GTP binding

Definition

Target type: molecularfunction

Binding to GTP, guanosine triphosphate. [GOC:ai]

GTP binding is a fundamental molecular interaction that plays a crucial role in a wide range of cellular processes. GTP, or guanosine triphosphate, is a nucleotide that serves as an energy source and a signaling molecule. The process of GTP binding involves the specific recognition and interaction of a protein with the GTP molecule. This interaction is mediated by a GTP-binding domain, a conserved structural motif found in many proteins. The GTP-binding domain typically consists of a series of alpha helices and beta sheets that form a pocket for the GTP molecule to bind. The interaction between the protein and GTP is highly specific and is driven by electrostatic interactions, hydrogen bonds, and van der Waals forces. The binding of GTP to the protein often triggers a conformational change, which can activate or deactivate the protein's function. This switch-like mechanism is essential for regulating protein activity and controlling cellular processes. The hydrolysis of GTP to GDP (guanosine diphosphate) is another important aspect of GTP binding. GTP hydrolysis is catalyzed by the GTPase activity of the protein, which breaks the phosphate bond in GTP and releases energy. The release of energy can be used to drive various cellular processes, such as protein translocation, vesicle trafficking, and signal transduction. In addition to its role in protein regulation, GTP binding is also involved in the assembly and disassembly of macromolecular structures, such as ribosomes and cytoskeletal filaments. The binding and hydrolysis of GTP can modulate the dynamic interactions between these structures, enabling them to adapt to changing cellular conditions.'
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Proteins (68)

Compounds (529)