboxylic acid.	2.07	1	alpha,beta-unsaturated monocarboxylic acid; diterpenoid; methyl-branched fatty acid; trienoic fatty acid
quercetin [no description available]	2.07	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.07	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
dinoprost Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.. prostaglandin F2alpha : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.	2.07	1	monocarboxylic acid; prostaglandins Falpha	human metabolite; mouse metabolite
biochanin a [no description available]	2.07	1	4'-methoxyisoflavones; 7-hydroxyisoflavones	antineoplastic agent; EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
formononetin [no description available]	2.07	1	4'-methoxyisoflavones; 7-hydroxyisoflavones	phytoestrogen; plant metabolite
prostaglandin b1 prostaglandin Bx: phospholipase A2 inhibitor; polymeric derivative of diketo-PGB1; mean MW 2,200. prostaglandin B1 : A member of the class of prostaglandins B that is prosta-8(12),13-dien-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 13E,15S-stereoisomer).	2.07	1	prostaglandins B	human metabolite
sterigmatocystin [no description available]	2.07	1	sterigmatocystins	metabolite
vitexin [no description available]	2.07	1	C-glycosyl compound; trihydroxyflavone	antineoplastic agent; EC 3.2.1.20 (alpha-glucosidase) inhibitor; plant metabolite; platelet aggregation inhibitor
acacetin 5,7-dihydroxy-4'-methoxyflavone : A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.	2.07	1	dihydroxyflavone; monomethoxyflavone	anticonvulsant; plant metabolite
apigenin Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.	2.07	1	trihydroxyflavone	antineoplastic agent; metabolite
luteolin [no description available]	2.07	1	3'-hydroxyflavonoid; tetrahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist
quercitrin [no description available]	2.07	1	alpha-L-rhamnoside; monosaccharide derivative; quercetin O-glycoside; tetrahydroxyflavone	antileishmanial agent; antioxidant; EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.14.18.1 (tyrosinase) inhibitor; plant metabolite
scopoletin [no description available]	2.07	1	hydroxycoumarin	plant growth regulator; plant metabolite
hymecromone Hymecromone: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID.	2.07	1	hydroxycoumarin	antineoplastic agent; hyaluronic acid synthesis inhibitor
alprostadil [no description available]	2.07	1	prostaglandins E	anticoagulant; human metabolite; platelet aggregation inhibitor; vasodilator agent
quercetin 3-o-glucopyranoside quercetin 3-O-glucopyranoside: structure in first source. quercetin 3-O-beta-D-glucopyranoside : A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells	2.07	1	beta-D-glucoside; monosaccharide derivative; quercetin O-glucoside; tetrahydroxyflavone	antineoplastic agent; antioxidant; antipruritic drug; bone density conservation agent; geroprotector; histamine antagonist; osteogenesis regulator; plant metabolite
rutin Hydroxyethylrutoside: Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.	2.07	1	disaccharide derivative; quercetin O-glucoside; rutinoside; tetrahydroxyflavone	antioxidant; metabolite
kaempferol [no description available]	2.07	1	7-hydroxyflavonol; flavonols; tetrahydroxyflavone	antibacterial agent; geroprotector; human blood serum metabolite; human urinary metabolite; human xenobiotic metabolite; plant metabolite
senecionine senecionine: RN given refers to parent cpd; structure. senecionine : A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio.	2.07	1	lactone; pyrrolizidine alkaloid; tertiary alcohol	plant metabolite
genistein [no description available]	2.07	1	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	2.07	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
butein [no description available]	2.07	1	chalcones; polyphenol	antineoplastic agent; antioxidant; EC 1.1.1.21 (aldehyde reductase) inhibitor; geroprotector; hypoglycemic agent; plant metabolite; radiosensitizing agent; tyrosine kinase inhibitor
sulfuretin sulfuretin: the chalcone C ring closes into a 5 instead of the more typical 6 membered ring leaving a phenyl methane at the 2 position instead of the typical phenyl	2.07	1	1-benzofurans
genistin genistin: glycoside of soy bean isoflavone, gentistein	2.07	1	7-hydroxyisoflavones 7-O-beta-D-glucoside
chartreusin chartreusin: structure	2.07	1	benzochromenone; glycoside
