Page last updated: 2024-11-11

cycloproparadicicol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

cycloproparadicicol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9820399
CHEMBL ID468439
SCHEMBL ID10149963
MeSH IDM0454829

Synonyms (3)

Synonym
CHEMBL468439
cycloproparadicicol
SCHEMBL10149963
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Heat shock protein HSP 90-betaHomo sapiens (human)ED500.16000.04500.10250.1600AID395896
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (23)

Processvia Protein(s)Taxonomy
telomere maintenance via telomeraseHeat shock protein HSP 90-betaHomo sapiens (human)
placenta developmentHeat shock protein HSP 90-betaHomo sapiens (human)
response to unfolded proteinHeat shock protein HSP 90-betaHomo sapiens (human)
virion attachment to host cellHeat shock protein HSP 90-betaHomo sapiens (human)
positive regulation of transforming growth factor beta receptor signaling pathwayHeat shock protein HSP 90-betaHomo sapiens (human)
regulation of protein ubiquitinationHeat shock protein HSP 90-betaHomo sapiens (human)
negative regulation of proteasomal ubiquitin-dependent protein catabolic processHeat shock protein HSP 90-betaHomo sapiens (human)
positive regulation of phosphoprotein phosphatase activityHeat shock protein HSP 90-betaHomo sapiens (human)
regulation of protein localizationHeat shock protein HSP 90-betaHomo sapiens (human)
negative regulation of apoptotic processHeat shock protein HSP 90-betaHomo sapiens (human)
positive regulation of nitric oxide biosynthetic processHeat shock protein HSP 90-betaHomo sapiens (human)
positive regulation of cell differentiationHeat shock protein HSP 90-betaHomo sapiens (human)
chaperone-mediated protein complex assemblyHeat shock protein HSP 90-betaHomo sapiens (human)
regulation of cell cycleHeat shock protein HSP 90-betaHomo sapiens (human)
chaperone-mediated protein foldingHeat shock protein HSP 90-betaHomo sapiens (human)
cellular response to interleukin-4Heat shock protein HSP 90-betaHomo sapiens (human)
supramolecular fiber organizationHeat shock protein HSP 90-betaHomo sapiens (human)
negative regulation of proteasomal protein catabolic processHeat shock protein HSP 90-betaHomo sapiens (human)
telomerase holoenzyme complex assemblyHeat shock protein HSP 90-betaHomo sapiens (human)
positive regulation of protein localization to cell surfaceHeat shock protein HSP 90-betaHomo sapiens (human)
cellular response to heatHeat shock protein HSP 90-betaHomo sapiens (human)
protein foldingHeat shock protein HSP 90-betaHomo sapiens (human)
protein stabilizationHeat shock protein HSP 90-betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (28)

Processvia Protein(s)Taxonomy
RNA bindingHeat shock protein HSP 90-betaHomo sapiens (human)
double-stranded RNA bindingHeat shock protein HSP 90-betaHomo sapiens (human)
protein bindingHeat shock protein HSP 90-betaHomo sapiens (human)
ATP bindingHeat shock protein HSP 90-betaHomo sapiens (human)
ATP hydrolysis activityHeat shock protein HSP 90-betaHomo sapiens (human)
protein kinase regulator activityHeat shock protein HSP 90-betaHomo sapiens (human)
kinase bindingHeat shock protein HSP 90-betaHomo sapiens (human)
protein kinase bindingHeat shock protein HSP 90-betaHomo sapiens (human)
MHC class II protein complex bindingHeat shock protein HSP 90-betaHomo sapiens (human)
nitric-oxide synthase regulator activityHeat shock protein HSP 90-betaHomo sapiens (human)
TPR domain bindingHeat shock protein HSP 90-betaHomo sapiens (human)
heat shock protein bindingHeat shock protein HSP 90-betaHomo sapiens (human)
ubiquitin protein ligase bindingHeat shock protein HSP 90-betaHomo sapiens (human)
peptide bindingHeat shock protein HSP 90-betaHomo sapiens (human)
identical protein bindingHeat shock protein HSP 90-betaHomo sapiens (human)
protein homodimerization activityHeat shock protein HSP 90-betaHomo sapiens (human)
histone deacetylase bindingHeat shock protein HSP 90-betaHomo sapiens (human)
ATP-dependent protein bindingHeat shock protein HSP 90-betaHomo sapiens (human)
protein folding chaperoneHeat shock protein HSP 90-betaHomo sapiens (human)
cadherin bindingHeat shock protein HSP 90-betaHomo sapiens (human)
protein dimerization activityHeat shock protein HSP 90-betaHomo sapiens (human)
tau protein bindingHeat shock protein HSP 90-betaHomo sapiens (human)
DNA polymerase bindingHeat shock protein HSP 90-betaHomo sapiens (human)
disordered domain specific bindingHeat shock protein HSP 90-betaHomo sapiens (human)
ATP-dependent protein folding chaperoneHeat shock protein HSP 90-betaHomo sapiens (human)
receptor ligand inhibitor activityHeat shock protein HSP 90-betaHomo sapiens (human)
histone methyltransferase bindingHeat shock protein HSP 90-betaHomo sapiens (human)
unfolded protein bindingHeat shock protein HSP 90-betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (23)

