Page last updated: 2024-10-24

inositol trisphosphate metabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. [GOC:mah]

Inositol trisphosphate (IP3) metabolic process is a fundamental signaling pathway that plays a crucial role in various cellular processes, including calcium signaling, cell growth, proliferation, and apoptosis. IP3 is a second messenger molecule generated from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by the enzyme phospholipase C (PLC). This hydrolysis is typically triggered by the activation of G protein-coupled receptors (GPCRs) or receptor tyrosine kinases (RTKs). Once produced, IP3 diffuses through the cytoplasm and binds to IP3 receptors (IP3Rs), which are ligand-gated calcium channels located on the endoplasmic reticulum (ER) membrane. Binding of IP3 to IP3Rs causes the channels to open, releasing calcium ions from the ER into the cytosol. This increase in cytosolic calcium concentration triggers a cascade of downstream signaling events that lead to various cellular responses. The metabolism of IP3 is tightly regulated to ensure proper signal transduction. IP3 is rapidly dephosphorylated by inositol polyphosphate 5-phosphatase (IPP5) to produce inositol 1,4,5-trisphosphate (IP4), which is further dephosphorylated by inositol polyphosphate 1-phosphatase (IPP1) to generate inositol 1,4-bisphosphate (IP2). IP2 can be further dephosphorylated to inositol monophosphate (IP1) and ultimately to inositol, which is recycled back to PIP2. The regulation of IP3 metabolism is critical for controlling calcium signaling and other cellular processes. Dysregulation of IP3 signaling has been implicated in a variety of diseases, including cancer, diabetes, and neurodegenerative disorders.'
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Proteins (2)

ProteinDefinitionTaxonomy
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQ66]Homo sapiens (human)
Inositol polyphosphate multikinaseAn inositol polyphosphate multikinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU5]Homo sapiens (human)

Compounds (16)

CompoundDefinitionClassesRoles
1,2-hexanoylphosphatidylcholine1,2-hexanoylphosphatidylcholine: RN given refers to cpd without isomeric designation
3',4'-dihydroxyflavone3',4'-dihydroxyflavone: inhibitors of arachidonic acid peroxidation
4',6-dihydroxyflavone4',6-dihydroxyflavone : A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 4' and 6.dihydroxyflavone
naringenin(S)-naringenin : The (S)-enantiomer of naringenin.(2S)-flavan-4-one;
naringenin
expectorant;
plant metabolite
eriodictyoleriodictyol : A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.

eriodictyol: structure
3'-hydroxyflavanones;
tetrahydroxyflavanone
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
acacetin5,7-dihydroxy-4'-methoxyflavone : A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.dihydroxyflavone;
monomethoxyflavone
anticonvulsant;
plant metabolite
apigeninChamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.trihydroxyflavoneantineoplastic agent;
metabolite
luteolin3'-hydroxyflavonoid;
tetrahydroxyflavone
angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
kaempferol7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone
antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
diosmetin3'-hydroxyflavonoid;
monomethoxyflavone;
trihydroxyflavone
angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
bone density conservation agent;
cardioprotective agent;
plant metabolite;
tropomyosin-related kinase B receptor agonist;
vasodilator agent
genkwaningenkwanin : A monomethoxyflavone that is apigenin in which the hydroxy group at position 7 is methylated.

genkwanin: structure
dihydroxyflavone;
monomethoxyflavone
metabolite
3-methylquercetinisorhamnetin : A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.7-hydroxyflavonol;
monomethoxyflavone;
tetrahydroxyflavone
anticoagulant;
EC 1.14.18.1 (tyrosinase) inhibitor;
metabolite
myricetin7-hydroxyflavonol;
hexahydroxyflavone
antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
rhamnetinrhamnetin : A monomethoxyflavone that is quercetin methylated at position 7.

rhamnetin: aglycone of xanthorhamnin; from Rhamnus
monomethoxyflavone;
tetrahydroxyflavone
anti-inflammatory agent;
antioxidant;
metabolite
4',7-dihydroxyflavone4',7-dihydroxyflavone : A dihydroxyflavone in which the two hydroxy substituents are located at positions 4' and 7.

4',7-dihydroxyflavone: inducer of nod gene
dihydroxyflavonemetabolite