methysticin [no description available]	2.07	1	2-pyranones; aromatic ether
yangonin yangonin: structure in first source	2.07	1	2-pyranones; aromatic ether
zearalenone Zearalenone: (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione. One of a group of compounds known under the general designation of resorcylic acid lactones. Cis, trans, dextro and levo forms have been isolated from the fungus Gibberella zeae (formerly Fusarium graminearum). They have estrogenic activity, cause toxicity in livestock as feed contaminant, and have been used as anabolic or estrogen substitutes.. zearalenone : A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.	2.07	1	macrolide; resorcinols	fungal metabolite; mycoestrogen
baicalein [no description available]	2.07	1	trihydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 4.1.1.17 (ornithine decarboxylase) inhibitor; ferroptosis inhibitor; geroprotector; hormone antagonist; plant metabolite; prostaglandin antagonist; radical scavenger
chrysin chrysin : A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.	2.07	1	7-hydroxyflavonol; dihydroxyflavone	anti-inflammatory agent; antineoplastic agent; antioxidant; EC 2.7.11.18 (myosin-light-chain kinase) inhibitor; hepatoprotective agent; plant metabolite
datiscetin datiscetin : A tetrahydroxyflavone that is 7-hydroxyflavonol bearing two additional hydroxy substituents at positions 2' and 5.	2.07	1	7-hydroxyflavonol; tetrahydroxyflavone
diosmetin [no description available]	2.07	1	3'-hydroxyflavonoid; monomethoxyflavone; trihydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; antioxidant; apoptosis inducer; bone density conservation agent; cardioprotective agent; plant metabolite; tropomyosin-related kinase B receptor agonist; vasodilator agent
diosmin [no description available]	2.07	1	dihydroxyflavanone; disaccharide derivative; glycosyloxyflavone; monomethoxyflavone; rutinoside	anti-inflammatory agent; antioxidant
fisetin [no description available]	2.07	1	3'-hydroxyflavonoid; 7-hydroxyflavonol; tetrahydroxyflavone	anti-inflammatory agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; metabolite; plant metabolite
galangin 5,7-dihydroxyflavonol: antimicrobial from the twigs of Populus nigra x Populus deltoides; structure in first source. galangin : A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.	2.07	1	7-hydroxyflavonol; trihydroxyflavone	antimicrobial agent; EC 3.1.1.3 (triacylglycerol lipase) inhibitor; plant metabolite
3-methylquercetin isorhamnetin : A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.	2.07	1	7-hydroxyflavonol; monomethoxyflavone; tetrahydroxyflavone	anticoagulant; EC 1.14.18.1 (tyrosinase) inhibitor; metabolite
morin morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria). morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.	2.07	1	7-hydroxyflavonol; pentahydroxyflavone	angiogenesis modulating agent; anti-inflammatory agent; antibacterial agent; antihypertensive agent; antineoplastic agent; antioxidant; EC 5.99.1.2 (DNA topoisomerase) inhibitor; hepatoprotective agent; metabolite; neuroprotective agent
myricetin [no description available]	2.07	1	7-hydroxyflavonol; hexahydroxyflavone	antineoplastic agent; antioxidant; cyclooxygenase 1 inhibitor; food component; geroprotector; hypoglycemic agent; plant metabolite
rhamnetin rhamnetin: aglycone of xanthorhamnin; from Rhamnus. rhamnetin : A monomethoxyflavone that is quercetin methylated at position 7.	2.07	1	monomethoxyflavone; tetrahydroxyflavone	anti-inflammatory agent; antioxidant; metabolite
robinetin robinetin: structure given in first source. robinetin : A pentahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 7, 3, 4' and 5'.	2.07	1	7-hydroxyflavonol; pentahydroxyflavone	plant metabolite
tamarixetin tamarixetin: isolated from Costsus spicatus. tamarixetin : A monomethoxyflavone that is quercetin methylated at position O-4'. Isolated from Cyperus teneriffae.	2.07	1	7-hydroxyflavonol; monomethoxyflavone; tetrahydroxyflavone	antioxidant; metabolite
wogonin wogonin: structure in first source. wogonin : A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.	2.07	1	dihydroxyflavone; monomethoxyflavone	angiogenesis inhibitor; antineoplastic agent; cyclooxygenase 2 inhibitor; plant metabolite
coumestrol Coumestrol: A daidzein derivative occurring naturally in forage crops which has some estrogenic activity.. coumestrol : A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.	2.07	1	coumestans; delta-lactone; polyphenol	anti-inflammatory agent; antioxidant; plant metabolite