Processvia Protein(s)Taxonomy
COP9 signalosomeHeat shock protein HSP 90-betaHomo sapiens (human)
protein folding chaperone complexHeat shock protein HSP 90-betaHomo sapiens (human)
extracellular regionHeat shock protein HSP 90-betaHomo sapiens (human)
nucleusHeat shock protein HSP 90-betaHomo sapiens (human)
nucleoplasmHeat shock protein HSP 90-betaHomo sapiens (human)
cytoplasmHeat shock protein HSP 90-betaHomo sapiens (human)
mitochondrionHeat shock protein HSP 90-betaHomo sapiens (human)
cytosolHeat shock protein HSP 90-betaHomo sapiens (human)
cell surfaceHeat shock protein HSP 90-betaHomo sapiens (human)
membraneHeat shock protein HSP 90-betaHomo sapiens (human)
secretory granule lumenHeat shock protein HSP 90-betaHomo sapiens (human)
melanosomeHeat shock protein HSP 90-betaHomo sapiens (human)
neuronal cell bodyHeat shock protein HSP 90-betaHomo sapiens (human)
dendritic growth coneHeat shock protein HSP 90-betaHomo sapiens (human)
axonal growth coneHeat shock protein HSP 90-betaHomo sapiens (human)
perinuclear region of cytoplasmHeat shock protein HSP 90-betaHomo sapiens (human)
extracellular exosomeHeat shock protein HSP 90-betaHomo sapiens (human)
dynein axonemal particleHeat shock protein HSP 90-betaHomo sapiens (human)
ficolin-1-rich granule lumenHeat shock protein HSP 90-betaHomo sapiens (human)
protein-containing complexHeat shock protein HSP 90-betaHomo sapiens (human)
aryl hydrocarbon receptor complexHeat shock protein HSP 90-betaHomo sapiens (human)
HSP90-CDC37 chaperone complexHeat shock protein HSP 90-betaHomo sapiens (human)
perinuclear region of cytoplasmHeat shock protein HSP 90-betaHomo sapiens (human)
plasma membraneHeat shock protein HSP 90-betaHomo sapiens (human)
cytosolHeat shock protein HSP 90-betaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID506966Inhibition of HSP90-mediated antiapoptotic activity in human H69AR cells assessed as induction of PARP cleavage at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID395895Cytotoxicity against human MCF7 cells2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
Discovery and development of heat shock protein 90 inhibitors.
AID506961Inhibition of HSP90-mediated antiapoptotic activity in human SKI-AC3 cells assessed as increase in caspase-3 activity at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID506968Inhibition of HSP90-mediated antiapoptotic activity in human WBA cells assessed as induction of PARP cleavage at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID506584Binding affinity to HSP90 in human NCI-H526 cells at 1 uM after 24 hrs by fluorescence polarization assay2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID506971Inhibition of HSP90-mediated antiapoptotic activity in human WBA cells assessed as increase in caspase-7 activity at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID506963Inhibition of HSP90-mediated antiapoptotic activity in human H69AR cells assessed as induction of caspase-3 cleavage at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID506967Inhibition of HSP90-mediated antiapoptotic activity in human SKI-AC3 cells assessed as induction of PARP cleavage at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID506960Inhibition of HSP90-mediated antiapoptotic activity in human H69AR cells assessed as increase in caspase-3 activity at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID506969Inhibition of HSP90-mediated antiapoptotic activity in human H69AR cells assessed as increase in caspase-7 activity at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID395896Inhibition of Hsp902009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
Discovery and development of heat shock protein 90 inhibitors.
AID506585Inhibition of HSP90-mediated proliferation of human NCI-H526 cells at 1 uM after 96 hrs by sulforhodamine B assay2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID506964Inhibition of HSP90-mediated antiapoptotic activity in human SKI-AC3 cells assessed as induction of caspase-3 cleavage at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID506965Inhibition of HSP90-mediated antiapoptotic activity in human WBA cells assessed as induction of caspase-3 cleavage at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID506962Inhibition of HSP90-mediated antiapoptotic activity in human WBA cells assessed as increase in caspase-3 activity at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
AID506970Inhibition of HSP90-mediated antiapoptotic activity in human SKI-AC3 cells assessed as increase in caspase-7 activity at 10 uM after 48 hrs by Western blot analysis2007Nature chemical biology, Aug, Volume: 3, Issue:8
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.41 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]