An EC 1.14.17.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen and with reduced ascorbate as one donor, and incorporation of one atom of oxygen) inhibitor that interferes with the action of dopamine monooxygenase (EC 1.14.17.1).
ChEBI ID: 139339
| Member | Definition | Class |
|---|---|---|
| 4-hydroxybenzaldehyde | A hydroxybenzaldehyde that is benzaldehyde substituted with a hydroxy group at position C-4. | 4-hydroxybenzaldehyde |
| nepicastat | A member of the class of 1,3-dihydroimidazole-2-thiones that is 1,3-dihydro-2H-imidazole-2-thione in which one of the nitrogens is substituted by a 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl group while the carbon adjacent to it is substituted by an aminomethyl group (the S enantiomer). It is a potent and selective inhibitor of both bovine and human dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. | nepicastat |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 16 (7.37) | 18.7374 |
| 1990's | 15 (6.91) | 18.2507 |
| 2000's | 61 (28.11) | 29.6817 |
| 2010's | 104 (47.93) | 24.3611 |
| 2020's | 21 (9.68) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (0.91%) | 5.53% |
| Reviews | 4 (1.82%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 214 (97.27%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 24.3667 | 4 | 4 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 4-aminobutyrate aminotransferase, mitochondrial | Homo sapiens (human) | IC50 | 16.5000 | 1 | 1 |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | IC50 | 1,000.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,082.5000 | 4 | 4 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 3.9900 | 1 | 1 |
| Succinate-semialdehyde dehydrogenase, mitochondrial | Homo sapiens (human) | IC50 | 24.7000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Nadph Dehydrogenase 1 | Saccharomyces cerevisiae (brewer's yeast) | Kd | 1.0000 | 1 | 1 |