daidzein [no description available]	2.07	1	7-hydroxyisoflavones	antineoplastic agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; phytoestrogen; plant metabolite
caffeic acid phenethyl ester phenethyl caffeate : An alkyl caffeate ester in which 2-phenylethyl is the alkyl component.	2.07	1	alkyl caffeate ester	anti-inflammatory agent; antibacterial agent; antineoplastic agent; antioxidant; antiviral agent; immunomodulator; metabolite; neuroprotective agent
rosmarinic acid rosmarinic acid: RN given refers to parent cpd; promote OT project. (R)-rosmarinic acid : A stereoisomer of rosmarinic acid having (R)-configuration.. rosmarinic acid : The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.	2.07	1	rosmarinic acid	geroprotector; plant metabolite
wedelolactone wedelolactone: antihepatotoxic coumestan from Eclipta prostrata and Wedelia calendulacea (both Asteraceae); structure given in first source. wedelolactone : A member of the class of coumestans that is coumestan with hydroxy substituents as positions 1, 8 and 9 and a methoxy substituent at position 3.	2.07	1	aromatic ether; coumestans; delta-lactone; polyphenol	antineoplastic agent; apoptosis inducer; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; hepatoprotective agent; metabolite
rottlerin rottlerin: an angiogenesis inhibitor; an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III; RN refers to (E)-isomer; do not confuse this chalcone with an anthraquinone that is also called rottlerin (RN 481-72-1);. rottlerin : A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.	2.07	1	aromatic ketone; benzenetriol; chromenol; enone; methyl ketone	anti-allergic agent; antihypertensive agent; antineoplastic agent; apoptosis inducer; K-ATP channel agonist; metabolite
ellagic acid [no description available]	2.07	1	catechols; cyclic ketone; lactone; organic heterotetracyclic compound; polyphenol	antioxidant; EC 1.14.18.1 (tyrosinase) inhibitor; EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor; EC 2.4.1.1 (glycogen phosphorylase) inhibitor; EC 2.5.1.18 (glutathione transferase) inhibitor; EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor; EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor; EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; food additive; fungal metabolite; geroprotector; plant metabolite; skin lightening agent
7-hydroxyflavone 7-hydroxyflavone : A hydroxyflavonoid in which the flavone nucleus is substituted at position 7 by a hydroxy group.	2.07	1	hydroxyflavonoid
prostaglandin a1 [no description available]	2.07	1	prostaglandins A
cerulenin Cerulenin: An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.. cerulenin : An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.	2.07	1	epoxide; monocarboxylic acid amide	antifungal agent; antiinfective agent; antilipemic drug; antimetabolite; antimicrobial agent; fatty acid synthesis inhibitor
rhoifolin rhoifolin: from many plants. apigenin 7-O-neohesperidoside : An apigenin derivative having an alpha-(1->2)-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group.	2.07	1	dihydroxyflavone; glycosyloxyflavone; neohesperidoside	metabolite
vitexin rhamnoside 2''-O-rhamnopyranosylvitexin: has both analgesic and anti-inflammatory activities; isolated from Alternanthera maritima; structure in first source. vitexin 2''-O-alpha-L-rhamnoside : A derivative of vitexin having an alpha-L-rhamnosyl residue attached at the 2''-position of the glucitol moiety.	2.07	1	C-glycosyl compound; disaccharide derivative; trihydroxyflavone	plant metabolite
domoic acid domoic acid: kainic acid analog, heterocyclic amino acid from seaweed; RN given refers to parent cpd; structure. domoic acid : An L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is produced by the diatomic algal Pseudo-nitzschia. It is an analogue of kainic acid and a neurotoxin which causes amnesic shellfish poisoning (ASP).	2.07	1	L-proline derivative; non-proteinogenic L-alpha-amino acid; pyrrolidinecarboxylic acid; tricarboxylic acid	algal metabolite; hapten; marine metabolite; neuromuscular agent; neurotoxin
isotretinoin Isotretinoin: A topical dermatologic agent that is used in the treatment of ACNE VULGARIS and several other skin diseases. The drug has teratogenic and other adverse effects.. isotretinoin : A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases.	2.07	1	retinoic acid	antineoplastic agent; keratolytic drug; teratogenic agent
