Page last updated: 2024-12-11

stigmasterol 3-o-beta-d-glucopyranoside

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

stigmasterol 3-O-beta-D-glucopyranoside: an antioxidant from Monochoria vaginalis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

stigmasterol 3-O-beta-D-glucoside : A steroid saponin that is (3beta,22E)-stigmasta-5,22-dien-3-ol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It is isolated from Symplocos lancifolia. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Symplocosgenus[no description available]Symplocaceae[no description available]

Cross-References

ID SourceID
PubMed CID6602508
CHEMBL ID447335
CHEBI ID68383
MeSH IDM0517312

Synonyms (19)

Synonym
(2r,3r,4s,5s,6r)-2-[[(3s,8s,9s,10r,13r,14s,17r)-17-[(e,1r,4s)-4-ethyl-1,5-dimethyl-hex-2-enyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
stigmasta-5,22-dien-3-o-.beta.-d-glucopyranoside
stigma-5,22-dien-3-beta-d-glucopyranoside
stigmasterol 3-o-beta-d-glucopyranoside
3-o-beta-d-glucopyranosylstigmasterol
stigmasterol 3-o-beta-d-glucoside
chebi:68383 ,
CHEMBL447335 ,
(2r,3r,4s,5s,6r)-2-[[(3s,8s,9s,10r,13r,14s,17r)-17-[(e,2r,5s)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
(3beta,22e)-stigmasta-5,22-dien-3-yl beta-d-glucopyranoside
stigmasteryl 3-beta-d-glucoside
bdbm50357395
stigmasteryl-3-o-beta-d-glucopyranoside
AKOS037515192
Q27136880
HY-N1200
CS-0016492
MS-30354
DTXSID601289039
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
phytosterolsSterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond.
steroid saponinAny saponin derived from a hydroxysteroid.
beta-D-glucosideAny D-glucoside in which the anomeric centre has beta-configuration.
monosaccharide derivativeA carbohydrate derivative that is formally obtained from a monosaccharide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Dual specificity protein phosphatase 3Homo sapiens (human)IC50 (µMol)60.70004.00005.97508.5000AID630399
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (17)

Processvia Protein(s)Taxonomy
MAPK cascadeTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
dephosphorylationDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of cell migrationDual specificity protein phosphatase 3Homo sapiens (human)
peptidyl-tyrosine dephosphorylationDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of epidermal growth factor receptor signaling pathwayDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of MAPK cascadeDual specificity protein phosphatase 3Homo sapiens (human)
positive regulation of mitotic cell cycleDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of JNK cascadeDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of T cell receptor signaling pathwayDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of T cell activationDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of chemotaxisDual specificity protein phosphatase 3Homo sapiens (human)
regulation of focal adhesion assemblyDual specificity protein phosphatase 3Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeDual specificity protein phosphatase 3Homo sapiens (human)
cellular response to epidermal growth factor stimulusDual specificity protein phosphatase 3Homo sapiens (human)
positive regulation of focal adhesion disassemblyDual specificity protein phosphatase 3Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityDual specificity protein phosphatase 3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (11)

Processvia Protein(s)Taxonomy
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
protein tyrosine phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
protein bindingDual specificity protein phosphatase 3Homo sapiens (human)
cytoskeletal protein bindingDual specificity protein phosphatase 3Homo sapiens (human)
protein tyrosine/serine/threonine phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
myosin phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
protein kinase bindingDual specificity protein phosphatase 3Homo sapiens (human)
receptor tyrosine kinase bindingDual specificity protein phosphatase 3Homo sapiens (human)
MAP kinase phosphatase activityDual specificity protein phosphatase 3Homo sapiens (human)
protein tyrosine kinase bindingDual specificity protein phosphatase 3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (8)

Processvia Protein(s)Taxonomy
nucleoplasmTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
cytoplasmic side of plasma membraneTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
microtubule cytoskeletonTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
mitotic spindleTyrosine-protein phosphatase non-receptor type 7Homo sapiens (human)
immunological synapseDual specificity protein phosphatase 3Homo sapiens (human)
nucleusDual specificity protein phosphatase 3Homo sapiens (human)
nucleoplasmDual specificity protein phosphatase 3Homo sapiens (human)
cytosolDual specificity protein phosphatase 3Homo sapiens (human)
cytosolDual specificity protein phosphatase 3Homo sapiens (human)
cytoplasmDual specificity protein phosphatase 3Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID336444Antitrypanosomal activity against Trypanosoma brucei brucei S427 blood stream trypomastigotes2002Journal of natural products, Oct, Volume: 65, Issue:10
Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanes.
AID336446Antileishmanial activity against Leishmania donovani (MHOM/ET/67/L82) promastigotes2002Journal of natural products, Oct, Volume: 65, Issue:10
Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanes.
AID336445Cytotoxicity against human KB cells2002Journal of natural products, Oct, Volume: 65, Issue:10
Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanes.
AID489305Antituberculosis activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 2 weeks by microbroth dilution method2010Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum.
AID630402Inhibition of GST-tagged human HePTP using pNpp as substrate after 30 mins2011Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22
Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2.
AID630399Inhibition of GST-tagged human VHR using pNpp as substrate after 30 mins2011Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22
Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2.
AID630398Inhibition of GST-tagged human SHP2 N-terminal SH2 domain deficient mutant PTP activity using pNpp as substrate after 30 mins2011Bioorganic & medicinal chemistry letters, Nov-15, Volume: 21, Issue:22
Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2.
AID356414Induction of NADPH:quinone reductase activity in mouse Hepa-1c1c7 cells assessed as drug level required to double specific enzyme activity2003Journal of natural products, Sep, Volume: 66, Issue:9
Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.
AID336443Antiprotozoal activity against Plasmodium falciparum K12002Journal of natural products, Oct, Volume: 65, Issue:10
Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanes.
AID489306Antituberculosis activity against Mycobacterium tuberculosis H37Rv ATCC 27294 in stationary phase culture at pH 5.8 up to 200 ug/ml after 3 days followed by washout from day 4 to week 4 by microbroth dilution method2010Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14
In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's6 (54.55)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.91

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.91 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.39 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.91)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]