protein-containing complex binding

Definition

Target type: molecularfunction

Binding to a macromolecular complex. [GOC:jl]

Protein-containing complex binding refers to the interaction of a protein with a complex composed of multiple protein subunits. These complexes can range in size and complexity, from simple dimers to large multi-protein assemblies. The molecular function of protein-containing complex binding encompasses a wide variety of interactions, including:

- **Recognition and binding:** Proteins can recognize and bind to specific protein complexes through interactions with their surface residues, including hydrophobic patches, electrostatic interactions, and hydrogen bonding. These interactions are often highly specific and are critical for mediating protein-protein interactions within the complex.
- **Scaffolding and assembly:** Some proteins act as scaffolds, providing a framework for the assembly of other proteins into functional complexes. These scaffold proteins can interact with multiple protein subunits, bringing them together in a specific spatial arrangement.
- **Regulation and control:** Protein-containing complex binding can play a crucial role in regulating the activity of proteins within the complex. Binding can alter the conformation or stability of a protein, influencing its enzymatic activity, signaling function, or other properties.
- **Signal transduction:** Protein-containing complexes are often involved in signal transduction pathways, where they act as intermediaries between different signaling molecules. Binding to specific complexes can trigger downstream signaling events, leading to cellular responses.
- **Cellular localization and trafficking:** Protein-containing complex binding can regulate the localization and trafficking of proteins within the cell. Interactions with specific complexes can target proteins to specific compartments or facilitate their movement between different locations.
- **Multi-protein complex formation:** Protein-containing complex binding is essential for the formation of multi-protein complexes, which carry out a diverse range of functions in the cell. These complexes can be involved in processes such as DNA replication, transcription, translation, and metabolism.

In summary, protein-containing complex binding is a fundamental molecular interaction that plays a crucial role in a variety of cellular processes. It allows proteins to recognize, assemble, regulate, and interact with other proteins within complex assemblies, ultimately contributing to the coordination and execution of cellular functions.'
"

Proteins (92)

Compounds (1,620)