cyclosporine ramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MF	2.07	1	homodetic cyclic peptide	anti-asthmatic drug; anticoronaviral agent; antifungal agent; antirheumatic drug; carcinogenic agent; dermatologic drug; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; geroprotector; immunosuppressive agent; metabolite
natamycin [no description available]	2.07	1	antibiotic antifungal drug; dicarboxylic acid monoester; epoxide; macrolide antibiotic; monosaccharide derivative; polyene antibiotic	antifungal agrochemical; antimicrobial food preservative; apoptosis inducer; bacterial metabolite; ophthalmology drug
sirolimus Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.. sirolimus : A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.	2.07	1	antibiotic antifungal drug; cyclic acetal; cyclic ketone; ether; macrolide lactam; organic heterotricyclic compound; secondary alcohol	antibacterial drug; anticoronaviral agent; antineoplastic agent; bacterial metabolite; geroprotector; immunosuppressive agent; mTOR inhibitor
brefeldin a [no description available]	2.07	1	macrolide antibiotic	Penicillium metabolite
cytochalasin b Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.. cytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.	2.07	1	cytochalasin; lactam; lactone; organic heterotricyclic compound	actin polymerisation inhibitor; metabolite; mycotoxin; platelet aggregation inhibitor
vinorelbine [no description available]	2.07	1	acetate ester; methyl ester; organic heteropentacyclic compound; organic heterotetracyclic compound; ring assembly; vinca alkaloid	antineoplastic agent; photosensitizing agent
bisdemethoxycurcumin curcumin III: structure in first source. bisdemethoxycurcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups.	2.07	1	beta-diketone; diarylheptanoid; enone; polyphenol	EC 3.2.1.1 (alpha-amylase) inhibitor; metabolite
andrographolide [no description available]	2.07	1	carbobicyclic compound; gamma-lactone; labdane diterpenoid; primary alcohol; secondary alcohol	anti-HIV agent; anti-inflammatory drug; antineoplastic agent; metabolite
isorhamnetin 3-o-glucoside isorhamnetin 3-O-glucoside: from the flowers of Persea gratissima; structure in first source. isorhamnetin 3-O-beta-D-glucopyranoside : A glycosyloxyflavone that is isorhamnetin substituted at position 3 by a beta-D-glucosyl residue.	2.07	1	beta-D-glucoside; glycosyloxyflavone; monomethoxyflavone; monosaccharide derivative; trihydroxyflavone	metabolite
6,7-dihydroxyflavone 6,7-dihydroxyflavone: intensifies effect of antibiotics on Staphylococcus aureus; structure in first source	2.07	1
flavokawain a flavokawain A: from kava extract, induces apoptosis in bladder cancer cells; structure in first source	2.07	1	chalcones
flavokawain b flavokawain B: from Piper methysticum Forst (Kava Kava) roots; structure in first source. flavokawain B : A member of the class of chalcones that consists of trans-chalcone substituted by hydroxy group at positions 2' and methoxy groups at positions 4' and 6'. Isolated from Piper methysticum and Piper rusbyi, it exhibits antileishmanial, anti-inflammatory and antineoplastic activities.	2.07	1	chalcones; dimethoxybenzene; phenols	anti-inflammatory agent; antileishmanial agent; antineoplastic agent; apoptosis inducer; metabolite
kavain [no description available]	2.07	1	racemate	glycine receptor antagonist
abscisic acid, (+,-)-isomer 2-cis-abscisic acid : A member of the class of abscisic acids in which the double bond betweeen positions 2 and 3 has cis- (natural) geometry.	2.07	1	abscisic acids	abscisic acid receptor agonist
veratrine Veratrine: A voltage-gated sodium channel activator.	2.07	1	alkaloid
vinblastine sulfate [no description available]	2.07	1
catharanthine [no description available]	2.07	1	alkaloid ester; bridged compound; methyl ester; monoterpenoid indole alkaloid; organic heteropentacyclic compound; tertiary amino compound
cytochalasin e cytochalasin E: structure	2.07	1	cytochalasan alkaloid	metabolite
cytochalasin d [no description available]	2.07	1
sinomenine sinomenine: isolated from root of Sinomenium acutum; antirheumatic, antineuralgic	2.07	1	morphinane alkaloid
ecdysterone Ecdysterone: A steroid hormone that regulates the processes of MOLTING or ecdysis in insects. Ecdysterone is the 20-hydroxylated ECDYSONE.. 20-hydroxyecdysone : An ecdysteroid that is ecdysone substituted by a hydroxy group at position 20.	2.07	1	14alpha-hydroxy steroid; 20-hydroxy steroid; 22-hydroxy steroid; 25-hydroxy steroid; 2beta-hydroxy steroid; 3beta-sterol; ecdysteroid; phytoecdysteroid	animal metabolite; plant metabolite
bleomycin [no description available]	2.07	1	bleomycin	antineoplastic agent; metabolite
bakuchiol bakuchiol: chief component of Psoralea corylifolia Linn; structure	2.07	1
zerumbone zerumbone: RN given for (E,E,E)-isomer; structure in first source. zerumbone : A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.	2.07	1	cyclic ketone; sesquiterpenoid	anti-inflammatory agent; glioma-associated oncogene inhibitor; plant metabolite
solanesol solanesol : A nonaprenol that is hexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-ol substituted by 9 methyl groups at positions 3, 7, 11, 15, 19, 23, 27, 31 and 35 (the all-trans0stereoisomer).	2.07	1	nonaprenol; primary alcohol	plant metabolite
(1S,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-[oxo-(3,4,5-trimethoxyphenyl)methoxy]-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylic acid methyl ester [no description available]	2.07	1	yohimban alkaloid
n-caproylsphingosine N-(hexanoyl)sphing-4-enine : An N-acylsphingosine consisting of sphing-4-enine bearing a hexanoyl group on nitrogen.	2.07	1	N-acylsphingosine
monorden monorden: inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II	2.53	2	cyclic ketone; enone; epoxide; macrolide antibiotic; monochlorobenzenes; phenols	antifungal agent; metabolite; tyrosine kinase inhibitor
ginkgolide b [no description available]	2.07	1
homatropine hydrobromide, (endo-(+-)-isomer) [no description available]	2.07	1
hydrocotarnine hydrobromide [no description available]	2.07	1
salsolinol hydrobromide [no description available]	2.07	1
lasalocid sodium lasalocid sodium : The sodium salt of lasalocid. It is a veterinary ionophore antibiotic used for prevention and treatment of coccidiosis in poultry.	2.07	1	benzoates; organic sodium salt	coccidiostat; ionophore
sclerotiorin sclerotiorin: isolated from monoverticillate Penicillia; RN given for (R-(R,S-(E,E)))-isomer; structure in first source	2.07	1	azaphilone
himbacine himbacine: muscarine receptor antagonist; RN given refers to (3S-(3alpha,3aalpha,4beta(1E,2(2R,6S)),4abeta,8aalpha,9aalpha))-isomer; structure given in first source. himbacine : A piperidine alkaloid that is decahydronaphtho[2,3-c]furan-1(3H)-one substituted by a methyl group at position 3 and a 2-[(2R,6S)-1,6-dimethylpiperidin-2-yl]ethenyl group at position 4. It has been isolated from the bark of Australian magnolias.	2.07	1	gamma-lactone; organic heterotricyclic compound; piperidine alkaloid	muscarinic antagonist
ebelactone b ebelactone B: esterase inhibitor; structure given in first source; see also ebelactone A	2.07	1
3-o-methylbutein 3-O-methylbutein: RN given refers to (E)-isomer; structure given in first source	2.07	1	chalcones
thermozymocidin thermozymocidin: a serine palmitoyltransferase inhibitor; FTY720 is an analog	2.07	1	alpha-amino fatty acid; hydroxy monocarboxylic acid; non-proteinogenic alpha-amino acid; sphingoid	antifungal agent; antimicrobial agent; antineoplastic agent; apoptosis inducer; EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor; fungal metabolite; immunosuppressive agent
marein marein: hypoglycemic from Coreopsis tinctoria; structure in first source	2.07	1	flavonoids; glycoside
hydroxyachillin hydroxyachillin: isolated from Tanacetum microphyllum; structure given in first source	2.07	1	gamma-lactone
butylscopolammonium bromide Butylscopolammonium Bromide: Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract.	2.07	1
fumagillin [no description available]	2.07	1	antibiotic antifungal drug; carboxylic ester; dicarboxylic acid monoester; meroterpenoid; organooxygen heterocyclic antibiotic; spiro-epoxide	angiogenesis inhibitor; antibacterial drug; antimicrobial agent; antiprotozoal drug; fungal metabolite; methionine aminopeptidase 2 inhibitor
artesunate artesunic acid: RN given for (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,(2aR*))-isomer; succinic ester of artemether	2.07	1	artemisinin derivative; cyclic acetal; dicarboxylic acid monoester; hemisuccinate; semisynthetic derivative; sesquiterpenoid	antimalarial; antineoplastic agent; ferroptosis inducer
vilazodone hydrochloride [no description available]	2.41	1	hydrochloride	antidepressant; serotonergic agonist; serotonin uptake inhibitor
vilazodone vilazodone : A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder.	2.41	1	1-benzofurans; indoles; monocarboxylic acid amide; N-alkylpiperazine; N-arylpiperazine; nitrile	antidepressant; serotonergic agonist; serotonin uptake inhibitor
anisodamine [no description available]	2.07	1
bufalin bufalin: cardiotonic; powerful anesthetic & one of the active constituents of the Chinese drug ch'an su(senso); in Japan prepared from skin of Bufo bufo garfarizans; RN given refers to (3beta,5beta)-isomer. bufalin : A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo.	2.07	1	14beta-hydroxy steroid; 3beta-hydroxy steroid	animal metabolite; anti-inflammatory agent; antineoplastic agent; cardiotonic drug
alpha-solanine [no description available]	2.07	1	glycoalkaloid; organic heterohexacyclic compound; steroid saponin; trisaccharide derivative	antineoplastic agent; apoptosis inducer; phytotoxin; plant metabolite
apigenin-7-o-rutinoside [no description available]	2.07	1
gambogic acid gambogic acid: RN given refers to (1R-(1alpha,1(Z),3abeta,5alpha,11beta,14aS*))-isomer	2.07	1	pyranoxanthones	metabolite
bn 52020 [no description available]	2.07	1
bibr 1532 [no description available]	2.41	1
carmine carminic acid : A tetrahydroxyanthraquinone that is that is 1,3,4,6-tetrahydroxy-9,10-anthraquinone substituted by a methyl group at position 8, a carboxy group at position 7 and a 1,5-anhydro-D-glucitol moiety at position 2 via a C-glycosidic linkage. It is a natural dye isolated from several insects such as Dactylopius coccus.	2.07	1	C-glycosyl compound; monocarboxylic acid; tetrahydroxyanthraquinone	animal metabolite; histological dye
bavachinin bavachinin: do not confuse with bavachin	2.07	1	flavanones
grayanotoxin iii grayanotoxin III: from leaves of Leucothoe grayana (Ericaceae); RN refers to (3beta,6beta,14R)-isomer; structure given in first source	2.07	1
Dihydrotanshinone I dihydrotanshinone I: extracted from Radix Salviae	2.07	1	abietane diterpenoid	anticoronaviral agent
calcimycin Calcimycin: An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.	2.07	1	benzoxazole
cinobufagin cinobufagin: isolated from Chinese medicinal preparation ch'an su; derived from toad venom	2.07	1	steroid lactone
atropine sulfate [no description available]	2.07	1
cannogenin thevetoside cannogenin thevetoside: from Thevetia neriifolia; minor descriptor (75-84); on-line & Index Medicus search CARDENOLIDES (77-84), CARDANOLIDES (75-76); RN given refers to (3beta,5beta)-isomer	2.07	1	cardenolide glycoside
eriodictyol 7-O-beta-D-glucopyranoside [no description available]	2.07	1	beta-D-glucoside; flavanone glycoside; monosaccharide derivative; trihydroxyflavanone	plant metabolite; radical scavenger
hypocrellin a hypocrellin A: isolated from fungus Hypocrella bambusae sacc	2.07	1
dihydrorobinetin dihydrorobinetin: structure in first source	2.07	1
monensin [no description available]	2.07	1
fps-zm1 FPS-ZM1: a neuroprotective agent and RAGE receptor antagonist; structure in first source	3.73	2
minocycline Minocycline: A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.. minocycline : A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.	2.07	1
dicumarol Dicumarol: An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.	2.07	1	hydroxycoumarin	anticoagulant; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; Hsp90 inhibitor; vitamin K antagonist
citrinin Citrinin: Antibiotic and mycotoxin from Aspergillus niveus and Penicillium citrinum.	2.07	1
vulpinic acid vulpinic acid: RN given refers to cpd without isomeric designation; structure given in first source; vulpinic acid refers to (E)-isomer	2.07	1	butenolide
ajmaline [no description available]	2.07	1
stemofoline stemofoline: RN given for (2S-(2alpha,3beta,4beta,5alpha,5abeta,6beta,8abeta,9S*))-isomer; structure in first source	3.25	1
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	2.07	1	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor
alpha-cyclopiazonic acid [no description available]	2.07	1	alpha-cyclopiazonic acids
n(delta)-(5-methyl-4-oxo-2-imidazolin-2-yl)ornithine N(delta)-(5-methyl-4-oxo-2-imidazolin-2-yl)ornithine: RN given for (L)-isomer; structure in first source	3.25	1

Condition	Relationship Strength	Studies
Hand Foot and Mouth Disease [description not available]	2.11	1
Hand, Foot and Mouth Disease A mild, highly infectious viral disease of children, characterized by vesicular lesions in the mouth and on the hands and feet. It is caused by coxsackieviruses A.	2.11	1
Hepatocellular Carcinoma [description not available]	2.13	1
Cancer of Liver [description not available]	2.13	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.13	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.13	1
Degenerative Diseases, Central Nervous System [description not available]	3.06	1
Benign Neoplasms [description not available]	4.56	3
Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	3.06	1
Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.	3.06	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	4.56	3
Neurodegenerative Diseases Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.	3.06	1
Alloxan Diabetes [description not available]	2.25	1
Diabetic Glomerulosclerosis [description not available]	2.25	1
Diabetic Nephropathies KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.	2.25	1
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1
Cancer of Mouth [description not available]	2.31	1
Mouth Neoplasms Tumors or cancer of the MOUTH.	2.31	1
Cancer of Lung [description not available]	2.41	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.41	1
Acute Confusional Senile Dementia [description not available]	2.41	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.41	1
Depression Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.	2.41	1

matrine

Cross-References

Synonyms (46)

Research Excerpts

Overview

Pharmacokinetics

Bioavailability

Drug Classes (1)

Protein Targets (2)

Potency Measurements

Activation Measurements

Biological Processes (46)

Molecular Functions (11)

Ceullar Components (7)

Bioassays (331)

Research

Studies (30)

Market Indicators

Research Demand Index: 51.56

Study Types

matrine

Related Flora

Cross-References

Synonyms (46)

Research Excerpts

Overview

Pharmacokinetics

Bioavailability

Drug Classes (1)

Protein Targets (2)

Potency Measurements

Activation Measurements

Biological Processes (46)

Molecular Functions (11)

Ceullar Components (7)

Bioassays (331)

Research

Studies (30)

Market Indicators

Research Demand Index: 51.56

Study Types

Related Drugs (413)

Related Conditions (25)